HUE045469T2 - Aeroszolizált levofloxacin alkalmazása cysticus fibrosis kezelésére - Google Patents

Aeroszolizált levofloxacin alkalmazása cysticus fibrosis kezelésére

Info

Publication number
HUE045469T2
HUE045469T2 HUE10814595A HUE10814595A HUE045469T2 HU E045469 T2 HUE045469 T2 HU E045469T2 HU E10814595 A HUE10814595 A HU E10814595A HU E10814595 A HUE10814595 A HU E10814595A HU E045469 T2 HUE045469 T2 HU E045469T2
Authority
HU
Hungary
Prior art keywords
treatment
cystic fibrosis
aerosolized levofloxacin
levofloxacin
aerosolized
Prior art date
Application number
HUE10814595A
Other languages
English (en)
Hungarian (hu)
Inventor
Jefferey Loutit
Elizabeth Morgan
Michael Dudley
David Griffith
Olga Lomovskaya
Original Assignee
Horizon Orphan Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43649672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE045469(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Horizon Orphan Llc filed Critical Horizon Orphan Llc
Publication of HUE045469T2 publication Critical patent/HUE045469T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE10814595A 2009-09-04 2010-09-03 Aeroszolizált levofloxacin alkalmazása cysticus fibrosis kezelésére HUE045469T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24009209P 2009-09-04 2009-09-04
US24923109P 2009-10-06 2009-10-06

Publications (1)

Publication Number Publication Date
HUE045469T2 true HUE045469T2 (hu) 2019-12-30

Family

ID=43649672

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE10814595A HUE045469T2 (hu) 2009-09-04 2010-09-03 Aeroszolizált levofloxacin alkalmazása cysticus fibrosis kezelésére

Country Status (26)

Country Link
US (4) US9700564B2 (instruction)
EP (2) EP2473170B1 (instruction)
JP (2) JP6180012B2 (instruction)
KR (1) KR20120100904A (instruction)
CN (1) CN102724983A (instruction)
AU (1) AU2010289326B2 (instruction)
BR (1) BR112012004692B8 (instruction)
CA (2) CA2938650C (instruction)
CL (1) CL2012000586A1 (instruction)
CY (1) CY1121883T1 (instruction)
DK (1) DK2473170T3 (instruction)
ES (1) ES2739979T3 (instruction)
HR (1) HRP20191408T1 (instruction)
HU (1) HUE045469T2 (instruction)
IL (1) IL218458A0 (instruction)
IN (1) IN2012DN02477A (instruction)
LT (1) LT2473170T (instruction)
MX (1) MX353288B (instruction)
NZ (1) NZ598484A (instruction)
PL (1) PL2473170T3 (instruction)
PT (1) PT2473170T (instruction)
RU (2) RU2563809C2 (instruction)
SI (1) SI2473170T1 (instruction)
SM (1) SMT201900440T1 (instruction)
WO (1) WO2011029059A1 (instruction)
ZA (1) ZA201202434B (instruction)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
KR20160150110A (ko) 2008-10-07 2016-12-28 랩터 파마슈티컬스 인코포레이티드 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
LT2473170T (lt) 2009-09-04 2019-10-10 Horizon Orphan Llc Aerozolizuoto levofloksacino panaudojimas cistinės fibrozės gydymui
EP3008088B1 (en) * 2013-06-13 2019-08-21 Research Institute at Nationwide Children's Hospital Compositions and methods for the treatment of burkholderia infections
CA2925293C (en) * 2013-09-24 2023-05-16 Universitat Zu Koln Compounds useful in the treatment of neoplastic diseases
AU2016303688B2 (en) 2015-07-31 2023-06-15 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
JP6966835B2 (ja) * 2016-02-05 2021-11-17 ホライズン オーファン リミテッド ライアビリティ カンパニー 嚢胞性線維症のためのフルオロキノロン製剤
CN110151793A (zh) * 2018-03-29 2019-08-23 中国人民解放军军事科学院军事医学研究院 鼠疫菌液体气溶胶肺递送感染小鼠模型
TWI848092B (zh) 2019-04-03 2024-07-11 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白調節劑
BR112022002604A2 (pt) 2019-08-14 2022-05-03 Vertex Pharma Processo de produção de moduladores de cftr
MX2022001828A (es) 2019-08-14 2022-06-08 Vertex Pharma Formas cristalinas de moduladores del regulador de conductancia transmembrana de la fibrosis quistica (cftr).
MX2023006770A (es) 2020-12-10 2023-08-14 Vertex Pharma Metodos de tratamiento para fibrosis quistica.
US11614795B2 (en) 2020-12-11 2023-03-28 International Business Machines Corporation Co-evolved user experience orchestrator
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung

