AU597325B2 - Substituted indoles - Google Patents

Substituted indoles Download PDF

Info

Publication number
AU597325B2
AU597325B2 AU67420/87A AU6742087A AU597325B2 AU 597325 B2 AU597325 B2 AU 597325B2 AU 67420/87 A AU67420/87 A AU 67420/87A AU 6742087 A AU6742087 A AU 6742087A AU 597325 B2 AU597325 B2 AU 597325B2
Authority
AU
Australia
Prior art keywords
group
compound
general formula
give
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU67420/87A
Other languages
English (en)
Other versions
AU6742087A (en
Inventor
David Edmund Bays
Ian Harold Coates
Michael Dennis Dowle
Colin David Eldred
Keith Mills
Alexander William Oxford
Colin Frederick Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU6742087A publication Critical patent/AU6742087A/en
Application granted granted Critical
Publication of AU597325B2 publication Critical patent/AU597325B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU67420/87A 1986-01-08 1987-01-08 Substituted indoles Ceased AU597325B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868600397A GB8600397D0 (en) 1986-01-08 1986-01-08 Chemical compounds
GB8600397 1986-01-08

Publications (2)

Publication Number Publication Date
AU6742087A AU6742087A (en) 1987-07-09
AU597325B2 true AU597325B2 (en) 1990-05-31

Family

ID=10591074

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67420/87A Ceased AU597325B2 (en) 1986-01-08 1987-01-08 Substituted indoles

Country Status (23)

Country Link
US (1) US4855314A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0240096A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS62228056A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR870007116A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1030409A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU597325B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE1000071A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH672637A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3700408A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK8787A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI870062A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2595351B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB8600397D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU198685B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL81201A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1205849B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU86732A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL8700026A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO870075L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ218868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH24741A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT84075B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA87105B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
GB8823731D0 (en) * 1988-10-10 1988-11-16 Smith Kline French Lab Biologically active compounds
ES2104708T3 (es) * 1990-06-07 1997-10-16 Zeneca Ltd Compuestos heterociclicos terapeuticos.
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
ES2104733T3 (es) * 1990-10-15 1997-10-16 Pfizer Derivados de indol.
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
CA2061520C (en) * 1991-03-27 2003-04-22 Lawrence J. Daher Delivery system for enhanced onset and increased potency
PL173875B1 (pl) * 1991-11-25 1998-05-29 Pfizer Sposób wytwarzania pochodnych indolu
TW288010B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1992-03-05 1996-10-11 Pfizer
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
BR9306201A (pt) 1992-04-07 1998-06-23 Pfizer Derivados de indol como agonistas 5-ht1
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
KR0179074B1 (ko) * 1992-04-10 1999-03-20 알렌 제이. 스피겔 5-ht1 작용물질로서의 아실아미노인돌 유도체
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
TW251284B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1992-11-02 1995-07-11 Pfizer
FR2707639B1 (fr) * 1993-06-30 1995-10-13 Pf Medicament Nouveaux composés indoliques dérivés d'arylamines comme ligands sélectifs des récepteurs 5HT1D et 5HT1B.
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
CN1129933A (zh) * 1993-08-31 1996-08-28 辉瑞大药厂 5-芳基吲哚衍生物
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
FR2749846B1 (fr) * 1996-06-17 1998-09-11 Pf Medicament Sel de methanesulfonate d'une arylpiperazine derivee de tryptamine et ses solvates pour usage pharmaceutique
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
KR100453078B1 (ko) * 2000-08-21 2004-10-15 주식회사 태평양 신규 티오우레아 화합물 및 이를 함유하는 약제학적 조성물
PT1517909E (pt) 2002-06-21 2007-01-31 Suven Life Sciences Ltd Novos arilcarbonilindoles tetracíclicos que possuem afinidade para o receptor de serotonina, úteis como agentes terapêuticos, processo para a sua preparação e composições farmacêuticas que os contêm
RU2340619C2 (ru) * 2002-06-21 2008-12-10 Сувен Лайф Сайенсиз Лимитед Новые тетрациклические арилсульфонилиндолы с аффинностью к серотониновым рецепторам, пригодные в качестве лекарственных средств, способ их получения и содержащие их фармацевтические композиции
ES2336664T3 (es) * 2002-06-21 2010-04-15 Suven Life Sciences Limited Arilaquil indoles que tienen afinidad por receptores de serotonina utiles como agentes terapeuticos, procesos para su preparacion y composiciones farmaceuticas que los contienen.
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
AU2003237599B2 (en) * 2002-11-28 2009-06-18 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
KR100739987B1 (ko) * 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌
US7645886B2 (en) * 2002-12-20 2010-01-12 Ciba Specialty Corporation Synthesis of amines and intermediates for the synthesis thereof
NZ572744A (en) 2006-06-12 2011-05-27 Novartis Ag Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2081717A (en) * 1980-08-12 1982-02-24 Glaxo Group Ltd Hereocyclic compounds
AU6741887A (en) * 1986-01-08 1987-07-09 Glaxo Group Limited Indole derivatives, processes for their preparation and pharmaceutical compositions containing them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
IT1171450B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici, procedimento per produrli e composizioni farmaceutiche che li contengono
GB8332434D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Production of chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2081717A (en) * 1980-08-12 1982-02-24 Glaxo Group Ltd Hereocyclic compounds
AU6741887A (en) * 1986-01-08 1987-07-09 Glaxo Group Limited Indole derivatives, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US4855314A (en) 1989-08-08
FI870062A7 (fi) 1987-07-09
ZA87105B (en) 1987-09-30
EP0240096A1 (en) 1987-10-07
NL8700026A (nl) 1987-08-03
BE1000071A4 (fr) 1988-02-02
HUT46891A (en) 1988-12-28
NO870075D0 (no) 1987-01-08
PT84075A (en) 1987-02-01
FR2595351B1 (fr) 1990-07-13
DK8787D0 (da) 1987-01-08
LU86732A1 (fr) 1988-02-02
IL81201A0 (en) 1987-08-31
IL81201A (en) 1991-06-10
DK8787A (da) 1987-07-09
IT8747507A0 (it) 1987-01-08
FR2595351A1 (fr) 1987-09-11
NO870075L (no) 1987-07-09
GB8700382D0 (en) 1987-02-11
FI870062A0 (fi) 1987-01-08
CN1030409A (zh) 1989-01-18
JPS62228056A (ja) 1987-10-06
PT84075B (pt) 1989-07-31
HU198685B (en) 1989-11-28
GB8600397D0 (en) 1986-02-12
IT1205849B (it) 1989-03-31
KR870007116A (ko) 1987-08-14
GB2185020A (en) 1987-07-08
NZ218868A (en) 1990-04-26
GB2185020B (en) 1990-05-16
AU6742087A (en) 1987-07-09
DE3700408A1 (de) 1987-07-09
PH24741A (en) 1990-10-01
CH672637A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-12-15

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