HU190774B - Process for preparing ether derivatives with pharmacological activity - Google Patents
Process for preparing ether derivatives with pharmacological activity Download PDFInfo
- Publication number
- HU190774B HU190774B HU801601A HU160180A HU190774B HU 190774 B HU190774 B HU 190774B HU 801601 A HU801601 A HU 801601A HU 160180 A HU160180 A HU 160180A HU 190774 B HU190774 B HU 190774B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- group
- formyl
- compound
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7922781 | 1979-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU190774B true HU190774B (en) | 1986-11-28 |
Family
ID=10506199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU801601A HU190774B (en) | 1979-06-29 | 1980-06-27 | Process for preparing ether derivatives with pharmacological activity |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4410537A (en, 2012) |
| EP (1) | EP0022229B1 (en, 2012) |
| JP (1) | JPS5649335A (en, 2012) |
| KR (2) | KR850000073B1 (en, 2012) |
| AU (1) | AU545274B2 (en, 2012) |
| DE (1) | DE3061269D1 (en, 2012) |
| DK (1) | DK159770C (en, 2012) |
| FI (1) | FI71929C (en, 2012) |
| GB (1) | GB2053218B (en, 2012) |
| GR (1) | GR68748B (en, 2012) |
| HU (1) | HU190774B (en, 2012) |
| IL (1) | IL60422A (en, 2012) |
| IT (1) | IT1133025B (en, 2012) |
| MW (1) | MW2380A1 (en, 2012) |
| OA (1) | OA06699A (en, 2012) |
| ZA (1) | ZA803880B (en, 2012) |
| ZM (1) | ZM5780A1 (en, 2012) |
| ZW (1) | ZW14480A1 (en, 2012) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2090830B (en) * | 1980-12-18 | 1984-09-26 | Wellcome Found | Formyl ether derivatives |
| GB8606913D0 (en) * | 1986-03-20 | 1986-04-23 | Hider R C | Treatment of sickle cell disease |
| US6083522A (en) | 1997-01-09 | 2000-07-04 | Neucoll, Inc. | Devices for tissue repair and methods for preparation and use thereof |
| US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| US7279597B1 (en) | 1999-11-05 | 2007-10-09 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
| RU2300516C2 (ru) * | 1999-11-05 | 2007-06-10 | Эмисфере Текнолоджиз, Инк. | Соединения феноксикарбоновой кислоты и композиции для доставки активных веществ |
| CZ20021570A3 (cs) * | 1999-11-05 | 2002-10-16 | Emisphere Technologies, Inc. | Fenylaminkarboxylové kyseliny a kompozice pro dodávání aktivních činidel |
| JP2003528068A (ja) | 2000-03-17 | 2003-09-24 | コリクサ コーポレイション | 新規両親媒性アルデヒドならびにアジュバントおよび免疫エフェクターとしてのそれらの使用 |
| US8246969B2 (en) | 2001-11-16 | 2012-08-21 | Skinmedica, Inc. | Compositions containing aromatic aldehydes and their use in treatments |
| CN103442702B (zh) | 2011-01-07 | 2016-02-10 | 阿勒根公司 | 黑色素改良组合物及其使用方法 |
| SI2797416T1 (sl) * | 2011-12-28 | 2017-12-29 | Global Blood Therapeutics, Inc. | Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva |
| WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| AU2014237340C1 (en) * | 2013-03-15 | 2018-11-08 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN111454200A (zh) | 2013-03-15 | 2020-07-28 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| AP2015008718A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EP3816155A1 (en) * | 2013-08-23 | 2021-05-05 | Virginia Commonwealth University | Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| RS61653B2 (sr) | 2014-02-07 | 2024-10-31 | Global Blood Therapeutics Inc | Kristalni polimorfni oblik slobodne baze 2-hidroksi-6-((2-(1-izopropil-1h-pirazol-5-il)piridin-3-il)metoksi)benzaldehid |
| SG11201707127VA (en) | 2015-03-06 | 2017-09-28 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| BR112018011272A2 (pt) | 2015-12-04 | 2018-11-21 | Global Blood Therapeutics Inc | regimes de dosagem para 2-hidróxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metóxi)benzaldeído |