Family Cites Families (268)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US696219A (en) 1901-08-23 1902-03-25 Paul Willemain Building containing acetylene-gas-generating apparatus.
US1014985A (en) 1908-12-22 1912-01-16 Luther H Van Zandt Semaphore.
US1023197A (en) 1910-11-21 1912-04-16 Ware Machine & Loom Company Picker-check.
US2587215A (en) 1949-04-27 1952-02-26 Frank P Priestly Inhalator
BE555319A (instruction) 1956-03-21 1900-01-01
US2858691A (en) 1956-09-04 1958-11-04 Mosler Lock Company Key changed tumbler clamp
BE556587A (instruction) 1957-01-31 1957-04-11
GB901107A (en) 1959-06-29 1962-07-11 Pfizer Therapeutic composition and method of preparing same
US3669113A (en) 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3507277A (en) 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3456646A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456645A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
US3456644A (en) 1967-01-19 1969-07-22 Dart Ind Inc Inhalation-actuated aerosol dispensing device
GB1268051A (en) 1968-06-07 1972-03-22 Fisons Pharmaceuticals Ltd Inhalation device
US3565070A (en) 1969-02-28 1971-02-23 Riker Laboratories Inc Inhalation actuable aerosol dispenser
US3636949A (en) 1969-08-08 1972-01-25 Armstrong Kropp Dev Corp Inhalation-initiated aerosol dispenser
BE758834A (fr) 1969-11-13 1971-05-12 Riker Laboratoires Inc Distributeur d'aerosol actionne par inhalation
GB1383761A (en) 1971-02-25 1974-02-12 Woodcraft Dc Inhalation device for use with an aerosol container
US3732864A (en) 1971-06-07 1973-05-15 Schering Corp Inhalation coordinated aerosol dispensing device
IT941426B (it) 1971-07-17 1973-03-01 Isf Spa Inalatore a camera di turbinio per sostanze medicamentose polveriformi
US3826255A (en) 1972-06-22 1974-07-30 Hudson Oxygen Therapy Sales Co Intermittent positive pressure breathing manifold
FR2224175B1 (instruction) 1973-04-04 1978-04-14 Isf Spa
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
IT1017153B (it) 1974-07-15 1977-07-20 Isf Spa Apparecchio per inalazioni
YU41046B (en) 1974-08-22 1986-10-31 Schering Ag Medicine inholating device
SU628930A1 (ru) 1974-11-26 1978-10-25 Московский научно-исследовательский институт туберкулеза Устройство дл введени порошкообразного лекарственного вещества
US3948264A (en) 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US4147166A (en) 1977-05-02 1979-04-03 American Cyanamid Company Oral inhalator powder dispenser
US4268460A (en) 1977-12-12 1981-05-19 Warner-Lambert Company Nebulizer
US4253468A (en) 1978-08-14 1981-03-03 Steven Lehmbeck Nebulizer attachment
US4263907A (en) 1979-05-14 1981-04-28 Lindsey Joseph W Respirator nebulizer
BR8007911A (pt) 1979-12-06 1981-06-16 Glaxo Group Ltd Inalador aperfeicoado
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
SE438261B (sv) 1981-07-08 1985-04-15 Draco Ab Anvendning i dosinhalator av ett perforerat membran
US4688218A (en) 1981-07-15 1987-08-18 Etablissement Public De Diffusion Dit "Telediffusion De France" Multiplex channels for continuous flow for numerical signal
US4470412A (en) 1982-03-19 1984-09-11 Trutek Research, Inc. Inhalation valve
US4510929A (en) 1982-04-30 1985-04-16 Bordoni Maurice E Disposable radioactive aerosol inhalation apparatus
US4730000A (en) 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4994599A (en) 1987-11-20 1991-02-19 Abbott Laboratories Intermediates for producing quinolone-3-carboxylic acids
US4649911A (en) 1983-09-08 1987-03-17 Baylor College Of Medicine Small particle aerosol generator for treatment of respiratory disease including the lungs
GB8328808D0 (en) 1983-10-28 1983-11-30 Riker Laboratories Inc Inhalation responsive dispensers
JPS60202822A (ja) 1984-03-28 1985-10-14 Dai Ichi Seiyaku Co Ltd 抗ウイルス薬
US4624251A (en) 1984-09-13 1986-11-25 Riker Laboratories, Inc. Apparatus for administering a nebulized substance
US4648393A (en) 1984-11-02 1987-03-10 Ackrad Laboratories, Inc. Breath activated medication spray
FR2575678B1 (fr) 1985-01-04 1988-06-03 Saint Gobain Vitrage Ejecteur pneumatique de poudre
US4805811A (en) 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
DK170473B1 (da) 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
