HRP20212000T1 - Aminotriazolopiridini kao inhibitori kinaze - Google Patents

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Publication number

HRP20212000T1

HRP20212000T1 HRP20212000TT HRP20212000T HRP20212000T1 HR P20212000 T1 HRP20212000 T1 HR P20212000T1 HR P20212000T T HRP20212000T T HR P20212000TT HR P20212000 T HRP20212000 T HR P20212000T HR P20212000 T1 HRP20212000 T1 HR P20212000T1

Authority

HR

Croatia

Prior art keywords

pyridin

triazolo

amino

methyl

carboxamide

Prior art date

2017-02-13

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• KGUHUVQIJHGHLX-UHFFFAOYSA-N 2h-triazolo[4,5-b]pyridin-5-amine Chemical class NC1=CC=C2NN=NC2=N1 KGUHUVQIJHGHLX-UHFFFAOYSA-N 0.000 title 1
• 229940043355 kinase inhibitor Drugs 0.000 title 1
• 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
• 125000000217 alkyl group Chemical group 0.000 claims 25
• DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 25
• 150000001875 compounds Chemical class 0.000 claims 20
• 235000005152 nicotinamide Nutrition 0.000 claims 14
• 239000011570 nicotinamide Substances 0.000 claims 14
• 150000003839 salts Chemical class 0.000 claims 14
• -1 C1-4 deuteroalkoxy Chemical group 0.000 claims 13
• 125000006712 (C1-C4) deuteroalkyl group Chemical group 0.000 claims 12
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 11
• 125000000623 heterocyclic group Chemical group 0.000 claims 11
• 125000003545 alkoxy group Chemical group 0.000 claims 10
• 125000005843 halogen group Chemical group 0.000 claims 10
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 9
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 9
• 125000003118 aryl group Chemical group 0.000 claims 8
• 229910052760 oxygen Inorganic materials 0.000 claims 8
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
• 229960003966 nicotinamide Drugs 0.000 claims 7
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 6
• 125000005345 deuteroalkyl group Chemical group 0.000 claims 6
• 125000005842 heteroatom Chemical group 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 6
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
• 125000001072 heteroaryl group Chemical group 0.000 claims 5
• 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 5
• 125000000041 C6-C10 aryl group Chemical group 0.000 claims 4
• 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 4
• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 125000004076 pyridyl group Chemical group 0.000 claims 4
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
• 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
• ZBRSRYXDAXQNQG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[1-[3-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NC(C)C2=CC(=CC=C2)OC(F)(F)F)=N1 ZBRSRYXDAXQNQG-UHFFFAOYSA-N 0.000 claims 2
• 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 2
• 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
• 125000004104 aryloxy group Chemical group 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000000168 pyrrolyl group Chemical group 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
• GPSHMKMHKNPMML-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-5-methoxy-N-(3-phenylbutyl)pyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCCC(C)C3=CC=CC=C3)C(=CN=2)OC)=N1 GPSHMKMHKNPMML-UHFFFAOYSA-N 0.000 claims 1
• JALSUPXWAGDVIK-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-5-methyl-N-(3-phenylbutyl)pyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCCC(C)C3=CC=CC=C3)C(=CN=2)C)=N1 JALSUPXWAGDVIK-UHFFFAOYSA-N 0.000 claims 1
• ZZVMOYDGLSUIMW-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-5-methyl-N-(3-phenylbutyl)pyrimidine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=NC=C(C(=N2)C(=O)NCCC(C)C2=CC=CC=C2)C)=N1 ZZVMOYDGLSUIMW-UHFFFAOYSA-N 0.000 claims 1
• CBIXMYAHBFPRGV-LLVKDONJSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-5-methoxypyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C(=CN=2)OC)=N1 CBIXMYAHBFPRGV-LLVKDONJSA-N 0.000 claims 1
• RWGMAGRPZMHQDV-GFCCVEGCSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-5-methylpyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C(=CN=2)C)=N1 RWGMAGRPZMHQDV-GFCCVEGCSA-N 0.000 claims 1
• WIKPPTSCIZQVEK-LLVKDONJSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-5-methylpyrimidine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=NC=C(C(=N2)C(=O)N[C@H](C)C2=C(C=CC(=C2)OC(F)(F)F)F)C)=N1 WIKPPTSCIZQVEK-LLVKDONJSA-N 0.000 claims 1
• CPYXUYLAGJBTDQ-GFCCVEGCSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-5-methylpyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)C(F)(F)F)F)C(=CN=2)C)=N1 CPYXUYLAGJBTDQ-GFCCVEGCSA-N 0.000 claims 1
• INGKMESSSSGZBB-LLVKDONJSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-5-methylpyrimidine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=NC=C(C(=N2)C(=O)N[C@H](C)C2=C(C=CC(=C2)C(F)(F)F)F)C)=N1 INGKMESSSSGZBB-LLVKDONJSA-N 0.000 claims 1
• GBAHCMOUBLEPDQ-LJQANCHMSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-methylpyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCC[C@@H](O)C3=CC=C(C=C3)Cl)C(=CN=2)C)=N1 GBAHCMOUBLEPDQ-LJQANCHMSA-N 0.000 claims 1
• HUTOHVKGVJIGNL-MRXNPFEDSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-methylpyrimidine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=NC=C(C(=N2)C(=O)NCC[C@@H](O)C2=CC=C(C=C2)Cl)C)=N1 HUTOHVKGVJIGNL-MRXNPFEDSA-N 0.000 claims 1
• GBAHCMOUBLEPDQ-IBGZPJMESA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-methylpyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCC[C@H](O)C3=CC=C(C=C3)Cl)C(=CN=2)C)=N1 GBAHCMOUBLEPDQ-IBGZPJMESA-N 0.000 claims 1
• HUTOHVKGVJIGNL-INIZCTEOSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-methylpyrimidine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=NC=C(C(=N2)C(=O)NCC[C@H](O)C2=CC=C(C=C2)Cl)C)=N1 HUTOHVKGVJIGNL-INIZCTEOSA-N 0.000 claims 1
• SDCJPHMZQOCHHI-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-5-methoxypyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCC3=C(C=CC(=C3)OC(F)(F)F)F)C(=CN=2)OC)=N1 SDCJPHMZQOCHHI-UHFFFAOYSA-N 0.000 claims 1
• QDWNKRBJJSVFES-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-5-methylpyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCC3=C(C=CC(=C3)OC(F)(F)F)F)C(=CN=2)C)=N1 QDWNKRBJJSVFES-UHFFFAOYSA-N 0.000 claims 1
• LUEGAYLEPPSDQR-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methoxypyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCC3=C(C=CC(=C3)C(F)(F)F)F)C(=CN=2)OC)=N1 LUEGAYLEPPSDQR-UHFFFAOYSA-N 0.000 claims 1
• SLCGMQMDSBTLSL-UHFFFAOYSA-N 2-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methylpyridine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=O)NCC3=C(C=CC(=C3)C(F)(F)F)F)C(=CN=2)C)=N1 SLCGMQMDSBTLSL-UHFFFAOYSA-N 0.000 claims 1
• AIOUQYUFHADEHR-UHFFFAOYSA-N 3-methylpyridine-2-carboxamide Chemical compound CC1=CC=CN=C1C(N)=O AIOUQYUFHADEHR-UHFFFAOYSA-N 0.000 claims 1
• SVDCHHNZOLWYTR-UHFFFAOYSA-N 4-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-5-methyl-N-(3-phenylbutyl)pyridine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CC(=NC=C2C)C(=O)NCCC(C)C2=CC=CC=C2)=N1 SVDCHHNZOLWYTR-UHFFFAOYSA-N 0.000 claims 1
• FPRQKSVYSQTMGN-UHFFFAOYSA-N 4-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-5-methylpyridine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CC(=NC=C2C)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 FPRQKSVYSQTMGN-UHFFFAOYSA-N 0.000 claims 1
