BR9914051A - Métodos para administração de antibióticos - Google Patents
Métodos para administração de antibióticosInfo
- Publication number
- BR9914051A BR9914051A BR9914051-9A BR9914051A BR9914051A BR 9914051 A BR9914051 A BR 9914051A BR 9914051 A BR9914051 A BR 9914051A BR 9914051 A BR9914051 A BR 9914051A
- Authority
- BR
- Brazil
- Prior art keywords
- administering
- daptomycin
- methods
- muscle toxicity
- skeletal muscle
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 3
- 229940088710 antibiotic agent Drugs 0.000 title abstract 3
- 231100000483 muscle toxicity Toxicity 0.000 abstract 6
- 108010013198 Daptomycin Proteins 0.000 abstract 5
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 abstract 5
- 229960005484 daptomycin Drugs 0.000 abstract 5
- 210000002027 skeletal muscle Anatomy 0.000 abstract 4
- 108010028921 Lipopeptides Proteins 0.000 abstract 2
- 229960002615 dalfopristin Drugs 0.000 abstract 2
- SUYRLXYYZQTJHF-VMBLUXKRSA-N dalfopristin Chemical compound O=C([C@@H]1N(C2=O)CC[C@H]1S(=O)(=O)CCN(CC)CC)O[C@H](C(C)C)[C@H](C)\C=C\C(=O)NC\C=C\C(\C)=C\[C@@H](O)CC(=O)CC1=NC2=CO1 SUYRLXYYZQTJHF-VMBLUXKRSA-N 0.000 abstract 2
- 108700028430 dalfopristin Proteins 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Patente de Invenção: <B>"MéTODOS PARA ADMINISTRAçãO DE ANTIBIóTICOS"<D>. A presente invenção refere-se a métodos para administrar uma quantidade eficaz terapeuticamente de daptomicina enquanto minimizando toxicidade do músculo esquelético. Os métodos fornecem administração de daptomicina em um intervalo de dosagem de 24 horas ou maior. Este intervalo de dosagem longo minimiza toxicidade do músculo esquelético e permite pico maior de concentração de daptomicina, o qual é relacionado a eficácia de daptomicina. A invenção também fornece métodos de administrar antibiótico de lipopeptídeos outros além de daptomicina enquanto minimizando toxicidade do músculo esquelético administrando uma quantidade eficaz terapeuticamente do antibiótico de lipopeptídeo em um intervalo de dosagem que não resulta em toxicidade muscular. A invenção também fornece métodos de administrar quinopristina/dalfopristina enquanto minimizando toxicidade do músculo esquelético administrando uma quantidade eficaz terapeuticamente de quinopristina/dalfopristina em um intervalo de dosagem que não resulta em toxicidade muscular.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10182898P | 1998-09-25 | 1998-09-25 | |
US12575099P | 1999-03-24 | 1999-03-24 | |
PCT/US1999/022366 WO2000018419A2 (en) | 1998-09-25 | 1999-09-24 | Methods for administration of antibiotics |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914051A true BR9914051A (pt) | 2001-06-19 |
Family
ID=26798675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914051-9A BR9914051A (pt) | 1998-09-25 | 1999-09-24 | Métodos para administração de antibióticos |
Country Status (26)
Country | Link |
---|---|
US (2) | US6468967B1 (pt) |
EP (2) | EP1674107B8 (pt) |
JP (4) | JP4184607B2 (pt) |
KR (2) | KR20100051735A (pt) |
CN (2) | CN1530136A (pt) |
AT (1) | ATE322280T1 (pt) |
AU (1) | AU764348B2 (pt) |
BR (1) | BR9914051A (pt) |
CA (1) | CA2344318C (pt) |
CY (3) | CY1105556T1 (pt) |
DE (3) | DE122006000049I2 (pt) |
DK (2) | DK1115417T3 (pt) |
ES (2) | ES2603086T3 (pt) |
HK (1) | HK1040363B (pt) |
HU (1) | HU230656B1 (pt) |
IS (2) | IS5890A (pt) |
LU (1) | LU91254I2 (pt) |
NL (1) | NL300232I2 (pt) |
NO (1) | NO20011454L (pt) |
NZ (1) | NZ510690A (pt) |