GB2178965B (en) 1985-07-30 1988-08-03 Glaxo Group Ltd Devices for administering medicaments to patients
US4977154A (en) 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US4809692A (en) 1986-01-31 1989-03-07 Trudell Medical Pediatric asthmatic medication inhaler
IT1204826B (it) 1986-03-04 1989-03-10 Chiesi Farma Spa Composizioni farmaceutiche per inalazione
US4926852B1 (en) 1986-06-23 1995-05-23 Univ Johns Hopkins Medication delivery system phase one
US4790305A (en) 1986-06-23 1988-12-13 The Johns Hopkins University Medication delivery system
JPS63188627A (ja) 1987-01-31 1988-08-04 Rooto Seiyaku Kk 抗アレルギ−・抗炎症剤
DE3704907A1 (de) 1987-02-17 1988-08-25 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren in kombination mit kortikosteroiden
US5119806A (en) 1987-05-12 1992-06-09 Glaxo Inc. Inhalation device
KR910000142B1 (ko) 1987-05-29 1991-01-21 니혼 다바고 상교오 가부시기가이샤 담배용 필터
RO107257B1 (ro) 1987-07-09 1993-10-30 Pfizer Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US4907538A (en) 1988-05-09 1990-03-13 Little Suamico Products Inc. Multiple bin cow feeder
US4832015A (en) 1988-05-19 1989-05-23 Trudell Medical Pediatric asthmatic inhaler
IT1217890B (it) 1988-06-22 1990-03-30 Chiesi Farma Spa Dispositivo per l'inalazione di aerosol dosati
FR2636716B1 (fr) 1988-09-21 1990-12-07 Staubli Sa Ets Dispositif pour l'accouplement des platines porte-elements des raccords multiples
DE68914932T2 (de) 1988-10-04 1994-08-11 Univ Johns Hopkins Inhalationsgerät für Aerosolen.
DK479189D0 (da) 1989-01-06 1989-09-28 Hans Gernot Schenk Inhalator
US5012803A (en) 1989-03-06 1991-05-07 Trudell Medical Modular medication inhaler
US5012804A (en) 1989-03-06 1991-05-07 Trudell Medical Medication inhaler with adult mask
GB8908647D0 (en) 1989-04-17 1989-06-01 Glaxo Group Ltd Device
EP0470154B1 (en) 1989-04-28 1996-06-05 Riker Laboratories, Inc. Dry powder inhalation device
US4955371A (en) 1989-05-08 1990-09-11 Transtech Scientific, Inc. Disposable inhalation activated, aerosol device for pulmonary medicine
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
JP3153549B2 (ja) 1989-12-29 2001-04-09 アボツト・ラボラトリーズ キノロンカルボン酸―金属イオン―酸錯体
US5113855A (en) 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5192548A (en) 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
GB9015077D0 (en) 1990-07-09 1990-08-29 Riker Laboratories Inc Inhaler
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
IT1243344B (it) 1990-07-16 1994-06-10 Promo Pack Sa Inalatore plurimonodose per medicamenti in polvere
US5060643A (en) 1990-08-07 1991-10-29 Tenax Corporation Breath-activated inhalation device
FR2665635A1 (fr) 1990-08-10 1992-02-14 Merck Sharp & Dohme Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation.
GB9026025D0 (en) 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
US5258528A (en) 1990-11-30 1993-11-02 Warner-Lambert Company Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group
US5217004A (en) 1990-12-13 1993-06-08 Tenax Corporation Inhalation actuated dispensing apparatus
US5040527A (en) 1990-12-18 1991-08-20 Healthscan Products Inc. Metered dose inhalation unit with slide means
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
AU651882B2 (en) 1991-05-14 1994-08-04 Visiomed Group Limited Aerosol inhalation device
AU2017592A (en) 1991-06-10 1993-01-12 Schering Corporation Non-chlorofluorocarbon aerosol formulations
DE69233690T2 (de) 1991-07-02 2008-01-24 Nektar Therapeutics, San Carlos Abgabevorrichtung für nebelförmige Medikamente
IT1250691B (it) 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
DK0540775T3 (da) 1991-11-07 1997-08-25 Ritzau Pari Werk Gmbh Paul Forstøver især til anvendelse i apparater til inhalationsterapi
DE4140689B4 (de) 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
DE4142238A1 (de) 1991-12-20 1993-06-24 Boehringer Ingelheim Kg Pulverinhalator mit pulvertraeger aus regelmaessigen mikrostrukturen
ATE158951T1 (de) 1992-05-29 1997-10-15 Ggu Gesundheits Umweltforsch Vorrichtung zur erzeugung inhalierbarer wirkstoffpartikel
US5785049A (en) 1994-09-21 1998-07-28 Inhale Therapeutic Systems Method and apparatus for dispersion of dry powder medicaments
