KR20160135739A - 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 - Google Patents

폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 Download PDF

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Publication number
KR20160135739A
KR20160135739A KR1020167027152A KR20167027152A KR20160135739A KR 20160135739 A KR20160135739 A KR 20160135739A KR 1020167027152 A KR1020167027152 A KR 1020167027152A KR 20167027152 A KR20167027152 A KR 20167027152A KR 20160135739 A KR20160135739 A KR 20160135739A
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KR
South Korea
Prior art keywords
group
nitrogen
rti
heterocycle
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020167027152A
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English (en)
Korean (ko)
Inventor
파멜라 브라운
마이클 도슨
모나 시모노빅
스티븐 보악스
에스더 두페르치
스티븐 제임스 스탠웨이
앙투아네트 윌슨
스티븐 프레드릭 모스
Original Assignee
뉴 파마 라이센스 홀딩스 리미티드
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Publication date
Priority claimed from GB201404301A external-priority patent/GB201404301D0/en
Priority claimed from GB201421019A external-priority patent/GB201421019D0/en
Application filed by 뉴 파마 라이센스 홀딩스 리미티드 filed Critical 뉴 파마 라이센스 홀딩스 리미티드
Priority to KR1020237036093A priority Critical patent/KR20230152779A/ko
Publication of KR20160135739A publication Critical patent/KR20160135739A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020167027152A 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 Ceased KR20160135739A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237036093A KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB201404301A GB201404301D0 (en) 2014-03-11 2014-03-11 Compounds and combinations
GB1404301.2 2014-03-11
GB1421019.9 2014-11-26
GB201421019A GB201421019D0 (en) 2014-11-26 2014-11-26 Compounds
PCT/EP2015/055046 WO2015135976A1 (en) 2014-03-11 2015-03-11 Polymyxin derivatives and their use in combination therapy together with different antibiotics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237036093A Division KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Publications (1)

Publication Number Publication Date
KR20160135739A true KR20160135739A (ko) 2016-11-28

Family

ID=52823596

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020167027152A Ceased KR20160135739A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
KR1020237036093A Pending KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020237036093A Pending KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Country Status (21)

Country Link
US (3) US20170073373A1 (enExample)
EP (1) EP3116897B1 (enExample)
JP (1) JP6785659B2 (enExample)
KR (2) KR20160135739A (enExample)
CN (1) CN106232617B (enExample)
AU (1) AU2015228898B2 (enExample)
CA (1) CA2940455C (enExample)
CY (1) CY1125175T1 (enExample)
DK (1) DK3116897T3 (enExample)
ES (1) ES2910072T3 (enExample)
HR (1) HRP20220387T1 (enExample)
IL (1) IL247243B (enExample)
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MX (1) MX359104B (enExample)
PL (1) PL3116897T3 (enExample)
PT (1) PT3116897T (enExample)
RS (1) RS63138B1 (enExample)
RU (1) RU2740190C2 (enExample)
SI (1) SI3116897T1 (enExample)
TW (1) TWI709575B (enExample)
WO (1) WO2015135976A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220111676A (ko) * 2021-02-02 2022-08-09 한국생명공학연구원 바이페닐 유도체 화합물을 유효성분으로 함유하는 항균 보조제 및 이의 용도

