HRP970281B1 - Carbapenem antibiotic, composition and method of preparation - Google Patents

Carbapenem antibiotic, composition and method of preparation

Info

Publication number
HRP970281B1
HRP970281B1 HR970281A HRP970281A HRP970281B1 HR P970281 B1 HRP970281 B1 HR P970281B1 HR 970281 A HR970281 A HR 970281A HR P970281 A HRP970281 A HR P970281A HR P970281 B1 HRP970281 B1 HR P970281B1
Authority
HR
Croatia
Prior art keywords
preparation
composition
carbapenem antibiotic
carbapenem
antibiotic
Prior art date
Application number
HR970281A
Other languages
English (en)
Inventor
Jeffrey A Zimmerman
John M Williams
Paul A Bergquist
Lisa M Dimichele
David C Dubost
Michael J Kaufman
Daniel R Sidler
William A Hunke
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309530&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP970281(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9612668.5A external-priority patent/GB9612668D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP970281A2 publication Critical patent/HRP970281A2/xx
Publication of HRP970281B1 publication Critical patent/HRP970281B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HR970281A 1996-05-28 1997-05-21 Carbapenem antibiotic, composition and method of preparation HRP970281B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1851896P 1996-05-28 1996-05-28
GBGB9612668.5A GB9612668D0 (en) 1996-06-18 1996-06-18 Carbapenem antibiotic composition and method of preparation

Publications (2)

Publication Number Publication Date
HRP970281A2 HRP970281A2 (en) 1998-06-30
HRP970281B1 true HRP970281B1 (en) 2002-04-30

Family

ID=26309530

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970281A HRP970281B1 (en) 1996-05-28 1997-05-21 Carbapenem antibiotic, composition and method of preparation

Country Status (34)

Country Link
EP (1) EP0863901B1 (no)
JP (2) JPH11509871A (no)
KR (2) KR100344479B1 (no)
CN (1) CN1067074C (no)
AT (1) ATE252584T1 (no)
AU (1) AU710102B2 (no)
BG (1) BG63821B1 (no)
CA (1) CA2227994C (no)
CO (1) CO4940412A1 (no)
CY (1) CY2437B1 (no)
CZ (1) CZ296381B6 (no)
DE (1) DE69725696T2 (no)
DK (1) DK0863901T3 (no)
DZ (1) DZ2242A1 (no)
EA (1) EA000534B1 (no)
EE (1) EE04678B1 (no)
ES (1) ES2208907T3 (no)
HK (1) HK1016176A1 (no)
HR (1) HRP970281B1 (no)
HU (1) HU229426B1 (no)
ID (1) ID16974A (no)
IL (1) IL123078A (no)
IS (1) IS2353B (no)
MX (1) MX9800808A (no)
NO (1) NO323815B1 (no)
NZ (1) NZ329649A (no)
PL (1) PL188917B1 (no)
PT (1) PT863901E (no)
RS (1) RS49583B (no)
SI (1) SI0863901T1 (no)
SK (1) SK284359B6 (no)
TR (1) TR199800146T1 (no)
TW (1) TW434014B (no)
WO (1) WO1997045430A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937079A4 (en) * 1996-10-28 2001-01-24 Merck & Co Inc CARBAPENEM-STABILIZED ANTIBIOTIC COMPOSITIONS AND PROCESS FOR PRODUCING THE SAME
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis
JP3245427B2 (ja) * 1997-06-16 2002-01-15 メルク エンド カンパニー インコーポレーテッド 安定化されたカルバペネム中間体および合成における使用
US6504027B1 (en) 1998-03-02 2003-01-07 Merck & Co., Inc. Decarboxylation process for synthesizing carbapenem antibiotics
JP4854899B2 (ja) * 1999-10-29 2012-01-18 メルク・シャープ・エンド・ドーム・コーポレイション カルバペネム系抗生物質組成物の処方方法
AR035728A1 (es) 2001-01-16 2004-07-07 Merck & Co Inc Proceso perfeccionado para la sintesis de carbapenem
CN101357918B (zh) * 2007-06-22 2011-05-18 山东轩竹医药科技有限公司 含有异硫脲基巯基吡咯烷的培南衍生物
CN101367815B (zh) * 2007-06-28 2012-07-04 山东轩竹医药科技有限公司 六元环甲酰胺取代的巯基吡咯烷碳青霉烯化合物
EP2229944A1 (en) 2007-12-12 2010-09-22 Dainippon Sumitomo Pharma Co., Ltd. Preparation composition
CN101550138B (zh) * 2008-04-03 2011-05-18 山东轩竹医药科技有限公司 巯基氮杂环烷酰胺醇取代的培南衍生物
US20110172201A1 (en) * 2008-06-11 2011-07-14 Ranbaxy Laboratories Limited Process for preparing a carbapenem antibiotic composition
CN102365266B (zh) 2009-03-31 2013-11-06 三菱综合材料株式会社 含氟n-烷基磺酰亚胺化合物及其制造方法、以及离子性化合物的制造方法
BRPI1014338B1 (pt) 2009-06-25 2019-12-24 Shell Int Research método para injetar água em uma formação contendo hidrocarbonetos, e, método para preparar uma água com salinidade elevada
US8889384B2 (en) 2010-10-07 2014-11-18 Shell Oil Company Process for the production of alcohols from biomass
WO2012061596A1 (en) 2010-11-05 2012-05-10 Shell Oil Company Treating biomass to produce materials useful for biofuels
WO2012088108A1 (en) 2010-12-20 2012-06-28 Shell Oil Company Process for the production of alcohols from biomass
CA2859391C (en) 2011-12-15 2019-12-17 Shell Internationale Research Maatschappij B.V. Method of treating byproducts from ethanol production
CA2873303C (en) 2012-05-17 2021-10-12 Phillip Guy Hamilton Process for producing volatile organic compounds from biomass material
CN103860485A (zh) * 2012-12-18 2014-06-18 深圳市海滨制药有限公司 一种厄他培南钠冻干制剂及其制备方法
CN106232826A (zh) 2014-04-17 2016-12-14 国际壳牌研究有限公司 生产发酵产品的方法
EP3180320B1 (en) 2014-08-14 2021-01-13 Shell International Research Maatschappij B.V. Process for preparing furfural from biomass

