HUE032727T2 - Biometric skeletons for industrial scale dispersion - Google Patents

Biometric skeletons for industrial scale dispersion Download PDF

Info

Publication number
HUE032727T2
HUE032727T2 HUE11801504A HUE11801504A HUE032727T2 HU E032727 T2 HUE032727 T2 HU E032727T2 HU E11801504 A HUE11801504 A HU E11801504A HU E11801504 A HUE11801504 A HU E11801504A HU E032727 T2 HUE032727 T2 HU E032727T2
Authority
HU
Hungary
Prior art keywords
biomatrix
cells
tissue
medium
scaffolds
Prior art date
Application number
HUE11801504A
Other languages
English (en)
Hungarian (hu)
Inventor
Marsha Lynn Roach
Richard Harold Malavarca
Yunfang Wang
Lola Cynthia Mcadams Reid
Original Assignee
Marsha Lynn Roach
Univ North Carolina Chapel Hill
Richard Harold Malavarca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marsha Lynn Roach, Univ North Carolina Chapel Hill, Richard Harold Malavarca filed Critical Marsha Lynn Roach
Publication of HUE032727T2 publication Critical patent/HUE032727T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/14—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material
    • C12N2710/20052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10151—Methods of production or purification of viral material
    • C12N2730/10152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24223—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24251—Methods of production or purification of viral material
    • C12N2770/24252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Peptides Or Proteins (AREA)
HUE11801504A 2010-07-02 2011-07-01 Biometric skeletons for industrial scale dispersion HUE032727T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36093910P 2010-07-02 2010-07-02

Publications (1)

Publication Number Publication Date
HUE032727T2 true HUE032727T2 (en) 2017-10-30

Family

ID=45402468

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE11801504A HUE032727T2 (en) 2010-07-02 2011-07-01 Biometric skeletons for industrial scale dispersion
HUE11801493A HUE032730T2 (en) 2010-07-02 2011-07-01 Biometric skeletons

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE11801493A HUE032730T2 (en) 2010-07-02 2011-07-01 Biometric skeletons

Country Status (11)