• BOUFASNPDHJSDN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-(3-phenylbutyl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCCC(C)C2=CC=CC=C2)=N1 BOUFASNPDHJSDN-UHFFFAOYSA-N 0.000 claims 1
• WUVJWYBGSLPNPL-IBIJPGRPSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-[(1R)-2,2,2-trideuterio-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)N[C@H](C([2H])([2H])[2H])C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)C)C)=N1 WUVJWYBGSLPNPL-IBIJPGRPSA-N 0.000 claims 1
• YPBKZXKVISABDP-IBIJPGRPSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-[(1R)-2,2,2-trideuterio-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)N[C@H](C([2H])([2H])[2H])C3=C(C=CC(=C3)C(F)(F)F)F)C=2)C)C)=N1 YPBKZXKVISABDP-IBIJPGRPSA-N 0.000 claims 1
• ZGYSGPOBNBSPTI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-[2-[3-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCCC2=CC(=CC=C2)OC(F)(F)F)=N1 ZGYSGPOBNBSPTI-UHFFFAOYSA-N 0.000 claims 1
• TXXVPYPILSHPLH-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-[[2-(2,2,2-trifluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC=C3)OCC(F)(F)F)C=2)C)C)=N1 TXXVPYPILSHPLH-UHFFFAOYSA-N 0.000 claims 1
• ZTXZLUKVYBDTTF-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-[[3-(2,2,2-trifluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=CC(=CC=C3)OCC(F)(F)F)C=2)C)C)=N1 ZTXZLUKVYBDTTF-UHFFFAOYSA-N 0.000 claims 1
• XQQRMANNNYYHHU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2,6-dimethyl-N-[[3-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=CC(=CC=C2)OC(F)(F)F)=N1 XQQRMANNNYYHHU-UHFFFAOYSA-N 0.000 claims 1
• AOIVHTCEBQXLGQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-(3-phenylbutyl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCCC(C)C2=CC=CC=C2)=N1 AOIVHTCEBQXLGQ-UHFFFAOYSA-N 0.000 claims 1
• NZZOLYDWFWOAHC-LLVKDONJSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)Cl)C)=N1 NZZOLYDWFWOAHC-LLVKDONJSA-N 0.000 claims 1
• HJWSTRACTDJYRW-SNVBAGLBSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)Cl)=N1 HJWSTRACTDJYRW-SNVBAGLBSA-N 0.000 claims 1
• AIXMVEAMLLPCFC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[(3,5-difluoro-2-propan-2-yloxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=C(C(=CC(=C2)F)F)OC(C)C)=N1 AIXMVEAMLLPCFC-UHFFFAOYSA-N 0.000 claims 1
• UGVQCRNLNPAJKA-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[[2-(oxolan-3-yloxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=C(C=CC=C2)OC2COCC2)=N1 UGVQCRNLNPAJKA-UHFFFAOYSA-N 0.000 claims 1
• KQEKBPBAGSOFIG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[[2-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=C(C=CC=C2)OC(F)(F)F)=N1 KQEKBPBAGSOFIG-UHFFFAOYSA-N 0.000 claims 1
• LBZBPEKCYRFDPP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 LBZBPEKCYRFDPP-UHFFFAOYSA-N 0.000 claims 1
• CPWGQCRFNLRUAN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)F)=N1 CPWGQCRFNLRUAN-UHFFFAOYSA-N 0.000 claims 1
• DZQAENMBSUPHOD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[[3-(cyclopropylmethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=CC(=CC=C2)OCC2CC2)=N1 DZQAENMBSUPHOD-UHFFFAOYSA-N 0.000 claims 1
• NRRXACFISJBLQB-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[[3-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NCC2=CC(=CC=C2)OC(F)(F)F)=N1 NRRXACFISJBLQB-UHFFFAOYSA-N 0.000 claims 1
• LBZBPEKCYRFDPP-QOWOAITPSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-chloro-N-[deuterio-[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)Cl)C(=O)NC([2H])C2=C(C=CC(=C2)OC(F)(F)F)F)=N1 LBZBPEKCYRFDPP-QOWOAITPSA-N 0.000 claims 1
• GPSQSOOVKARKBJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethoxy-N-(3-phenylbutyl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCCC(C)C2=CC=CC=C2)=N1 GPSQSOOVKARKBJ-UHFFFAOYSA-N 0.000 claims 1
• XCMBUSSVAGONCD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethoxy-N-[2-(2-phenoxyphenyl)ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCCC2=C(C=CC=C2)OC2=CC=CC=C2)=N1 XCMBUSSVAGONCD-UHFFFAOYSA-N 0.000 claims 1
• DZHDUUGWAVBVTM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethoxy-N-[[1-(2-fluorophenyl)cyclopropyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2(CC2)C2=C(C=CC=C2)F)=N1 DZHDUUGWAVBVTM-UHFFFAOYSA-N 0.000 claims 1
• QCRMBCCPRSTJPP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethoxy-N-[[2-(2,2,2-trifluoroethylsulfanyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC=C2)SCC(F)(F)F)=N1 QCRMBCCPRSTJPP-UHFFFAOYSA-N 0.000 claims 1
• QJKTWOXONGNBFA-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethoxy-N-[[2-[2-(hydroxymethyl)phenyl]sulfonylphenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC=C2)S(=O)(=O)C2=C(C=CC=C2)CO)=N1 QJKTWOXONGNBFA-UHFFFAOYSA-N 0.000 claims 1
• OYEUVJIQKVNPNZ-GFCCVEGCSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethyl-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)CC)=N1 OYEUVJIQKVNPNZ-GFCCVEGCSA-N 0.000 claims 1
• OYEUVJIQKVNPNZ-LBPRGKRZSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethyl-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)CC)=N1 OYEUVJIQKVNPNZ-LBPRGKRZSA-N 0.000 claims 1
• YSVNZRINTUXEJF-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-ethyl-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC(=C3)C(F)(F)F)F)C=2)CC)=N1 YSVNZRINTUXEJF-UHFFFAOYSA-N 0.000 claims 1
• WGHFNAVRGMDLLN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[(2-propan-2-yloxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2)OC(C)C)=N1 WGHFNAVRGMDLLN-UHFFFAOYSA-N 0.000 claims 1
• ISLIAMXUVUKELM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[1-[2-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NC(C)C2=C(C=CC=C2)OC(F)(F)F)=N1 ISLIAMXUVUKELM-UHFFFAOYSA-N 0.000 claims 1
• KMQVXMBMZYSYGC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[1-[3-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NC(C)C2=CC(=CC=C2)OC(F)(F)F)=N1 KMQVXMBMZYSYGC-UHFFFAOYSA-N 0.000 claims 1
• GBHQMOHQCDIASD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[2-[2-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCCC2=C(C=CC=C2)OC(F)(F)F)=N1 GBHQMOHQCDIASD-UHFFFAOYSA-N 0.000 claims 1
• YKIWFRYGOAMINY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[2-[3-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCCC2=CC(=CC=C2)OC(F)(F)F)=N1 YKIWFRYGOAMINY-UHFFFAOYSA-N 0.000 claims 1
• XGENMMUBUBNADK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[2-(2-methylpropoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC=C3)OCC(C)C)C=2)OC)C)=N1 XGENMMUBUBNADK-UHFFFAOYSA-N 0.000 claims 1
• QADAEQSQJIZEBM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[2-(morpholin-4-ylmethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC=C3)CN3CCOCC3)C=2)OC)C)=N1 QADAEQSQJIZEBM-UHFFFAOYSA-N 0.000 claims 1
• DSZDTUDZQQAPFA-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[2-(oxan-4-yloxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2)OC2CCOCC2)=N1 DSZDTUDZQQAPFA-UHFFFAOYSA-N 0.000 claims 1
• KWPMLWJXQZQWLT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[2-(propan-2-yloxymethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC=C3)COC(C)C)C=2)OC)C)=N1 KWPMLWJXQZQWLT-UHFFFAOYSA-N 0.000 claims 1
• CFXNEFZIKBEOHJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[2-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2)OC(F)(F)F)=N1 CFXNEFZIKBEOHJ-UHFFFAOYSA-N 0.000 claims 1
• OXHIGLGLEMKOQH-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[3-(2,2,2-trifluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=CC(=CC=C3)OCC(F)(F)F)C=2)OC)C)=N1 OXHIGLGLEMKOQH-UHFFFAOYSA-N 0.000 claims 1
• GSKGBAQDNGSOBC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[3-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=NC=CC=C3OCC(F)(F)F)C=2)OC)C)=N1 GSKGBAQDNGSOBC-UHFFFAOYSA-N 0.000 claims 1
• UMVMLSIMAQAHJZ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[3-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=CC(=CC=C2)OC(F)(F)F)=N1 UMVMLSIMAQAHJZ-UHFFFAOYSA-N 0.000 claims 1
• BCSUWMMZXBVJDA-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-6-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=CC(=CC=C2)C(F)(F)F)=N1 BCSUWMMZXBVJDA-UHFFFAOYSA-N 0.000 claims 1
• UDQMKNPRLPYGSM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-(2-methyl-3-phenylpropyl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC(CC2=CC=CC=C2)C)=N1 UDQMKNPRLPYGSM-UHFFFAOYSA-N 0.000 claims 1
• UKEFSDVYSWIQKE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-(3-phenylpropyl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCCCC2=CC=CC=C2)=N1 UKEFSDVYSWIQKE-UHFFFAOYSA-N 0.000 claims 1
• UELLPYQSIHWAFA-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-(4-phenylbutan-2-yl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NC(C)CCC2=CC=CC=C2)=N1 UELLPYQSIHWAFA-UHFFFAOYSA-N 0.000 claims 1
• KGXAVVWBTYOJKQ-KMKPOHAJSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(1R)-2,2,2-trideuterio-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@H](C([2H])([2H])[2H])C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)OC)=N1 KGXAVVWBTYOJKQ-KMKPOHAJSA-N 0.000 claims 1
• VNIVMDMSMAMBGR-LBBMYNEISA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(1R)-2,2,2-trideuterio-1-[3-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@H](C([2H])([2H])[2H])C3=CC(=CC=C3)OC(F)(F)F)C=2)OC)=N1 VNIVMDMSMAMBGR-LBBMYNEISA-N 0.000 claims 1
• HMNOKZUEFPRFHW-DCLJDFQTSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(1S)-2,2,2-trideuterio-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@@H](C([2H])([2H])[2H])C3=C(C=CC(=C3)C(F)(F)F)F)C=2)OC)=N1 HMNOKZUEFPRFHW-DCLJDFQTSA-N 0.000 claims 1
• VYXYCPAZUXDDTR-AEFFLSMTSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(1S,2R)-2-phenylcyclopropyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)N[C@@H]2[C@H](C2)C2=CC=CC=C2)=N1 VYXYCPAZUXDDTR-AEFFLSMTSA-N 0.000 claims 1
• BRWACOUEISVFHX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(2-methoxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC)=N1 BRWACOUEISVFHX-UHFFFAOYSA-N 0.000 claims 1
• CWABMHRFNQZDMV-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(2-phenoxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC2=CC=CC=C2)=N1 CWABMHRFNQZDMV-UHFFFAOYSA-N 0.000 claims 1
• FTEDHPNNJSKEQU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(2-propan-2-yloxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC(C)C)=N1 FTEDHPNNJSKEQU-UHFFFAOYSA-N 0.000 claims 1
• XGMRAQLFKTZPCE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(2-propan-2-ylsulfanylphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)SC(C)C)=N1 XGMRAQLFKTZPCE-UHFFFAOYSA-N 0.000 claims 1
• UJKJFMJAKSMGMT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(2-pyridin-2-yloxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC2=NC=CC=C2)=N1 UJKJFMJAKSMGMT-UHFFFAOYSA-N 0.000 claims 1
• LNPXIDWQMAWECR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[(3-propan-2-yloxyphenyl)methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=CC(=CC=C2)OC(C)C)=N1 LNPXIDWQMAWECR-UHFFFAOYSA-N 0.000 claims 1
• BZAUKAOBEBMNPV-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(1,1,2,2-tetrafluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC(C(F)F)(F)F)=N1 BZAUKAOBEBMNPV-UHFFFAOYSA-N 0.000 claims 1
• HDROYTKKHDNYRL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(2,2,2-trifluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)OCC(F)(F)F)C=2)OC)=N1 HDROYTKKHDNYRL-UHFFFAOYSA-N 0.000 claims 1
• RNCVIFFJQDTVDR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(2-methylpropoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)OCC(C)C)C=2)OC)=N1 RNCVIFFJQDTVDR-UHFFFAOYSA-N 0.000 claims 1
• AICFRIMCGDLLTK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(4-methylpiperidin-1-yl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)N2CCC(CC2)C)=N1 AICFRIMCGDLLTK-UHFFFAOYSA-N 0.000 claims 1
• GNTKZDQLLWHSAN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(morpholin-4-ylmethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)CN2CCOCC2)=N1 GNTKZDQLLWHSAN-UHFFFAOYSA-N 0.000 claims 1
• FUNZBKPNPDUDOE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(oxan-4-yloxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC2CCOCC2)=N1 FUNZBKPNPDUDOE-UHFFFAOYSA-N 0.000 claims 1
• XQJLKPOQCZHUND-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(oxolan-3-yloxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC2COCC2)=N1 XQJLKPOQCZHUND-UHFFFAOYSA-N 0.000 claims 1
• FQHRDRXWGYQBSQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(propan-2-yloxymethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)COC(C)C)C=2)OC)=N1 FQHRDRXWGYQBSQ-UHFFFAOYSA-N 0.000 claims 1
• WWJSVBRRRYMJAL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[2-(pyrrolidine-1-carbonyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)C(=O)N3CCCC3)C=2)OC)=N1 WWJSVBRRRYMJAL-UHFFFAOYSA-N 0.000 claims 1
• KYDZMIHICCXBSC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-[[3-(trifluoromethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=CC(=CC=C2)C(F)(F)F)=N1 KYDZMIHICCXBSC-UHFFFAOYSA-N 0.000 claims 1
• IRYRKPQXFMEUNY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methoxy-N-methyl-N-[[3-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)N(CC2=CC(=CC=C2)OC(F)(F)F)C)=N1 IRYRKPQXFMEUNY-UHFFFAOYSA-N 0.000 claims 1
• LCYCDZFVFLEWQK-IBIJPGRPSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[(1R)-2,2,2-trideuterio-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@H](C([2H])([2H])[2H])C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)C)=N1 LCYCDZFVFLEWQK-IBIJPGRPSA-N 0.000 claims 1
• XDRUBPJAKPCQJT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[2-[3-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCCC2=CC(=CC=C2)OC(F)(F)F)=N1 XDRUBPJAKPCQJT-UHFFFAOYSA-N 0.000 claims 1
• YHPYSANTMYSECD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[[2-(2,2,2-trifluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)OCC(F)(F)F)C=2)C)=N1 YHPYSANTMYSECD-UHFFFAOYSA-N 0.000 claims 1
• NNEXOBFADGAKPG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[[2-(2-methylpropoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)OCC(C)C)C=2)C)=N1 NNEXOBFADGAKPG-UHFFFAOYSA-N 0.000 claims 1
• AFJDIBYXDAMWNQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[[3-(2,2,2-trifluoroethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=CC(=CC=C3)OCC(F)(F)F)C=2)C)=N1 AFJDIBYXDAMWNQ-UHFFFAOYSA-N 0.000 claims 1
• PWTFSZYOSLVDPE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-2-methyl-N-[[3-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=CC(=CC=C2)OC(F)(F)F)=N1 PWTFSZYOSLVDPE-UHFFFAOYSA-N 0.000 claims 1