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX355217B (es) * 2011-11-18 2018-04-10 New Pharma Licence Holdings Ltd Derivados de polimixina.
US10047126B2 (en) 2014-04-01 2018-08-14 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
EP3233889B1 (en) 2014-12-16 2022-07-06 Shanghai MicuRx Pharmaceutical Co., Ltd. Antimicrobial polymyxins for treatment of bacterial infections
CN105030744B (zh) * 2015-07-09 2019-04-19 广州英赛特生物技术有限公司 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用
JP7367950B2 (ja) * 2015-09-29 2023-10-24 モナッシュ ユニバーシティ 抗菌性ポリミキシン誘導体化合物
JP6744622B2 (ja) * 2016-06-16 2020-08-19 学校法人上智学院 ピペリジン化合物の製造方法
WO2019084628A1 (en) 2017-11-02 2019-05-09 The University Of Queensland Peptide antibiotics
DK3810633T3 (da) 2018-06-25 2024-01-15 Spero Therapeutics Inc Forbindelser
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
WO2021150792A1 (en) 2020-01-21 2021-07-29 Micurx Pharmaceuticals, Inc. Novel compounds and composition for targeted therapy of kidney-associated cancers
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
CN120574287B (zh) * 2025-06-10 2026-07-03 中国药科大学 一种抗菌肽、组合物及应用
CN120699105B (zh) * 2025-08-19 2025-11-21 中国药科大学 一种氘代抗菌肽及其组合物和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
BRPI0715095B8 (pt) * 2006-08-11 2021-05-25 Northern Antibiotics Oy derivado de polimixina da fórmula geral (i); produto de combinação; composição farmacêutica; método para se sensibilizar bactérias gram-negativas a um agente antibacteriano; método para o desenvolvimento de antibióticos; método para a redução da toxicidade de polimixinas, octapeptinas naturais e seus derivados durante a aplicação das mesmas no tratamento de infecções em um indivíduo; método para melhorar as propriedades farmacocinéticas, de polimixinas, octapeptinas naturais e seus derivados; método para a sensibilização de bactérias gram-negativas clinicamente importantes a um complemento de mecanismo de defesa presente no soro; uso de um derivado; e processo para a preparação de um derivado de polimixina da fórmula (i).
WO2010075416A1 (en) * 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN101851270A (zh) * 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
US8415307B1 (en) * 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
MX355217B (es) * 2011-11-18 2018-04-10 New Pharma Licence Holdings Ltd Derivados de polimixina.
HUE059544T2 (hu) * 2013-05-22 2022-11-28 Spero Therapeutics Inc Polimixin-származékok és ezek alkalmazása kombinációs terápiában különbözõ antibiotikumokkal

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220111676A (ko) * 2021-02-02 2022-08-09 한국생명공학연구원 바이페닐 유도체 화합물을 유효성분으로 함유하는 항균 보조제 및 이의 용도
US12599575B2 (en) 2021-02-02 2026-04-14 Korea Research Institute Of Bioscience And Biotechnology Antimicrobial adjuvant containing biphenyl derivative compound as active ingredient, and uses thereof

Also Published As

Publication number Publication date
PL3116897T3 (pl) 2022-05-30
MX359104B (es) 2018-09-14
IL247243B (en) 2020-04-30
SI3116897T1 (sl) 2022-06-30
RS63138B1 (sr) 2022-05-31
EP3116897A1 (en) 2017-01-18
JP6785659B2 (ja) 2020-11-18
ES2910072T3 (es) 2022-05-11
CA2940455A1 (en) 2015-09-17
HRP20220387T1 (hr) 2022-05-27
CN106232617A (zh) 2016-12-14
IL247243A0 (en) 2016-09-29
AU2015228898A1 (en) 2016-10-20
US20230322858A1 (en) 2023-10-12
RU2016139978A3 (enExample) 2018-10-17
JP2017510570A (ja) 2017-04-13
AU2015228898B2 (en) 2018-11-15
MX2016011682A (es) 2017-04-27
US20170073373A1 (en) 2017-03-16
PT3116897T (pt) 2022-04-07
EP3116897B1 (en) 2022-03-02
DK3116897T3 (da) 2022-03-28
TW201617362A (zh) 2016-05-16
CN106232617B (zh) 2022-06-24
US20210221848A1 (en) 2021-07-22
RU2740190C2 (ru) 2021-01-12
KR20230152779A (ko) 2023-11-03
CY1125175T1 (el) 2024-12-13
LT3116897T (lt) 2022-05-10
CA2940455C (en) 2023-03-21
TWI709575B (zh) 2020-11-11
WO2015135976A1 (en) 2015-09-17
RU2016139978A (ru) 2018-04-13

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