HUE025294T2 - New chemokine-binding polypeptides that are able to inhibit the process of autoimmunity, inflammation and cancer - Google Patents

New chemokine-binding polypeptides that are able to inhibit the process of autoimmunity, inflammation and cancer Download PDF

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Publication number
HUE025294T2
HUE025294T2 HUE10735337A HUE10735337A HUE025294T2 HU E025294 T2 HUE025294 T2 HU E025294T2 HU E10735337 A HUE10735337 A HU E10735337A HU E10735337 A HUE10735337 A HU E10735337A HU E025294 T2 HUE025294 T2 HU E025294T2
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pro
ser
polypeptide
leu
thr
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HUE10735337A
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English (en)
Hungarian (hu)
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Michal Abraham
Orly Eizenberg
Amnon Peled
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Biokine Therapeutics Ltd
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Publication of HUE025294T2 publication Critical patent/HUE025294T2/en

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
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HUE10735337A 2009-06-15 2010-06-15 New chemokine-binding polypeptides that are able to inhibit the process of autoimmunity, inflammation and cancer HUE025294T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21349309P 2009-06-15 2009-06-15

Publications (1)

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HUE025294T2 true HUE025294T2 (en) 2016-02-29

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HUE10735337A HUE025294T2 (en) 2009-06-15 2010-06-15 New chemokine-binding polypeptides that are able to inhibit the process of autoimmunity, inflammation and cancer

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US (3) US8685398B2 (OSRAM)
EP (1) EP2443137B1 (OSRAM)
JP (1) JP5784010B2 (OSRAM)
KR (1) KR20120046163A (OSRAM)
CN (1) CN102482324B (OSRAM)
BR (1) BRPI1009716A2 (OSRAM)
CA (1) CA2765188A1 (OSRAM)
DK (1) DK2443137T3 (OSRAM)
HU (1) HUE025294T2 (OSRAM)
MX (1) MX2011013457A (OSRAM)
WO (1) WO2010146584A1 (OSRAM)

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CN102481332A (zh) 2009-06-14 2012-05-30 拜欧肯疗法有限公司 用于提高血小板水平的肽疗法
KR20120046163A (ko) 2009-06-15 2012-05-09 바이오카인 테라퓨틱스 리미티드 자가면역, 염증 및 암의 과정을 저해할 수 있는 신규한 케모카인 결합 폴리펩타이드류
WO2012095849A1 (en) 2011-01-10 2012-07-19 Biokine Therapeutics Ltd. Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma
WO2013160895A1 (en) 2012-04-24 2013-10-31 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
CN107698664A (zh) * 2014-09-05 2018-02-16 马恒标 大蒜中提取得到的抗肿瘤活性的多肽
US20170226157A1 (en) * 2014-12-09 2017-08-10 Biokine Therapeutics Ltd. Compositions and methods for the treatment of ocular diseases
WO2017009842A2 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
EP3390378B1 (en) 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
DK3390364T3 (da) 2015-12-17 2020-10-12 Biokine Therapeutics Ltd Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
BR112018016924A2 (pt) 2016-02-23 2019-01-02 Biokine Therapeutics Ltd método de seleção de regime de tratamento para indivíduo que tem leucemia mieloide aguda (lma), método de maximização de resposta ao tratamento de leucemia mieloide aguda (lma), método de tratamento de lma, antagonista de cxcr4 e agente quimioterápico no tratamento de lma
CN112567053A (zh) * 2018-08-10 2021-03-26 潘泽尔纳疗法有限公司 重组核酸构建体
KR20200044321A (ko) * 2018-10-19 2020-04-29 아이진 주식회사 염증성 질환의 예방 또는 치료용 약학적 조성물
IL288144B2 (en) 2019-05-15 2024-03-01 Alonbio Ltd Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death
KR102736939B1 (ko) * 2021-09-30 2024-12-03 (주)케어젠 항염증 활성을 갖는 펩타이드 및 이의 용도
KR102609822B1 (ko) * 2021-10-05 2023-12-06 (주)케어젠 항염증 활성을 갖는 펩타이드와 이의 용도

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WO2007052173A2 (en) * 2005-02-23 2007-05-10 Endocube S.A.S. Activity of thap-family chemokine-binding domains
JP2009531022A (ja) 2006-02-17 2009-09-03 ラパポート ファミリー インスティテュート フォー リサーチ イン ザ メディカル サイエンシーズ Ｃｃｒ５／ｃｃｒ５リガンド関連疾患を治療するための分子およびその使用方法
KR20120046163A (ko) 2009-06-15 2012-05-09 바이오카인 테라퓨틱스 리미티드 자가면역, 염증 및 암의 과정을 저해할 수 있는 신규한 케모카인 결합 폴리펩타이드류

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JP2012529906A (ja) 2012-11-29
US20120087921A1 (en) 2012-04-12
EP2443137B1 (en) 2015-05-20
US20170015708A1 (en) 2017-01-19
US8685398B2 (en) 2014-04-01
WO2010146584A1 (en) 2010-12-23
BRPI1009716A2 (pt) 2016-10-11
US9493557B2 (en) 2016-11-15
DK2443137T3 (en) 2015-08-24
US20140154249A1 (en) 2014-06-05
CA2765188A1 (en) 2010-12-23
CN102482324A (zh) 2012-05-30
MX2011013457A (es) 2012-05-08
CN102482324B (zh) 2014-07-02

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