PL (2) | PL203689B1 (pt) |
PT (2) | PT1674107T (pt) |
RU (1) | RU2363489C9 (pt) |
SI (2) | SI1674107T1 (pt) |
TR (1) | TR200100841T2 (pt) |
WO (1) | WO2000018419A2 (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1530136A (zh) | 1998-09-25 | 2004-09-22 | ������ҩ������˾ | 抗生素的给药方法 |
EP2298790A1 (en) | 1999-12-15 | 2011-03-23 | Cubist Pharmaceuticals, Inc. | Daptomycin analogs as antibacterial agents |
US6696412B1 (en) | 2000-01-20 | 2004-02-24 | Cubist Pharmaceuticals, Inc. | High purity lipopeptides, Lipopeptide micelles and processes for preparing same |
US20060014674A1 (en) | 2000-12-18 | 2006-01-19 | Dennis Keith | Methods for preparing purified lipopeptides |
WO2002059145A1 (en) * | 2000-12-18 | 2002-08-01 | Cubist Pharmaceuticals, Inc. | Methods for preparing purified lipopeptides |
ATE535539T1 (de) * | 2000-12-18 | 2011-12-15 | Cubist Pharm Inc | Verfahren zur herstellung gereinigter lipopeptide |
EP1932853A1 (en) | 2001-08-06 | 2008-06-18 | Cubist Pharmaceutical Inc. | Novel depsipeptides and process for preparing same |
AU2003274927A1 (en) * | 2002-08-23 | 2004-03-11 | Genome Therapeutics Corporation | Methods and reagents for preventing bacteremias |
US20050277581A1 (en) * | 2002-11-18 | 2005-12-15 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
US20060074014A1 (en) * | 2002-11-18 | 2006-04-06 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
US20050220862A1 (en) | 2004-03-31 | 2005-10-06 | Bernstein Joel E | Compositions with reduced hepatotoxicity |
US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
US20060014677A1 (en) * | 2004-07-19 | 2006-01-19 | Isotechnika International Inc. | Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds |
US20080051326A1 (en) * | 2004-11-12 | 2008-02-28 | Alexander Dylan C | Antiinfective Lipopeptides |
US7838532B2 (en) * | 2005-05-18 | 2010-11-23 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US20070238630A1 (en) * | 2006-03-29 | 2007-10-11 | Phillips Douglas H | Subcutaneous skin cleanser |
EP2018864A1 (en) * | 2007-07-23 | 2009-01-28 | Biomet Deutschland GmbH | Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition |
AU2009222020A1 (en) * | 2008-03-04 | 2009-09-11 | Elan Pharma International Limited | Stable liquid formulations of anti-infective agents and adjusted anti-infective agent dosing regimens |
ES2763184T3 (es) | 2008-07-17 | 2020-05-27 | Acorda Therapeutics Inc | Dosificación terapéutica de una neurregulina en el tratamiento o profilaxis de la insuficiencia cardíaca |
DE102008046610A1 (de) * | 2008-09-09 | 2010-03-11 | Biomet Deutschland Gmbh | Verwendung einer pharmazeutischen Zusammensetzung zur lokalen Infektionstherapie sowie Medizinprodukt |
BRPI0920026B1 (pt) | 2008-10-07 | 2023-11-07 | Horizon Orphan Llc | Composição farmacêutica e respectivos usos |
DK2346509T3 (da) | 2008-10-07 | 2020-08-03 | Horizon Orphan Llc | Inhalation af levofloxacin til at reducere lungeinflammation |
WO2010048630A1 (en) | 2008-10-24 | 2010-04-29 | Los Angeles Biomedical Reserch Institute At Harbor-Ucla Medical Center | Anti-infective hydroxy-phenyl-benzoates and methods of use |
MX2011006803A (es) * | 2008-12-22 | 2011-09-06 | Cubist Pharm Inc | Agentes antibacterianos novedosos para el tratamiento de infecciones gram positivas. |
NZ593892A (en) | 2008-12-23 | 2013-11-29 | Biosource Pharm Inc | Antibiotic compositions for the treatment of gram negative infections |
US8450300B2 (en) * | 2009-07-13 | 2013-05-28 | Cempra Pharmaceuticals Inc. | Fusidic acid dosing regimens for treatment of bacterial infections |