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES525492A0 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CA2091309A1 (en) * 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds

Also Published As

Publication number Publication date
RS49583B (sr) 2007-04-10
BG102273A (bg) 1998-09-30
JP5255983B2 (ja) 2013-08-07
PL188917B1 (pl) 2005-05-31
IL123078A0 (en) 1998-09-24
SI0863901T1 (en) 2004-04-30
PL324746A1 (en) 1998-06-08
TR199800146T1 (xx) 1998-06-22
IS2353B (is) 2008-04-15
DE69725696T2 (de) 2004-07-29
JPH11509871A (ja) 1999-08-31
ID16974A (id) 1997-11-27
JP2009084284A (ja) 2009-04-23
EP0863901A1 (en) 1998-09-16
CZ296381B6 (cs) 2006-03-15
WO1997045430A1 (en) 1997-12-04
ES2208907T3 (es) 2004-06-16
HU229426B1 (en) 2013-12-30
BG63821B1 (bg) 2003-02-28
EA199800180A1 (ru) 1998-08-27
PT863901E (pt) 2004-02-27
CA2227994C (en) 2002-06-25
EP0863901B1 (en) 2003-10-22
HRP970281A2 (en) 1998-06-30
EE04678B1 (et) 2006-08-15
MX9800808A (es) 1998-04-30
KR19990036052A (no) 1999-05-25
CZ25398A3 (cs) 1998-07-15
DZ2242A1 (fr) 2002-12-18
CN1198162A (zh) 1998-11-04
DE69725696D1 (de) 2003-11-27
CO4940412A1 (es) 2000-07-24
HK1016176A1 (en) 1999-10-29
EE9800022A (et) 1998-08-17
AU710102B2 (en) 1999-09-16
NZ329649A (en) 1998-11-25
IL123078A (en) 2002-03-10
ATE252584T1 (de) 2003-11-15
NO980380D0 (no) 1998-01-28
SK284359B6 (sk) 2005-02-04
DK0863901T3 (da) 2004-02-16
TW434014B (en) 2001-05-16
CN1067074C (zh) 2001-06-13
IS4663A (is) 1998-01-27
YU4198A (sh) 1998-12-23
NO323815B1 (no) 2007-07-09
CY2437B1 (en) 2004-11-12
SK10998A3 (en) 1998-08-05
HUP9901567A3 (en) 2000-03-28
EA000534B1 (ru) 1999-10-28
KR100403497B1 (ko) 2003-10-30
HUP9901567A2 (hu) 1999-09-28
NO980380L (no) 1998-03-16
KR100344479B1 (ko) 2002-10-31
AU3077597A (en) 1998-01-05
CA2227994A1 (en) 1997-12-04

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

PNAN Change of the applicant name, address/residence

Owner name: SCHERING CORPORATION, US

Owner name: MERCK SHARP & DOHME CORP., US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20160503

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20170521