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
EG20543A (en) 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
NZ250105A (en) 1992-11-09 1996-07-26 Monaghan Canadian Ltd Inhalator mask; one-way valve opens upon exhalation
NZ259241A (en) 1992-12-18 1996-12-20 Schering Corp Inhaler including a counter ring, a nozzle to break powder agglomerates and spring-biased, bi-directionally rotatable metering plate and powder house
US5558085A (en) 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5934272A (en) 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5709202A (en) 1993-05-21 1998-01-20 Aradigm Corporation Intrapulmonary delivery of aerosolized formulations
US5532239A (en) 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US5388572A (en) 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5404781A (en) 1994-06-09 1995-04-11 Ko Shin Electric And Machinery Co., Ltd. Anti-sway means for a saw web
US5642730A (en) 1994-06-17 1997-07-01 Trudell Medical Limited Catheter system for delivery of aerosolized medicine for use with pressurized propellant canister
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
JP4484247B2 (ja) 1995-02-24 2010-06-16 エラン ファーマ インターナショナル，リミティド ナノ粒子分散体を含有するエアロゾル
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US6427682B1 (en) 1995-04-05 2002-08-06 Aerogen, Inc. Methods and apparatus for aerosolizing a substance
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
CZ294782B6 (cs) 1995-06-21 2005-03-16 Sofotec Gmbh & Co. Kg Inhalátor pro prášková léčiva
CA2176298C (en) 1995-06-27 2009-01-27 Dennis D. Copeland A single high dose fluoroquinolone treatment
AUPN417395A0 (en) 1995-07-14 1995-08-10 Techbase Pty. Ltd. An improved spacer
JP5042447B2 (ja) 1995-07-21 2012-10-03 第一三共株式会社 混合製剤
GB9515182D0 (en) 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
SE9502799D0 (sv) 1995-08-10 1995-08-10 Astra Ab Device in inhalers
CZ293747B6 (cs) 1995-12-21 2004-07-14 Pfizer Inc. Vodný farmaceutický roztok vhodný pro injekční podávání hostiteli a jeho použití
US5694920A (en) 1996-01-25 1997-12-09 Abrams; Andrew L. Inhalation device
US6026809A (en) 1996-01-25 2000-02-22 Microdose Technologies, Inc. Inhalation device
US5823179A (en) 1996-02-13 1998-10-20 1263152 Ontario Inc. Nebulizer apparatus and method
US6083922A (en) 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
FR2747311B1 (fr) 1996-04-10 1998-08-14 Pf Medicament Inhalateur a poudre et a air comprime
US6838552B1 (en) 1997-08-14 2005-01-04 Vanderbilt University Diagnosis and management of infection caused by Chlamydia
US6579854B1 (en) 1996-08-14 2003-06-17 Vanderbilt University Diagnosis and management of infection caused by chlamydia
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
CA2227314A1 (en) 1997-01-24 1998-07-24 Hoechst Aktiengesellschaft Preparation of concealed taste preparations of antibacterially active quinolone derivatives
US6349719B2 (en) 1997-02-24 2002-02-26 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US6006747A (en) 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6406880B1 (en) 1997-05-02 2002-06-18 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US6756369B2 (en) 1997-05-06 2004-06-29 Vanderbilt University Diagnosis and management of infection caused by Chlamydia
US6884784B1 (en) 1997-05-06 2005-04-26 Vanderbilt University Diagnosis and management of infection caused by chlamydia
US6664239B2 (en) 1997-05-06 2003-12-16 Vanderbilt University Diagnosis and management of infection caused by Chlamydia
US6890526B2 (en) 1997-05-06 2005-05-10 Vanderbilt University Methods and reagents for the treatment of multiple sclerosis
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US20010044584A1 (en) 1997-08-28 2001-11-22 Kensey Kenneth R. In vivo delivery methods and compositions
US6293279B1 (en) 1997-09-26 2001-09-25 Trudell Medical International Aerosol medication delivery apparatus and system
US20030082107A1 (en) 1997-10-01 2003-05-01 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating an infectious disease or cancer
CA2301569A1 (en) 1997-10-08 1999-04-15 Martin P. Redmon Dosage form for aerosol administration
US6003512A (en) 1997-11-13 1999-12-21 Lovelace Respiratory Research Institute Dust gun-aerosol generator and generation
