HRP960032A2 - New oral pharmaceutical dosage form - Google Patents
New oral pharmaceutical dosage form Download PDFInfo
- Publication number
- HRP960032A2 HRP960032A2 HR9500422-2A HRP960032A HRP960032A2 HR P960032 A2 HRP960032 A2 HR P960032A2 HR P960032 A HRP960032 A HR P960032A HR P960032 A2 HRP960032 A2 HR P960032A2
- Authority
- HR
- Croatia
- Prior art keywords
- dosage form
- granules
- tablet
- enteric coating
- proton pump
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title claims description 68
- 239000010410 layer Substances 0.000 claims description 164
- 239000003826 tablet Substances 0.000 claims description 145
- 239000008187 granular material Substances 0.000 claims description 109
- 239000002702 enteric coating Substances 0.000 claims description 72
- 238000009505 enteric coating Methods 0.000 claims description 72
- 150000001875 compounds Chemical class 0.000 claims description 68
- 230000000844 anti-bacterial effect Effects 0.000 claims description 66
- 229940126409 proton pump inhibitor Drugs 0.000 claims description 64
- 239000000612 proton pump inhibitor Substances 0.000 claims description 64
- 230000004888 barrier function Effects 0.000 claims description 50
- 229960002626 clarithromycin Drugs 0.000 claims description 38
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims description 38
- 239000002253 acid Substances 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 31
- 239000000126 substance Substances 0.000 claims description 31
- 229960000282 metronidazole Drugs 0.000 claims description 27
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 27
- 239000013543 active substance Substances 0.000 claims description 25
- 239000000654 additive Substances 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 25
- 239000002775 capsule Substances 0.000 claims description 24
- 239000007931 coated granule Substances 0.000 claims description 23
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 21
- 229960000381 omeprazole Drugs 0.000 claims description 20
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 208000015181 infectious disease Diseases 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 10
- 238000007906 compression Methods 0.000 claims description 9
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 8
- 229960003174 lansoprazole Drugs 0.000 claims description 8
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 7
- 229960003022 amoxicillin Drugs 0.000 claims description 6
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 6
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000007909 solid dosage form Substances 0.000 claims description 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
- 239000007892 solid unit dosage form Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 3
- 229960004770 esomeprazole Drugs 0.000 claims description 3
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims description 3
- 159000000003 magnesium salts Chemical group 0.000 claims description 3
- 206010019375 Helicobacter infections Diseases 0.000 claims description 2
- 159000000011 group IA salts Chemical class 0.000 claims description 2
- 208000012895 Gastric disease Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000007916 tablet composition Substances 0.000 claims 1
- 239000011162 core material Substances 0.000 description 40
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 28
- -1 alkylalkyloxy Chemical group 0.000 description 17
- 238000000576 coating method Methods 0.000 description 16
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 13
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- 238000005469 granulation Methods 0.000 description 12
- 230000003179 granulation Effects 0.000 description 12
- 239000000843 powder Substances 0.000 description 12
- 235000000346 sugar Nutrition 0.000 description 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 10
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 10
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 9
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- 239000008213 purified water Substances 0.000 description 9
- 239000006187 pill Substances 0.000 description 8
- 239000004014 plasticizer Substances 0.000 description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
- KWORUUGOSLYAGD-UHFFFAOYSA-N magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]benzimidazol-1-ide Chemical compound [Mg+2].N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C.N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C KWORUUGOSLYAGD-UHFFFAOYSA-N 0.000 description 7
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- 229920000642 polymer Polymers 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 235000002639 sodium chloride Nutrition 0.000 description 7
- 229940079832 sodium starch glycolate Drugs 0.000 description 7
- 239000008109 sodium starch glycolate Substances 0.000 description 7
- 229920003109 sodium starch glycolate Polymers 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 239000000454 talc Substances 0.000 description 7
- 229910052623 talc Inorganic materials 0.000 description 7
- 230000002378 acidificating effect Effects 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 239000012055 enteric layer Substances 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 6
