HU223205B1 - Helyileg alkalmazható készítmény peptidszerű gyógyhatású vegyületek élő szervezetbe vitelére - Google Patents
Helyileg alkalmazható készítmény peptidszerű gyógyhatású vegyületek élő szervezetbe vitelére Download PDFInfo
- Publication number
- HU223205B1 HU223205B1 HU9603327A HUP9603327A HU223205B1 HU 223205 B1 HU223205 B1 HU 223205B1 HU 9603327 A HU9603327 A HU 9603327A HU P9603327 A HUP9603327 A HU P9603327A HU 223205 B1 HU223205 B1 HU 223205B1
- Authority
- HU
- Hungary
- Prior art keywords
- peptide
- composition according
- component
- insulin
- iii
- Prior art date
Links
- 239000012049 topical pharmaceutical composition Substances 0.000 title claims description 15
- 150000001875 compounds Chemical class 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 39
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 34
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims abstract description 18
- 102000004877 Insulin Human genes 0.000 claims abstract description 17
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (24)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9603327A HU223205B1 (hu) | 1996-12-03 | 1996-12-03 | Helyileg alkalmazható készítmény peptidszerű gyógyhatású vegyületek élő szervezetbe vitelére |
AT97943081T ATE213954T1 (de) | 1996-12-03 | 1997-09-08 | Topisches präparat zur abgabe eines peptidarzneimittels in lebewesen |
EA199900438A EA002023B1 (ru) | 1996-12-03 | 1997-09-08 | Фармацевтическая композиция местного применения для введения в живой организм, содержащая пептидное лекарственное средство |
BR9714945-4A BR9714945A (pt) | 1996-12-03 | 1997-09-08 | Composição topicamente aplicável para introdução de fármacos peptidaceosos em organismos vivos |
APAP/P/1999/001554A AP1065A (en) | 1996-12-03 | 1997-09-08 | Topical preparation for introducing peptidaceous pharmacons in living organisms. |
SK687-99A SK284306B6 (sk) | 1996-12-03 | 1997-09-08 | Topický prípravok na zavádzanie peptidických farmák do živých organizmov |
IL12991597A IL129915A0 (en) | 1996-12-03 | 1997-09-08 | Topical preparation for introducing peptidaceous pharmacons in living organisms |
CA002272604A CA2272604A1 (en) | 1996-12-03 | 1997-09-08 | Topical preparation for introducing peptidaceous pharmacons in living organisms |
DE69710918T DE69710918T2 (de) | 1996-12-03 | 1997-09-08 | Topisches präparat zur abgabe eines peptidarzneimittels in lebewesen |
KR10-1999-7004908A KR100466757B1 (ko) | 1996-12-03 | 1997-09-08 | 생체에 펩티드성 약물을 유입시키기 위한 국소 제제 |
ES97943081T ES2174291T3 (es) | 1996-12-03 | 1997-09-08 | Preparacion topica para introducir medicamentos peptidicos en organismos vivos. |
CN97180273A CN1239436A (zh) | 1996-12-03 | 1997-09-08 | 用于将肽药物引入生物体的局部制剂 |
NZ336045A NZ336045A (en) | 1996-12-03 | 1997-09-08 | Topical preparation containing a polypeptide, an epithelizing agent and capsaicine, histamine and/or cantharis extract |
AU44688/97A AU744380B2 (en) | 1996-12-03 | 1997-09-08 | Topical preparation for introducing peptidaceous pharmacons in living organisms |
EP97943081A EP0942743B1 (de) | 1996-12-03 | 1997-09-08 | Topisches präparat zur abgabe eines peptidarzneimittels in lebewesen |
PCT/HU1997/000049 WO1998024470A1 (en) | 1996-12-03 | 1997-09-08 | Topical preparation for introducing peptidaceous pharmacons in living organisms |
US09/319,282 US6399566B1 (en) | 1996-12-03 | 1997-09-08 | Topical preparation for introducing insulin in living organisms |
CZ19991920A CZ289788B6 (cs) | 1996-12-03 | 1997-09-08 | Topický přípravek pro zavádění peptidických farmak do ľivých organismů |
JP52537298A JP2001505222A (ja) | 1996-12-03 | 1997-09-08 | 生物体にペプチド系医薬を導入するための局所用製剤 |
DK97943081T DK0942743T3 (da) | 1996-12-03 | 1997-09-08 | Topisk præparat til indføring af peptid-farmaka i levende organismer |
TR1999/01232T TR199901232T2 (xx) | 1996-12-03 | 1997-09-08 | Canl� organizmalara peptitli farmakonlar�n verilmesi i�in lokal terkip. |
IS5052A IS5052A (is) | 1996-12-03 | 1999-05-18 | Samsetning til að bera á húð til að innleiða peptíðtengd lyf í lifandi lífverur |
NO992668A NO992668D0 (no) | 1996-12-03 | 1999-06-02 | Topisk preparat for innf°ring av farmas°ytisk aktive peptidforbindelser i levende organismer |
OA9900140A OA11180A (en) | 1996-12-03 | 1999-06-23 | Topical preparation for introducing peptidaceous pharmacons in living organisms |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9603327A HU223205B1 (hu) | 1996-12-03 | 1996-12-03 | Helyileg alkalmazható készítmény peptidszerű gyógyhatású vegyületek élő szervezetbe vitelére |
Publications (4)