DE1149602T1 (de) 1997-11-19 2002-04-04 Microflow Engineering S.A., Neuenburg/Neuchatel Sprühvorrichtung für einen für die Atemtherapie geeigneten Inhalator
ID21415A (id) 1997-12-05 1999-06-10 Upjohn Co Senyawa-senyawa antibiotik magnesium quinolon
US6192876B1 (en) 1997-12-12 2001-02-27 Astra Aktiebolag Inhalation apparatus and method
US6223746B1 (en) 1998-02-12 2001-05-01 Iep Pharmaceutical Devices Inc. Metered dose inhaler pump
US6026807A (en) 1998-02-27 2000-02-22 Diemolding Corporation Metered dose inhaler cloud chamber
GB9810299D0 (en) 1998-05-15 1998-07-15 Glaxo Group Ltd Use of nitric oxide synthase inhibitors
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
ES2234266T3 (es) 1998-07-24 2005-06-16 Jago Research Ag Formulaciones medicas para aerosoles.
CA2307632C (en) 1998-08-21 2007-05-22 Senju Pharmaceutical Co., Ltd. Aqueous liquid pharmaceutical composition
BR9914051A (pt) 1998-09-25 2001-06-19 Cubist Pharm Inc Métodos para administração de antibióticos
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
GB2343122B (en) 1998-10-26 2003-01-08 Medic Aid Ltd Improvements in and relating to nebulisers
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
US6584971B1 (en) 1999-01-04 2003-07-01 Medic-Aid Limited Drug delivery apparatus
US6350199B1 (en) 1999-03-16 2002-02-26 International Game Technology Interactive gaming machine and method with customized game screen presentation
US7919119B2 (en) 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6338443B1 (en) 1999-06-18 2002-01-15 Mercury Enterprises, Inc. High efficiency medical nebulizer
CA2282066C (en) 1999-06-29 2010-09-07 Smithkline Beecham Corporation Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
US20020061281A1 (en) 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6576224B1 (en) 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US6586008B1 (en) 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
JP4859320B2 (ja) 1999-10-29 2012-01-25 ネクター セラピューティックス 改良された分散性を有する乾燥粉末組成物
US6294178B1 (en) 1999-11-01 2001-09-25 Robert E. Weinstein Method and device for coordinating topical and oral sinusitis treatments
DK1225898T3 (da) 1999-11-01 2003-09-15 Alcon Inc Farmaceutisk præparat indeholdende et fluorquinolonantibiotisk lægemiddel og xanthangummi
US6962151B1 (en) 1999-11-05 2005-11-08 Pari GmbH Spezialisten für effektive Inhalation Inhalation nebulizer
US20010049366A1 (en) 2000-02-09 2001-12-06 Alcon Universal Ltd. Topical solution formulations containing an antibiotic and a corticosteroid
US6663890B2 (en) 2000-02-24 2003-12-16 Advancis Pharmaceutical Corp. Metronidazole antibiotic product, use and formulation thereof
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6667057B2 (en) 2000-02-24 2003-12-23 Advancis Pharmaceutical Corp. Levofloxacin antibiotic product, use and formulation thereof
US6667042B2 (en) 2000-02-24 2003-12-23 Advancis Pharmaceutical Corp. Fluroquinilone antibiotic product, use and formulation thereof
US6669948B2 (en) 2000-02-24 2003-12-30 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6730320B2 (en) 2000-02-24 2004-05-04 Advancis Pharmaceutical Corp. Tetracycline antibiotic product, use and formulation thereof
US6663891B2 (en) 2000-02-24 2003-12-16 Advancis Pharmaceutical Corp. Erythromyacin antibiotic product, use and formulation thereof
CA2406185C (en) 2000-04-11 2011-03-15 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
US20020076437A1 (en) 2000-04-12 2002-06-20 Sanjeev Kothari Flashmelt oral dosage formulation
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US6716819B2 (en) 2000-05-19 2004-04-06 University Of Iowa Research Foundation Use of xylitol to reduce ionic strength and activate endogenous antimicrobials for prevention and treatment of infections
PE20020044A1 (es) 2000-06-16 2002-01-30 Upjohn Co Tiazina oxazolidinona
US6492328B2 (en) 2000-06-28 2002-12-10 The University Of Iowa Research Foundation Novispirins: antimicrobial peptides
AU2001278864A1 (en) 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
WO2002007682A1 (en) 2000-07-26 2002-01-31 Vyden John K Methods for treating atopic disorders
