HRP20210928T1 - Soli ili ko-kristali 3- (3-dimetilamino-1-etil-2-metil-propil)-fenola - Google Patents

Soli ili ko-kristali 3- (3-dimetilamino-1-etil-2-metil-propil)-fenola Download PDF

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HRP20210928T1
HRP20210928T1 HRP20210928TT HRP20210928T HRP20210928T1 HR P20210928 T1 HRP20210928 T1 HR P20210928T1 HR P20210928T T HRP20210928T T HR P20210928TT HR P20210928 T HRP20210928 T HR P20210928T HR P20210928 T1 HRP20210928 T1 HR P20210928T1
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Croatia
Prior art keywords
pain
salt
crystal
dimethylamino
phenol
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HRP20210928TT
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Michael Gruss
Magda Kraszewski
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Grünenthal GmbH
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Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of HRP20210928T1 publication Critical patent/HRP20210928T1/hr

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Claims (8)

1. Sol ili kokristal od (a) (1R, 2R) -3- (3-dimetilamino-1-etil-2-metil-propil) –fenola, i (b1) L - (+) - vinske kiseline.
2. Sol ili kokristal prema zahtjevu 1, naznačeno time što je sol ili kokristal komponente (a) i komponente (b1) prisutna u kristalnom i / ili amorfnom obliku.
3. Sol ili kokristal prema bilo kojem od prethodnih zahtjeva, naznačeno time što je stehiometrija komponente (a) i (b1) u rasponu od 1: 0.4 do 1: 2.1, poželjno u rasponu od 1: 0.4 do 1: 1.
4. Lijek koji sadrži barem jednu sol ili kokristal prema bilo kojem od prethodnih zahtjeva.
5. Lijek prema zahtjevu 4, naznačen time što je čvrst, poželjno u obliku tablete.
6. Lijek prema zahtjevu 4 ili 5, naznačen time što je lijek formuliran za oralnu primjenu.
7. Barem jedna sol ili kokristal prema bilo kojem od zahtjeva 1 do 3 za uporabu u liječenju boli.
8. Barem jedna sol ili kokristal prema zahtjevu 7, naznačeno time što se bol odabire iz skupine koja se sastoji od upalne boli, neuropatske boli, akutne boli, kronične boli, visceralne boli, boli migrene i boli povezane s rakom.
HRP20210928TT 2010-07-23 2021-06-09 Soli ili ko-kristali 3- (3-dimetilamino-1-etil-2-metil-propil)-fenola HRP20210928T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10007672 2010-07-23
EP19214275.0A EP3656765B1 (en) 2010-07-23 2011-07-22 Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

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HRP20210928T1 true HRP20210928T1 (hr) 2021-11-26

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HRP20210343TT HRP20210343T1 (hr) 2010-07-23 2021-03-01 Soli ili ko-kristali 3-(3-dimetilamino-1-etil-2-metil-propil)-fenola
HRP20210928TT HRP20210928T1 (hr) 2010-07-23 2021-06-09 Soli ili ko-kristali 3- (3-dimetilamino-1-etil-2-metil-propil)-fenola

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HRP20210343TT HRP20210343T1 (hr) 2010-07-23 2021-03-01 Soli ili ko-kristali 3-(3-dimetilamino-1-etil-2-metil-propil)-fenola

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US (1) US9133142B2 (hr)
EP (8) EP3636629A1 (hr)
JP (4) JP5968884B2 (hr)
KR (2) KR20190026065A (hr)
CN (4) CN106831456A (hr)
AU (8) AU2011281923C1 (hr)
CA (2) CA3078668A1 (hr)
CY (2) CY1123852T1 (hr)
DK (2) DK3650439T3 (hr)
ES (2) ES2860676T3 (hr)
HK (1) HK1250231A1 (hr)
HR (2) HRP20210343T1 (hr)
HU (2) HUE054507T2 (hr)
LT (2) LT3650439T (hr)
MX (2) MX341072B (hr)
PL (2) PL3650439T3 (hr)
PT (2) PT3650439T (hr)
RS (2) RS61515B1 (hr)
SI (2) SI3650439T1 (hr)
WO (1) WO2012010316A1 (hr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10250083A1 (de) 2002-06-17 2003-12-24 Gruenenthal Gmbh Gegen Missbrauch gesicherte Darreichungsform
CA3078668A1 (en) * 2010-07-23 2012-01-26 Grunenthal Gmbh Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
WO2013111161A2 (en) * 2012-01-10 2013-08-01 Msn Laboratories Limited Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
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