HRP960129B1 - NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION - Google Patents

NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION

Info

Publication number
HRP960129B1
HRP960129B1 HR960129A HRP960129A HRP960129B1 HR P960129 B1 HRP960129 B1 HR P960129B1 HR 960129 A HR960129 A HR 960129A HR P960129 A HRP960129 A HR P960129A HR P960129 B1 HRP960129 B1 HR P960129B1
Authority
HR
Croatia
Prior art keywords
pyrazinones
preparation
novel pyrido
antiasthmatic activity
antiasthmatic
Prior art date
Application number
HR960129A
Other languages
English (en)
Inventor
Norbert Hoefgen
Thomas Buechner
Ute Achterrath-Tuckermann
Stefan Szelenyi
Bernhard Kutscher
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HRP960129A2 publication Critical patent/HRP960129A2/hr
Publication of HRP960129B1 publication Critical patent/HRP960129B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR960129A 1995-03-24 1996-03-20 NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION HRP960129B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19510965A DE19510965A1 (de) 1995-03-24 1995-03-24 Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
HRP960129A2 HRP960129A2 (en) 1997-08-31
HRP960129B1 true HRP960129B1 (en) 2002-12-31

Family

ID=7757727

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960129A HRP960129B1 (en) 1995-03-24 1996-03-20 NOVEL PYRIDO(3,2-e) PYRAZINONES WITH ANTIASTHMATIC ACTIVITY AND PROCESS FOR THEIR PREPARATION

Country Status (30)

Country Link
US (1) US5723463A (fr)
EP (1) EP0736532B1 (fr)
JP (1) JP4124280B2 (fr)
KR (1) KR100401395B1 (fr)
CN (1) CN1058968C (fr)
AR (1) AR002039A1 (fr)
AT (1) ATE217624T1 (fr)
AU (1) AU697908B2 (fr)
BR (1) BR9601093A (fr)
CA (1) CA2172472C (fr)
CZ (1) CZ290784B6 (fr)
DE (2) DE19510965A1 (fr)
DK (1) DK0736532T3 (fr)
ES (1) ES2174989T3 (fr)
HR (1) HRP960129B1 (fr)
HU (1) HUP9600731A3 (fr)
IL (1) IL117621A (fr)
MX (1) MX9601069A (fr)
NO (1) NO307091B1 (fr)
NZ (1) NZ286232A (fr)
PL (1) PL184800B1 (fr)
PT (1) PT736532E (fr)
RU (1) RU2143433C1 (fr)
SG (1) SG43249A1 (fr)
SI (1) SI0736532T1 (fr)
SK (1) SK36596A3 (fr)
TR (1) TR199600217A2 (fr)
TW (1) TW426682B (fr)
UA (1) UA45319C2 (fr)
ZA (1) ZA962270B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
IL144156A0 (en) * 1999-01-20 2002-05-23 Dresden Arzneimittel Use of imidazo [1,5-a]-pyrido [3,2-e] -pyrazinones as medicaments
EA006685B1 (ru) 1999-08-21 2006-02-24 Алтана Фарма Аг Синергетическая композиция
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
US6465465B1 (en) 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
KR20050115331A (ko) 2003-04-01 2005-12-07 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 불임증 포스포디에스터라제의 억제제
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
TWI417095B (zh) * 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
CN101553491B (zh) * 2006-12-13 2013-05-29 Aska制药株式会社 喹喔啉衍生物
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
EA019085B1 (ru) 2007-09-14 2014-01-30 Янссен Фармасьютикалз, Инк. 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны
US9114138B2 (en) 2007-09-14 2015-08-25 Janssen Pharmaceuticals, Inc. 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones
TW200927731A (en) * 2007-09-14 2009-07-01 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
JP5433582B2 (ja) * 2007-11-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． イミダゾ［１，２−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
AU2008329072A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-A) pyrazines as inhibitors of phosphodiesterase 10
JP2011505366A (ja) 2007-11-30 2011-02-24 ワイス・エルエルシー ホスホエステラーゼ１０の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ［１，５−ａ］ピラジン
WO2010025890A1 (fr) 2008-09-02 2010-03-11 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Dérivés de 3-azabicyclo[3.1.0]hexyle comme modulateurs des récepteurs métabotropiques du glutamate
AU2009304293B2 (en) 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CA2760259C (fr) 2009-05-12 2018-05-01 Janssen Pharmaceuticals, Inc. Derives de la 1,2,4-triazolo [4,3-a] pyridine et leur utilisation en tant que modulateurs allosteriques positifs des recepteurs mglur2
JP5634506B2 (ja) 2009-05-12 2014-12-03 ジャンセン ファーマシューティカルズ， インコーポレイテッド １，２，３−トリアゾロ［４，３−ａ］ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用
ES2552455T3 (es) 2010-11-08 2015-11-30 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
JP5852666B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
LT3096790T (lt) 2014-01-21 2019-10-10 Janssen Pharmaceutica, N.V. Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
WO2015110435A1 (fr) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinaisons comprenant des modulateurs allostériques positifs ou des agonistes orthostériques de sous-type 2 de récepteur glutamatergique métabotrope, et leur utilisation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5166344A (en) * 1989-05-31 1992-11-24 Berlex Laboratories, Inc. Process for the preparation of imidazoquinoxalinones
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
WO1992022552A1 (fr) * 1991-06-14 1992-12-23 The Upjohn Company IMIDAZO[1,5-a]QUINOXALINES
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
JP3252483B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ３環性トリアゾロ誘導体の製造方法
JP3252484B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ４，５−ジヒドロ［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体の製造方法
DE4329970A1 (de) * 1993-03-31 1994-10-06 Basf Ag Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung
FR2704547B1 (fr) * 1993-04-30 1995-06-09 Adir Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
CN1041931C (zh) * 1993-05-06 1999-02-03 诺沃-诺迪斯克有限公司 [1,2,4]三唑并[4,3－a]喹喔啉化合物,它们的制备及其应用
CA2112290C (fr) * 1993-12-23 2004-06-01 John R. Francis Circuit de restitution de signaux d'horloge pour recepteur de signaux video numeriques serie
JP3240462B2 (ja) * 1996-05-24 2001-12-17 株式会社ケンウッド 光ディスク装置の光ピックアップサーボ装置