• LICWGWARGCTPGJ-LLVKDONJSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-6-chloro-N-[(1R)-1-[2-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC=C(C(=O)N[C@H](C)C3=C(C=CC=C3)OC(F)(F)F)C=2)Cl)=N1 LICWGWARGCTPGJ-LLVKDONJSA-N 0.000 claims 1
• LIOILPGZIMYGLX-JTQLQIEISA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-6-chloro-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC=C(C(=O)N[C@@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)Cl)=N1 LIOILPGZIMYGLX-JTQLQIEISA-N 0.000 claims 1
• CPQOSZDGUORUCT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-6-chloro-N-[[2-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC=C(C(=O)NCC3=C(C=CC=C3)OC(F)(F)F)C=2)Cl)=N1 CPQOSZDGUORUCT-UHFFFAOYSA-N 0.000 claims 1
• GGYZVSPZUYFWRU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-6-chloro-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C=CC(=CC2=N1)C1=C(Cl)N=CC(=C1)C(=O)NCC1=C(F)C=CC(OC(F)(F)F)=C1 GGYZVSPZUYFWRU-UHFFFAOYSA-N 0.000 claims 1
• VRJZHHDZPRVFEU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-6-chloro-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC=C(C(=O)NCC3=C(C=CC(=C3)C(F)(F)F)F)C=2)Cl)=N1 VRJZHHDZPRVFEU-UHFFFAOYSA-N 0.000 claims 1
• NEUKEZRLRZDTQS-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-6-chloro-N-[[5-fluoro-2-(trifluoromethoxy)phenyl]methyl]pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC=C(C(=O)NCC3=C(C=CC(=C3)F)OC(F)(F)F)C=2)Cl)=N1 NEUKEZRLRZDTQS-UHFFFAOYSA-N 0.000 claims 1
• LBRJDCNGNKXZQV-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-benzhydrylpyrazol-4-yl)-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NC=2C=NN(C=2)C(C2=CC=CC=C2)C2=CC=CC=C2)=N1 LBRJDCNGNKXZQV-UHFFFAOYSA-N 0.000 claims 1
• TUBWGZNHDMHXKR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-benzylimidazol-4-yl)-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NC=3N=CN(C=3)CC3=CC=CC=C3)C=2)C)=N1 TUBWGZNHDMHXKR-UHFFFAOYSA-N 0.000 claims 1
• WOFHRTYFVJQSJI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-benzylpyrazol-4-yl)-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NC=2C=NN(C=2)CC2=CC=CC=C2)=N1 WOFHRTYFVJQSJI-UHFFFAOYSA-N 0.000 claims 1
• CLHUFYYMHMQKCJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2-hydroxy-3-phenoxypropyl)-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC(COC2=CC=CC=C2)O)=N1 CLHUFYYMHMQKCJ-UHFFFAOYSA-N 0.000 claims 1
• VTUOFXFKBBNVEX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2-hydroxy-3-phenylpropyl)-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC(CC2=CC=CC=C2)O)=N1 VTUOFXFKBBNVEX-UHFFFAOYSA-N 0.000 claims 1
• KGXAVVWBTYOJKQ-BINOJTDESA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-(trideuteriomethoxy)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)OC([2H])([2H])[2H])=N1 KGXAVVWBTYOJKQ-BINOJTDESA-N 0.000 claims 1
• LAJIJRWZDWSILF-CYBMUJFWSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methoxy-N,6-dimethylpyridine-3-carboxamide Chemical compound COC1=NC(C)=C(C=C1C(=O)N(C)[C@H](C)C1=C(F)C=CC(OC(F)(F)F)=C1)C1=CC2=NC(N)=NN2C=C1 LAJIJRWZDWSILF-CYBMUJFWSA-N 0.000 claims 1
• JMPWCWLRGLADRZ-CYBMUJFWSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-N,2-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N(C)[C@H](C)C3=C(C=CC(=C3)OC(F)(F)F)F)C=2)C)=N1 JMPWCWLRGLADRZ-CYBMUJFWSA-N 0.000 claims 1
• LXQSTUUWORZZHD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-chloro-6-phenoxyphenyl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2OC2=CC=CC=C2)Cl)=N1 LXQSTUUWORZZHD-UHFFFAOYSA-N 0.000 claims 1
• CEWGSUBFJFVISM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclohexyloxyphenyl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2)OC2CCCCC2)=N1 CEWGSUBFJFVISM-UHFFFAOYSA-N 0.000 claims 1
• JREKFKWRSGCVMU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxy-5-fluorophenyl)methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC(=C2)F)OC2CCCC2)=N1 JREKFKWRSGCVMU-UHFFFAOYSA-N 0.000 claims 1
• QNCSNFUAEIVMCT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxy-5-fluorophenyl)methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC(=C2)F)OC2CCCC2)=N1 QNCSNFUAEIVMCT-UHFFFAOYSA-N 0.000 claims 1
• XLMKFSVEOUWDTO-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxy-5-fluorophenyl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC(=C2)F)OC2CCCC2)=N1 XLMKFSVEOUWDTO-UHFFFAOYSA-N 0.000 claims 1
• OWZXYMUDKHPARY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxy-5-fluorophenyl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC(=C2)F)OC2CCCC2)=N1 OWZXYMUDKHPARY-UHFFFAOYSA-N 0.000 claims 1
• HTGWORFQVPYZIY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxy-6-fluorophenyl)methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2F)OC2CCCC2)=N1 HTGWORFQVPYZIY-UHFFFAOYSA-N 0.000 claims 1
• PPMHLJALUBLNFJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxy-6-fluorophenyl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2F)OC2CCCC2)=N1 PPMHLJALUBLNFJ-UHFFFAOYSA-N 0.000 claims 1
• AJAYYXYJHDTSIL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxyphenyl)methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC=C2)OC2CCCC2)=N1 AJAYYXYJHDTSIL-UHFFFAOYSA-N 0.000 claims 1
• DSZDEMKMKXPNCG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxyphenyl)methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2)OC2CCCC2)=N1 DSZDEMKMKXPNCG-UHFFFAOYSA-N 0.000 claims 1
• IUKPZJNHRWOFCP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxyphenyl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC2CCCC2)=N1 IUKPZJNHRWOFCP-UHFFFAOYSA-N 0.000 claims 1
• CSVGEFGRBXNRCD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxyphenyl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2)OC2CCCC2)=N1 CSVGEFGRBXNRCD-UHFFFAOYSA-N 0.000 claims 1
• ZSBXMMULSJNJMM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxypyridin-3-yl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC=2C(=NC=CC=2)OC2CCCC2)=N1 ZSBXMMULSJNJMM-UHFFFAOYSA-N 0.000 claims 1
• YYBRENARHLTSAR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopentyloxypyridin-3-yl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC=2C(=NC=CC=2)OC2CCCC2)=N1 YYBRENARHLTSAR-UHFFFAOYSA-N 0.000 claims 1
• XHUIMAYBTGSKEC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopropyloxy-3,5-difluorophenyl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC3)C=2)OC)=N1 XHUIMAYBTGSKEC-UHFFFAOYSA-N 0.000 claims 1
• WMEXDTJZVIAOHO-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-cyclopropyloxy-3,5-difluorophenyl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC3)C=2)C)=N1 WMEXDTJZVIAOHO-UHFFFAOYSA-N 0.000 claims 1
• JEMONVMZAYQPMP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-ethylphenyl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)CC)=N1 JEMONVMZAYQPMP-UHFFFAOYSA-N 0.000 claims 1
• IXAPPSSPMNQUCY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(2-fluoro-5-methoxyphenyl)methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC(=C3)OC)F)C=2)OC)C)=N1 IXAPPSSPMNQUCY-UHFFFAOYSA-N 0.000 claims 1
• UNADVNWWYXDGQP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3-cyclopentyloxypyridin-2-yl)methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=NC=CC=C2OC2CCCC2)=N1 UNADVNWWYXDGQP-UHFFFAOYSA-N 0.000 claims 1
