HRP20220387T1 - Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima - Google Patents
Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima Download PDFInfo
- Publication number
- HRP20220387T1 HRP20220387T1 HRP20220387TT HRP20220387T HRP20220387T1 HR P20220387 T1 HRP20220387 T1 HR P20220387T1 HR P20220387T T HRP20220387T T HR P20220387TT HR P20220387 T HRP20220387 T HR P20220387T HR P20220387 T1 HRP20220387 T1 HR P20220387T1
- Authority
- HR
- Croatia
- Prior art keywords
- laa
- group
- substituted
- nitrogen
- carbon
- Prior art date
Links
- 108010040201 Polymyxins Proteins 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 22
- 229910052799 carbon Inorganic materials 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 8
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 150000001721 carbon Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 6
- OGNSCSPNOLGXSM-UHFFFAOYSA-N 2,4-diaminobutyric acid Chemical compound NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 125000006586 (C3-C10) cycloalkylene group Chemical group 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 125000004474 heteroalkylene group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241001135756 Alphaproteobacteria Species 0.000 claims 1
- 241000604933 Bdellovibrio Species 0.000 claims 1
- 101100240518 Caenorhabditis elegans nhr-12 gene Proteins 0.000 claims 1
- 241000588923 Citrobacter Species 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical group CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- 241000588772 Morganella morganii Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 241000122971 Stenotrophomonas Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 241000607477 Yersinia pseudotuberculosis Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
- 229940076266 morganella morganii Drugs 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 150000002829 nitrogen Chemical class 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N ornithyl group Chemical group N[C@@H](CCCN)C(=O)O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
| GB201421019A GB201421019D0 (en) | 2014-11-26 | 2014-11-26 | Compounds |
| EP15715172.1A EP3116897B1 (en) | 2014-03-11 | 2015-03-11 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
| PCT/EP2015/055046 WO2015135976A1 (en) | 2014-03-11 | 2015-03-11 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220387T1 true HRP20220387T1 (hr) | 2022-05-27 |
Family
ID=52823596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220387TT HRP20220387T1 (hr) | 2014-03-11 | 2015-03-11 | Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20170073373A1 (enExample) |
| EP (1) | EP3116897B1 (enExample) |
| JP (1) | JP6785659B2 (enExample) |
| KR (2) | KR20160135739A (enExample) |
| CN (1) | CN106232617B (enExample) |
| AU (1) | AU2015228898B2 (enExample) |
| CA (1) | CA2940455C (enExample) |
| CY (1) | CY1125175T1 (enExample) |
| DK (1) | DK3116897T3 (enExample) |
| ES (1) | ES2910072T3 (enExample) |
| HR (1) | HRP20220387T1 (enExample) |
| IL (1) | IL247243B (enExample) |
| LT (1) | LT3116897T (enExample) |
| MX (1) | MX359104B (enExample) |
| PL (1) | PL3116897T3 (enExample) |
| PT (1) | PT3116897T (enExample) |
| RS (1) | RS63138B1 (enExample) |
| RU (1) | RU2740190C2 (enExample) |
| SI (1) | SI3116897T1 (enExample) |
| TW (1) | TWI709575B (enExample) |
| WO (1) | WO2015135976A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140091724A (ko) * | 2011-11-18 | 2014-07-22 | 노박타 바이오시스템스 리미티드 | 폴리믹신 유도체 |
| CN106414480B (zh) | 2014-04-01 | 2020-08-04 | 莫纳什大学 | 作为抗微生物化合物的多黏菌素衍生物 |