Country Link
US (7) US8802081B2 (enExample)
EP (6) EP2588027B8 (enExample)
JP (7) JP2013539960A (enExample)
CN (4) CN105713868A (enExample)
DK (2) DK2588027T3 (enExample)
ES (6) ES2946590T3 (enExample)
HU (2) HUE032727T2 (enExample)
LT (2) LT2588027T (enExample)
PL (2) PL2588083T3 (enExample)
PT (2) PT2588083T (enExample)
WO (2) WO2012003450A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2946590T3 (es) * 2010-07-02 2023-07-21 Univ North Carolina Chapel Hill Andamios de biomatriz para dispersión a escala industrial
NL2009145C2 (en) * 2012-07-06 2014-01-07 Xeltis B V Implant.
CN103536967B (zh) * 2012-07-10 2016-04-13 上海微创医疗器械（集团）有限公司 一种制备细胞外基质支架材料的脱细胞方法
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CN105164250A (zh) 2013-03-15 2015-12-16 米罗马特里克斯医疗公司 灌注脱细胞化的肝脏在胰岛细胞再细胞化中的用途
DK2968418T3 (da) * 2013-03-15 2024-01-15 Nutech Medical Inc Præparater afledt af placentamaterialer til fremstilling og anvendelse deraf
HUE042704T2 (hu) * 2013-04-08 2019-07-29 Regentys Corp Eljárás és készítmény gyulladásos bélbetegség kezelésére kolektómia nélkül
MX2016001247A (es) 2013-07-30 2016-08-17 Musculoskeletal Transplant Foundation Matrices derivadas de tejido suave acelular y metodos para preparar las mismas.
CN103432627B (zh) * 2013-08-26 2015-03-25 北京瑞健高科生物科技有限公司 一种制备动物脱细胞组织基质材料的方法及其制备的组织基质材料
CA2944181C (en) 2014-03-27 2019-09-17 Salk Institute For Biological Studies Compositions and methods for treating type 1 and type 2 diabetes and related disorders
GB201409858D0 (en) * 2014-06-03 2014-07-16 Ucl Business Plc Human liver scaffolds
CN104288837B (zh) * 2014-09-11 2016-04-13 杨淑珍 一种脱细胞真皮基质及其制备方法和用途
EP3262157A4 (en) 2015-02-27 2018-12-05 Salk Institute for Biological Studies Reprogramming progenitor compositions and methods of use therefore
CN104928241B (zh) * 2015-03-27 2018-04-13 北京康爱瑞浩生物科技股份有限公司 一种增强型nk细胞的活化方法及细胞制备方法
US10683484B2 (en) * 2015-06-12 2020-06-16 National University Of Singapore Derivation of hepatic stem cells and mature liver cell types and uses thereof
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN106884002B (zh) * 2015-12-15 2021-03-19 上海市针灸经络研究所 一种稳定的结肠上皮细胞培养方法
CN105833353B (zh) * 2016-05-09 2018-04-20 拜欧迪赛尔（北京）生物科技有限公司 一种生物工程脱细胞真皮基质的制备及用途
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
EP3936610A1 (en) 2016-05-25 2022-01-12 Salk Institute for Biological Studies Compositions and methods for organoid generation and disease modeling
CA3030166A1 (en) * 2016-07-12 2018-01-18 The University Of North Carolina At Chapel Hill Biomatrix scaffolds for use in diagnosing and modeling cancer
CN106362212A (zh) * 2016-10-21 2017-02-01 华中科技大学同济医学院附属协和医院 一种用于去除组织细胞的亲脂性去细胞溶液、试剂盒和方法
GB2555787A (en) * 2016-11-07 2018-05-16 Landberg Goran Diagnostic methods
EP3548895B1 (de) * 2016-11-30 2024-07-03 Bruker Daltonics GmbH & Co. KG Aufbereitung lebendiger, mikrobieller proben und mikroorganismen für anschliessende massenspektrometrische messung und auswertung
CA3066710A1 (en) * 2017-06-12 2018-12-20 The University Of North Carolina At Chapel Hill Patch graft compositions for cell engraftment
JP2020529267A (ja) * 2017-07-31 2020-10-08 ドゥ カント ザゴ, アレシャンドリDO CANTO ZAGO, Alexandre 迅速なストラットの被覆および血管内皮の被覆を促進するためのデバイスおよび方法
EP3470096A1 (en) * 2017-10-13 2019-04-17 Erasmus University Medical Center Rotterdam Elastin reduction allowing recellularization of cartilage implants
WO2019129646A1 (en) * 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Tissue sample preparation system
WO2019222170A1 (en) * 2018-05-14 2019-11-21 Roosterbio, Inc. Methods and compositions related to extracellular material derived from hypertonic cell solutions
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
CN108753686B (zh) * 2018-06-22 2021-06-22 中国人民解放军军事科学院军事医学研究院 组织工程肝脏模型、其构建方法及其应用
CN108753687B (zh) * 2018-06-22 2021-04-16 中国人民解放军军事科学院军事医学研究院 微肝组织培养模型、其构建方法及其应用
CN109735490A (zh) * 2019-03-06 2019-05-10 福建省海西细胞生物工程有限公司 一种脂肪干细胞提取方法
CN110257335B (zh) * 2019-04-10 2020-09-29 首都医科大学附属北京天坛医院 单层或多层的3d脑胶质瘤细胞培养模型及其构建方法和应用
JP7547383B2 (ja) 2019-05-16 2024-09-09 レスメド・プロプライエタリー・リミテッド 医療デバイスにおける双方向通信
WO2021045373A1 (ko) * 2019-09-04 2021-03-11 한국생명공학연구원 증식 가능한 간 오가노이드
CN110559485B (zh) * 2019-09-25 2021-02-02 北京大清生物技术股份有限公司 一种生物组织基质材料及其制备方法与应用
DE102019130568A1 (de) 2019-11-13 2021-05-20 Aesculap Ag Chirurgischer Fräser mit verbesserter Spanabfuhr
CN111110919A (zh) * 2019-12-30 2020-05-08 广东泓志生物科技有限公司 大网膜脱细胞基质材料的制备方法及软骨组织的构建方法
JP7623017B2 (ja) * 2020-02-14 2025-01-28 セルアートジェン インコーポレイテッド 臓器オルガノイドの培養及び移植のための脱細胞臓器組織由来の支持体及びその製造方法
CN111760072B (zh) * 2020-08-24 2022-09-23 鲁峰 脂肪来源的真皮内填充物及其制备和应用
CN114748208B (zh) * 2022-04-15 2024-01-12 柔脉医疗(深圳)有限公司 一种可原位检测多种化学、生物成分的组织工程支架
CN115948331B (zh) * 2022-10-17 2024-10-22 中国人民解放军西部战区总医院 一种从小鼠胆囊中分离获取间充质干细胞的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19569C (de) ANNA ERBER in Brieg Neuerungen an der unter Nr. 17581 patentirten Handlaterne
CA2155186A1 (en) 1993-02-01 1994-08-18 Kevin M. Ulmer Methods and apparatus for dna sequencing
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6149891A (en) * 1995-05-31 2000-11-21 Israel Humanitarian Foundation Ltd. X-ray contrast medium and method for protecting against harmful effects thereof
US20020177551A1 (en) 2000-05-31 2002-11-28 Terman David S. Compositions and methods for treatment of neoplastic disease
DE60121450T2 (de) * 2000-08-16 2007-02-15 Duke University Mittels gewebetechnologie hergestellte dezellularisierte gegenstände und gewebe
AU2002243980B2 (en) * 2001-02-14 2007-08-23 Robert J. Hariri Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
EP1404388B1 (en) 2001-06-28 2013-10-23 Cook Biotech, Inc. Graft prosthesis devices containing renal capsule collagen
US20040187877A1 (en) * 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
CN100412188C (zh) * 2003-02-21 2008-08-20 Uab研究基金会 生物活性天然生物基质组合物
WO2005002601A1 (en) 2003-06-25 2005-01-13 Badylak Stephen F Conditioned matrix compositions for tissue restoration
AU2004252568B2 (en) * 2003-06-27 2011-06-30 Ethicon, Incorporated Regeneration and repair of neural tissue using postpartum-derived cells
MX2007015541A (es) * 2005-06-10 2008-03-06 Celgene Corp Composiciones de colageno de placenta humana proceso para su preparacion, metodos de uso y equipos que contienen las composiciones.
WO2007018165A1 (ja) * 2005-08-10 2007-02-15 Toray Industries, Inc. スポンジ状構造体および粉末、ならびにそれらの製造方法
US9944900B2 (en) 2006-01-18 2018-04-17 Hemacell Perfusion Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells
US8241908B2 (en) * 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
CN106178118A (zh) * 2008-09-30 2016-12-07 加利福尼亚大学董事会 用于组织修复的使用细胞外基质的组合物和方法
US20120064050A1 (en) * 2009-02-04 2012-03-15 Yale University Tissue Engineering of Lung
US9277999B2 (en) * 2009-02-27 2016-03-08 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds
ES2650450T3 (es) * 2010-06-30 2018-01-18 Miromatrix Medical Inc. Uso de órganos descelularizados por perfusión para recelularización adaptada
ES2946590T3 (es) * 2010-07-02 2023-07-21 Univ North Carolina Chapel Hill Andamios de biomatriz para dispersión a escala industrial