CA2767614C (en) * | 2009-07-13 | 2019-01-15 | Cempra Pharmaceuticals Inc. | Fusidic acid dosing regimens for treatment of bacterial infections |
IN2012DN02477A (pt) | 2009-09-04 | 2015-08-21 | Mpex Pharmaceuticals Inc | |
RU2607526C2 (ru) | 2009-11-23 | 2017-01-10 | Кьюбист Фармасьютикалз ЭлЭлСи | Липопептидные композиции и родственные способы |
US8247394B2 (en) | 2010-06-02 | 2012-08-21 | Cempra Pharmaceuticals Inc. | Methods of treating urethritis and related infections using fusidic acid |
US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
WO2013059610A1 (en) | 2011-10-20 | 2013-04-25 | Trius Therapeutics, Inc. | Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use |
RU2014143821A (ru) | 2012-03-30 | 2016-05-27 | Кьюбист Фармасьютикалз, Инк. | 1, 3, 4-ОКСАДИАЗОЛЬНЫЕ И 1, 3, 4-ТИАДИАЗОЛЬНЫЕ ИНГИБИТОРЫ β-ЛАКТАМАЗЫ |
NZ706286A (en) * | 2012-09-11 | 2018-05-25 | Hospira Australia Pty Ltd | Daptomycin formulations and uses thereof |
CN103006562B (zh) * | 2013-01-21 | 2014-09-17 | 西南大学 | 达托霉素醇质体制剂 |
CA2904387C (en) | 2013-03-15 | 2021-12-07 | Melinta Therapeutics, Inc. | Methods of treating infections in overweight and obese patients using antibiotics |
US11667674B2 (en) | 2016-04-08 | 2023-06-06 | Versitech Limited | Antibacterial cyclic lipopeptides |
US10647746B2 (en) | 2016-04-08 | 2020-05-12 | Versitech Limited | Antibacterial cyclic lipopeptides |
JP2019515007A (ja) * | 2016-05-13 | 2019-06-06 | スペロ ポテンシエーター インコーポレイテッドSpero Potentiator, Inc. | 新規カチオン性ペプチドspr741による、抗生物質活性の増強 |
CN114788814B (zh) * | 2021-01-26 | 2023-10-13 | 浙江创新生物有限公司 | 一种高稳定性的注射用达托霉素组合物及其制备方法和其应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE32333E (en) | 1978-10-16 | 1987-01-20 | Eli Lilly And Company | A-21978 Antibiotics and process for their production |
USRE32455E (en) | 1978-10-16 | 1987-07-07 | Eli Lilly And Company | A-21978 antibiotics and process for their production |
USRE32310E (en) | 1982-05-21 | 1986-12-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
USRE32311E (en) | 1982-05-21 | 1986-12-16 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
US4524135A (en) | 1982-05-21 | 1985-06-18 | Eli Lilly And Company | A-21978C cyclic peptides |
US4537717A (en) | 1982-05-21 | 1985-08-27 | Eli Lilly And Company | Derivatives of A-21978C cyclic peptides |
US4482487A (en) | 1982-05-21 | 1984-11-13 | Eli Lilly And Company | A-21978C cyclic peptides |
US4885243A (en) | 1984-10-09 | 1989-12-05 | Eli Lilly And Company | Process for producing A-21978C derivatives |
US4800157A (en) | 1985-09-09 | 1989-01-24 | Eli Lilly And Company | Process for producing the A-21978C antibiotics |
US4874843A (en) | 1987-12-03 | 1989-10-17 | Eli Lilly And Company | Chromatographic purification process |
CA1315229C (en) | 1987-06-10 | 1993-03-30 | Patrick J. Baker | Chromatographic purification process |
CA2011365A1 (en) * | 1989-03-06 | 1990-09-06 | Eugene L. Inman | Diluent formulation for daptomycin |
FR2755857B1 (fr) * | 1996-11-19 | 1998-12-24 | Rhone Poulenc Rorer Sa | Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation |
FR2772272B1 (fr) * | 1997-12-16 | 2000-01-14 | Rhone Poulenc Rorer Sa | Compositions pharmaceutiques a base de dalfopristine et de quinupristine et leur preparation |
CN1530136A (zh) | 1998-09-25 | 2004-09-22 | ������ҩ������˾ | 抗生素的给药方法 |
US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
-
1999
- 1999-09-24 CN CNA200410031708XA patent/CN1530136A/zh active Pending