| CN107108699A (zh) | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| US9771394B2 (en) | 2014-12-16 | 2017-09-26 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| CN105030744B (zh) * | 2015-07-09 | 2019-04-19 | 广州英赛特生物技术有限公司 | 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用 |
| CA3000032A1 (en) * | 2015-09-29 | 2017-04-06 | Monash University | Antimicrobial polymyxin derivative compounds |
| JP6744622B2 (ja) * | 2016-06-16 | 2020-08-19 | 学校法人上智学院 | ピペリジン化合物の製造方法 |
| AU2018359018B2 (en) | 2017-11-02 | 2022-11-24 | The University Of Queensland | Peptide antibiotics |
| WO2020002325A1 (en) * | 2018-06-25 | 2020-01-02 | Spero Therapeutics, Inc. | Compounds |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| US20230141981A1 (en) | 2020-01-21 | 2023-05-11 | Shanghai Micurx Pharmaceuticals Co., Ltd | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| TW202233649A (zh) | 2020-11-06 | 2022-09-01 | 美商斯佩羅治療學股份有限公司 | 化合物 |
| CN120699105B (zh) * | 2025-08-19 | 2025-11-21 | 中国药科大学 | 一种氘代抗菌肽及其组合物和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| KR101502453B1 (ko) * | 2006-08-11 | 2015-03-24 | 노던 안티바이오틱스 리미티드 | 폴리믹신 유도체들 및 이들의 용도 |
| TW201035111A (en) * | 2008-12-23 | 2010-10-01 | Biosource Pharm Inc | Antibiotic compositions for the treatment of gram negative infections |
| CN101851270A (zh) * | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| US8415307B1 (en) * | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012168820A1 (en) * | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| KR20140091724A (ko) * | 2011-11-18 | 2014-07-22 | 노박타 바이오시스템스 리미티드 | 폴리믹신 유도체 |
| BR112015029309A2 (pt) * | 2013-05-22 | 2017-07-25 | New Pharma Licence Holdings Ltd | derivados de polimixina e seu uso em terapia de combinação junto com antibióticos diferentes |
-
2015
- 2015-03-11 US US15/125,415 patent/US20170073373A1/en not_active Abandoned
- 2015-03-11 CA CA2940455A patent/CA2940455C/en active Active
- 2015-03-11 AU AU2015228898A patent/AU2015228898B2/en active Active
- 2015-03-11 PL PL15715172T patent/PL3116897T3/pl unknown
- 2015-03-11 DK DK15715172.1T patent/DK3116897T3/da active
- 2015-03-11 MX MX2016011682A patent/MX359104B/es active IP Right Grant
- 2015-03-11 JP JP2016556784A patent/JP6785659B2/ja active Active
- 2015-03-11 HR HRP20220387TT patent/HRP20220387T1/hr unknown
- 2015-03-11 SI SI201531832T patent/SI3116897T1/sl unknown
- 2015-03-11 RU RU2016139978A patent/RU2740190C2/ru active
- 2015-03-11 EP EP15715172.1A patent/EP3116897B1/en active Active
- 2015-03-11 TW TW104107773A patent/TWI709575B/zh active
- 2015-03-11 KR KR1020167027152A patent/KR20160135739A/ko not_active Ceased
- 2015-03-11 ES ES15715172T patent/ES2910072T3/es active Active
- 2015-03-11 PT PT157151721T patent/PT3116897T/pt unknown
- 2015-03-11 LT LTEPPCT/EP2015/055046T patent/LT3116897T/lt unknown
- 2015-03-11 CN CN201580011858.0A patent/CN106232617B/zh active Active
- 2015-03-11 KR KR1020237036093A patent/KR20230152779A/ko active Pending
- 2015-03-11 RS RS20220387A patent/RS63138B1/sr unknown
- 2015-03-11 WO PCT/EP2015/055046 patent/WO2015135976A1/en not_active Ceased
-
2016
- 2016-08-11 IL IL247243A patent/IL247243B/en active IP Right Grant
-
2021
- 2021-01-25 US US17/157,393 patent/US20210221848A1/en not_active Abandoned
-
2022
- 2022-04-20 CY CY20221100299T patent/CY1125175T1/el unknown
-
2023
- 2023-03-24 US US18/126,270 patent/US20230322858A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CY1125175T1 (el) | 2024-12-13 |
| CA2940455A1 (en) | 2015-09-17 |
| DK3116897T3 (da) | 2022-03-28 |
| CA2940455C (en) | 2023-03-21 |
| LT3116897T (lt) | 2022-05-10 |
| TW201617362A (zh) | 2016-05-16 |
| AU2015228898B2 (en) | 2018-11-15 |
| KR20230152779A (ko) | 2023-11-03 |
| EP3116897B1 (en) | 2022-03-02 |