• QTCOVZOTVXFKRU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3-cyclopentyloxypyridin-2-yl)methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=NC=CC=C2OC2CCCC2)=N1 QTCOVZOTVXFKRU-UHFFFAOYSA-N 0.000 claims 1
• MRXGCKPSFVKHBF-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3-cyclopentyloxypyridin-2-yl)methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=NC=CC=C2OC2CCCC2)=N1 MRXGCKPSFVKHBF-UHFFFAOYSA-N 0.000 claims 1
• JGKVEIHLYOIAKC-HXUWFJFHSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC[C@@H](O)C2=CC=C(C=C2)Cl)=N1 JGKVEIHLYOIAKC-HXUWFJFHSA-N 0.000 claims 1
• AAUXZIKATMUCTI-LJQANCHMSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC[C@@H](O)C2=CC=C(C=C2)Cl)=N1 AAUXZIKATMUCTI-LJQANCHMSA-N 0.000 claims 1
• VCATZNOHJNXWNN-LJQANCHMSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC[C@@H](O)C2=CC=C(C=C2)Cl)=N1 VCATZNOHJNXWNN-LJQANCHMSA-N 0.000 claims 1
• DIQBQIMROIGLRX-IBGZPJMESA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-1-benzylpyrrolidin-3-yl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)N[C@@H]2CN(CC2)CC2=CC=CC=C2)=N1 DIQBQIMROIGLRX-IBGZPJMESA-N 0.000 claims 1
• JGKVEIHLYOIAKC-FQEVSTJZSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC[C@H](O)C2=CC=C(C=C2)Cl)=N1 JGKVEIHLYOIAKC-FQEVSTJZSA-N 0.000 claims 1
• AAUXZIKATMUCTI-IBGZPJMESA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC[C@H](O)C2=CC=C(C=C2)Cl)=N1 AAUXZIKATMUCTI-IBGZPJMESA-N 0.000 claims 1
• FUARSVCNRXAGKF-IBGZPJMESA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC[C@H](O)C2=CC=C(C=C2)Cl)=N1 FUARSVCNRXAGKF-IBGZPJMESA-N 0.000 claims 1
• MXJOJOBEDQVCNB-SFHVURJKSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC[C@H](O)C2=CC=C(C=C2)Cl)=N1 MXJOJOBEDQVCNB-SFHVURJKSA-N 0.000 claims 1
• VCATZNOHJNXWNN-IBGZPJMESA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC[C@H](O)C2=CC=C(C=C2)Cl)=N1 VCATZNOHJNXWNN-IBGZPJMESA-N 0.000 claims 1
• LCYCDZFVFLEWQK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NC(C)C2=C(C=CC(=C2)OC(F)(F)F)F)=N1 LCYCDZFVFLEWQK-UHFFFAOYSA-N 0.000 claims 1
• DVBXOBNOQIIWQT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[3-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC(CC3=CC=C(C=C3)F)(C)O)C=2)C)=N1 DVBXOBNOQIIWQT-UHFFFAOYSA-N 0.000 claims 1
• ISBUGGSQKVFFDC-SJLPKXTDSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[(1S,2S)-2-(4-fluorophenyl)cyclopropyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NC[C@@H]2[C@H](C2)C2=CC=C(C=C2)F)=N1 ISBUGGSQKVFFDC-SJLPKXTDSA-N 0.000 claims 1
• VPABCXVQTUPWBH-NVXWUHKLSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[(1S,2S)-2-[(4-bromo-2-fluorophenoxy)methyl]cyclopropyl]methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NC[C@@H]2[C@H](C2)COC2=C(C=C(C=C2)Br)F)=N1 VPABCXVQTUPWBH-NVXWUHKLSA-N 0.000 claims 1
• QUNXJDWPMCFVHP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(1-cyclopentylethoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC(C)C2CCCC2)=N1 QUNXJDWPMCFVHP-UHFFFAOYSA-N 0.000 claims 1
• QVPRQHOAVOQMAY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(2,6-dimethyloxan-4-yl)oxy-3,5-difluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OC(C3)C)C)C=2)C)C)=N1 QVPRQHOAVOQMAY-UHFFFAOYSA-N 0.000 claims 1
• AWSFLDLZYSACLD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(2,6-dimethyloxan-4-yl)oxy-3,5-difluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OC(C3)C)C)C=2)OC)C)=N1 AWSFLDLZYSACLD-UHFFFAOYSA-N 0.000 claims 1
• KHKZXMRSAFSWGL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(2,6-dimethyloxan-4-yl)oxy-3,5-difluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OC(C3)C)C)C=2)OC)=N1 KHKZXMRSAFSWGL-UHFFFAOYSA-N 0.000 claims 1
• HIXGYVFKZXFEJL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(2,6-dimethyloxan-4-yl)oxy-3,5-difluorophenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OC(C3)C)C)C=2)C)=N1 HIXGYVFKZXFEJL-UHFFFAOYSA-N 0.000 claims 1
• CWJDBCAUOVEOAB-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(3,3-difluoropyrrolidine-1-carbonyl)-3,5-difluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)C(=O)N3CC(CC3)(F)F)C=2)OC)C)=N1 CWJDBCAUOVEOAB-UHFFFAOYSA-N 0.000 claims 1
• APEWMUSCVSJKKM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(3,3-difluoropyrrolidine-1-carbonyl)-3-fluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC=C3)F)C(=O)N3CC(CC3)(F)F)C=2)OC)C)=N1 APEWMUSCVSJKKM-UHFFFAOYSA-N 0.000 claims 1
• HIAUNIJEHOSAIR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(3,3-difluoropyrrolidine-1-carbonyl)-3-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC=C3)F)C(=O)N3CC(CC3)(F)F)C=2)OC)=N1 HIAUNIJEHOSAIR-UHFFFAOYSA-N 0.000 claims 1
• RHKHCNGGBBHTRP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(3,3-difluoropyrrolidine-1-carbonyl)-5-fluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC(=C3)F)C(=O)N3CC(CC3)(F)F)C=2)OC)C)=N1 RHKHCNGGBBHTRP-UHFFFAOYSA-N 0.000 claims 1
• XURHWFDGDCWPHE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(3,3-difluoropyrrolidine-1-carbonyl)-5-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound COC1=NC=C(C=C1C(=O)NCC1=C(C=CC(F)=C1)C(=O)N1CCC(F)(F)C1)C1=CC2=NC(N)=NN2C=C1 XURHWFDGDCWPHE-UHFFFAOYSA-N 0.000 claims 1
• RPUBZSHCEVWKDP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(3,3-difluoropyrrolidine-1-carbonyl)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3)C(=O)N3CC(CC3)(F)F)C=2)OC)=N1 RPUBZSHCEVWKDP-UHFFFAOYSA-N 0.000 claims 1
• UCXHERZGVNOVKM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(4-fluorophenoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OC2=CC=C(C=C2)F)=N1 UCXHERZGVNOVKM-UHFFFAOYSA-N 0.000 claims 1
• HCZDATYQRBVPSG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(azepan-1-ylsulfonyl)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)S(=O)(=O)N2CCCCCC2)=N1 HCZDATYQRBVPSG-UHFFFAOYSA-N 0.000 claims 1
• CGCORBOXVUSONI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)-6-fluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2F)OCC2CCC2)=N1 CGCORBOXVUSONI-UHFFFAOYSA-N 0.000 claims 1
• OCVMVNIUTJHXPJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)-6-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2F)OCC2CCC2)=N1 OCVMVNIUTJHXPJ-UHFFFAOYSA-N 0.000 claims 1
• GTWLSYSCQUQUCD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)phenyl]methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC=C2)OCC2CCC2)=N1 GTWLSYSCQUQUCD-UHFFFAOYSA-N 0.000 claims 1
• DWPVDXPUIDCMOL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OCC2CCC2)=N1 DWPVDXPUIDCMOL-UHFFFAOYSA-N 0.000 claims 1
• FHJIXSNESMVREU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2)OCC2CCC2)=N1 FHJIXSNESMVREU-UHFFFAOYSA-N 0.000 claims 1
• TWRHRAIZBUWCEZ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)pyridin-3-yl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC=2C(=NC=CC=2)OCC2CCC2)=N1 TWRHRAIZBUWCEZ-UHFFFAOYSA-N 0.000 claims 1
• LXJAQLCRLXNNEH-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)pyridin-3-yl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC=2C(=NC=CC=2)OCC2CCC2)=N1 LXJAQLCRLXNNEH-UHFFFAOYSA-N 0.000 claims 1
• GRQVHYNEOVZYOZ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)pyridin-3-yl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC=2C(=NC=CC=2)OCC2CCC2)=N1 GRQVHYNEOVZYOZ-UHFFFAOYSA-N 0.000 claims 1
• XDKFWVYKZUPQFM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)pyridin-3-yl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC=2C(=NC=CC=2)OCC2CCC2)=N1 XDKFWVYKZUPQFM-UHFFFAOYSA-N 0.000 claims 1