AU2001286852A1 (en) 2000-08-29 2002-03-13 Chiron Corporation Quinoline antibacterial compounds and methods of use thereof
CN1247188C (zh) 2000-09-19 2006-03-29 第一制药株式会社 药物组合物
US6298656B1 (en) 2000-09-29 2001-10-09 Siemens Westinghouse Power Corporation Compressed air steam generator for cooling combustion turbine transition section
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6689769B2 (en) 2000-12-21 2004-02-10 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
US6626173B2 (en) 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
MXPA03008056A (es) 2001-03-05 2004-10-15 Johnson & Johnson Composiciones farmaceuticas liquidas con sabor oculto.
US6523536B2 (en) 2001-03-12 2003-02-25 Birdsong Medical Devices, Inc. Dual-canister inhaler having a spacer and easy to operate lever mechanism
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6589955B2 (en) 2001-06-20 2003-07-08 Bristol-Myers Squibb Company Pediatric formulation of gatifloxacin
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US20030138403A1 (en) 2001-06-29 2003-07-24 Maxygen Aps Interferon formulations
TR200401980T4 (tr) 2001-07-02 2004-09-21 Chiesi Farmaceutici S.P.A. Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu
AU2002350622B2 (en) 2001-10-24 2006-09-14 Pari Pharma Gmbh Kit for the preparation of a pharmaceutical composition
AU2002364562A1 (en) 2001-12-13 2003-06-30 Activbiotics, Inc. Metal complexes and formulations of rifamycin analogues and uses therof
US20030143265A1 (en) 2001-12-19 2003-07-31 Seiichi Araki Method for treatment of sepsis
US20030171340A1 (en) 2002-02-07 2003-09-11 Jenefir Isbister Methods of disease treatment using metal-complexed tetracycline antibiotics
CA2477979A1 (en) 2002-03-05 2003-09-18 Transave, Inc. An inhalation system for treatment of intracellular infections
US20050208124A1 (en) 2002-03-11 2005-09-22 Eisai Co., Ltd. Drugs containing riboflavin-type compounds
JP4290381B2 (ja) 2002-04-11 2009-07-01 学校法人 聖マリアンナ医科大学 ピリドンカルボン酸化合物含有エマルション
US7607436B2 (en) 2002-05-06 2009-10-27 The Research Foundation Of State University Of New York Methods, devices and formulations for targeted endobronchial therapy
CA2483914A1 (en) 2002-05-07 2003-11-20 Nektar Therapeutics Capsules for dry powder inhalers and methods of making and using same
US7423153B2 (en) 2002-05-10 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin
US20040045546A1 (en) 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
US20040152701A1 (en) 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
AU2003285625A1 (en) 2002-12-16 2004-07-09 Ranbaxy Laboratories Limited Pure levofloxacin hemihydrate and processes for preparation thereof
MXPA05007466A (es) 2003-01-09 2006-03-08 Arizeke Pharmaceuticals Inc Metodos para el tratamiento de enfermedades pulmonares.
NZ541681A (en) 2003-02-10 2009-02-28 Bayer Healthcare Ag Treatment of bacterial diseases of the respiratory organs by locally applying ciprofloxacin and its salts
US20060258677A1 (en) 2003-02-15 2006-11-16 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of gatifloxacin and processes for preparation
DK1459739T3 (da) 2003-03-19 2008-05-19 Jordanian Pharmaceutical Mfg Ikke-hydroskopiske farmaceutiske sammensætninger indeholdende ikke-hydratiserede quinolin-carboxylsyrer
DE10318235A1 (de) 2003-04-22 2004-11-11 Clariant Gmbh Leicht dispergierbare Pigmente mit schneller Farbstärkeentwicklung
US20070248693A1 (en) 2003-08-02 2007-10-25 Elizabeth Mazzio Nutraceutical composition and method of use for treatment / prevention of cancer
ES2622522T3 (es) 2003-08-26 2017-07-06 The Regents Of The University Of Colorado, A Body Corporate Inhibidores de la actividad proteasa de serina y su uso en métodos y composiciones para el tratamiento de infecciones bacterianas
SE0302665D0 (sv) 2003-10-07 2003-10-07 Astrazeneca Ab Novel Process
CN1312076C (zh) 2003-10-14 2007-04-25 长沙理工大学 应用铬铁合金为原料生产的陶瓷玻璃色料及其生产方法
RU2341267C2 (ru) 2003-10-15 2008-12-20 Пари Фарма Гмбх Жидкий препарат, содержащий тобрамицин
BRPI0416654A (pt) 2003-11-17 2007-01-16 Nektar Therapeutics introdução de aerossol a um circuito ventilador
US7452524B2 (en) 2004-01-27 2008-11-18 Gilead Sciences, Inc. Method for improvement of tolerance for therapeutically effective agents delivered by inhalation
