JP6785659B2 - 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 - Google Patents
異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 Download PDFInfo
- Publication number
- JP6785659B2 JP6785659B2 JP2016556784A JP2016556784A JP6785659B2 JP 6785659 B2 JP6785659 B2 JP 6785659B2 JP 2016556784 A JP2016556784 A JP 2016556784A JP 2016556784 A JP2016556784 A JP 2016556784A JP 6785659 B2 JP6785659 B2 JP 6785659B2
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC1C(*)C(*)=CN(*)C1C Chemical compound CC1C(*)C(*)=CN(*)C1C 0.000 description 11
- JCJWFANICPQWOM-GICMACPYSA-N CCCCCCCC[C@H](CN(C1)C(OC(C)(C)C)=O)C1C(O)=O Chemical compound CCCCCCCC[C@H](CN(C1)C(OC(C)(C)C)=O)C1C(O)=O JCJWFANICPQWOM-GICMACPYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201404301A GB201404301D0 (en) | 2014-03-11 | 2014-03-11 | Compounds and combinations |
| GB1404301.2 | 2014-03-11 | ||
| GB201421019A GB201421019D0 (en) | 2014-11-26 | 2014-11-26 | Compounds |
| GB1421019.9 | 2014-11-26 | ||
| PCT/EP2015/055046 WO2015135976A1 (en) | 2014-03-11 | 2015-03-11 | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510570A JP2017510570A (ja) | 2017-04-13 |
| JP2017510570A5 JP2017510570A5 (enExample) | 2018-06-07 |
| JP6785659B2 true JP6785659B2 (ja) | 2020-11-18 |
Family
ID=52823596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556784A Active JP6785659B2 (ja) | 2014-03-11 | 2015-03-11 | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20170073373A1 (enExample) |
| EP (1) | EP3116897B1 (enExample) |
| JP (1) | JP6785659B2 (enExample) |
| KR (2) | KR20160135739A (enExample) |
| CN (1) | CN106232617B (enExample) |
| AU (1) | AU2015228898B2 (enExample) |
| CA (1) | CA2940455C (enExample) |
| CY (1) | CY1125175T1 (enExample) |
| DK (1) | DK3116897T3 (enExample) |
| ES (1) | ES2910072T3 (enExample) |
| HR (1) | HRP20220387T1 (enExample) |
| IL (1) | IL247243B (enExample) |
| LT (1) | LT3116897T (enExample) |
| MX (1) | MX359104B (enExample) |
| PL (1) | PL3116897T3 (enExample) |
| PT (1) | PT3116897T (enExample) |
| RS (1) | RS63138B1 (enExample) |
| RU (1) | RU2740190C2 (enExample) |
| SI (1) | SI3116897T1 (enExample) |
| TW (1) | TWI709575B (enExample) |
| WO (1) | WO2015135976A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014012016A2 (pt) * | 2011-11-18 | 2017-05-16 | Cantab Anti-Infectives Ltd | compostos |
| US10047126B2 (en) | 2014-04-01 | 2018-08-14 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| WO2016083531A1 (en) | 2014-11-26 | 2016-06-02 | New Pharma Licence Holdings Limited | Compounds |
| EP3233889B1 (en) | 2014-12-16 | 2022-07-06 | Shanghai MicuRx Pharmaceutical Co., Ltd. | Antimicrobial polymyxins for treatment of bacterial infections |
| CN105030744B (zh) * | 2015-07-09 | 2019-04-19 | 广州英赛特生物技术有限公司 | 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用 |
| CN108350034B (zh) * | 2015-09-29 | 2022-03-11 | 莫纳什大学 | 抗微生物的多黏菌素衍生的化合物 |
| JP6744622B2 (ja) * | 2016-06-16 | 2020-08-19 | 学校法人上智学院 | ピペリジン化合物の製造方法 |
| WO2019084628A1 (en) | 2017-11-02 | 2019-05-09 | The University Of Queensland | Peptide antibiotics |
| CN112789287B (zh) | 2018-06-25 | 2024-06-21 | 云顶新耀医药科技有限公司 | 化合物 |
| CN111690040A (zh) * | 2019-03-12 | 2020-09-22 | 上海来益生物药物研究开发中心有限责任公司 | 多粘菌素衍生物、其制备方法和应用 |
| WO2021150792A1 (en) | 2020-01-21 | 2021-07-29 | Micurx Pharmaceuticals, Inc. | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| WO2022098950A1 (en) | 2020-11-06 | 2022-05-12 | Spero Therapeutics, Inc. | Compounds |
| CN120699105B (zh) * | 2025-08-19 | 2025-11-21 | 中国药科大学 | 一种氘代抗菌肽及其组合物和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| KR20150008198A (ko) * | 2006-08-11 | 2015-01-21 | 노던 안티바이오틱스 리미티드 | 폴리믹신 유도체들 및 이들의 용도 |
| AR074874A1 (es) * | 2008-12-23 | 2011-02-16 | Biosource Pharm Inc | Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto. |