| RU2740190C2 (ru) | 2021-01-12 |
| AU2015228898A1 (en) | 2016-10-20 |
| EP3116897A1 (en) | 2017-01-18 |
| PL3116897T3 (pl) | 2022-05-30 |
| SI3116897T1 (sl) | 2022-06-30 |
| JP2017510570A (ja) | 2017-04-13 |
| CN106232617A (zh) | 2016-12-14 |
| ES2910072T3 (es) | 2022-05-11 |
| US20170073373A1 (en) | 2017-03-16 |
| IL247243B (en) | 2020-04-30 |
| RU2016139978A3 (enExample) | 2018-10-17 |
| RU2016139978A (ru) | 2018-04-13 |
| RS63138B1 (sr) | 2022-05-31 |
| US20230322858A1 (en) | 2023-10-12 |
| KR20160135739A (ko) | 2016-11-28 |
| MX359104B (es) | 2018-09-14 |
| US20210221848A1 (en) | 2021-07-22 |
| TWI709575B (zh) | 2020-11-11 |
| WO2015135976A1 (en) | 2015-09-17 |
| PT3116897T (pt) | 2022-04-07 |
| CN106232617B (zh) | 2022-06-24 |
| JP6785659B2 (ja) | 2020-11-18 |
| MX2016011682A (es) | 2017-04-27 |
| IL247243A0 (en) | 2016-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20220387T1 (hr) | Derivati polimiksina i njihova upotreba u kombinacijskoj terapiji zajedno s različitim antibioticima | |
| BR112016022785B8 (pt) | composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3-dioxigenase (ido), composição farmacêutica, e, uso de composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3dioxigenase (ido) ou de um sal farmaceuticamente aceitável do mesmo para fabricação de um medicamento | |
| PE20140039A1 (es) | Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina | |
| AR093924A2 (es) | Inhibidores macrociclicos de serina proteasas de hepatitis c | |
| AR101261A1 (es) | Compuesto de tetrahidropirrolo[1,2:3,4]imidazo[1,2-c]pirimidin-1(6h)-ona y composición farmacéutica que lo comprende | |
| ZA202200828B (en) | 6,7-dihydro-5h-pyrido[2,3-c]pyridazine derivatives and related compounds as bcl-xl protein inhibitors and pro-apoptotic agents for treating cancer | |
| PE20160588A1 (es) | Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos | |
| AR086254A1 (es) | Derivados de imidazol utiles para el tratamiento de artritis | |
| AR073760A1 (es) | Derivados heterociclicos y metodos de uso de los mismos | |
| RU2012108874A (ru) | Композиции, содержащие расщепляемые ферментами опиоидные пролекарства с модифицированным кетоном и их дополнительные ингибиторы | |
| JP2017510570A5 (enExample) | ||
| CY1123137T1 (el) | Ιμιδαζο[1.2α]πυριδινες για αντιμετωπιση ή προληψη υπερουριχαιμιας ή ουρικης αρθριτιδας | |
| PE20090876A1 (es) | Nuevos derivados de 6-aril/heteroalquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion principalmente como inhibidores de cmet | |
| TW200800945A (en) | Macrocylic inhibitors of hepatitis c virus | |
| JP2016527186A5 (enExample) | ||
| JP2010539081A (ja) | 大環状化合物および治療方法 | |
| EA201591804A1 (ru) | Производные 2-((4-амино-3-(3-фтор-5-гидроксифенил)-1h-пиразоло[3,4-d]пиримидин-1-ил)метил)-3-(2-(трифторметил)бензил)хиназолин-4(3h)-она и их применение в качестве ингибиторов фосфоинозитид-3-киназы | |
| EA201891050A1 (ru) | Соединения пирроло-, пиразоло-, имидазопиримидина и пиридина, которые ингибируют mnk1 и mnk2 | |
| EA201300617A1 (ru) | β-ЛАКТАМОВЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ β-ЛАКТАМАЗЫ И ИХ ПРИМЕНЕНИЕ | |
| HRP20210484T1 (hr) | Antimikrobna sredstva koja se temelje na imidazolu | |
| AR120174A1 (es) | Inhibidores del factor d del complemento para administración oral | |
| AR057162A1 (es) | Compuestos de benzamida como inhibidores de la enzima histona desacetilasa (hdac) | |
| HRP20151419T1 (hr) | Derivati 2-okso-1-imidazolidinil imidazotiadiazola | |
| MX2019012759A (es) | Derivados de pirrolopirimidina utiles como inhibidores de la replicacion de los virus de la gripe. | |
| AR096728A1 (es) | Derivados de estratrieno-tiazol terapéuticamente activos |