CY1124978T1 - Αμινοτριαζολοπυριμιδινες ως αναστολεις κινασων - Google Patents
Αμινοτριαζολοπυριμιδινες ως αναστολεις κινασωνInfo
- Publication number
- CY1124978T1 CY1124978T1 CY20221100043T CY221100043T CY1124978T1 CY 1124978 T1 CY1124978 T1 CY 1124978T1 CY 20221100043 T CY20221100043 T CY 20221100043T CY 221100043 T CY221100043 T CY 221100043T CY 1124978 T1 CY1124978 T1 CY 1124978T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aminotriazolopyrimidines
- kinase inhibitors
- diastereomers
- prodrugs
- stereoisomers
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Ενώσεις που έχουν τον χημικό τύπο (Ι) (ΙΧ), και εναντιομερή, και διαστερεομερή, στερεοϊσομερή, φαρμακευτικώς αποδεκτά άλατα και προφάρμακα εξ αυτών, είναι χρήσιμες(-α) ως διαμορφωτές κινασών, που συμπεριλαμβάνουν διαμόρφωση RIPK1. Όλες οι μεταβλητές είναι όπως ορίζονται στο παρόν (Ι), (ΙΙ), (ΙΙΙ), (IV),(V), (VI), (VII), (VIII), (IX).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762458144P | 2017-02-13 | 2017-02-13 | |
| PCT/US2018/017755 WO2018148626A1 (en) | 2017-02-13 | 2018-02-12 | Aminotriazolopyridines as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124978T1 true CY1124978T1 (el) | 2023-01-05 |
Family
ID=61283335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20221100043T CY1124978T1 (el) | 2017-02-13 | 2022-01-18 | Αμινοτριαζολοπυριμιδινες ως αναστολεις κινασων |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10913738B2 (el) |
| EP (1) | EP3580220B1 (el) |
| JP (1) | JP7097373B2 (el) |
| KR (1) | KR102549952B1 (el) |
| CN (1) | CN110520423B (el) |
| AU (1) | AU2018217488B2 (el) |
| BR (1) | BR112019016635A2 (el) |
| CA (1) | CA3053484A1 (el) |
| CY (1) | CY1124978T1 (el) |
| DK (1) | DK3580220T3 (el) |
| EA (1) | EA039808B1 (el) |
| ES (1) | ES2902676T3 (el) |
| HR (1) | HRP20212000T1 (el) |
| HU (1) | HUE057801T2 (el) |
| IL (1) | IL268614B (el) |
| LT (1) | LT3580220T (el) |
| MA (1) | MA47460A (el) |
| MX (1) | MX2019009555A (el) |
| PL (1) | PL3580220T3 (el) |
| PT (1) | PT3580220T (el) |
| RS (1) | RS62801B1 (el) |
| SG (1) | SG11201907335UA (el) |
| SI (1) | SI3580220T1 (el) |
| WO (1) | WO2018148626A1 (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20212000T1 (hr) * | 2017-02-13 | 2022-04-01 | Bristol-Myers Squibb Company | Aminotriazolopiridini kao inhibitori kinaze |
| WO2019089442A1 (en) * | 2017-10-30 | 2019-05-09 | Bristol-Myers Squibb Company | Aminoimidazopyridines as kinase inhibitors |
| WO2019147782A1 (en) | 2018-01-26 | 2019-08-01 | Bristol-Myers Squibb Company | Aminopyrrolotriazines as kinase inhibitors |
| JP2021531256A (ja) * | 2018-07-09 | 2021-11-18 | リーバー インスティチュート インコーポレイテッドLieber Institute, Inc. | ＮａＶ１．８を阻害するピリダジン化合物 |
| ES2945220T3 (es) | 2018-09-13 | 2023-06-29 | Bristol Myers Squibb Co | Indazol carboxamidas como inhibidores de cinasas |
| EP3901147B1 (en) * | 2019-01-25 | 2023-11-22 | Beijing Scitech-MQ Pharmaceuticals Limited | Acylamino bridged heterocyclic compound, and composition and application thereof |
| JP7323637B2 (ja) * | 2019-03-22 | 2023-08-08 | ▲勁▼方医▲薬▼科技（上海）有限公司 | 置換複素環式アミド化合物、その調製方法、及びその医薬的使用 |
| WO2021160109A1 (zh) * | 2020-02-13 | 2021-08-19 | 劲方医药科技(上海)有限公司 | 二氢萘啶酮类化合物，其制法与医药上的用途 |
| CN114262322A (zh) * | 2020-09-16 | 2022-04-01 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| AR123793A1 (es) * | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
| TWI824626B (zh) * | 2021-08-02 | 2023-12-01 | 大陸商勁方醫藥科技(上海)有限公司 | Ripk1抑制劑的晶型及其酸式鹽和其酸式鹽的晶型 |
| AU2022328136A1 (en) | 2021-08-10 | 2023-11-30 | Abbvie Inc. | Nicotinamide ripk1 inhibitors |
| CN118647617A (zh) | 2022-03-16 | 2024-09-13 | 江苏恒瑞医药股份有限公司 | 稠杂环类化合物、其制备方法及其在医药上的应用 |
| CN116574053A (zh) * | 2022-06-21 | 2023-08-11 | 中国药科大学 | Ripk1激酶靶点抑制剂及其医药用途 |
| WO2024146945A1 (en) | 2023-01-07 | 2024-07-11 | Syngenta Crop Protection Ag | Novel carboxamide and sulfonamide pesticidal compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006004702A1 (en) | 2004-06-25 | 2006-01-12 | Amgen Inc. | Condensed triazoles and indazoles useful in treating citokines mediated diseases and other diseases |
| CN101437519A (zh) | 2006-03-31 | 2009-05-20 | 艾博特公司 | 吲唑化合物 |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| WO2009068482A1 (en) | 2007-11-27 | 2009-06-04 | Cellzome Limited | Amino triazoles as pi3k inhibitors |
| WO2010007100A1 (en) | 2008-07-15 | 2010-01-21 | Cellzome Ltd | 7-substituted amino triazoles as pi3k inhibitors |
| WO2010057877A1 (en) | 2008-11-18 | 2010-05-27 | Cellzome Limited | 7-pyridinyl- or phenyl- substituted triazolo [1, 5 -a] pyridines as pi3k inhibitors |
| EP2393813B1 (en) | 2009-02-04 | 2013-07-31 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11 ß-hydroxysteroid dehydrogenase 1 useful for the treatment of diseases related to elevated level of cortisol |
| EP2897949B1 (en) | 2012-09-18 | 2018-01-10 | Bristol-Myers Squibb Company | Iap antagonists |
| BR112015030774A2 (pt) | 2013-06-10 | 2017-07-25 | Bayer Pharma AG | novos compostos para o tratamento de câncer |
| CN106573006A (zh) * | 2014-08-21 | 2017-04-19 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为药物的rip1激酶抑制剂杂环酰胺 |
| WO2017077968A1 (ja) | 2015-11-05 | 2017-05-11 | 住友化学株式会社 | 縮合複素環化合物 |
| WO2018017435A1 (en) | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof |
| WO2018139436A1 (ja) | 2017-01-24 | 2018-08-02 | 住友化学株式会社 | 縮合複素環化合物及びそれを含有する組成物 |
| HRP20212000T1 (hr) * | 2017-02-13 | 2022-04-01 | Bristol-Myers Squibb Company | Aminotriazolopiridini kao inhibitori kinaze |
| WO2019089442A1 (en) | 2017-10-30 | 2019-05-09 | Bristol-Myers Squibb Company | Aminoimidazopyridines as kinase inhibitors |
| WO2019147782A1 (en) | 2018-01-26 | 2019-08-01 | Bristol-Myers Squibb Company | Aminopyrrolotriazines as kinase inhibitors |
| AR123793A1 (es) * | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
-
2018
- 2018-02-12 HR HRP20212000TT patent/HRP20212000T1/hr unknown
- 2018-02-12 LT LTEPPCT/US2018/017755T patent/LT3580220T/lt unknown
- 2018-02-12 PT PT187074984T patent/PT3580220T/pt unknown
- 2018-02-12 ES ES18707498T patent/ES2902676T3/es active Active
- 2018-02-12 RS RS20220021A patent/RS62801B1/sr unknown
- 2018-02-12 WO PCT/US2018/017755 patent/WO2018148626A1/en unknown
- 2018-02-12 DK DK18707498.4T patent/DK3580220T3/da active
- 2018-02-12 MA MA047460A patent/MA47460A/fr unknown
- 2018-02-12 AU AU2018217488A patent/AU2018217488B2/en active Active
- 2018-02-12 EP EP18707498.4A patent/EP3580220B1/en active Active
- 2018-02-12 HU HUE18707498A patent/HUE057801T2/hu unknown
- 2018-02-12 CA CA3053484A patent/CA3053484A1/en active Pending
- 2018-02-12 KR KR1020197026464A patent/KR102549952B1/ko active IP Right Grant
- 2018-02-12 PL PL18707498T patent/PL3580220T3/pl unknown
- 2018-02-12 EA EA201991915A patent/EA039808B1/ru unknown
- 2018-02-12 MX MX2019009555A patent/MX2019009555A/es unknown
- 2018-02-12 US US16/484,604 patent/US10913738B2/en active Active
- 2018-02-12 CN CN201880024064.1A patent/CN110520423B/zh active Active
- 2018-02-12 SI SI201830511T patent/SI3580220T1/sl unknown
- 2018-02-12 BR BR112019016635A patent/BR112019016635A2/pt unknown
- 2018-02-12 JP JP2019543377A patent/JP7097373B2/ja active Active
- 2018-02-12 SG SG11201907335UA patent/SG11201907335UA/en unknown
-
2019
- 2019-08-09 IL IL268614A patent/IL268614B/en unknown
-
2020
- 2020-12-09 US US17/116,016 patent/US20220315580A1/en active Pending
-
2022
- 2022-01-18 CY CY20221100043T patent/CY1124978T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20212000T1 (hr) | 2022-04-01 |
| EA039808B1 (ru) | 2022-03-16 |
| AU2018217488A1 (en) | 2019-10-03 |
| PL3580220T3 (pl) | 2022-02-07 |
| LT3580220T (lt) | 2021-12-27 |
| JP7097373B2 (ja) | 2022-07-07 |
| CN110520423B (zh) | 2022-08-23 |
| WO2018148626A1 (en) | 2018-08-16 |
| KR102549952B1 (ko) | 2023-06-29 |
| RS62801B1 (sr) | 2022-02-28 |
| PT3580220T (pt) | 2022-01-03 |
| DK3580220T3 (da) | 2022-01-10 |
| JP2020507582A (ja) | 2020-03-12 |
| BR112019016635A2 (pt) | 2020-04-07 |
| EP3580220B1 (en) | 2021-11-17 |
| CA3053484A1 (en) | 2018-08-16 |
| MA47460A (fr) | 2019-12-18 |
| EA201991915A1 (ru) | 2019-12-30 |
| IL268614B (en) | 2021-12-01 |
| US20220315580A1 (en) | 2022-10-06 |
| SG11201907335UA (en) | 2019-09-27 |
| CN110520423A (zh) | 2019-11-29 |
| MX2019009555A (es) | 2019-10-02 |
| HUE057801T2 (hu) | 2022-06-28 |
| US20190389859A1 (en) | 2019-12-26 |
| SI3580220T1 (sl) | 2022-01-31 |
| ES2902676T3 (es) | 2022-03-29 |
| IL268614A (en) | 2019-10-31 |
| EP3580220A1 (en) | 2019-12-18 |
| US10913738B2 (en) | 2021-02-09 |
| KR20190117006A (ko) | 2019-10-15 |
| AU2018217488B2 (en) | 2021-09-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124978T1 (el) | Αμινοτριαζολοπυριμιδινες ως αναστολεις κινασων | |
| CY1124984T1 (el) | Αμινοïμιδαζοπυριδινες ως αναστολεις κινασων | |
| CY1122821T1 (el) | Παραγωγα 1,3-βενζοδιοξολιου ως αναστολεις εζη1 ή/και εζη2 | |
| CY1124187T1 (el) | Ετεροκυκλικα αμιδια ως αναστολεις κινασης | |
| EA201892128A1 (ru) | Гетероциклические амиды, полезные в качестве модуляторов | |
| CY1124173T1 (el) | Υποκατεστημενες ενωσεις αμινοπουρινης, συνθεσεις αυτων και μεθοδοι θεραπειας με αυτες | |
| CY1123487T1 (el) | Διαμορφωτες του ρυθμιστη αγωγιμοτητας διαμεμβρανης κυστικης ινωσης | |
| UY36999A (es) | Derivados de aryl oxadiazol fungicidas | |
| CY1122340T1 (el) | Αντιπολλαπλασιαστικες ενωσεις και μεθοδοι χρησης αυτων | |
| UY37062A (es) | Derivados de aryl oxadiazol fungicidas | |
| UY36925A (es) | Derivados de aril oxadiazol fungicidas | |
| UY37623A (es) | Derivados de oxadiazol tiofeno fungicidas | |
| MX2018015563A (es) | Acidos de carbamoiloximetil triazol ciclohexilo como antagonistas de acido lisofosfatidico (lpa). | |
| UY37487A (es) | Amidas heterocíclicas como inhibidores de quinasa | |
| CY1117905T1 (el) | Αναστολεις πρωτεϊνικης κινασης | |
| MX2021002617A (es) | Indazol carboxamidas como inhibidores de cinasas. | |
| EA201100992A1 (ru) | Карбазолкарбоксамидные соединения, применимые в качестве ингибиторов киназы | |
| CL2017002745A1 (es) | Nuevos compuestos y derivados de sulfonimidoilpurinona para el tratamiento y profilaxis de infecciones víricas | |
| CR11229A (es) | Pirimidil ciclopentanos como inhibidores de proteina cinasa akt | |
| MX2022002976A (es) | Inhibidores selectivos de jak1. | |
| MX2021002509A (es) | 1h-indazol carboxamidas como inhibidores de proteina cinasa de interaccion con receptor 1 (ripk1). | |
| CY1125082T1 (el) | Υποκατεστημενα τριαζολια και μεθοδοι που σχετιζονται με αυτα | |
| CY1118371T1 (el) | Αναστολεις του iap | |
| MY198004A (en) | Antitumoral compounds | |
| CO2018004213A2 (es) | Compuesto piranodipiridínico |