HU173438B - Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom - Google Patents

Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Info

Publication number
HU173438B
HU173438B HU75CI1623A HUCI001623A HU173438B HU 173438 B HU173438 B HU 173438B HU 75CI1623 A HU75CI1623 A HU 75CI1623A HU CI001623 A HUCI001623 A HU CI001623A HU 173438 B HU173438 B HU 173438B
Authority
HU
Hungary
Prior art keywords
pyrido
antiinflammatory
tetrahydro
oxo
pyrimidine derivatives
Prior art date
Application number
HU75CI1623A
Other languages
English (en)
Hungarian (hu)
Inventor
Zoltan Meszaros
Istvan Hermecz
Agnes Horvath
Peter Szentmiklosi
Agoston David
Sandor Virag
Jozsef Knoll
DEBRECZY Lelle VASVARINE
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to HU75CI1623A priority Critical patent/HU173438B/hu
Priority to BG036221A priority patent/BG31227A4/bg
Priority to IL50930A priority patent/IL50930A/xx
Priority to US05/742,464 priority patent/US4460771A/en
Priority to AU19759/76A priority patent/AU512256B2/en
Priority to IN2075/CAL/76A priority patent/IN148945B/en
Priority to EG725/76A priority patent/EG12495A/xx
Priority to DE19762653257 priority patent/DE2653257A1/de
Priority to SE7613140A priority patent/SE433353B/sv
Priority to GR52262A priority patent/GR61820B/el
Priority to NLAANVRAGE7613140,A priority patent/NL188948C/xx
Priority to DD7600195963A priority patent/DD130431A5/xx
Priority to RO7688555A priority patent/RO73522A/ro
Priority to GB49273/76A priority patent/GB1531963A/en
Priority to RO76101145A priority patent/RO79705A/ro
Priority to AT873576A priority patent/AT359506B/de
Priority to FR7635550A priority patent/FR2332755A1/fr
Priority to FI763401A priority patent/FI62085C/fi
Priority to MX998376U priority patent/MX7138E/es
Priority to CA266,711A priority patent/CA1088531A/en
Priority to ES453690A priority patent/ES453690A1/es
Priority to YU02890/76A priority patent/YU289076A/xx
Priority to DK534076A priority patent/DK153150C/da
Priority to SU762424104A priority patent/SU664565A3/ru
Priority to PL1976209750A priority patent/PL109657B1/pl
Priority to CS767665A priority patent/CS203135B2/cs
Priority to MX765170U priority patent/MX5178E/es
Priority to PL19395676A priority patent/PL102865B1/pl
Priority to CH1493176A priority patent/CH630378A5/de
Priority to JP51141797A priority patent/JPS5914033B2/ja
Priority to BE172806A priority patent/BE848868A/xx
Priority to SU772537600A priority patent/SU698532A3/ru
Priority to CS78543A priority patent/CS203136B2/cs
Priority to US06/014,689 priority patent/US4472398A/en
Priority to IN519/CAL/79A priority patent/IN148961B/en
Publication of HU173438B publication Critical patent/HU173438B/hu
Priority to AT418079A priority patent/AT362382B/de
Priority to CH38381A priority patent/CH630379A5/de
Priority to US06/364,753 priority patent/US4495189A/en
Priority to YU01475/83A priority patent/YU147583A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU75CI1623A 1975-11-27 1975-11-27 Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom HU173438B (hu)

Priority Applications (39)