- 1999-09-24 DE DE200612000049 patent/DE122006000049I2/de active Active
- 1999-09-24 KR KR1020107006807A patent/KR20100051735A/ko not_active Application Discontinuation
- 1999-09-24 PT PT60066974T patent/PT1674107T/pt unknown
- 1999-09-24 AT AT99949913T patent/ATE322280T1/de active
- 1999-09-24 PL PL348328A patent/PL203689B1/pl unknown
- 1999-09-24 JP JP2000571937A patent/JP4184607B2/ja not_active Expired - Lifetime
- 1999-09-24 EP EP06006697.4A patent/EP1674107B8/en not_active Expired - Lifetime
- 1999-09-24 DK DK99949913T patent/DK1115417T3/da active
- 1999-09-24 PT PT99949913T patent/PT1115417E/pt unknown
- 1999-09-24 PL PL384274A patent/PL206091B1/pl unknown
- 1999-09-24 HU HU0103874A patent/HU230656B1/hu unknown
- 1999-09-24 WO PCT/US1999/022366 patent/WO2000018419A2/en active IP Right Grant
- 1999-09-24 EP EP99949913A patent/EP1115417B1/en not_active Revoked
- 1999-09-24 KR KR1020017003735A patent/KR20010075327A/ko not_active Application Discontinuation
- 1999-09-24 US US09/406,568 patent/US6468967B1/en not_active Expired - Lifetime
- 1999-09-24 DE DE69930758T patent/DE69930758T2/de not_active Expired - Lifetime
- 1999-09-24 BR BR9914051-9A patent/BR9914051A/pt not_active Application Discontinuation
- 1999-09-24 DE DE1999630758 patent/DE122006000049I1/de active Pending
- 1999-09-24 TR TR2001/00841T patent/TR200100841T2/xx unknown
- 1999-09-24 AU AU62687/99A patent/AU764348B2/en not_active Expired
- 1999-09-24 CA CA002344318A patent/CA2344318C/en not_active Expired - Lifetime
- 1999-09-24 ES ES06006697.4T patent/ES2603086T3/es not_active Expired - Lifetime
- 1999-09-24 CN CNB998124982A patent/CN1150029C/zh not_active Ceased
- 1999-09-24 ES ES99949913T patent/ES2259845T3/es not_active Expired - Lifetime
- 1999-09-24 NZ NZ510690A patent/NZ510690A/xx not_active IP Right Cessation
- 1999-09-24 SI SI9931082A patent/SI1674107T1/sl unknown
- 1999-09-24 SI SI9930904T patent/SI1115417T1/sl unknown
- 1999-09-24 DK DK06006697.4T patent/DK1674107T3/en active
-
2001
- 2001-03-14 IS IS5890A patent/IS5890A/is unknown
- 2001-03-22 NO NO20011454A patent/NO20011454L/no not_active Application Discontinuation
-
2002
- 2002-01-09 HK HK02100152.2A patent/HK1040363B/zh not_active IP Right Cessation
- 2002-02-20 US US10/082,544 patent/US6852689B2/en not_active Expired - Lifetime
-
2003
- 2003-05-27 JP JP2003149968A patent/JP2003321389A/ja not_active Withdrawn
-
2004
- 2004-03-04 RU RU2004106569/14A patent/RU2363489C9/ru active
- 2004-08-17 JP JP2004237765A patent/JP2004339238A/ja not_active Withdrawn
-
2006
- 2006-04-18 CY CY20061100536T patent/CY1105556T1/el unknown
- 2006-06-23 NL NL300232C patent/NL300232I2/nl unknown
- 2006-06-28 LU LU91254C patent/LU91254I2/fr unknown
- 2006-07-18 CY CY200600003C patent/CY2006003I2/el unknown
- 2006-09-22 JP JP2006258107A patent/JP2006335773A/ja not_active Withdrawn
-
2009
- 2009-03-10 IS IS8807A patent/IS8807A/is unknown
-
2016
- 2016-11-24 CY CY20161101219T patent/CY1118334T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: CUBIST PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020100048642/RJ DE 31/05/2010. |
|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 10 (VIII) E 11 DA LPI. |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
B25E | Requested change of name of applicant rejected |
Owner name: CUBIST PHARMACEUTICALS, INC. (US) |
|
B25H | Request for change of headquarter rejected |
Owner name: CUBIST PHARMACEUTICALS, INC. (US) |