• LMYRYXIJHKNHKB-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclobutylmethoxy)pyridin-3-yl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC=2C(=NC=CC=2)OCC2CCC2)=N1 LMYRYXIJHKNHKB-UHFFFAOYSA-N 0.000 claims 1
• UVTKNDUIUXFDEC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclohexylmethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2)OCC2CCCCC2)=N1 UVTKNDUIUXFDEC-UHFFFAOYSA-N 0.000 claims 1
• FBDVLDAHMWHMAO-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-3,5-difluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CCCC2)=N1 FBDVLDAHMWHMAO-UHFFFAOYSA-N 0.000 claims 1
• OHVDCKUMMUPYIE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-3,5-difluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CCCC2)=N1 OHVDCKUMMUPYIE-UHFFFAOYSA-N 0.000 claims 1
• CBITUJNEDATPAH-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-3,5-difluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CCCC2)=N1 CBITUJNEDATPAH-UHFFFAOYSA-N 0.000 claims 1
• CPNLSQKKSPXLDU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-3,5-difluorophenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CCCC2)=N1 CPNLSQKKSPXLDU-UHFFFAOYSA-N 0.000 claims 1
• HXWWQHKWDMFEQU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-3,5-difluorophenyl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CCCC2)=N1 HXWWQHKWDMFEQU-UHFFFAOYSA-N 0.000 claims 1
• ZQFNUKATMUYQCO-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-4,6-difluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C=C(C=C2F)F)OCC2CCCC2)=N1 ZQFNUKATMUYQCO-UHFFFAOYSA-N 0.000 claims 1
• NGTNNVLKBPFCKN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-4,6-difluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=C(C=C2F)F)OCC2CCCC2)=N1 NGTNNVLKBPFCKN-UHFFFAOYSA-N 0.000 claims 1
• RDCAEKQSSBDOKV-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-4,6-difluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=C(C=C2F)F)OCC2CCCC2)=N1 RDCAEKQSSBDOKV-UHFFFAOYSA-N 0.000 claims 1
• CNEDQTMTOJINAW-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-4,6-difluorophenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=C(C=C2F)F)OCC2CCCC2)=N1 CNEDQTMTOJINAW-UHFFFAOYSA-N 0.000 claims 1
• KQYRVQGGNCGBME-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-4,6-difluorophenyl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC2=C(C=C(C=C2F)F)OCC2CCCC2)=N1 KQYRVQGGNCGBME-UHFFFAOYSA-N 0.000 claims 1
• RUETYUMINIEOPR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-4-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=C(C=C2)F)OCC2CCCC2)=N1 RUETYUMINIEOPR-UHFFFAOYSA-N 0.000 claims 1
• HZJWOWQTTQBXLK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-5-fluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C=CC(=C2)F)OCC2CCCC2)=N1 HZJWOWQTTQBXLK-UHFFFAOYSA-N 0.000 claims 1
• QAPMDWPFWLCDQK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-5-fluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC(=C2)F)OCC2CCCC2)=N1 QAPMDWPFWLCDQK-UHFFFAOYSA-N 0.000 claims 1
• ZDMHOXACTPMSCL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-5-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC(=C2)F)OCC2CCCC2)=N1 ZDMHOXACTPMSCL-UHFFFAOYSA-N 0.000 claims 1
• FQPSCPVVEZWAEE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-5-fluorophenyl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC2=C(C=CC(=C2)F)OCC2CCCC2)=N1 FQPSCPVVEZWAEE-UHFFFAOYSA-N 0.000 claims 1
• ORIHYWWCELLXMP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-6-fluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2F)OCC2CCCC2)=N1 ORIHYWWCELLXMP-UHFFFAOYSA-N 0.000 claims 1
• JWRGEJCXOKMOHE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)-6-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2F)OCC2CCCC2)=N1 JWRGEJCXOKMOHE-UHFFFAOYSA-N 0.000 claims 1
• GMVJZCKPZPYVBL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C=CC=C2)OCC2CCCC2)=N1 GMVJZCKPZPYVBL-UHFFFAOYSA-N 0.000 claims 1
• VIEMBQKRFCMBQX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2)OCC2CCCC2)=N1 VIEMBQKRFCMBQX-UHFFFAOYSA-N 0.000 claims 1
• ZWDLVORWWHHOLB-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2)OCC2CCCC2)=N1 ZWDLVORWWHHOLB-UHFFFAOYSA-N 0.000 claims 1
• NEPCGTOOWNBYFX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)phenyl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC2=C(C=CC=C2)OCC2CCCC2)=N1 NEPCGTOOWNBYFX-UHFFFAOYSA-N 0.000 claims 1
• ONUNGHZYWZJJAS-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)pyridin-3-yl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC=2C(=NC=CC=2)OCC2CCCC2)=N1 ONUNGHZYWZJJAS-UHFFFAOYSA-N 0.000 claims 1
• PORZBVNZFYOHJT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)pyridin-3-yl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC=2C(=NC=CC=2)OCC2CCCC2)=N1 PORZBVNZFYOHJT-UHFFFAOYSA-N 0.000 claims 1
• RLLMLSFEHUOAIT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)pyridin-3-yl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC=2C(=NC=CC=2)OCC2CCCC2)=N1 RLLMLSFEHUOAIT-UHFFFAOYSA-N 0.000 claims 1
• QQMCPBFSSIDGSG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopentylmethoxy)pyridin-3-yl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC=2C(=NC=CC=2)OCC2CCCC2)=N1 QQMCPBFSSIDGSG-UHFFFAOYSA-N 0.000 claims 1
• GAURRJFMLZVXNT-WORMITQPSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-3,5-difluorophenyl]-deuteriomethyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NC([2H])C2=C(C(=CC(=C2)F)F)OCC2CC2)=N1 GAURRJFMLZVXNT-WORMITQPSA-N 0.000 claims 1
• XQRWNHMCBPFFFD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CC2)=N1 XQRWNHMCBPFFFD-UHFFFAOYSA-N 0.000 claims 1
• SYCBDGJRUJQOLN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CC2)=N1 SYCBDGJRUJQOLN-UHFFFAOYSA-N 0.000 claims 1
• WWEODBXGLDIPCB-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CC2)=N1 WWEODBXGLDIPCB-UHFFFAOYSA-N 0.000 claims 1
• GAURRJFMLZVXNT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CC2)=N1 GAURRJFMLZVXNT-UHFFFAOYSA-N 0.000 claims 1
• ZIVJKRFMWGVMTR-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC2=C(C(=CC(=C2)F)F)OCC2CC2)=N1 ZIVJKRFMWGVMTR-UHFFFAOYSA-N 0.000 claims 1
• VASSBSWPHOVHEC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-4-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=C(C=C2)F)OCC2CC2)=N1 VASSBSWPHOVHEC-UHFFFAOYSA-N 0.000 claims 1
• FFWVYOPRGXVDBQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-6-fluorophenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2F)OCC2CC2)=N1 FFWVYOPRGXVDBQ-UHFFFAOYSA-N 0.000 claims 1
• AEVHAEYUQRPBLV-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-6-fluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC=C2F)OCC2CC2)=N1 AEVHAEYUQRPBLV-UHFFFAOYSA-N 0.000 claims 1
• VNJXBLYWTZMTDI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)-6-fluorophenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2F)OCC2CC2)=N1 VNJXBLYWTZMTDI-UHFFFAOYSA-N 0.000 claims 1
• HANRYQQBYHIBEY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C=CC=C2)OCC2CC2)=N1 HANRYQQBYHIBEY-UHFFFAOYSA-N 0.000 claims 1
• BWMIYWHJLBGCQC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)phenyl]methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC=C2)OCC2CC2)=N1 BWMIYWHJLBGCQC-UHFFFAOYSA-N 0.000 claims 1
• CGDLAECEGSRRRC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC=C2)OCC2CC2)=N1 CGDLAECEGSRRRC-UHFFFAOYSA-N 0.000 claims 1
