HU198685B - Process for production of new derivatives of indoline - Google Patents

Process for production of new derivatives of indoline Download PDF

Info

Publication number
HU198685B
HU198685B HU873020A HU302087A HU198685B HU 198685 B HU198685 B HU 198685B HU 873020 A HU873020 A HU 873020A HU 302087 A HU302087 A HU 302087A HU 198685 B HU198685 B HU 198685B
Authority
HU
Hungary
Prior art keywords
formula
compound
solution
ethanol
ethyl
Prior art date
Application number
HU873020A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT46891A (en
Inventor
Keith Mills
Colin D Eldred
Alexander W Oxford
Ian H Coates
David E Bays
Colin F Webb
Michael D Dowle
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to HU873020A priority Critical patent/HU198685B/hu
Publication of HUT46891A publication Critical patent/HUT46891A/hu
Publication of HU198685B publication Critical patent/HU198685B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU873020A 1986-01-08 1987-07-03 Process for production of new derivatives of indoline HU198685B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU873020A HU198685B (en) 1986-01-08 1987-07-03 Process for production of new derivatives of indoline

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868600397A GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds
HU873020A HU198685B (en) 1986-01-08 1987-07-03 Process for production of new derivatives of indoline

Publications (2)

Publication Number Publication Date
HUT46891A HUT46891A (en) 1988-12-28
HU198685B true HU198685B (en) 1989-11-28

Family

ID=10591074

Family Applications (1)

Application Number Title Priority Date Filing Date
HU873020A HU198685B (en) 1986-01-08 1987-07-03 Process for production of new derivatives of indoline

Country Status (23)

Country Link
US (1) US4855314A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0240096A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS62228056A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR870007116A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1030409A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU597325B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE1000071A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH672637A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3700408A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK8787A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI870062A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2595351B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB8600397D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU198685B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL81201A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1205849B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU86732A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8700026A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO870075L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ218868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH24741A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT84075B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA87105B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8724912D0 (en) 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8823731D0 (en) * 1988-10-10 1988-11-16 Smith Kline French Lab Biologically active compounds
EP0486666B1 (en) * 1990-06-07 1997-08-13 Zeneca Limited Therapeutic heterocyclic compounds
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
PL168919B1 (pl) * 1990-10-15 1996-05-31 Pfizer Sposób wytwarzania nowych pochodnych indolu PL PL PL PL
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
CA2061520C (en) * 1991-03-27 2003-04-22 Lawrence J. Daher Delivery system for enhanced onset and increased potency
UA41297C2 (uk) * 1991-11-25 2001-09-17 Пфайзер, Інк. Похідні індолу, фармацевтична композиція і спосіб лікування
TW288010B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1992-03-05 1996-10-11 Pfizer
NZ251086A (en) 1992-04-07 1996-09-25 Pfizer Substituted indole derivatives and medicaments
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
NZ251047A (en) * 1992-04-10 1996-09-25 Pfizer Acylaminoindole derivatives and medicaments
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1992-11-02 1995-07-11 Pfizer
FR2707639B1 (fr) * 1993-06-30 1995-10-13 Pf Medicament Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
US5849739A (en) * 1993-08-31 1998-12-15 Pfizer Inc. 5-arylindole derivatives
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
US20030153596A1 (en) * 2000-08-21 2003-08-14 Suh Young Ger Novel thiourea derivatives and the pharmaceutical compositions containing the same
MXPA04012834A (es) * 2002-06-21 2005-04-25 Suven Life Sciences Ltd Arilalquil indoles novedosos que tienen afinidad por el receptor de la serotonina, utiles como agentes terapeuticos, proceso para su preparacion y composiciones farmaceuticas que los contienen.
WO2004000849A2 (en) * 2002-06-21 2003-12-31 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
ATE343580T1 (de) 2002-06-21 2006-11-15 Suven Life Sciences Ltd Tetracyclische arylcarbonyl indole mit serotoninrezeptoraffinität als arzneimittel, verfahren zu ihrer herstellung und pharmazeutische zubereitungen
US7875605B2 (en) * 2002-11-28 2011-01-25 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
AU2003285759B2 (en) 2002-11-28 2010-01-28 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
NZ540841A (en) * 2002-12-18 2008-08-29 Suven Life Sciences Ltd Tetracyclic 3-substituted indoles having serotonin receptor affinity
CN1729174B (zh) * 2002-12-20 2015-10-21 西巴特殊化学品控股有限公司 胺的合成以及用于合成胺的中间体
NZ572744A (en) 2006-06-12 2011-05-27 Novartis Ag Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
AU550010B2 (en) * 1980-08-12 1986-02-27 Glaxo Group Limited 5-tryptaminoacetamides, carbamates and ureas
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
GB2185020A (en) 1987-07-08
GB8700382D0 (en) 1987-02-11
PT84075B (pt) 1989-07-31
IL81201A0 (en) 1987-08-31
IT8747507A0 (it) 1987-01-08
ZA87105B (en) 1987-09-30
GB8600397D0 (en) 1986-02-12
GB2185020B (en) 1990-05-16
NL8700026A (nl) 1987-08-03
NO870075L (no) 1987-07-09
NZ218868A (en) 1990-04-26
CN1030409A (zh) 1989-01-18
NO870075D0 (no) 1987-01-08
PH24741A (en) 1990-10-01
AU6742087A (en) 1987-07-09
CH672637A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-12-15
HUT46891A (en) 1988-12-28
DE3700408A1 (de) 1987-07-09
BE1000071A4 (fr) 1988-02-02
LU86732A1 (fr) 1988-02-02
FR2595351A1 (fr) 1987-09-11
IT1205849B (it) 1989-03-31
FR2595351B1 (fr) 1990-07-13
IL81201A (en) 1991-06-10
FI870062A7 (fi) 1987-07-09
KR870007116A (ko) 1987-08-14
EP0240096A1 (en) 1987-10-07
AU597325B2 (en) 1990-05-31
FI870062A0 (fi) 1987-01-08
DK8787A (da) 1987-07-09
US4855314A (en) 1989-08-08
JPS62228056A (ja) 1987-10-06
DK8787D0 (da) 1987-01-08
PT84075A (en) 1987-02-01

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee