AR123793A1 - Compuestos de triazolopiridinilo como inhibidores de quinasas - Google Patents
Compuestos de triazolopiridinilo como inhibidores de quinasasInfo
- Publication number
- AR123793A1 AR123793A1 ARP210102843A ARP210102843A AR123793A1 AR 123793 A1 AR123793 A1 AR 123793A1 AR P210102843 A ARP210102843 A AR P210102843A AR P210102843 A ARP210102843 A AR P210102843A AR 123793 A1 AR123793 A1 AR 123793A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- haloalkyl
- deuteroc1
- deuteroalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 8
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 4
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 3
- 229910052805 deuterium Inorganic materials 0.000 abstract 3
- 125000005345 deuteroalkyl group Chemical group 0.000 abstract 3
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000003566 oxetanyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 abstract 1
- -1 OCD3 Chemical group 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos que tienen la fórmula (1) y enantiómeros y diastereómeros, estereoisómeros, sales farmacéuticamente aceptables de los mismos, son útiles como moduladores de quinasas, incluida la modulación RIPK1. Todas las variables son como se definen en el presente documento. Reivindicación 1: Un compuesto que tiene la fórmula (1), o una sal del mismo, en donde R¹ es H, alquilo C₁₋₃, alcoxilo C₁₋₃, haloalquilo C₁₋₃, haloalcoxilo C₁₋₃, deuteroalquilo C₁₋₃, deuteroalcoxilo C₁₋₃, halógeno, o ciclopropilo; R² es H, o halo; R³ es H, halo, o alquilo C₁₋₃ o deuteroalquilo C₁₋₃; R⁴ es H o F; R⁵ᵃ y R⁵ᵇ son cada uno independientemente H, deuterio, alquilo C₁₋₃ o haloalquilo C₁₋₃; alternativamente, R⁵ᵃ y R⁵ᵇ se unen para formar ciclopropilo; R⁶ᵃ y R⁶ᵇ son cada uno independientemente H, deuterio, OH, F, alquilo C₁₋₃, o C(O)-4-fluorofenilo; alternativamente, R⁶ᵃ y R⁶ᵇ son =O, o se unen para formar ciclopropilo o oxetanilo; R⁷ᵃ y R⁷ᵇ son cada uno independientemente H, deuterio, OH, OP(O)(OR)₂, OC(O)NH₂, NH₂, F, alquilo C₁₋₃, alcoxi C₁₋₃, OCD₃, o haloalquilo C₁₋₃; alternativamente, R⁷ᵃ y R⁷ᵇ son =O, o se unen para formar ciclopropilo o oxetanilo; R es H o alquilo C₁₋₃; R⁸ es H, F, Cl, alquilo C₁₋₃, alcoxi C₁₋₃, deuteroalquilo C₁₋₃, o deuteroalcoxi C₁₋₃; R⁹ es H o CH₃; el anillo Z es fenilo, un anillo heteroarilo de 6 miembros que tiene 1 - 2 átomos de nitrógeno, ciclohexilo, ciclopentilo, o ciclobutilo; Y es F, Cl, alquilo C₁₋₃, alcoxi C₁₋₃, CN, haloalquilo C₁₋₃, haloalcoxi C₁₋₃, deuteroalquilo C₁₋₃, deuteroalcoxi C₁₋₃, C(O)OCH₃, o C&
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063093463P | 2020-10-19 | 2020-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123793A1 true AR123793A1 (es) | 2023-01-11 |
Family
ID=78536657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102843A AR123793A1 (es) | 2020-10-19 | 2021-10-14 | Compuestos de triazolopiridinilo como inhibidores de quinasas |
Country Status (23)
Country | Link |
---|---|
US (2) | US11767322B2 (es) |
EP (2) | EP4229056B1 (es) |
JP (1) | JP2023546166A (es) |
KR (1) | KR20230092960A (es) |
CN (1) | CN116802181A (es) |
AR (1) | AR123793A1 (es) |
AU (1) | AU2021364302A1 (es) |
CA (1) | CA3196059A1 (es) |
CL (1) | CL2023001123A1 (es) |
CO (1) | CO2023004926A2 (es) |
DK (1) | DK4229056T3 (es) |
FI (1) | FI4229056T3 (es) |
HR (1) | HRP20240739T1 (es) |
IL (1) | IL302113A (es) |
LT (1) | LT4229056T (es) |
MX (1) | MX2023004492A (es) |
PE (1) | PE20240219A1 (es) |
PL (1) | PL4229056T3 (es) |
PT (1) | PT4229056T (es) |
RS (1) | RS65620B1 (es) |
SI (1) | SI4229056T1 (es) |
TW (1) | TW202233614A (es) |
WO (1) | WO2022086828A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3580220T (lt) * | 2017-02-13 | 2021-12-27 | Bristol-Myers Squibb Company | Aminotriazolopiridinai, kaip kinazės inhibitoriai |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005077948A1 (ja) | 2004-02-16 | 2005-08-25 | Daiichi Pharmaceutical Co., Ltd. | 抗真菌作用複素環化合物 |
MXPA06014637A (es) | 2004-06-25 | 2007-02-12 | Amgen Inc | Triazoles e indazoles condensados utiles en el tratamiento de enfermedades mediadas por citocinas y otras enfermedades. |
ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
EP2277881A4 (en) | 2008-04-18 | 2011-09-07 | Shionogi & Co | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K |
WO2010007099A1 (en) | 2008-07-15 | 2010-01-21 | Cellzome Limited | 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors |
WO2010007100A1 (en) | 2008-07-15 | 2010-01-21 | Cellzome Ltd | 7-substituted amino triazoles as pi3k inhibitors |
WO2010057877A1 (en) | 2008-11-18 | 2010-05-27 | Cellzome Limited | 7-pyridinyl- or phenyl- substituted triazolo [1, 5 -a] pyridines as pi3k inhibitors |
CA2750517A1 (en) | 2009-02-04 | 2010-08-12 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2897949B1 (en) | 2012-09-18 | 2018-01-10 | Bristol-Myers Squibb Company | Iap antagonists |
EA201501175A1 (ru) | 2013-06-10 | 2016-10-31 | Байер Фарма Акциенгезельшафт | Новые соединения для лечения злокачественного новообразования |
BR112017003546A2 (pt) | 2014-08-21 | 2017-12-05 | Glaxosmithkline Ip Dev Ltd | amidas heterocíclicas como inibidores de rip1 quinase como medicamentos |
US10214537B2 (en) | 2014-10-22 | 2019-02-26 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds |
ES2749679T3 (es) | 2014-10-22 | 2020-03-23 | Bristol Myers Squibb Co | Compuestos de pirrolotriazina amina sustituidos como inhibidores de PI3k |
EP3372604B1 (en) | 2015-11-05 | 2021-12-01 | Sumitomo Chemical Company, Limited | Condensed heterocyclic compound |
WO2018017435A1 (en) | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof |
US11161843B2 (en) | 2017-01-24 | 2021-11-02 | Sumitomo Chemical Company, Limited | Fused heterocyclic compound and composition containing same |
LT3580220T (lt) | 2017-02-13 | 2021-12-27 | Bristol-Myers Squibb Company | Aminotriazolopiridinai, kaip kinazės inhibitoriai |
WO2018237370A1 (en) | 2017-06-23 | 2018-12-27 | Accro Bioscience Inc. | HETEROARYL COMPOUNDS AS INHIBITORS OF THE NECROSIS, COMPOSITION AND METHOD OF USE THEREOF |
ES2905948T3 (es) * | 2017-10-30 | 2022-04-12 | Bristol Myers Squibb Co | Aminoimidazopiridazinas como inhibidores de cinasa |
US11618753B2 (en) | 2018-01-26 | 2023-04-04 | Bristol-Myers Squibb Company | Aminopyrrolotriazines as kinase inhibitors |
KR20210060517A (ko) | 2018-09-13 | 2021-05-26 | 브리스톨-마이어스 스큅 컴퍼니 | 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드 |
AU2019339355A1 (en) | 2018-09-13 | 2021-05-13 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES USED AS JANUS KINASE 2 INHIBITORS AND ASSOCIATED USES |
WO2020192562A1 (zh) | 2019-03-22 | 2020-10-01 | 劲方医药科技(上海)有限公司 | 取代的杂环酰胺类化合物,其制法与医药上的用途 |
US20220380355A1 (en) | 2019-10-03 | 2022-12-01 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
CN114230565B (zh) | 2020-09-09 | 2023-10-27 | 成都奥睿药业有限公司 | 5-取代吲哚3-酰胺衍生物及其制备方法和用途 |
-
2021
- 2021-10-14 AR ARP210102843A patent/AR123793A1/es unknown
- 2021-10-18 US US17/503,516 patent/US11767322B2/en active Active
- 2021-10-18 EP EP21805787.5A patent/EP4229056B1/en active Active
- 2021-10-18 KR KR1020237016535A patent/KR20230092960A/ko unknown
- 2021-10-18 SI SI202130138T patent/SI4229056T1/sl unknown
- 2021-10-18 JP JP2023523570A patent/JP2023546166A/ja active Pending
- 2021-10-18 CA CA3196059A patent/CA3196059A1/en active Pending
- 2021-10-18 EP EP24159615.4A patent/EP4364737A3/en active Pending
- 2021-10-18 CN CN202180070933.6A patent/CN116802181A/zh active Pending
- 2021-10-18 HR HRP20240739TT patent/HRP20240739T1/hr unknown
- 2021-10-18 DK DK21805787.5T patent/DK4229056T3/da active
- 2021-10-18 IL IL302113A patent/IL302113A/en unknown
- 2021-10-18 PE PE2023001446A patent/PE20240219A1/es unknown
- 2021-10-18 MX MX2023004492A patent/MX2023004492A/es unknown
- 2021-10-18 AU AU2021364302A patent/AU2021364302A1/en active Pending
- 2021-10-18 PL PL21805787.5T patent/PL4229056T3/pl unknown
- 2021-10-18 LT LTEPPCT/US2021/055340T patent/LT4229056T/lt unknown
- 2021-10-18 RS RS20240656A patent/RS65620B1/sr unknown
- 2021-10-18 TW TW110138596A patent/TW202233614A/zh unknown
- 2021-10-18 PT PT218057875T patent/PT4229056T/pt unknown
- 2021-10-18 WO PCT/US2021/055340 patent/WO2022086828A1/en active Application Filing
- 2021-10-18 FI FIEP21805787.5T patent/FI4229056T3/fi active
-
2023
- 2023-04-18 CL CL2023001123A patent/CL2023001123A1/es unknown
- 2023-04-19 CO CONC2023/0004926A patent/CO2023004926A2/es unknown
- 2023-07-06 US US18/347,703 patent/US20240109888A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CL2023001123A1 (es) | 2023-09-22 |
IL302113A (en) | 2023-06-01 |
RS65620B1 (sr) | 2024-07-31 |
PL4229056T3 (pl) | 2024-06-10 |
EP4364737A3 (en) | 2024-08-07 |
PE20240219A1 (es) | 2024-02-16 |
AU2021364302A1 (en) | 2023-06-22 |
PT4229056T (pt) | 2024-05-21 |
DK4229056T3 (da) | 2024-07-15 |
US11767322B2 (en) | 2023-09-26 |
EP4229056A1 (en) | 2023-08-23 |
HRP20240739T1 (hr) | 2024-08-30 |
CN116802181A (zh) | 2023-09-22 |
US20220119388A1 (en) | 2022-04-21 |
MX2023004492A (es) | 2023-05-10 |
LT4229056T (lt) | 2024-06-10 |
JP2023546166A (ja) | 2023-11-01 |
EP4364737A2 (en) | 2024-05-08 |
US20240109888A1 (en) | 2024-04-04 |
CO2023004926A2 (es) | 2023-05-08 |
FI4229056T3 (fi) | 2024-06-18 |
AU2021364302A9 (en) | 2024-05-02 |
SI4229056T1 (sl) | 2024-06-28 |
CA3196059A1 (en) | 2022-04-28 |
TW202233614A (zh) | 2022-09-01 |
KR20230092960A (ko) | 2023-06-26 |
WO2022086828A1 (en) | 2022-04-28 |
EP4229056B1 (en) | 2024-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR119821A1 (es) | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t | |
AR094537A1 (es) | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa | |
AR111419A1 (es) | Compuestos fusionados de indazol piridona como antivirales | |
PE20201202A1 (es) | Inhibidores de cinasa dependientes de ciclina | |
AR054047A1 (es) | Derivados de fenilquinazolina | |
AR094452A1 (es) | COMPUESTOS HETEROCÍCLICOS SUSTITUIDOS CON AMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O INFa | |
AR093403A1 (es) | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA UTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL23 Y/O INFa | |
AR106798A1 (es) | Inhibidores pirazol de acc y usos de los mismos | |
PE20190336A1 (es) | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
ES2589558T3 (es) | Derivados de pirimidin pirazolilo | |
PE20212070A1 (es) | Moduladores de trex1 | |
CO6170361A2 (es) | Composiciones y metodos para modular receptores de c-kit y pdgfr | |
AR095530A1 (es) | Moduladores de p2x7 | |
AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
AR096613A1 (es) | Moduladores de la acetil-coa carboxilasa | |
AR072192A1 (es) | Derivados de tiazolil-piperidina | |
AR093503A1 (es) | Derivados de n-(piridin-2-il)pirimidin-4-amina que contienen un grupo sulfoximina | |
AR123793A1 (es) | Compuestos de triazolopiridinilo como inhibidores de quinasas | |
AR058205A1 (es) | 5-fenil-3,6-dihidro-2-oxo-6h-[1,3,4] tiadiazinas sustituidas | |
EA201692189A1 (ru) | Соединения фосфина золота (i) в качестве антибактериальных агентов | |
AR054877A1 (es) | Derivados de ciclobutano-3-eno-1,2-diona como inhibidores,reguladores y/o moduladores de quinasas | |
AR059886A1 (es) | Derivados de amidas como inhibidores de renina | |
AR103414A1 (es) | Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 | |
AR101964A1 (es) | Compuestos de imidazopiridazina como moduladores de pi3k | |
AR101528A1 (es) | Inhibidores de cdk9 quinasa de pirrolo[2,3-b]piridina |