Application Number Priority Date Filing Date Title
HU75CI1623A HU173438B (hu) 1975-11-27 1975-11-27 Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
BG036221A BG31227A4 (bg) 1975-11-27 1976-11-16 Метод за получаване на рацемични или оптично активни пирамидо (1,2 а)хетероциклични съединения
IL50930A IL50930A (en) 1975-11-27 1976-11-17 1-alkyl-4-oxo-1,6,7,8-tetrahydro-4h-pyrido(1,2-a)pyrimidine-3-carboxamide derivatives,their preparation and pharmaceutical compositions containing them
US05/742,464 US4460771A (en) 1975-11-27 1976-11-17 Antiphlogistic and anticoagulant condensed pyrimidine derivatives
AU19759/76A AU512256B2 (en) 1975-11-27 1976-11-18 Condensed pyrimidine derivatives
IN2075/CAL/76A IN148945B (sv) 1975-11-27 1976-11-19
EG725/76A EG12495A (en) 1975-11-27 1976-11-23 Process for preparing of new antiplogistic and anticoagulant condensed pyrimidine derivatives and pharmaceutical compositions containing the same compounds
DE19762653257 DE2653257A1 (de) 1975-11-27 1976-11-24 Neue kondensierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als entzuendungshemmende und die gerinnung des blutes hemmende arzneimittel
SE7613140A SE433353B (sv) 1975-11-27 1976-11-24 Analogiforfarande for framstellning av pyrido/1,2-a/pyrimidiner med antiflogistisk och koagulationshemmande verkan
GR52262A GR61820B (en) 1975-11-27 1976-11-25 Preparation process of new antiphlogistic and anti-freezing derivatives of condensed pyrimidine and pharmaceutical compositions containing them
NLAANVRAGE7613140,A NL188948C (nl) 1975-11-27 1976-11-25 Werkwijze ter bereiding van pyrido(1,2a)pyrimidines met werking tegen ontstekingen en tegen bloedstolling en werkwijze voor de bereiding van farmaceuttische preparaten die deze bevatten.
DD7600195963A DD130431A5 (de) 1975-11-27 1976-11-25 Verfahren zur herstellung neuer kondensierter pyrimidin-derivate
RO7688555A RO73522A (ro) 1975-11-27 1976-11-25 Procedeu de preparare a 3-carbamoil sau 3-(n-acetylcarbamoil)-1,6-d&metil-4-oxo-1,6,7,8-tetrahidro-4h-pirido-1,2 a-pirimidinei
GB49273/76A GB1531963A (en) 1975-11-27 1976-11-25 Pyrido(1,2alpha)pyrimidine derivatives
RO76101145A RO79705A (ro) 1975-11-27 1976-11-25 Procedeu pentru prepararea unor derivati ai pitimidinei
AT873576A AT359506B (de) 1975-11-27 1976-11-25 Verfahren zur herstellung von neuen, hetero- cyclischen pyrimido(1,2-a)-verbindungen und deren optisch aktiven isomeren
FR7635550A FR2332755A1 (fr) 1975-11-27 1976-11-25 Nouveaux derives de pyrimidine condenses a proprietes antiphlogistiques et anticoagulantes
FI763401A FI62085C (fi) 1975-11-27 1976-11-25 Analogifoerfarande foer framstaellning av nya terapeutiskt anvaendbara 4-oxo-1,6,7,8-tetrahydro-4h-pyrido-(1,2-a)-pyrimidinderivat
CA266,711A CA1088531A (en) 1975-11-27 1976-11-26 Antiphlogistic anticoagulant condensed pyrimidine derivatives process for the preparation thereof and pharmaceutical compositions containing the same compound
MX998376U MX7138E (es) 1975-11-27 1976-11-26 Procedimiento para preparar compuestos pirimido(1,2a)heterociclicos
ES453690A ES453690A1 (es) 1975-11-27 1976-11-26 Procedimiento para la preparacion de compuestos heterocicli-cos.
YU02890/76A YU289076A (en) 1975-11-27 1976-11-26 Process for obtaining new condensed pyrimidine derivatives
DK534076A DK153150C (da) 1975-11-27 1976-11-26 Analogifremgangsmaade til fremstilling af 4-oxo-1,6,7,8-tetrahydro-4h-pyridooe1,2aaapyrimidinderivater
SU762424104A SU664565A3 (ru) 1975-11-27 1976-11-26 Способ получени пиридо (1,2а) пиримидинов или их оптических изомеров
PL1976209750A PL109657B1 (en) 1975-11-27 1976-11-26 Method of producing new derivatives of pyrido/1,2a/pyrimidine
CS767665A CS203135B2 (en) 1975-11-27 1976-11-26 Method of producing racemic or optically active pyrimido/1,2a/heterocyclic compounds
MX765170U MX5178E (es) 1975-11-27 1976-11-26 Procedimiento para preparar compuesto pirimido(1,2a)heterociclicos
PL19395676A PL102865B1 (pl) 1975-11-27 1976-11-26 Sposob wytwarzania nowych pochodnych pirydo/1,2a/pirymidyny
CH1493176A CH630378A5 (de) 1975-11-27 1976-11-26 Verfahren zur herstellung neuer kondensierter pyrimidin-derivate.
JP51141797A JPS5914033B2 (ja) 1975-11-27 1976-11-27 新規な縮合ピリミジン誘導体とその製法
BE172806A BE848868A (fr) 1975-11-27 1976-11-29 Nouveaux derives de pyrimidine condenses a proprietes antiphlogistiques et anticoagulantes,
SU772537600A SU698532A3 (ru) 1975-11-27 1977-11-03 Способ получени производных пиридо (1,2-а) пиримидина
CS78543A CS203136B2 (cs) 1975-11-27 1978-01-26 Způsob výroby racemických nebo opticky aktivních pyrimido[1,2a]- heterocyklických sloučenin
US06/014,689 US4472398A (en) 1975-11-27 1979-02-23 Condensed pyrimidines
IN519/CAL/79A IN148961B (sv) 1975-11-27 1979-05-18
AT418079A AT362382B (de) 1975-11-27 1979-06-12 Verfahren zur herstellung von neuen pyrimido (1,2-a)heterocyclen sowie ihren optisch aktiven isomeren
CH38381A CH630379A5 (de) 1975-11-27 1981-01-21 Verfahren zur herstellung von neuen pyrimido(1,2-a)heterocyclen.
US06/364,753 US4495189A (en) 1975-11-27 1982-04-02 Condensed pyrimidines
YU01475/83A YU147583A (en) 1975-11-27 1983-07-08 Process for making new condensed pirimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU75CI1623A HU173438B (hu) 1975-11-27 1975-11-27 Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Publications (1)