Also Published As

Publication number Publication date
NO307091B1 (no) 2000-02-07
TR199600217A2 (tr) 1996-10-21
KR100401395B1 (ko) 2003-12-24
CA2172472C (fr) 2000-01-18
CN1140173A (zh) 1997-01-15
HRP960129A2 (en) 1997-08-31
EP0736532A1 (fr) 1996-10-09
HUP9600731A2 (en) 1997-01-28
AR002039A1 (es) 1998-01-07
ZA962270B (en) 1996-09-30
SK36596A3 (en) 1997-02-05
PT736532E (pt) 2002-10-31
PL184800B1 (pl) 2002-12-31
AU4825796A (en) 1996-10-03
MX9601069A (es) 1997-02-28
IL117621A (en) 1999-05-09
HUP9600731A3 (en) 1997-04-28
NO961173L (no) 1996-09-25
EP0736532B1 (fr) 2002-05-15
KR960034204A (ko) 1996-10-22
CN1058968C (zh) 2000-11-29
JPH08269059A (ja) 1996-10-15
NO961173D0 (no) 1996-03-22
DE19510965A1 (de) 1996-09-26
ATE217624T1 (de) 2002-06-15
CZ290784B6 (cs) 2002-10-16
CA2172472A1 (fr) 1996-09-25
CZ74796A3 (en) 1996-10-16
BR9601093A (pt) 1998-01-06
RU2143433C1 (ru) 1999-12-27
UA45319C2 (uk) 2002-04-15
IL117621A0 (en) 1996-07-23
AU697908B2 (en) 1998-10-22
US5723463A (en) 1998-03-03
JP4124280B2 (ja) 2008-07-23
DK0736532T3 (da) 2002-09-02
TW426682B (en) 2001-03-21
PL313434A1 (en) 1996-09-30
NZ286232A (en) 1996-10-28
HU9600731D0 (en) 1996-05-28
ES2174989T3 (es) 2002-11-16
SI0736532T1 (en) 2002-08-31
DE59609201D1 (de) 2002-06-20
SG43249A1 (en) 1997-10-17

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