• GKQPEVLQDXWCGP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(cyclopropylmethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC=C2)OCC2CC2)=N1 GKQPEVLQDXWCGP-UHFFFAOYSA-N 0.000 claims 1
• JETKXXXCJJHYND-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-(difluoromethoxy)phenyl]methyl]-2-ethoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OCC)C(=O)NCC2=C(C=CC=C2)OC(F)F)=N1 JETKXXXCJJHYND-UHFFFAOYSA-N 0.000 claims 1
• XQRWNHMCBPFFFD-XUWBISKJSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-[cyclopropyl(dideuterio)methoxy]-3,5-difluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC([2H])([2H])C3CC3)C=2)C)C)=N1 XQRWNHMCBPFFFD-XUWBISKJSA-N 0.000 claims 1
• OIJNDMDILVSJJL-VTNORMIGSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-[cyclopropyl(dideuterio)methoxy]-3,5-difluorophenyl]methyl]-6-methyl-2-(trideuteriomethoxy)pyridine-3-carboxamide Chemical compound [2H]C([2H])([2H])Oc1nc(C)c(cc1C(=O)NCc1cc(F)cc(F)c1OC([2H])([2H])C1CC1)-c1ccn2nc(N)nc2c1 OIJNDMDILVSJJL-VTNORMIGSA-N 0.000 claims 1
• SOPAERBFNJVLTK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)Cl)=N1 SOPAERBFNJVLTK-UHFFFAOYSA-N 0.000 claims 1
• AHHQOQSADBNMAZ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)Cl)=N1 AHHQOQSADBNMAZ-UHFFFAOYSA-N 0.000 claims 1
• UPWPGDIMVGXUSC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 UPWPGDIMVGXUSC-UHFFFAOYSA-N 0.000 claims 1
• LNIJDPPSFWHQCM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 LNIJDPPSFWHQCM-UHFFFAOYSA-N 0.000 claims 1
• FSUZQJVSGBZQQB-FIBGUPNXSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-methoxy-N-(trideuteriomethyl)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)N(C([2H])([2H])[2H])CC3=C(C=CC(=C3)OC(F)(F)F)F)C=2)OC)=N1 FSUZQJVSGBZQQB-FIBGUPNXSA-N 0.000 claims 1
• HFQKGWQIGVBMNM-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 HFQKGWQIGVBMNM-UHFFFAOYSA-N 0.000 claims 1
• XCYLBCUYTNJHRZ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 XCYLBCUYTNJHRZ-UHFFFAOYSA-N 0.000 claims 1
• XNRDDWLEKPMYDP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C=NC=2C)C(=O)NCC2=C(C=CC(=C2)OC(F)(F)F)F)=N1 XNRDDWLEKPMYDP-UHFFFAOYSA-N 0.000 claims 1
• UANKDRSWTOLJDI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)F)=N1 UANKDRSWTOLJDI-UHFFFAOYSA-N 0.000 claims 1
• VFBRSOPRSZKVJI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)F)=N1 VFBRSOPRSZKVJI-UHFFFAOYSA-N 0.000 claims 1
• VNCRYKVYTCTHHQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)F)=N1 VNCRYKVYTCTHHQ-UHFFFAOYSA-N 0.000 claims 1
• OZRHVEVBQAKKEN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=C(C=CC(=C2)C(F)(F)F)F)=N1 OZRHVEVBQAKKEN-UHFFFAOYSA-N 0.000 claims 1
• ZDZUWRQUYCODSE-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC=C3OCC(F)(F)F)F)C=2)C)C)=N1 ZDZUWRQUYCODSE-UHFFFAOYSA-N 0.000 claims 1
• SGOLKUHFQRXPGV-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC=C3OCC(F)(F)F)F)C=2)OC)C)=N1 SGOLKUHFQRXPGV-UHFFFAOYSA-N 0.000 claims 1
• UFOMZQAOMVJVDQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC=C3OCC(F)(F)F)F)C=2)C)=N1 UFOMZQAOMVJVDQ-UHFFFAOYSA-N 0.000 claims 1
• YTLSDLUDKQHQCO-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methyloxan-4-yl)oxyphenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OCC3)C)C=2)C)C)=N1 YTLSDLUDKQHQCO-UHFFFAOYSA-N 0.000 claims 1
• FJOODPAYANULCW-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methyloxan-4-yl)oxyphenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OCC3)C)C=2)OC)C)=N1 FJOODPAYANULCW-UHFFFAOYSA-N 0.000 claims 1
• HNBWTTLAWUXGCK-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methyloxan-4-yl)oxyphenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OCC3)C)C=2)OC)=N1 HNBWTTLAWUXGCK-UHFFFAOYSA-N 0.000 claims 1
• ZRHHKYVITMMFLF-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methyloxan-4-yl)oxyphenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3CC(OCC3)C)C=2)C)=N1 ZRHHKYVITMMFLF-UHFFFAOYSA-N 0.000 claims 1
• RMDHIQCSBGPSBT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methylpropoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OCC(C)C)C=2)OC)C)=N1 RMDHIQCSBGPSBT-UHFFFAOYSA-N 0.000 claims 1
• QPAJNXKHYNBAJT-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methylpropoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound O(C)C1=NC=C(C2=CC3=NC(N)=NN3C=C2)C=C1C(=O)NCC1=CC(=CC(=C1OCC(C)C)F)F QPAJNXKHYNBAJT-UHFFFAOYSA-N 0.000 claims 1
• BALHVCBJIJZNCA-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(2-methylpropoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OCC(C)C)C=2)C)=N1 BALHVCBJIJZNCA-UHFFFAOYSA-N 0.000 claims 1
• SALNBPAPPBKAFD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3COCCC3)C=2)OC)C)=N1 SALNBPAPPBKAFD-UHFFFAOYSA-N 0.000 claims 1
• HIIJQBPXUFFNOG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3COCCC3)C=2)OC)=N1 HIIJQBPXUFFNOG-UHFFFAOYSA-N 0.000 claims 1
• NPSPPMIEJSGNKU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3COCCC3)C=2)C)=N1 NPSPPMIEJSGNKU-UHFFFAOYSA-N 0.000 claims 1
• QSGWWQWMDFNJBF-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(oxetan-3-yloxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3COC3)C=2)OC)=N1 QSGWWQWMDFNJBF-UHFFFAOYSA-N 0.000 claims 1
• ANNOCDZKGCASAX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-(oxolan-3-yloxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)OC3COCC3)C=2)C)=N1 ANNOCDZKGCASAX-UHFFFAOYSA-N 0.000 claims 1
• HCDPCXRQIWINJG-GOSISDBHSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)O[C@H]3CN(CC3)C)C=2)OC)C)=N1 HCDPCXRQIWINJG-GOSISDBHSA-N 0.000 claims 1
• XQMTYQGAYKMCNK-QGZVFWFLSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-[(3R)-oxolan-3-yl]oxyphenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)O[C@H]3COCC3)C=2)OC)C)=N1 XQMTYQGAYKMCNK-QGZVFWFLSA-N 0.000 claims 1
• LLCAFFLVACGLJE-QGZVFWFLSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-[(3R)-oxolan-3-yl]oxyphenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)O[C@H]3COCC3)C=2)OC)=N1 LLCAFFLVACGLJE-QGZVFWFLSA-N 0.000 claims 1
• ZUJIOUSECXNDRI-SFHVURJKSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-[(3S)-oxolan-3-yl]oxyphenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)O[C@@H]3COCC3)C=2)C)C)=N1 ZUJIOUSECXNDRI-SFHVURJKSA-N 0.000 claims 1
• XQMTYQGAYKMCNK-KRWDZBQOSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-[(3S)-oxolan-3-yl]oxyphenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)O[C@@H]3COCC3)C=2)OC)C)=N1 XQMTYQGAYKMCNK-KRWDZBQOSA-N 0.000 claims 1
• LLCAFFLVACGLJE-KRWDZBQOSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3,5-difluoro-2-[(3S)-oxolan-3-yl]oxyphenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC(=C3)F)F)O[C@@H]3COCC3)C=2)OC)=N1 LLCAFFLVACGLJE-KRWDZBQOSA-N 0.000 claims 1
• RZFLCELXPRBDLB-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclobutylmethoxy)pyridin-2-yl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=NC=CC=C2OCC2CCC2)=N1 RZFLCELXPRBDLB-UHFFFAOYSA-N 0.000 claims 1
• UJDQMHMNKJMMGX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopentylmethoxy)pyridin-2-yl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=NC=CC=C2OCC2CCCC2)=N1 UJDQMHMNKJMMGX-UHFFFAOYSA-N 0.000 claims 1
• PKHYOAJFTYCSSU-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopentylmethoxy)pyridin-2-yl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=NC=CC=C2OCC2CCCC2)=N1 PKHYOAJFTYCSSU-UHFFFAOYSA-N 0.000 claims 1
• MTMBEWJANSETMG-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopentylmethoxy)pyridin-2-yl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=NC=CC=C2OCC2CCCC2)=N1 MTMBEWJANSETMG-UHFFFAOYSA-N 0.000 claims 1
• IPFCMIGTVPEKQD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopropylmethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NCC2=CC(=CC=C2)OCC2CC2)=N1 IPFCMIGTVPEKQD-UHFFFAOYSA-N 0.000 claims 1
• URLJLSLMSZUZMH-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopropylmethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=CC(=CC=C2)OCC2CC2)=N1 URLJLSLMSZUZMH-UHFFFAOYSA-N 0.000 claims 1
• IQGPZYJRWVCZLJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopropylmethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=CC(=CC=C2)OCC2CC2)=N1 IQGPZYJRWVCZLJ-UHFFFAOYSA-N 0.000 claims 1
• NBVLPDWQIQGWLO-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopropylmethoxy)pyridin-2-yl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)OC)C(=O)NCC2=NC=CC=C2OCC2CC2)=N1 NBVLPDWQIQGWLO-UHFFFAOYSA-N 0.000 claims 1
• OVZMUMRGNXYFGL-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(cyclopropylmethoxy)pyridin-2-yl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NCC2=NC=CC=C2OCC2CC2)=N1 OVZMUMRGNXYFGL-UHFFFAOYSA-N 0.000 claims 1
• GUGBFQIDARZOTN-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-(difluoromethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=CC(=CC=C2)OC(F)F)=N1 GUGBFQIDARZOTN-UHFFFAOYSA-N 0.000 claims 1
• CGBIZRAWNVFMFX-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC(=C3)C(F)(F)F)Cl)F)C=2)OC)C)=N1 CGBIZRAWNVFMFX-UHFFFAOYSA-N 0.000 claims 1
• MSYPKVRRNSYZFJ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-fluoro-2-(morpholin-4-ylmethyl)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C(=CC=C3)F)CN3CCOCC3)C=2)OC)C)=N1 MSYPKVRRNSYZFJ-UHFFFAOYSA-N 0.000 claims 1
• BXUVJWZIFWFJRI-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-fluoro-2-(morpholin-4-ylmethyl)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC=C3)F)CN3CCOCC3)C=2)OC)=N1 BXUVJWZIFWFJRI-UHFFFAOYSA-N 0.000 claims 1
• WJAUEAVOFICJPQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-fluoro-2-(pyrrolidin-1-ylmethyl)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound COC1=NC(C)=C(C=C1C(=O)NCC1=C(CN2CCCC2)C(F)=CC=C1)C1=CC2=NC(N)=NN2C=C1 WJAUEAVOFICJPQ-UHFFFAOYSA-N 0.000 claims 1
• MNELBTPJIDGWEY-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NCC2=CC(=CC(=C2)C(F)(F)F)F)=N1 MNELBTPJIDGWEY-UHFFFAOYSA-N 0.000 claims 1
• UOMROTZCBHNSGQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC(=C3)OCC3CC3)F)C=2)C)C)=N1 UOMROTZCBHNSGQ-UHFFFAOYSA-N 0.000 claims 1
• ZRVHBPJNAWMUTD-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC(=C3)F)OCC(F)(F)F)C=2)C)C)=N1 ZRVHBPJNAWMUTD-UHFFFAOYSA-N 0.000 claims 1
• BMZYQEMWLCRGQH-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC(=C3)F)OCC(F)(F)F)C=2)OC)=N1 BMZYQEMWLCRGQH-UHFFFAOYSA-N 0.000 claims 1
• DFLHDAROJAZXLC-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C=CC(=C3)F)OCC(F)(F)F)C=2)C)=N1 DFLHDAROJAZXLC-UHFFFAOYSA-N 0.000 claims 1
• AXEKYQZLAVAOOS-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[5-fluoro-2-(trifluoromethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NCC3=C(C=CC(=C3)F)OC(F)(F)F)C=2)OC)C)=N1 AXEKYQZLAVAOOS-UHFFFAOYSA-N 0.000 claims 1
• KRLUKYSNQUNABP-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[6-(cyclopropylmethoxy)-2,3-difluorophenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC=C3OCC3CC3)F)F)C=2)OC)=N1 KRLUKYSNQUNABP-UHFFFAOYSA-N 0.000 claims 1
• TUSWDVJENCFZJQ-UHFFFAOYSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[[6-(cyclopropylmethoxy)-2,3-difluorophenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NCC3=C(C(=CC=C3OCC3CC3)F)F)C=2)C)=N1 TUSWDVJENCFZJQ-UHFFFAOYSA-N 0.000 claims 1
• UPWPGDIMVGXUSC-MMIHMFRQSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[deuterio-[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2,6-dimethylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)C)C(=O)NC([2H])C2=C(C=CC(=C2)OC(F)(F)F)F)=N1 UPWPGDIMVGXUSC-MMIHMFRQSA-N 0.000 claims 1
• LNIJDPPSFWHQCM-MMIHMFRQSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[deuterio-[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2C)OC)C(=O)NC([2H])C2=C(C=CC(=C2)OC(F)(F)F)F)=N1 LNIJDPPSFWHQCM-MMIHMFRQSA-N 0.000 claims 1
• XCYLBCUYTNJHRZ-MMIHMFRQSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[deuterio-[2-fluoro-5-(trifluoromethoxy)phenyl]methyl]-2-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=C(C(=NC=2)C)C(=O)NC([2H])C2=C(C=CC(=C2)OC(F)(F)F)F)=N1 XCYLBCUYTNJHRZ-MMIHMFRQSA-N 0.000 claims 1
• VNCRYKVYTCTHHQ-NJFDCKJNSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[dideuterio-[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-(trideuteriomethoxy)pyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NC([2H])([2H])C3=C(C=CC(=C3)C(F)(F)F)F)C=2)OC([2H])([2H])[2H])=N1 VNCRYKVYTCTHHQ-NJFDCKJNSA-N 0.000 claims 1
• VFBRSOPRSZKVJI-KBMKNGFXSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[dideuterio-[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-6-methylpyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C(=NC(=C(C(=O)NC([2H])([2H])C3=C(C=CC(=C3)C(F)(F)F)F)C=2)OC)C)=N1 VFBRSOPRSZKVJI-KBMKNGFXSA-N 0.000 claims 1
• VNCRYKVYTCTHHQ-KBMKNGFXSA-N 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[dideuterio-[2-fluoro-5-(trifluoromethyl)phenyl]methyl]-2-methoxypyridine-3-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C=2C=NC(=C(C(=O)NC([2H])([2H])C3=C(C=CC(=C3)C(F)(F)F)F)C=2)OC)=N1 VNCRYKVYTCTHHQ-KBMKNGFXSA-N 0.000 claims 1
• YWHLQRBHQNPUNT-UHFFFAOYSA-N 6-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-methoxy-N-(3-phenylbutyl)pyrazine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CN=C(C(=N2)C(=O)NCCC(C)C2=CC=CC=C2)OC)=N1 YWHLQRBHQNPUNT-UHFFFAOYSA-N 0.000 claims 1
• IDGPQAAVVVRENK-UHFFFAOYSA-N 6-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-methoxy-N-(3-phenylbutyl)pyridazine-4-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CC(=C(N=N2)OC)C(=O)NCCC(C)C2=CC=CC=C2)=N1 IDGPQAAVVVRENK-UHFFFAOYSA-N 0.000 claims 1
• VBEVQWLFSITJHZ-WQRHAFOGSA-N 6-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-methoxy-N-[(1R)-2,2,2-trideuterio-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyrazine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CN=C(C(=N2)C(=O)N[C@H](C([2H])([2H])[2H])C2=C(C=CC(=C2)OC(F)(F)F)F)OC)=N1 VBEVQWLFSITJHZ-WQRHAFOGSA-N 0.000 claims 1
• HFIYDMRBOZOWEA-UHFFFAOYSA-N 6-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-3-methyl-N-(3-phenylbutyl)pyridine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CC=C(C(=N2)C(=O)NCCC(C)C2=CC=CC=C2)C)=N1 HFIYDMRBOZOWEA-UHFFFAOYSA-N 0.000 claims 1
• LYIBAQNEVDDFDX-LLVKDONJSA-N 6-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-3-methoxypyridine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CC=C(C(=N2)C(=O)N[C@H](C)C2=C(C=CC(=C2)OC(F)(F)F)F)OC)=N1 LYIBAQNEVDDFDX-LLVKDONJSA-N 0.000 claims 1
• XFFGJUOYBNZPBY-GFCCVEGCSA-N 6-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-3-methylpyridine-2-carboxamide Chemical compound NC1=NN2C(C=C(C=C2)C2=CC=C(C(=N2)C(=O)N[C@H](C)C2=C(C=CC(=C2)OC(F)(F)F)F)C)=N1 XFFGJUOYBNZPBY-GFCCVEGCSA-N 0.000 claims 1
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