Publication Number | Publication Date |
---|---|
HU9603327D0 HU9603327D0 (en) | 1997-01-28 |
HUP9603327A2 HUP9603327A2 (hu) | 1998-10-28 |
HUP9603327A3 HUP9603327A3 (en) | 1998-11-30 |
HU223205B1 true HU223205B1 (hu) | 2004-03-29 |
Family
ID=89994502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9603327A HU223205B1 (hu) | 1996-12-03 | 1996-12-03 | Helyileg alkalmazható készítmény peptidszerű gyógyhatású vegyületek élő szervezetbe vitelére |
Country Status (24)
Country | Link |
---|---|
US (1) | US6399566B1 (de) |
EP (1) | EP0942743B1 (de) |
JP (1) | JP2001505222A (de) |
KR (1) | KR100466757B1 (de) |
CN (1) | CN1239436A (de) |
AP (1) | AP1065A (de) |
AT (1) | ATE213954T1 (de) |
AU (1) | AU744380B2 (de) |
BR (1) | BR9714945A (de) |
CA (1) | CA2272604A1 (de) |
CZ (1) | CZ289788B6 (de) |
DE (1) | DE69710918T2 (de) |
DK (1) | DK0942743T3 (de) |
EA (1) | EA002023B1 (de) |
ES (1) | ES2174291T3 (de) |
HU (1) | HU223205B1 (de) |
IL (1) | IL129915A0 (de) |
IS (1) | IS5052A (de) |
NO (1) | NO992668D0 (de) |
NZ (1) | NZ336045A (de) |
OA (1) | OA11180A (de) |
SK (1) | SK284306B6 (de) |
TR (1) | TR199901232T2 (de) |
WO (1) | WO1998024470A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU225734B1 (en) * | 1999-07-28 | 2007-07-30 | Zoltan Dardai | Multilayer plaster for introducing peptidaceous pharmacons in living organisms and process for producing thereof |
AU6751000A (en) * | 1999-07-30 | 2001-02-19 | Maxim Pharmaceuticals, Inc. | Use of histamine as a drug delivery enhancing compound for use in transmucosal or transdermal delivery |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US7423004B2 (en) | 2003-01-31 | 2008-09-09 | Smithkline Beecham Corporation | Solid dispersion compositions |
US8637096B2 (en) | 2009-12-04 | 2014-01-28 | Curtis C. Stojan | Compositions and method for enhancing insulin activity |
KR101457263B1 (ko) * | 2012-02-03 | 2014-11-07 | 단국대학교 산학협력단 | 파스의 제조방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3009143A1 (de) | 1980-03-10 | 1981-10-01 | Hans Dr Bauersfeld | Arzneimittelzubereitung und deren verwendung |
JPS5879913A (ja) * | 1981-11-09 | 1983-05-13 | Taizo Ayukawa | ヘアトニツク組成物 |
DE69130706D1 (de) * | 1990-04-05 | 1999-02-11 | Nurture Inc | Verfahren zur beseitigung von ausgelaufendem öl |
CH687053A5 (fr) * | 1993-10-05 | 1996-09-13 | Crina | Additifs pour l'alimentation animale et procédé pour leur préparation. |
US5686100A (en) * | 1994-11-22 | 1997-11-11 | E.R. Squibb & Sons, Inc. | Prophylactic and therapeutic treatment of skin sensitization and irritation |
AUPN089295A0 (en) * | 1995-02-02 | 1995-03-02 | International Diabetes Institute | Treatment of diabetic neuropathy |
-
1996
- 1996-12-03 HU HU9603327A patent/HU223205B1/hu not_active IP Right Cessation
-
1997
- 1997-09-08 CA CA002272604A patent/CA2272604A1/en not_active Abandoned
- 1997-09-08 JP JP52537298A patent/JP2001505222A/ja active Pending
- 1997-09-08 DK DK97943081T patent/DK0942743T3/da active
- 1997-09-08 CN CN97180273A patent/CN1239436A/zh active Pending
- 1997-09-08 US US09/319,282 patent/US6399566B1/en not_active Expired - Fee Related
- 1997-09-08 BR BR9714945-4A patent/BR9714945A/pt not_active IP Right Cessation
- 1997-09-08 ES ES97943081T patent/ES2174291T3/es not_active Expired - Lifetime
- 1997-09-08 DE DE69710918T patent/DE69710918T2/de not_active Expired - Fee Related
- 1997-09-08 CZ CZ19991920A patent/CZ289788B6/cs not_active IP Right Cessation
- 1997-09-08 NZ NZ336045A patent/NZ336045A/xx unknown
- 1997-09-08 WO PCT/HU1997/000049 patent/WO1998024470A1/en active IP Right Grant
- 1997-09-08 AU AU44688/97A patent/AU744380B2/en not_active Ceased
- 1997-09-08 KR KR10-1999-7004908A patent/KR100466757B1/ko not_active IP Right Cessation
- 1997-09-08 AT AT97943081T patent/ATE213954T1/de not_active IP Right Cessation
- 1997-09-08 TR TR1999/01232T patent/TR199901232T2/xx unknown
- 1997-09-08 AP APAP/P/1999/001554A patent/AP1065A/en active
- 1997-09-08 EP EP97943081A patent/EP0942743B1/de not_active Expired - Lifetime
- 1997-09-08 SK SK687-99A patent/SK284306B6/sk unknown
- 1997-09-08 EA EA199900438A patent/EA002023B1/ru not_active IP Right Cessation
- 1997-09-08 IL IL12991597A patent/IL129915A0/xx unknown
-
1999
- 1999-05-18 IS IS5052A patent/IS5052A/is unknown
- 1999-06-02 NO NO992668A patent/NO992668D0/no not_active Application Discontinuation
- 1999-06-23 OA OA9900140A patent/OA11180A/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HFG4 | Patent granted, date of granting |
Effective date: 20040218 |
|
MM4A | Lapse of definitive patent protection due to non-payment of fees |