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 6
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 6
- 229920000136 polysorbate Polymers 0.000 description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 6
- 239000007900 aqueous suspension Substances 0.000 description 5
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 229950008882 polysorbate Drugs 0.000 description 5
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 5
- 239000001692 EU approved anti-caking agent Substances 0.000 description 4
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
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- 238000001125 extrusion Methods 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
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- 239000000395 magnesium oxide Substances 0.000 description 4
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- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
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- 239000002700 tablet coating Substances 0.000 description 4
- 239000001069 triethyl citrate Substances 0.000 description 4
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 4
- 235000013769 triethyl citrate Nutrition 0.000 description 4
- 229910001845 yogo sapphire Inorganic materials 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- 239000004098 Tetracycline Substances 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
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- 150000003522 tetracyclines Chemical class 0.000 description 3
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- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229910020038 Mg6Al2 Inorganic materials 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
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- 150000001413 amino acids Chemical class 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
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- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 2
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- MQEUGMWHWPYFDD-UHFFFAOYSA-N magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical compound [Mg].N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-UHFFFAOYSA-N 0.000 description 2
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- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
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- A61P31/04—Antibacterial agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9500422A SE9500422D0 (sv) | 1995-02-06 | 1995-02-06 | New oral pharmaceutical dosage forms |
| US46477595A | 1995-06-07 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP960032A2 true HRP960032A2 (en) | 1997-10-31 |
Family
ID=26662219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR9500422-2A HRP960032A2 (en) | 1995-02-06 | 1996-01-23 | New oral pharmaceutical dosage form |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6136344A (de) |
| EP (1) | EP0754061B1 (de) |
| JP (1) | JP3699122B2 (de) |
| CN (1) | CN1098104C (de) |
| AR (1) | AR002275A1 (de) |
| AT (1) | ATE219377T1 (de) |
| AU (1) | AU689372B2 (de) |
| BR (1) | BR9605111A (de) |
| CA (1) | CA2186039C (de) |
| CZ (1) | CZ293196A3 (de) |
| DE (1) | DE69621885T2 (de) |
| DK (1) | DK0754061T3 (de) |
| EE (1) | EE9600118A (de) |
| ES (1) | ES2176436T3 (de) |
| FI (1) | FI119174B (de) |
| HR (1) | HRP960032A2 (de) |
| HU (1) | HUP9603064A2 (de) |
| IL (1) | IL117041A (de) |
| IS (1) | IS4360A (de) |
| MA (1) | MA23801A1 (de) |
| MX (1) | MX9604354A (de) |
| NO (1) | NO316865B1 (de) |
| NZ (1) | NZ301408A (de) |
| PL (1) | PL316684A1 (de) |
| PT (1) | PT754061E (de) |
| SE (1) | SE9500422D0 (de) |
| SK (1) | SK126096A3 (de) |
| TR (1) | TR199600786T1 (de) |
| TW (1) | TW474825B (de) |
| WO (1) | WO1996024375A1 (de) |
| ZA (1) | ZA96365B (de) |
Families Citing this family (88)
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|---|---|---|---|---|
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| US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| SE9600070D0 (sv) * | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| SE9702000D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
| SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| WO1999001454A1 (en) * | 1997-07-03 | 1999-01-14 | Du Pont Pharmaceuticals Company | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
| SI9700186B (sl) * | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
| JP2001513570A (ja) * | 1997-08-25 | 2001-09-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | 上部胃腸管不調治療用複合製剤 |
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| US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| EP1037607B1 (de) * | 1997-12-08 | 2004-02-25 | ALTANA Pharma AG | Neue suppositoriumsform mit säureempfindliche wirkstoffe |
| SE9704869D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulaton II |
| SE9704870D0 (sv) | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulation I |
| EP2263660B1 (de) | 1998-05-18 | 2017-09-27 | Takeda Pharmaceutical Company Limited | Im Munde zerfallende Tablette |
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| US20060182802A1 (en) | 1998-07-28 | 2006-08-17 | Toshihiro Shimizu | Rapidly disintegrable solid preparation |
