HU192152B - Process for preparing new imidazole derivatives - Google Patents

Process for preparing new imidazole derivatives Download PDF

Info

Publication number
HU192152B
HU192152B HU832382A HU238283A HU192152B HU 192152 B HU192152 B HU 192152B HU 832382 A HU832382 A HU 832382A HU 238283 A HU238283 A HU 238283A HU 192152 B HU192152 B HU 192152B
Authority
HU
Hungary
Prior art keywords
formula
methoxy
amino
group
alkyl
Prior art date
Application number
HU832382A
Other languages
English (en)
Hungarian (hu)
Inventor
Norbert Hauel
Volkhard Austel
Joachim Heider
Manfred Reiffen
Willi Diederen
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of HU192152B publication Critical patent/HU192152B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU832382A 1982-07-01 1983-06-30 Process for preparing new imidazole derivatives HU192152B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823224512 DE3224512A1 (de) 1982-07-01 1982-07-01 Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
HU192152B true HU192152B (en) 1987-05-28

Family

ID=6167285

Family Applications (1)

Application Number Title Priority Date Filing Date
HU832382A HU192152B (en) 1982-07-01 1983-06-30 Process for preparing new imidazole derivatives

Country Status (23)

Country Link
US (2) US4582837A (en, 2012)
EP (1) EP0098448A3 (en, 2012)
JP (1) JPS5927875A (en, 2012)
KR (1) KR840005432A (en, 2012)
AU (1) AU1642883A (en, 2012)
CS (1) CS254319B2 (en, 2012)
DD (1) DD210271A5 (en, 2012)
DE (1) DE3224512A1 (en, 2012)
DK (1) DK301383A (en, 2012)
ES (3) ES523709A0 (en, 2012)
FI (1) FI832022A7 (en, 2012)
GB (1) GB2122995B (en, 2012)
GR (1) GR78598B (en, 2012)
HU (1) HU192152B (en, 2012)
IL (1) IL69111A0 (en, 2012)
NO (1) NO832356L (en, 2012)
NZ (1) NZ204766A (en, 2012)
PH (1) PH20810A (en, 2012)
PL (2) PL142880B1 (en, 2012)
PT (1) PT76968B (en, 2012)
SU (2) SU1316559A3 (en, 2012)
YU (1) YU143283A (en, 2012)
ZA (1) ZA834777B (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867200B1 (en) 1998-12-18 2005-03-15 Axys Pharmaceuticals, Inc. (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
GR850426B (en, 2012) * 1984-02-24 1985-06-18 Lilly Co Eli
PL147842B1 (en) * 1984-05-12 1989-08-31 Method of obtaining novel pyroisobenzimidazoles
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4720501A (en) * 1985-10-09 1988-01-19 Chemi Linz Aktiengesellschaft 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and salts thereof useful in the treatment of myocardial insufficiency
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DE10015866A1 (de) * 2000-03-30 2001-10-11 Bayer Ag Aryl- und Heteroarylsulfonate
EP1294718A2 (en) 2000-06-14 2003-03-26 Warner-Lambert Company Llc 6,5-fused bicyclic heterocycles
NZ528835A (en) * 2001-03-12 2005-05-27 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2003211942A1 (en) * 2002-02-14 2003-09-04 Shionogi And Co., Ltd. Process for production of 2,3-diaminopyridine derivatives
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
CA2533990A1 (en) * 2003-08-08 2005-02-17 Avanir Pharmaceuticals Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
KR20080035594A (ko) * 2005-07-01 2008-04-23 닛뽕 케미파 가부시키가이샤 크산틴옥시다아제 저해제
JP5175730B2 (ja) * 2005-08-15 2013-04-03 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｔｐｏ模倣剤としての化合物および組成物
EP2038259A1 (en) * 2006-06-29 2009-03-25 F.Hoffmann-La Roche Ag Benzimidazole derivatives, method for the production thereof, their use as fxr agonists and pharmaceutical preparations containing the same
CL2007003443A1 (es) * 2006-11-30 2008-07-11 Wyeth6 3 Compuestos derivados de benzoxazoles sustituidos; procedimiento de preparacion, utiles como agentes estrogenicos.
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
US9233961B2 (en) 2013-03-15 2016-01-12 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
LT3083627T (lt) 2013-12-19 2018-12-27 Novartis Ag [1,2,4]triazolo[1,5-a]pirimidino dariniai kaip protozoano proteasomos inhibitoriai, skirti parazitinių ligų tokių kaip leišmaniozė, gydymui
AR099677A1 (es) * 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
CN108290884A (zh) * 2015-11-16 2018-07-17 先正达参股股份有限公司 具有含硫取代基的杀有害生物活性杂环衍生物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867200B1 (en) 1998-12-18 2005-03-15 Axys Pharmaceuticals, Inc. (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors

Also Published As

Publication number Publication date
PH20810A (en) 1987-04-24
ES8500056A1 (es) 1984-10-01
DK301383A (da) 1984-01-02
IL69111A0 (en) 1983-10-31
EP0098448A2 (de) 1984-01-18
PL142880B1 (en) 1987-12-31
DD210271A5 (de) 1984-06-06
FI832022L (fi) 1984-01-02
CS254319B2 (en) 1988-01-15
FI832022A0 (fi) 1983-06-06
ZA834777B (en) 1985-03-27
ES8500242A1 (es) 1984-10-01
KR840005432A (ko) 1984-11-12
FI832022A7 (fi) 1984-01-02
ES523709A0 (es) 1984-10-01
DE3224512A1 (de) 1984-01-05
GR78598B (en, 2012) 1984-09-27
PL144589B1 (en) 1988-06-30
GB2122995B (en) 1986-02-12
NZ204766A (en) 1986-09-10
NO832356L (no) 1984-01-02
SU1316559A3 (ru) 1987-06-07
PT76968A (de) 1983-07-01
ES8500241A1 (es) 1984-10-01
ES529174A0 (es) 1984-10-01
YU143283A (en) 1986-06-30
EP0098448A3 (de) 1985-04-03
US4696931A (en) 1987-09-29
GB8317732D0 (en) 1983-08-03
JPS5927875A (ja) 1984-02-14
SU1179924A3 (ru) 1985-09-15
ES529175A0 (es) 1984-10-01
DK301383D0 (da) 1983-06-30
US4582837A (en) 1986-04-15
AU1642883A (en) 1984-01-05
PT76968B (de) 1986-04-09
GB2122995A (en) 1984-01-25
PL242770A1 (en) 1986-10-21

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