HUE028495T2 - Új piperidinvegyület vagy sói - Google Patents
Új piperidinvegyület vagy sói Download PDFInfo
- Publication number
- HUE028495T2 HUE028495T2 HUE13755229A HUE13755229A HUE028495T2 HU E028495 T2 HUE028495 T2 HU E028495T2 HU E13755229 A HUE13755229 A HU E13755229A HU E13755229 A HUE13755229 A HU E13755229A HU E028495 T2 HUE028495 T2 HU E028495T2
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- HU
- Hungary
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- compound
- rti
- salt
- esetben esetben
- Prior art date
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- 150000003839 salts Chemical class 0.000 title claims description 43
- -1 piperidine compound Chemical class 0.000 title claims description 27
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title description 12
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
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| JP2012043303 | 2012-02-29 | ||
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| TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
| US9012475B2 (en) | 2013-08-27 | 2015-04-21 | Taiho Pharmaceutical Co., Ltd. | Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor |
| KR101430209B1 (ko) * | 2014-03-06 | 2014-08-14 | 강원대학교산학협력단 | 단백질 키나아제 활성 측정 방법 및 이를 위한 키트 |
| TWI693218B (zh) * | 2014-11-14 | 2020-05-11 | 美商美國禮來大藥廠 | 極光ａ激酶抑制劑 |
| CN104758286B (zh) * | 2015-03-05 | 2016-09-14 | 南京工业大学 | 1-苄基-4-(2,4-二氯苯乙胺基)哌啶在制备抗肿瘤药物中的应用 |
| US11028069B2 (en) | 2016-12-22 | 2021-06-08 | Taiho Pharmaceutical Co., Ltd. | Salt of substituted piperidine compound |
| JP7227968B2 (ja) * | 2018-05-29 | 2023-02-22 | 大鵬薬品工業株式会社 | 抗腫瘍剤及び腫瘍治療方法 |
| CN112239465A (zh) * | 2019-07-16 | 2021-01-19 | 微境生物医药科技(上海)有限公司 | 极光激酶抑制剂及其用途 |
| CN112898292A (zh) * | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型极光激酶抑制剂及其用途 |
| TWI785474B (zh) * | 2020-01-22 | 2022-12-01 | 大陸商北京加科思新藥研發有限公司 | 用作選擇性Aurora A抑制劑的新型雜環化合物 |
| CN117836285A (zh) * | 2021-07-28 | 2024-04-05 | 北京加科思新药研发有限公司 | Aurora a选择性抑制剂的多晶型及其用途 |
| CA3247183A1 (en) | 2022-04-08 | 2023-10-12 | Eli Lilly And Company | TREATMENT METHOD INCLUDING KRAS G12C INHIBITORS AND AURORA A INHIBITORS |
| WO2024088193A1 (en) * | 2022-10-26 | 2024-05-02 | Js Innopharm (Suzhou) Ltd. | Combination of aurora a and parp inhibitors for treatment of cancers |
| US20260166024A1 (en) * | 2022-10-26 | 2026-06-18 | Js Innopharm (Suzhou) Ltd. | An aurora a inhibitor for use in treatments of cancers |
| WO2024230647A1 (zh) * | 2023-05-05 | 2024-11-14 | 苏州信诺维医药科技股份有限公司 | 杂环类化合物、其药物组合物和其应用 |
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| BR0116493A (pt) | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| WO2006046734A2 (ja) * | 2004-10-29 | 2006-05-04 | Banyu Pharma Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
| GB0509227D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| US7737151B2 (en) | 2005-08-18 | 2010-06-15 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
| EP1917258A2 (en) | 2005-08-26 | 2008-05-07 | SmithKline Beecham Corporation | Pyrimidinyl-pyrazole inhibitors of aurora kinases |
| BRPI0616630B8 (pt) | 2005-09-30 | 2021-05-25 | Miikana Therapeutics Inc | compostos de pirazol substituídos |
| MX2008011769A (es) | 2006-03-20 | 2008-09-25 | Hoffmann La Roche | Derivados de ftalazinona pirazol, su fabricacion y uso como agentes farmaceuticos. |
| WO2007107469A1 (en) | 2006-03-20 | 2007-09-27 | F. Hoffmann-La Roche Ag | Methods of inhibiting btk and syk protein kinases |
| JP2008081492A (ja) * | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| GB0705656D0 (en) | 2007-03-23 | 2007-05-02 | Addex Pharmaceuticals Sa | Novel compounds E1 |
| CA2707360A1 (en) | 2007-06-20 | 2008-12-24 | Merck Sharp & Dohme Corp. | Diphenyl substituted alkanes |
| WO2009104802A1 (en) * | 2008-02-22 | 2009-08-27 | Banyu Pharmaceutical Co., Ltd. | Novel aminopyridine derivatives having aurora a selective inhibitory action |
| WO2010111050A1 (en) * | 2009-03-23 | 2010-09-30 | Banyu Pharmaceutical Co., Ltd. | Novel aminopyridine derivatives having aurora a selective inhibitory action |
| AU2010229140A1 (en) * | 2009-03-24 | 2011-11-10 | Msd K.K. | Novel aminopyridine derivatives having Aurora A selective inhibitory action |
| TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
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- 2013-02-27 KR KR1020147023717A patent/KR101677823B1/ko active Active
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- 2013-02-27 WO PCT/JP2013/055064 patent/WO2013129443A1/ja not_active Ceased
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