EP1732527A2 (en) 2004-03-17 2006-12-20 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
US7148404B2 (en) 2004-05-04 2006-12-12 Novozymes A/S Antimicrobial polypeptides
WO2005113579A1 (en) 2004-05-21 2005-12-01 Mpex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors and methods of treating bacterial infections
US7632869B2 (en) 2004-05-24 2009-12-15 Bausch & Lomb Incorporated Antimicrobial compositions and uses thereof
AU2005258040A1 (en) 2004-06-21 2006-01-05 Novartis Ag Compositions comprising amphotericin b
DE602005020796D1 (de) 2004-07-22 2010-06-02 Bend Res Inc Geschmacksabdeckende formulierung mit einer retardierten wirkstoffformulierung und/oder schnell löslichem cyclodextrin
WO2006033713A2 (en) 2004-08-09 2006-03-30 Chiron Corporation Methods for ciprofloxacin inhalation
US7388077B2 (en) 2004-11-12 2008-06-17 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding the same
EP1841415A2 (en) 2005-01-20 2007-10-10 Sirtris Pharmaceuticals, Inc. Use of sirtuin-activating compounds for treating flushing and drug induced weight gain
CN101128206A (zh) 2005-01-21 2008-02-20 沃纳奇尔科特公司 固体剂型形式的四环素类金属络合物
US20090062404A1 (en) 2005-03-24 2009-03-05 Daiichi Sankyo Company, Limited Pharmaceutical composition
CA2603179A1 (en) 2005-04-05 2006-10-12 The Scripps Research Institute Compositions and methods for enhancing drug sensitivity and treating drug resistant infections and diseases
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
DK2594272T3 (en) * 2005-05-18 2018-09-03 Horizon Orphan Llc Aerosolized fluoroquinolones and their applications
MX2008000131A (es) 2005-07-01 2008-04-04 Cinv Ag Dispositivos medicos que comprenden un material compuesto reticulado.
AU2006326456A1 (en) 2005-12-14 2007-06-21 Activbiotics Pharma Llc Rifamycin analogs and uses thereof
WO2007085057A1 (en) 2006-01-25 2007-08-02 The Council Of The Queensland Institute Of Medical Research A medical protocol
US20070248581A1 (en) 2006-01-30 2007-10-25 The University Of Chicago Mgra is a redox regulator of antibiotic sensitivity and virulence
MX2008010222A (es) * 2006-02-10 2008-10-17 Pari Pharma Gmbh Antibioticos nebulizados para terapia de inhalacion.
US8193079B2 (en) 2006-02-10 2012-06-05 The Regents Of The University Of California Method for conductivity control of (Al,In,Ga,B)N
WO2007095187A2 (en) 2006-02-13 2007-08-23 Trustees Of Boston University Compositions and methods for antibiotic potentiation and drug discovery
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
SI2032521T1 (sl) 2006-06-27 2010-02-26 Sandoz Ag Nov postopek za pripravo soli
WO2008025560A1 (en) 2006-09-01 2008-03-06 Pari Pharma Gmbh Methods for taste masking of nebulised compositions for nasal and pulmonary inhalation therapy
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8080394B2 (en) 2007-04-27 2011-12-20 Brigham And Women's Hospital Method for determining predisposition to pulmonary infection
GB0719248D0 (en) 2007-10-03 2007-11-14 Generics Uk Ltd Compounds and methods for pharmaceutical use
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
US20090197212A1 (en) 2008-02-04 2009-08-06 Maxitrol Company Premix Burner Control System and Method
JP5727927B2 (ja) 2008-05-15 2015-06-03 ノバルティス アーゲー フルオロキノロンの肺送達
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
KR20160150110A (ko) * 2008-10-07 2016-12-28 랩터 파마슈티컬스 인코포레이티드 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
CA2759874C (en) 2009-04-24 2016-11-08 Mpex Pharmaceuticals, Inc. Methods of treating a pulmonary bacterial infection using fluoroquinolones
EP2467138A4 (en) * 2009-08-19 2013-11-06 Mpex Pharmaceuticals Inc USE OF AEROSOLIZED ANTIBIOTICS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE LUNG DISEASE
KR20120102587A (ko) 2009-08-19 2012-09-18 엠펙스 파마슈티컬즈, 인코포레이티드 리보플라빈 기반의 에어로졸 및 실험에서 플라시보로서의 용도
LT2473170T (lt) 2009-09-04 2019-10-10 Horizon Orphan Llc Aerozolizuoto levofloksacino panaudojimas cistinės fibrozės gydymui
US20150299122A1 (en) 2012-08-31 2015-10-22 Alectos Therapeutics Inc. Glycosidase inhibitors and uses thereof
CN107848970B (zh) 2015-07-30 2021-07-06 地平线孤儿病有限责任公司 岩藻糖苷酶抑制剂