| RU2753543C1 (ru) * | 2016-02-08 | 2021-08-17 | Бейондспринг Фармасьютикалс, Инк. | Композиции, содержащие тукаресол или его аналоги |
| TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| CN118304304A (zh) | 2016-06-06 | 2024-07-09 | 大连万春布林医药有限公司 | 用于减少中性粒细胞减少症的组合物和方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| US11401241B2 (en) * | 2018-03-22 | 2022-08-02 | Virginia Commonwealth University | Aromatic aldehydes with sustained and enhanced in vitro and in vivo pharmacologic activity to treat sickle cell disease |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| TWI841630B (zh) | 2018-11-19 | 2024-05-11 | 美商全球血液治療公司 | 血紅素的調節劑 |
| US20240197723A1 (en) | 2021-04-09 | 2024-06-20 | Beyondspring Pharmaceuticals, Inc. | Therapeutic compositions and methods for treating tumors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU36787A1 (en, 2012) * | 1958-04-30 | |||
| CH543472A (fr) * | 1969-01-31 | 1973-10-31 | Orchimed Sa | Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques |
| CH550776A (de) | 1971-03-05 | 1974-06-28 | Ciba Geigy Ag | Herstellung neuer bis-stilbenverbindungen. |
| DE2209128C3 (de) | 1971-03-05 | 1981-10-22 | CIBA-GEIGY AG, 4002 Basel | Bis-Stilbenverbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller |
| GB1511645A (en) * | 1974-05-31 | 1978-05-24 | Univ Ife | Sickle cell anaemia treatment |
| US4137309A (en) * | 1976-10-14 | 1979-01-30 | The Procter & Gamble Company | Therapeutic treatment |
-
1980
- 1980-06-27 DE DE8080103657T patent/DE3061269D1/de not_active Expired
- 1980-06-27 EP EP80103657A patent/EP0022229B1/en not_active Expired
- 1980-06-27 AU AU59697/80A patent/AU545274B2/en not_active Ceased
- 1980-06-27 DK DK279780A patent/DK159770C/da not_active IP Right Cessation
- 1980-06-27 ZM ZM57/80A patent/ZM5780A1/xx unknown
- 1980-06-27 FI FI802052A patent/FI71929C/fi not_active IP Right Cessation
- 1980-06-27 GR GR62311A patent/GR68748B/el unknown
- 1980-06-27 MW MW23/80A patent/MW2380A1/xx unknown
- 1980-06-27 GB GB8021219A patent/GB2053218B/en not_active Expired
- 1980-06-27 IT IT49108/80A patent/IT1133025B/it active
- 1980-06-27 HU HU801601A patent/HU190774B/hu not_active IP Right Cessation
- 1980-06-27 JP JP8764580A patent/JPS5649335A/ja active Granted
- 1980-06-27 ZW ZW144/80A patent/ZW14480A1/xx unknown
- 1980-06-27 ZA ZA00803880A patent/ZA803880B/xx unknown
- 1980-06-27 KR KR1019800002541A patent/KR850000073B1/ko not_active Expired
- 1980-06-27 IL IL60422A patent/IL60422A/xx not_active IP Right Cessation
- 1980-08-09 OA OA57193A patent/OA06699A/xx unknown
-
1981
- 1981-06-09 US US06/271,950 patent/US4410537A/en not_active Expired - Lifetime
-
1984
- 1984-03-13 KR KR1019840001263A patent/KR850000072B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK279780A (da) | 1980-12-30 |
| IT1133025B (it) | 1986-07-09 |
| AU545274B2 (en) | 1985-07-11 |
| AU5969780A (en) | 1981-01-08 |
| GB2053218A (en) | 1981-02-04 |
| FI71929B (fi) | 1986-11-28 |
| IL60422A0 (en) | 1980-09-16 |
| KR850000073B1 (ko) | 1985-02-18 |
| KR850000072B1 (ko) | 1985-02-18 |
| KR830002693A (ko) | 1983-05-30 |
| EP0022229A1 (en) | 1981-01-14 |
| ZM5780A1 (en) | 1983-11-21 |
| GB2053218B (en) | 1984-01-25 |
| GR68748B (en, 2012) | 1982-02-16 |
| DK159770B (da) | 1990-12-03 |
| KR840004668A (ko) | 1984-10-22 |
| EP0022229B1 (en) | 1982-12-08 |
| IT8049108A0 (it) | 1980-06-27 |
| IL60422A (en) | 1984-06-29 |
| JPH0154339B2 (en, 2012) | 1989-11-17 |
| MW2380A1 (en) | 1982-03-10 |
| US4410537A (en) | 1983-10-18 |
| DE3061269D1 (en) | 1983-01-13 |
| JPS5649335A (en) | 1981-05-02 |
| FI802052A7 (fi) | 1980-12-30 |
| ZW14480A1 (en) | 1982-03-17 |
| FI71929C (fi) | 1987-03-09 |
| OA06699A (fr) | 1982-05-31 |
| DK159770C (da) | 1991-04-22 |
| ZA803880B (en) | 1982-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |