HUE043962T2 - Diszubsztituált oktahidro-pirrolo[3,4-C]pirrolok mint orexin receptor modulátorok - Google Patents

Diszubsztituált oktahidro-pirrolo[3,4-C]pirrolok mint orexin receptor modulátorok

Info

Publication number
HUE043962T2
HUE043962T2 HUE16163733A HUE16163733A HUE043962T2 HU E043962 T2 HUE043962 T2 HU E043962T2 HU E16163733 A HUE16163733 A HU E16163733A HU E16163733 A HUE16163733 A HU E16163733A HU E043962 T2 HUE043962 T2 HU E043962T2
Authority
HU
Hungary
Prior art keywords
dropyrrolo
octahy
pyrroles
disubstituted
receptor modulators
Prior art date
Application number
HUE16163733A
Other languages
English (en)
Hungarian (hu)
Inventor
Wenying Chai
Michael LETAVIC
Kiev Ly
Daniel Pippel
Dale Rudolph
Kathleen Strother
Brad Savall
Chandravadan Shah
Brock Shireman
Akinola Soyode-Johnson
Emily Stocking
Devin Swanson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HUE043962T2 publication Critical patent/HUE043962T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
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  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE16163733A 2009-10-23 2010-10-21 Diszubsztituált oktahidro-pirrolo[3,4-C]pirrolok mint orexin receptor modulátorok HUE043962T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23

Publications (1)

Publication Number Publication Date
HUE043962T2 true HUE043962T2 (hu) 2019-09-30

Family

ID=43385633

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE16163733A HUE043962T2 (hu) 2009-10-23 2010-10-21 Diszubsztituált oktahidro-pirrolo[3,4-C]pirrolok mint orexin receptor modulátorok
HUE10773477A HUE028650T2 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE10773477A HUE028650T2 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators

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Country Link
US (8) US8653263B2 (enExample)
EP (3) EP2491038B1 (enExample)
JP (1) JP5759470B2 (enExample)
KR (3) KR101859409B1 (enExample)
CN (1) CN102781942B (enExample)
AR (2) AR078731A1 (enExample)
AU (2) AU2010310595B2 (enExample)
BR (1) BR112012010820B1 (enExample)
CA (1) CA2778484C (enExample)
CL (1) CL2010001162A1 (enExample)
CO (1) CO6541572A2 (enExample)
CR (1) CR20120273A (enExample)
CY (2) CY1117743T1 (enExample)
DK (2) DK3093291T3 (enExample)
EA (1) EA022766B1 (enExample)
EC (1) ECSP12011908A (enExample)
ES (2) ES2585806T3 (enExample)
HR (2) HRP20160781T1 (enExample)
HU (2) HUE043962T2 (enExample)
IL (1) IL219234A (enExample)
JO (2) JO3267B1 (enExample)
LT (1) LT3093291T (enExample)
ME (2) ME02437B (enExample)
MX (1) MX2012004753A (enExample)
NI (1) NI201200062A (enExample)
NZ (1) NZ599629A (enExample)
PE (1) PE20110404A1 (enExample)
PH (1) PH12012500796A1 (enExample)
PL (2) PL2491038T3 (enExample)
PT (2) PT3093291T (enExample)
RS (2) RS54945B1 (enExample)
SI (2) SI2491038T1 (enExample)
SM (2) SMT201900392T1 (enExample)
TR (1) TR201910327T4 (enExample)
TW (1) TWI481613B (enExample)
UA (1) UA107812C2 (enExample)
UY (1) UY32966A (enExample)
WO (1) WO2011050198A1 (enExample)

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EP2491038B1 (en) * 2009-10-23 2016-04-06 Janssen Pharmaceutica N.V. Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
MX343837B (es) 2011-11-08 2016-11-24 Actelion Pharmaceuticals Ltd Derivados de 2 - (1,2,3 -triazol - 2 - il) benzamida y 3 - (1,2,3 - triazol - 2 - il) picolinamida.
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
ES2617863T3 (es) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de bencimidazol-prolina
US9682966B2 (en) * 2012-08-16 2017-06-20 The Scripps Research Institute Kappa opioid ligands
SG11201502493XA (en) 2012-10-10 2015-04-29 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
CA2902135A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
TW201444849A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
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