Also Published As

Publication number Publication date
DK2588083T3 (en) 2017-06-19
US10246678B2 (en) 2019-04-02
EP3216444B1 (en) 2020-03-11
EP3192862A1 (en) 2017-07-19
US20200002667A1 (en) 2020-01-02
LT2588083T (lt) 2017-06-12
CN103491898B (zh) 2015-11-25
JP2013535961A (ja) 2013-09-19
JP2018143249A (ja) 2018-09-20
JP2019017392A (ja) 2019-02-07
HK1243928A1 (en) 2018-07-27
ES2946590T3 (es) 2023-07-21
US8802081B2 (en) 2014-08-12
WO2012003450A2 (en) 2012-01-05
CN105713868A (zh) 2016-06-29
EP2588027B8 (en) 2017-07-26
PT2588083T (pt) 2017-06-26
PT2588027T (pt) 2017-06-23
PL2588083T3 (pl) 2017-08-31
LT2588027T (lt) 2017-06-12
EP2588027A1 (en) 2013-05-08
CN103249404A (zh) 2013-08-14
EP3603622B1 (en) 2023-03-08
ES2624742T3 (es) 2017-07-17
JP2017055764A (ja) 2017-03-23
JP6308781B2 (ja) 2018-04-11
ES2916580T3 (es) 2022-07-01
ES2879246T3 (es) 2021-11-22
PL2588027T3 (pl) 2017-09-29
EP2588083A4 (en) 2013-11-13
EP2588083A2 (en) 2013-05-08
EP3581171B1 (en) 2022-03-09
JP2017079757A (ja) 2017-05-18
ES2791312T3 (es) 2020-11-03
EP3581171A1 (en) 2019-12-18
CN106362211A (zh) 2017-02-01
EP3603622A1 (en) 2020-02-05
EP3216444A1 (en) 2017-09-13
HUE032730T2 (en) 2017-10-30
US20130137176A1 (en) 2013-05-30
US10640747B2 (en) 2020-05-05
ES2626145T3 (es) 2017-07-24
JP6527272B2 (ja) 2019-06-05
US20150110753A1 (en) 2015-04-23
JP6612722B2 (ja) 2019-11-27
EP2588083B1 (en) 2017-03-08
US9944896B2 (en) 2018-04-17
US20190024043A1 (en) 2019-01-24
JP2013539960A (ja) 2013-10-31
US20130195811A1 (en) 2013-08-01
DK2588027T3 (en) 2017-06-19
WO2012003450A3 (en) 2012-04-05
EP2588027B1 (en) 2017-03-08
WO2012003463A1 (en) 2012-01-05
US20170015974A1 (en) 2017-01-19
CN103491898A (zh) 2014-01-01
HK1193018A1 (zh) 2014-09-12
US9102913B2 (en) 2015-08-11
US20160024463A1 (en) 2016-01-28
JP2019017393A (ja) 2019-02-07
EP3192862B1 (en) 2021-04-07
EP2588027A4 (en) 2013-12-11

Similar Documents

Publication Publication Date Title
US10640747B2 (en) Biomatrix scaffolds for industrial scale dispersal
HK1180206A (en) Biomatrix scaffolds for industrial scale dispersal
HK1180206B (en) Biomatrix scaffolds for industrial scale dispersal
HK40023076B (en) Biomatrix scaffolds for industrial scale dispersal
HK1243928B (en) Biomatrix scaffolds for industrial scale dispersal
HK40023076A (en) Biomatrix scaffolds for industrial scale dispersal
HK1180235A (en) Biomatrix scaffolds
HK1180235B (en) Biomatrix scaffolds
HK1233552A1 (en) Biomatrix scaffolds
HK1188143A (en) Biomatrix scaffolds
HK1193018B (en) Biomatrix scafolds for industrial scale dispersal