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| DE19850445A1 (de) * | 1998-11-02 | 2000-05-04 | Falk Pharma Gmbh | Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen |
| US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
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| FR2793688B1 (fr) * | 1999-05-21 | 2003-06-13 | Ethypharm Lab Prod Ethiques | Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques |
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| AU3762801A (en) * | 2000-03-09 | 2001-09-17 | Andrew Ilchyshyn | Treatment of inflammatory dermatoses comprising erythromycin or clarythromycin metronidazole and a gastrointestinal hydrogen pump inhibitor |
| US20020064555A1 (en) * | 2000-09-29 | 2002-05-30 | Dan Cullen | Proton pump inhibitor formulation |
| SI20720A (sl) * | 2000-11-20 | 2002-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nov farmacevtski pripravek v obliki celuloznih kapsul uporaben za derivate benzimidazola |
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| JP4993652B2 (ja) * | 2004-03-31 | 2012-08-08 | リンテック株式会社 | 経口投与剤 |
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| US20030228363A1 (en) * | 2002-06-07 | 2003-12-11 | Patel Mahendra R. | Stabilized pharmaceutical compositons containing benzimidazole compounds |
| EP1534278A4 (de) | 2002-08-01 | 2006-09-06 | Nitromed Inc | Nitrosierte protonenpumpen-hemmer, zusammensetzungen und anwendungsverfahren |
| US6852238B2 (en) * | 2002-08-29 | 2005-02-08 | Steller Technology Company | Layered tablet water treatment compositions and method of use |
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| FR2845289B1 (fr) * | 2002-10-04 | 2004-12-03 | Ethypharm Sa | Spheroides, procede de preparation et compositions pharmaceutiques. |
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| WO2006030297A1 (en) * | 2004-09-17 | 2006-03-23 | Ranbaxy Laboratories Limited | Taste masked granules comprising clarithromycin, hydrocolloids and a coating |
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| EP1803450A1 (de) | 2006-01-03 | 2007-07-04 | Ferrer Internacional, S.A. | Pharmazeutische Zusammensetzungen zur Eradikation von Helicobacter Pylori |
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| CA2654402A1 (en) * | 2006-06-01 | 2007-12-06 | Adel Penhasi | Multiple unit pharmaceutical formulation |
| RU2467747C2 (ru) * | 2006-07-25 | 2012-11-27 | Векта Лтд. | Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi |
| AU2007276874B2 (en) * | 2006-07-28 | 2010-08-19 | Dr. Reddy's Laboratories Ltd. | Granular pharmaceutical compositions |
| RU2006132127A (ru) * | 2006-09-06 | 2008-03-20 | Государственное Учреждение Научный Центр Здоровьядетей Российской Академии Медицинских Наук (Гу Нцзд Рамн) (Ru) | Применение нифуроксазида в качестве компонента комбинированной лекарственной терапии заболеваний, ассоциированных с helicobacter pylori, и способ лечения, направленный на эрадикацию возбудителя |
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1995
- 1995-02-06 SE SE9500422A patent/SE9500422D0/xx unknown
-
1996
- 1996-01-17 ZA ZA96365A patent/ZA96365B/xx unknown
- 1996-01-18 TW TW085100582A patent/TW474825B/zh active
- 1996-01-23 HR HR9500422-2A patent/HRP960032A2/hr not_active Application Discontinuation
- 1996-02-02 PL PL96316684A patent/PL316684A1/xx unknown
- 1996-02-02 BR BR9605111A patent/BR9605111A/pt not_active IP Right Cessation
- 1996-02-02 ES ES96902558T patent/ES2176436T3/es not_active Expired - Lifetime
- 1996-02-02 US US08/628,712 patent/US6136344A/en not_active Expired - Fee Related
- 1996-02-02 SK SK1260-96A patent/SK126096A3/sk unknown
- 1996-02-02 NZ NZ301408A patent/NZ301408A/en not_active IP Right Cessation
- 1996-02-02 CN CN96190196A patent/CN1098104C/zh not_active Expired - Fee Related
- 1996-02-02 MX MX9604354A patent/MX9604354A/es unknown
- 1996-02-02 DE DE69621885T patent/DE69621885T2/de not_active Expired - Lifetime
- 1996-02-02 EP EP96902558A patent/EP0754061B1/de not_active Expired - Lifetime
- 1996-02-02 JP JP52419096A patent/JP3699122B2/ja not_active Expired - Fee Related
- 1996-02-02 DK DK96902558T patent/DK0754061T3/da active
- 1996-02-02 AT AT96902558T patent/ATE219377T1/de not_active IP Right Cessation
- 1996-02-02 TR TR96/00786T patent/TR199600786T1/xx unknown
- 1996-02-02 EE EE9600118A patent/EE9600118A/xx unknown
- 1996-02-02 PT PT96902558T patent/PT754061E/pt unknown
- 1996-02-02 CZ CZ962931A patent/CZ293196A3/cs unknown
- 1996-02-02 WO PCT/SE1996/000125 patent/WO1996024375A1/en active IP Right Grant
- 1996-02-02 CA CA002186039A patent/CA2186039C/en not_active Expired - Fee Related
- 1996-02-02 HU HU9603064A patent/HUP9603064A2/hu unknown
- 1996-02-02 AU AU46822/96A patent/AU689372B2/en not_active Ceased
- 1996-02-05 AR ARP960101281A patent/AR002275A1/es not_active Application Discontinuation
- 1996-02-05 MA MA24156A patent/MA23801A1/fr unknown
- 1996-02-05 IL IL11704196A patent/IL117041A/xx not_active IP Right Cessation
- 1996-09-17 IS IS4360A patent/IS4360A/is unknown
- 1996-10-04 NO NO19964212A patent/NO316865B1/no not_active IP Right Cessation
- 1996-10-04 FI FI963984A patent/FI119174B/fi active IP Right Grant
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