| CN101851270A (zh) * | 2009-04-03 | 2010-10-06 | 梁浩 | 一种多粘菌素衍生物及其制备方法 |
| US8415307B1 (en) * | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012168820A1 (en) * | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| BR112014012016A2 (pt) * | 2011-11-18 | 2017-05-16 | Cantab Anti-Infectives Ltd | compostos |
| BR112015029309A2 (pt) * | 2013-05-22 | 2017-07-25 | New Pharma Licence Holdings Ltd | derivados de polimixina e seu uso em terapia de combinação junto com antibióticos diferentes |
-
2015
- 2015-03-11 LT LTEPPCT/EP2015/055046T patent/LT3116897T/lt unknown
- 2015-03-11 RU RU2016139978A patent/RU2740190C2/ru active
- 2015-03-11 KR KR1020167027152A patent/KR20160135739A/ko not_active Ceased
- 2015-03-11 WO PCT/EP2015/055046 patent/WO2015135976A1/en not_active Ceased
- 2015-03-11 AU AU2015228898A patent/AU2015228898B2/en active Active
- 2015-03-11 PT PT157151721T patent/PT3116897T/pt unknown
- 2015-03-11 JP JP2016556784A patent/JP6785659B2/ja active Active
- 2015-03-11 CA CA2940455A patent/CA2940455C/en active Active
- 2015-03-11 US US15/125,415 patent/US20170073373A1/en not_active Abandoned
- 2015-03-11 TW TW104107773A patent/TWI709575B/zh active
- 2015-03-11 EP EP15715172.1A patent/EP3116897B1/en active Active
- 2015-03-11 KR KR1020237036093A patent/KR20230152779A/ko active Pending
- 2015-03-11 RS RS20220387A patent/RS63138B1/sr unknown
- 2015-03-11 MX MX2016011682A patent/MX359104B/es active IP Right Grant
- 2015-03-11 PL PL15715172T patent/PL3116897T3/pl unknown
- 2015-03-11 HR HRP20220387TT patent/HRP20220387T1/hr unknown
- 2015-03-11 ES ES15715172T patent/ES2910072T3/es active Active
- 2015-03-11 DK DK15715172.1T patent/DK3116897T3/da active
- 2015-03-11 CN CN201580011858.0A patent/CN106232617B/zh active Active
- 2015-03-11 SI SI201531832T patent/SI3116897T1/sl unknown
-
2016
- 2016-08-11 IL IL247243A patent/IL247243B/en active IP Right Grant
-
2021
- 2021-01-25 US US17/157,393 patent/US20210221848A1/en not_active Abandoned
-
2022
- 2022-04-20 CY CY20221100299T patent/CY1125175T1/el unknown
-
2023
- 2023-03-24 US US18/126,270 patent/US20230322858A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI709575B (zh) | 2020-11-11 |
| LT3116897T (lt) | 2022-05-10 |
| HRP20220387T1 (hr) | 2022-05-27 |
| US20230322858A1 (en) | 2023-10-12 |
| RS63138B1 (sr) | 2022-05-31 |
| WO2015135976A1 (en) | 2015-09-17 |
| RU2016139978A3 (enExample) | 2018-10-17 |
| SI3116897T1 (sl) | 2022-06-30 |
| PT3116897T (pt) | 2022-04-07 |
| DK3116897T3 (da) | 2022-03-28 |
| IL247243A0 (en) | 2016-09-29 |
| CA2940455A1 (en) | 2015-09-17 |
| CY1125175T1 (el) | 2024-12-13 |
| AU2015228898A1 (en) | 2016-10-20 |
| AU2015228898B2 (en) | 2018-11-15 |
| CN106232617B (zh) | 2022-06-24 |
| CA2940455C (en) | 2023-03-21 |
| EP3116897A1 (en) | 2017-01-18 |
| KR20160135739A (ko) | 2016-11-28 |
| MX359104B (es) | 2018-09-14 |
| JP2017510570A (ja) | 2017-04-13 |
| CN106232617A (zh) | 2016-12-14 |
| ES2910072T3 (es) | 2022-05-11 |
| IL247243B (en) | 2020-04-30 |
| RU2016139978A (ru) | 2018-04-13 |
| US20170073373A1 (en) | 2017-03-16 |
| US20210221848A1 (en) | 2021-07-22 |
| EP3116897B1 (en) | 2022-03-02 |
| TW201617362A (zh) | 2016-05-16 |
| KR20230152779A (ko) | 2023-11-03 |
| MX2016011682A (es) | 2017-04-27 |
| PL3116897T3 (pl) | 2022-05-30 |
| RU2740190C2 (ru) | 2021-01-12 |
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| JP6785659B2 (ja) | 異なった抗生物質と一緒の組合せ療法におけるポリミキシン誘導体及びその使用 | |
| KR102354902B1 (ko) | 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 | |
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| JPH0820597A (ja) | トロンビン阻害作用を有する複素環カルボニル化合物 | |
| HK1240940B (en) | Polymyxin derivatives and their use in combination therapy together with different antibiotics | |
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