Publication Number Publication Date
HU173438B true HU173438B (hu) 1979-05-28

Family

ID=10994587

Family Applications (1)

Application Number Title Priority Date Filing Date
HU75CI1623A HU173438B (hu) 1975-11-27 1975-11-27 Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Country Status (28)

Country Link
US (2) US4460771A (sv)
JP (1) JPS5914033B2 (sv)
AT (1) AT359506B (sv)
AU (1) AU512256B2 (sv)
BE (1) BE848868A (sv)
BG (1) BG31227A4 (sv)
CA (1) CA1088531A (sv)
CH (2) CH630378A5 (sv)
CS (1) CS203135B2 (sv)
DD (1) DD130431A5 (sv)
DE (1) DE2653257A1 (sv)
DK (1) DK153150C (sv)
EG (1) EG12495A (sv)
ES (1) ES453690A1 (sv)
FI (1) FI62085C (sv)
FR (1) FR2332755A1 (sv)
GB (1) GB1531963A (sv)
GR (1) GR61820B (sv)
HU (1) HU173438B (sv)
IL (1) IL50930A (sv)
IN (1) IN148945B (sv)
MX (1) MX5178E (sv)
NL (1) NL188948C (sv)
PL (1) PL109657B1 (sv)
RO (2) RO73522A (sv)
SE (1) SE433353B (sv)
SU (2) SU664565A3 (sv)
YU (2) YU289076A (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180701B (en) * 1977-12-29 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
HU183408B (en) * 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
HU186607B (en) * 1982-03-31 1985-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing pharmaceutical composition with synergetic antiinflammatory activity
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4772475A (en) * 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
US5252572A (en) * 1988-02-03 1993-10-12 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
HU201551B (en) * 1988-02-03 1990-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
JP4498922B2 (ja) * 2002-07-09 2010-07-07 アクテリオン ファーマシューティカルズ リミテッド ７，８，９，１０−テトラヒドロ−６Ｈ−アゼピノ、６，７，８，９−テトラヒドロ−ピリドおよび２，３−ジヒドロ−２Ｈ−ピロロ［２，１−ｂ］−キナゾリノン誘導体
US7772232B2 (en) * 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
CA2587406A1 (en) * 2004-11-16 2006-05-26 Limerick Neurosciences, Inc. Methods and compositions for treating pain

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT286990B (de) * 1966-11-02 1971-01-11 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von neuen Homopyrimidazol-Derivaten sowie von deren Salzen
US3642797A (en) * 1968-06-10 1972-02-15 Sterling Drug Inc 4h-pyrido(1 2-a)pyrimidin-4-ones
HU168014B (sv) * 1973-03-30 1976-02-28
US4209622A (en) * 1973-03-30 1980-06-24 Chinoin Gygyszer es Vegyeszeti Termekek Gyara Rt. 3-(Ethoxycarbonyl-methyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine
HU168541B (sv) * 1973-11-24 1976-05-28
US4022897A (en) * 1974-03-04 1977-05-10 E. R. Squibb & Sons, Inc. CNS active compounds
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4066766A (en) * 1975-03-03 1978-01-03 Pfizer Inc. 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents

Also Published As

Publication number Publication date
JPS5914033B2 (ja) 1984-04-02
EG12495A (en) 1980-12-31
FR2332755B1 (sv) 1978-12-22
AU1975976A (en) 1978-05-25
DK153150C (da) 1988-10-24
RO73522A (ro) 1981-11-04
PL109657B1 (en) 1980-06-30
IN148945B (sv) 1981-07-25
JPS5268198A (en) 1977-06-06
FI62085B (fi) 1982-07-30
AU512256B2 (en) 1980-10-02
SE433353B (sv) 1984-05-21
SU698532A3 (ru) 1979-11-15
CH630378A5 (de) 1982-06-15
MX5178E (es) 1983-04-20
CH630379A5 (de) 1982-06-15
NL188948B (nl) 1992-06-16
AT359506B (de) 1980-11-10
FI763401A (sv) 1977-05-28
FR2332755A1 (fr) 1977-06-24
CA1088531A (en) 1980-10-28
IL50930A0 (en) 1977-01-31
NL7613140A (nl) 1977-06-01
NL188948C (nl) 1992-11-16
BG31227A4 (bg) 1981-11-16
DE2653257C2 (sv) 1989-04-20
US4472398A (en) 1984-09-18
GR61820B (en) 1979-01-22
SU664565A3 (ru) 1979-05-25
CS203135B2 (en) 1981-02-27
FI62085C (fi) 1982-11-10
RO79705A (ro) 1982-08-17
YU147583A (en) 1986-06-30
ES453690A1 (es) 1977-12-01
US4460771A (en) 1984-07-17
DK534076A (da) 1977-05-28
DE2653257A1 (de) 1977-06-02
DD130431A5 (de) 1978-03-29
ATA873576A (de) 1980-04-15
IL50930A (en) 1981-06-29
GB1531963A (en) 1978-11-15
SE7613140L (sv) 1977-05-28
BE848868A (fr) 1977-03-16
DK153150B (da) 1988-06-20
YU289076A (en) 1983-12-31

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee