CA2765188A1 - Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer - Google Patents

Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer Download PDF

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Publication number
CA2765188A1
CA2765188A1 CA2765188A CA2765188A CA2765188A1 CA 2765188 A1 CA2765188 A1 CA 2765188A1 CA 2765188 A CA2765188 A CA 2765188A CA 2765188 A CA2765188 A CA 2765188A CA 2765188 A1 CA2765188 A1 CA 2765188A1
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Prior art keywords
polypeptide
chemokine
domain
seq
administration
Prior art date
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Abandoned
Application number
CA2765188A
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English (en)
French (fr)
Inventor
Michal Abraham
Orly Eizenberg
Amnon Peled
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biokine Therapeutics Ltd
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Biokine Therapeutics Ltd
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Filing date
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Publication of CA2765188A1 publication Critical patent/CA2765188A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
CA2765188A 2009-06-15 2010-06-15 Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer Abandoned CA2765188A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21349309P 2009-06-15 2009-06-15
US61/213,493 2009-06-15
PCT/IL2010/000473 WO2010146584A1 (en) 2009-06-15 2010-06-15 Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer

Publications (1)

Publication Number Publication Date
CA2765188A1 true CA2765188A1 (en) 2010-12-23

Family

ID=42933139

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2765188A Abandoned CA2765188A1 (en) 2009-06-15 2010-06-15 Novel chemokine binding polypeptides capable of inhibiting the course of autoimmunity, inflammation and cancer

Country Status (11)

Country Link
US (3) US8685398B2 (OSRAM)
EP (1) EP2443137B1 (OSRAM)
JP (1) JP5784010B2 (OSRAM)
KR (1) KR20120046163A (OSRAM)
CN (1) CN102482324B (OSRAM)
BR (1) BRPI1009716A2 (OSRAM)
CA (1) CA2765188A1 (OSRAM)
DK (1) DK2443137T3 (OSRAM)
HU (1) HUE025294T2 (OSRAM)
MX (1) MX2011013457A (OSRAM)
WO (1) WO2010146584A1 (OSRAM)

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AU2003261723A1 (en) 2002-08-27 2004-03-19 Takeda Chemical Industries, Ltd. Cxcr4 antagonist and use thereof
EP2094274A4 (en) 2006-12-21 2011-05-11 Biokine Therapeutics Ltd T-140 PEPTIDE ANALOGUE WITH CXCR4 SUPERAGONIST ACTIVITY FOR BONE MARROW RECOVERY
CN102481332A (zh) 2009-06-14 2012-05-30 拜欧肯疗法有限公司 用于提高血小板水平的肽疗法
KR20120046163A (ko) 2009-06-15 2012-05-09 바이오카인 테라퓨틱스 리미티드 자가면역, 염증 및 암의 과정을 저해할 수 있는 신규한 케모카인 결합 폴리펩타이드류
WO2012095849A1 (en) 2011-01-10 2012-07-19 Biokine Therapeutics Ltd. Peptides and compositions for the treatment of neuroectodermal derived tumors and retinoblastoma
WO2013160895A1 (en) 2012-04-24 2013-10-31 Biokine Therapeutics Ltd. Peptides and use thereof in the treatment of large cell lung cancer
CN107698664A (zh) * 2014-09-05 2018-02-16 马恒标 大蒜中提取得到的抗肿瘤活性的多肽
US20170226157A1 (en) * 2014-12-09 2017-08-10 Biokine Therapeutics Ltd. Compositions and methods for the treatment of ocular diseases
WO2017009842A2 (en) 2015-07-16 2017-01-19 Biokine Therapeutics Ltd. Compositions and methods for treating cancer
EP3390378B1 (en) 2015-12-17 2022-03-30 AlonBio Ltd. Small molecules against cancer
DK3390364T3 (da) 2015-12-17 2020-10-12 Biokine Therapeutics Ltd Små molekyler til hæmning af kemokinaktivitet og/eller cancercellevækst
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
BR112018016924A2 (pt) 2016-02-23 2019-01-02 Biokine Therapeutics Ltd método de seleção de regime de tratamento para indivíduo que tem leucemia mieloide aguda (lma), método de maximização de resposta ao tratamento de leucemia mieloide aguda (lma), método de tratamento de lma, antagonista de cxcr4 e agente quimioterápico no tratamento de lma
CN112567053A (zh) * 2018-08-10 2021-03-26 潘泽尔纳疗法有限公司 重组核酸构建体
KR20200044321A (ko) * 2018-10-19 2020-04-29 아이진 주식회사 염증성 질환의 예방 또는 치료용 약학적 조성물
IL288144B2 (en) 2019-05-15 2024-03-01 Alonbio Ltd Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death
KR102736939B1 (ko) * 2021-09-30 2024-12-03 (주)케어젠 항염증 활성을 갖는 펩타이드 및 이의 용도
KR102609822B1 (ko) * 2021-10-05 2023-12-06 (주)케어젠 항염증 활성을 갖는 펩타이드와 이의 용도

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US20030221931A1 (en) 2002-02-28 2003-12-04 Steve Marsh Sliding device
WO2007052173A2 (en) * 2005-02-23 2007-05-10 Endocube S.A.S. Activity of thap-family chemokine-binding domains
JP2009531022A (ja) 2006-02-17 2009-09-03 ラパポート ファミリー インスティテュート フォー リサーチ イン ザ メディカル サイエンシーズ Ｃｃｒ５／ｃｃｒ５リガンド関連疾患を治療するための分子およびその使用方法
KR20120046163A (ko) 2009-06-15 2012-05-09 바이오카인 테라퓨틱스 리미티드 자가면역, 염증 및 암의 과정을 저해할 수 있는 신규한 케모카인 결합 폴리펩타이드류

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JP2012529906A (ja) 2012-11-29
US20120087921A1 (en) 2012-04-12
HUE025294T2 (en) 2016-02-29
EP2443137B1 (en) 2015-05-20
US20170015708A1 (en) 2017-01-19
US8685398B2 (en) 2014-04-01
WO2010146584A1 (en) 2010-12-23
BRPI1009716A2 (pt) 2016-10-11
US9493557B2 (en) 2016-11-15
DK2443137T3 (en) 2015-08-24
US20140154249A1 (en) 2014-06-05
CN102482324A (zh) 2012-05-30
MX2011013457A (es) 2012-05-08
CN102482324B (zh) 2014-07-02

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