HUE041987T2 - 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók - Google Patents

4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók

Info

Publication number
HUE041987T2
HUE041987T2 HUE12733505A HUE12733505A HUE041987T2 HU E041987 T2 HUE041987 T2 HU E041987T2 HU E12733505 A HUE12733505 A HU E12733505A HU E12733505 A HUE12733505 A HU E12733505A HU E041987 T2 HUE041987 T2 HU E041987T2
Authority
HU
Hungary
Prior art keywords
benzamides
imidazopyridazin
imidazotriazine
btk inhibitors
btk
Prior art date
Application number
HUE12733505A
Other languages
English (en)
Hungarian (hu)
Inventor
Tjeerd A Barf
Christiaan Jans
De Adrianus Man
Arthur A Oubrie
Hans C A Raaijmakers
Johannes Rewinkel
Jan-Gerard Sterrenburg
Jacobus C H M Wijkmans
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47557677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE041987(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HUE041987T2 publication Critical patent/HUE041987T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HUE12733505A 2011-07-19 2012-07-11 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók HUE041987T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161509397P 2011-07-19 2011-07-19
EP11174578 2011-07-19

Publications (1)

Publication Number Publication Date
HUE041987T2 true HUE041987T2 (hu) 2019-06-28

Family

ID=47557677

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE12733505A HUE041987T2 (hu) 2011-07-19 2012-07-11 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók
HUE19215783A HUE056249T2 (hu) 2011-07-19 2012-07-11 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-inhibitorok
HUS2100012C HUS2100012I1 (hu) 2011-07-19 2021-04-14 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók

Family Applications After (2)

Application Number Title Priority Date Filing Date
HUE19215783A HUE056249T2 (hu) 2011-07-19 2012-07-11 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-inhibitorok
HUS2100012C HUS2100012I1 (hu) 2011-07-19 2021-04-14 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók

Country Status (38)

Country Link
US (7) US9290504B2 (show.php)
EP (4) EP2734522B1 (show.php)
JP (6) JP5826931B2 (show.php)
KR (2) KR101702727B1 (show.php)
CN (2) CN103889987B (show.php)
AU (4) AU2012285987C1 (show.php)
BR (1) BR112014001255B1 (show.php)
CA (1) CA2841886C (show.php)
CL (1) CL2014000130A1 (show.php)
CO (1) CO6940411A2 (show.php)
CR (1) CR20140030A (show.php)
CY (2) CY2021010I1 (show.php)
DK (2) DK3689878T3 (show.php)
DO (1) DOP2014000008A (show.php)
EA (2) EA034558B1 (show.php)
EC (1) ECSP14013217A (show.php)
ES (3) ES2950569T3 (show.php)
GT (1) GT201400009A (show.php)
HR (2) HRP20190135T1 (show.php)
HU (3) HUE041987T2 (show.php)
IL (3) IL230511B (show.php)
IN (1) IN2014CN00408A (show.php)
LT (1) LT2734522T (show.php)
MA (1) MA35348B1 (show.php)
MX (1) MX342983B (show.php)
MY (1) MY192354A (show.php)
PE (1) PE20141681A1 (show.php)
PH (2) PH12014500148A1 (show.php)
PL (2) PL2734522T3 (show.php)
PT (1) PT3689878T (show.php)
RS (2) RS62760B1 (show.php)
SG (1) SG10201605913VA (show.php)
SI (2) SI2734522T1 (show.php)
SM (2) SMT202100729T1 (show.php)
TN (1) TN2014000027A1 (show.php)
UA (1) UA115312C2 (show.php)
WO (1) WO2013010868A1 (show.php)
ZA (1) ZA202109164B (show.php)

Families Citing this family (116)

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US20120101114A1 (en) * 2007-03-28 2012-04-26 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase
KR101580714B1 (ko) 2010-06-03 2016-01-04 파마싸이클릭스 엘엘씨 브루톤 티로신 인산화효소(ｂｔｋ)의 억제제의 용도
SI2710005T1 (sl) 2011-05-17 2017-03-31 Principia Biopharma Inc. Zaviralci tirozinske kinaze
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
EA201490265A1 (ru) 2011-07-13 2014-12-30 Фармасайкликс, Инк. Ингибиторы тирозинкиназы брутона
SI2734522T1 (sl) * 2011-07-19 2019-03-29 Merck Sharp & Dohme B.V. 4-IMIDAZOPIRIDAZIN-1-IL-BENZAMIDI IN 4-IMIDAZOTRIAZIN-1-IL-BENZAMIDI kot BTK-INHIBITORJI
EP2548877A1 (en) 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
BR112015001690A2 (pt) 2012-07-24 2017-11-07 Pharmacyclics Inc mutações associadas com a resistência a inibidores da tirosina quinase de bruton (btk)
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