Also Published As

Publication number Publication date
RU2015130524A (ru) 2018-12-21
US20200000817A1 (en) 2020-01-02
CA2773033A1 (en) 2011-03-10
ZA201202434B (en) 2013-06-26
EP2473170A4 (en) 2013-05-15
JP6180012B2 (ja) 2017-08-16
US9700564B2 (en) 2017-07-11
BR112012004692A2 (pt) 2020-06-02
BR112012004692B1 (pt) 2021-04-13
MX353288B (es) 2018-01-08
PT2473170T (pt) 2019-08-23
US20210228589A1 (en) 2021-07-29
IN2012DN02477A (instruction) 2015-08-21
AU2010289326B2 (en) 2015-09-24
BR112012004692B8 (pt) 2021-05-25
RU2012111458A (ru) 2013-10-10
CL2012000586A1 (es) 2012-09-14
CA2938650C (en) 2018-01-09
AU2010289326A1 (en) 2012-03-22
WO2011029059A1 (en) 2011-03-10
NZ598484A (en) 2014-02-28
ES2739979T3 (es) 2020-02-05
SMT201900440T1 (it) 2019-11-13
CN102724983A (zh) 2012-10-10
HRP20191408T1 (hr) 2019-11-15
IL218458A0 (en) 2012-04-30
KR20120100904A (ko) 2012-09-12
DK2473170T3 (da) 2019-08-12
PL2473170T3 (pl) 2020-03-31
US10231975B2 (en) 2019-03-19
JP2013503907A (ja) 2013-02-04
CA2938650A1 (en) 2011-03-10
JP2016034949A (ja) 2016-03-17
MX2012002731A (es) 2012-08-01
LT2473170T (lt) 2019-10-10
CY1121883T1 (el) 2020-10-14
US20120276153A1 (en) 2012-11-01
EP2473170A1 (en) 2012-07-11
US20180085376A1 (en) 2018-03-29
RU2563809C2 (ru) 2015-09-20
CA2773033C (en) 2016-10-11
EP3569235A1 (en) 2019-11-20
US10792289B2 (en) 2020-10-06
EP2473170B1 (en) 2019-06-19
SI2473170T1 (sl) 2019-10-30

Similar Documents

Publication Publication Date Title
HUE045469T2 (hu) Aeroszolizált levofloxacin alkalmazása cysticus fibrosis kezelésére
IL217899A0 (en) Composition for the treatment of cystic fibrosis
HUE059033T2 (hu) Benzoxaborol-származékok bakteriális fertõzések kezelésére
DK2386610T3 (da) Forbedrede overtræk med lav titandioxidandel
BR112013014943A2 (pt) compostos úteis para o tratamento de aids
ZA201100101B (en) Universal atomizer
SMT201700099B (it) Nuova composizione per il trattamento di fibrosi cistica
HUE040085T2 (hu) PDE7 inhibitorok alkalmazása mozgási rendellenességek kezelésére
AP2013006987A0 (en) Heterocyclic compounds suitable for the treatment of dyslipidemia
DK2386609T3 (da) Forbedrede overtræk med lav titandioxidandel
IL210290A0 (en) Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis
IL245995A0 (en) Prophylactic or medical agent for fibrosis
GB201000499D0 (en) Treatment of cystic fibrosis
HK1149904A (en) Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis
GB201000571D0 (en) Treatment of cystic fibrosis
AU2012900572A0 (en) Compositions and methods for the treatment of cystic fibrosis
GB0809319D0 (en) The treatment of puritus
GB0704989D0 (en) Treatment of influenza
HK1189818A (en) Combinations comprising macitentan for the treatment of glioblastoma multiforme
GB0804468D0 (en) Treatment of influenza