AU545274B2 - 5-(2-formyl-3-hydroxyphenoxy) - pentanoic acid derivatives - Google Patents

5-(2-formyl-3-hydroxyphenoxy) - pentanoic acid derivatives

Info

Publication number
AU545274B2
AU545274B2 AU59697/80A AU5969780A AU545274B2 AU 545274 B2 AU545274 B2 AU 545274B2 AU 59697/80 A AU59697/80 A AU 59697/80A AU 5969780 A AU5969780 A AU 5969780A AU 545274 B2 AU545274 B2 AU 545274B2
Authority
AU
Australia
Prior art keywords
hydroxyphenoxy
formyl
acid derivatives
pentanoic acid
pentanoic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59697/80A
Other languages
English (en)
Other versions
AU5969780A (en
Inventor
Geoffrey Kneen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of AU5969780A publication Critical patent/AU5969780A/en
Application granted granted Critical
Publication of AU545274B2 publication Critical patent/AU545274B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/74—Unsaturated compounds containing —CHO groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU59697/80A 1979-06-29 1980-06-27 5-(2-formyl-3-hydroxyphenoxy) - pentanoic acid derivatives Ceased AU545274B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7922781 1979-06-29
GB7922781 1979-06-29

Publications (2)

Publication Number Publication Date
AU5969780A AU5969780A (en) 1981-01-08
AU545274B2 true AU545274B2 (en) 1985-07-11

Family

ID=10506199

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59697/80A Ceased AU545274B2 (en) 1979-06-29 1980-06-27 5-(2-formyl-3-hydroxyphenoxy) - pentanoic acid derivatives

Country Status (18)

Country Link
US (1) US4410537A (en, 2012)
EP (1) EP0022229B1 (en, 2012)
JP (1) JPS5649335A (en, 2012)
KR (2) KR850000073B1 (en, 2012)
AU (1) AU545274B2 (en, 2012)
DE (1) DE3061269D1 (en, 2012)
DK (1) DK159770C (en, 2012)
FI (1) FI71929C (en, 2012)
GB (1) GB2053218B (en, 2012)
GR (1) GR68748B (en, 2012)
HU (1) HU190774B (en, 2012)
IL (1) IL60422A (en, 2012)
IT (1) IT1133025B (en, 2012)
MW (1) MW2380A1 (en, 2012)
OA (1) OA06699A (en, 2012)
ZA (1) ZA803880B (en, 2012)
ZM (1) ZM5780A1 (en, 2012)
ZW (1) ZW14480A1 (en, 2012)

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IL64573A (en) * 1980-12-18 1985-04-30 Wellcome Found Derivatives of formylphenoxyalkanoic acids and formylphenoxymethylbenzoic acids,their preparation and pharmaceutical formulations containing them
GB8606913D0 (en) * 1986-03-20 1986-04-23 Hider R C Treatment of sickle cell disease
WO1998030141A2 (en) 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Devices for tissue repair and methods for preparation and use thereof
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
RU2300516C2 (ru) * 1999-11-05 2007-06-10 Эмисфере Текнолоджиз, Инк. Соединения феноксикарбоновой кислоты и композиции для доставки активных веществ
CZ20021554A3 (cs) * 1999-11-05 2002-10-16 Emisphere Technologies, Inc. Deriváty fenoxykarboxylové sloučeniny a prostředky pro dodávání aktivní sloľky
EP1265840A2 (en) * 2000-03-17 2002-12-18 Corixa Corporation Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
CA2823647C (en) 2011-01-07 2016-07-19 Allergan, Inc. Compositions comprising substituted benzaldehydes and use thereof for lightening skin or treating hyperpigmenation and hypermelanosis disorders
SI3141542T1 (sl) 2011-12-28 2020-11-30 Global Blood Therapeutics, Inc. Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
EP2970308B1 (en) 2013-03-15 2021-07-14 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
ES2852054T3 (es) * 2013-03-15 2021-09-10 Global Blood Therapeutics Inc Compuestos y usos de los mismos para la modulación de hemoglobina
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EP3036222A2 (en) * 2013-08-23 2016-06-29 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN105431147A (zh) 2014-02-07 2016-03-23 全球血液疗法股份有限公司 2-羟基-6-((2-(1-异丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)苯甲醛的游离碱的结晶多晶型物
MX383691B (es) 2015-03-06 2025-03-14 Beyondspring Pharmaceuticals Inc Método de tratamiento de cáncer asociado con una mutación de ras.
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
WO2017096230A1 (en) 2015-12-04 2017-06-08 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
BR112018016054A2 (pt) * 2016-02-08 2019-02-12 Beyondspring Pharmaceuticals, Inc. composições farmacêuticas e/ou métodos para tratar câncer e/ou para romper vasculatura de tumor associada ao câncer em indivíduo
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2019182938A1 (en) * 2018-03-22 2019-09-26 Virginia Commonwealth University Aromatic aldehydes with sustained and enhanced in vitro and in vivo pharmacologic activity to treat sickle cell disease
ES2966707T3 (es) 2018-10-01 2024-04-23 Global Blood Therapeutics Inc Moduladores de la hemoglobina para el tratamiento de la drepanocitosis
SI3880654T1 (sl) 2018-11-19 2022-04-29 Global Blood Therapeutics, Inc. 2-formil-3-hidroksifeniloksimetilne spojine, zmožne modulirati hemoglobin
JP2024513505A (ja) 2021-04-09 2024-03-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 腫瘍を治療するための組成物及び方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL236575A (en, 2012) * 1958-04-30
CH543472A (fr) * 1969-01-31 1973-10-31 Orchimed Sa Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques
DE2209128C3 (de) 1971-03-05 1981-10-22 CIBA-GEIGY AG, 4002 Basel Bis-Stilbenverbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller
CH550776A (de) 1971-03-05 1974-06-28 Ciba Geigy Ag Herstellung neuer bis-stilbenverbindungen.
GB1511645A (en) * 1974-05-31 1978-05-24 Univ Ife Sickle cell anaemia treatment
US4137309A (en) * 1976-10-14 1979-01-30 The Procter & Gamble Company Therapeutic treatment

Also Published As

Publication number Publication date
DK159770C (da) 1991-04-22
GB2053218A (en) 1981-02-04
KR830002693A (ko) 1983-05-30
ZA803880B (en) 1982-02-24
US4410537A (en) 1983-10-18
JPH0154339B2 (en, 2012) 1989-11-17
ZW14480A1 (en) 1982-03-17
OA06699A (fr) 1982-05-31
IT8049108A0 (it) 1980-06-27
FI71929B (fi) 1986-11-28
IT1133025B (it) 1986-07-09
FI802052A7 (fi) 1980-12-30
KR850000073B1 (ko) 1985-02-18
ZM5780A1 (en) 1983-11-21
DK279780A (da) 1980-12-30
DK159770B (da) 1990-12-03
MW2380A1 (en) 1982-03-10
DE3061269D1 (en) 1983-01-13
KR850000072B1 (ko) 1985-02-18
KR840004668A (ko) 1984-10-22
FI71929C (fi) 1987-03-09
AU5969780A (en) 1981-01-08
GB2053218B (en) 1984-01-25
GR68748B (en, 2012) 1982-02-16
IL60422A0 (en) 1980-09-16
IL60422A (en) 1984-06-29
JPS5649335A (en) 1981-05-02
EP0022229A1 (en) 1981-01-14
HU190774B (en) 1986-11-28
EP0022229B1 (en) 1982-12-08

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