HRP20201285T1 - Reagensi sirp-alfa visokog afiniteta - Google Patents

Reagensi sirp-alfa visokog afiniteta Download PDF

Info

Publication number
HRP20201285T1
HRP20201285T1 HRP20201285TT HRP20201285T HRP20201285T1 HR P20201285 T1 HRP20201285 T1 HR P20201285T1 HR P20201285T T HRP20201285T T HR P20201285TT HR P20201285 T HRP20201285 T HR P20201285T HR P20201285 T1 HRP20201285 T1 HR P20201285T1
Authority
HR
Croatia
Prior art keywords
polypeptide
sirpα
affinity
amino acid
polypeptide according
Prior art date
Application number
HRP20201285TT
Other languages
English (en)
Croatian (hr)
Inventor
Aaron Michael RING
Kenan Christopher GARCIA
Kipp Andrew WEISKOPF
Aron M. Levin
Irving L. Weissman
Original Assignee
The Board Of Trustees Of The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Publication of HRP20201285T1 publication Critical patent/HRP20201285T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20201285TT 2012-01-17 2013-01-17 Reagensi sirp-alfa visokog afiniteta HRP20201285T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261587247P 2012-01-17 2012-01-17
PCT/US2013/021937 WO2013109752A1 (en) 2012-01-17 2013-01-17 High affinity sirp-alpha reagents
EP13738232.1A EP2804617B9 (en) 2012-01-17 2013-01-17 High affinity sirp-alpha reagents

Publications (1)

Publication Number Publication Date
HRP20201285T1 true HRP20201285T1 (hr) 2020-11-13

Family

ID=48799653

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20201285TT HRP20201285T1 (hr) 2012-01-17 2013-01-17 Reagensi sirp-alfa visokog afiniteta

Country Status (19)

Country Link
US (4) US9944911B2 (enExample)
EP (2) EP2804617B9 (enExample)
JP (5) JP6460796B2 (enExample)
CN (2) CN104136037B (enExample)
AU (1) AU2013209736C1 (enExample)
CA (1) CA2861307C (enExample)
CY (1) CY1123419T1 (enExample)
DK (1) DK2804617T3 (enExample)
ES (1) ES2816647T3 (enExample)
HK (1) HK1253217A1 (enExample)
HR (1) HRP20201285T1 (enExample)
HU (1) HUE050875T2 (enExample)
LT (1) LT2804617T (enExample)
PL (1) PL2804617T3 (enExample)
PT (1) PT2804617T (enExample)
RS (1) RS60606B1 (enExample)
SI (1) SI2804617T1 (enExample)
SM (1) SMT202000689T1 (enExample)
WO (1) WO2013109752A1 (enExample)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2804617T (pt) * 2012-01-17 2020-09-10 Univ Leland Stanford Junior Reagentes sirp-alfa de alta afinidade
SMT201900453T1 (it) 2012-02-06 2019-11-13 Inhibrx Inc Anticorpi anti cd47 e relativi metodi d'uso
SI2931752T1 (sl) 2012-12-17 2019-12-31 Trillium Therapeutics Inc. Zdravljenje bolezenskih celic CD47+ s fuzijami ALFA-FC SIRP
CN112245586A (zh) 2013-03-15 2021-01-22 小利兰·斯坦福大学托管委员会 用于实现治疗有效剂量的抗cd47剂的方法
US10064925B2 (en) 2013-04-29 2018-09-04 The Board Of Trustees Of The Leland Stanford Junior University Use of anti-CD47 agents to enhance immunization
EP3046627B1 (en) 2013-09-18 2019-10-23 The Board of Trustees of the Leland Stanford Junior University Modulation of efferocytosis pathways for treatment of atherosclerotic disease
ES2811274T3 (es) 2014-04-18 2021-03-11 Univ Leland Stanford Junior Anticuerpos monoclonales humanizados y quiméricos para CD99
PL3177640T3 (pl) 2014-08-08 2020-11-02 The Board Of Trustees Of The Leland Stanford Junior University Charakteryzujące się wysokim powinowactwem środki terapeutyczne naśladujące PD-11 i sposoby ich wykorzystania
WO2016023001A1 (en) * 2014-08-08 2016-02-11 The Board Of Trustees Of The Leland Stanford Junior University Multispecific high affinity pd-1 agents and methods of use
US10087257B2 (en) 2014-08-08 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University SIRP alpha-antibody fusion proteins
GB2532619A (en) * 2014-08-08 2016-05-25 Alexo Therapeutics Int Sirp-Alpha Variant Constructs And Uses Thereof
HUE046661T2 (hu) 2014-08-15 2020-03-30 Merck Patent Gmbh SIRP-alfa immunglobulin fúziós proteinek
PL3656869T5 (pl) 2014-08-26 2025-06-09 The Board Of Trustees Of The Leland Stanford Junior University Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego
EP3194024B1 (en) * 2014-09-15 2020-08-05 The Board of Trustees of the Leland Stanford Junior University Targeting aneurysm disease by modulating phagocytosis pathways
EP3012271A1 (en) 2014-10-24 2016-04-27 Effimune Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
US10316094B2 (en) 2014-10-24 2019-06-11 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for inducing phagocytosis of MHC class I positive cells and countering anti-CD47/SIRPA resistance
EP3221358B1 (en) * 2014-11-18 2021-07-21 Janssen Pharmaceutica, N.V. Cd47 antibodies, methods, and uses
EA037654B1 (ru) * 2014-12-30 2021-04-27 Селджин Корпорейшн Анти-cd47-антитела и их применения
ES2941387T3 (es) 2015-02-27 2023-05-22 Univ Leland Stanford Junior Terapia de combinación para el tratamiento de la ateroesclerosis
CN106146670B (zh) * 2015-04-24 2019-01-15 宜明昂科生物医药技术（上海）有限公司 一种新的重组双功能融合蛋白及其制备和应用
US10358472B2 (en) 2015-05-06 2019-07-23 The Board Of Trustees Of The Leland Stanford Junior University High affinity CD47 analogs
CA2994935A1 (en) 2015-05-18 2016-11-24 Ab Initio Biotherapeutics, Inc. Sirp polypeptide compositions and methods of use
BR102016018074A2 (pt) * 2015-08-07 2021-11-16 ALX Oncology Inc. Construção variante de sirp-alfa, seu método de preparação e seus usos, molécula de ácido nucleico, vetor, célula hospedeira, e composição farmacêutica
ES2881771T3 (es) 2015-08-07 2021-11-30 Alx Oncology Inc Constructos que tienen un dominio de SIRP-alfa o variante del mismo
JP7198083B2 (ja) 2015-08-26 2022-12-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｃｄ４７遮断及び免疫同時刺激アゴニストを用いた標的細胞の枯渇亢進
WO2017100462A2 (en) 2015-12-11 2017-06-15 The Board Of Trustees Of The Leland Stanford Junior University Treatment of cancer with dual targeting of cd47 and egfr
SI3402820T1 (sl) 2016-01-11 2021-04-30 Forty Seven, Inc. Humanizirana, mišja ali himerna monoklonska protitelesa proti-CD47
SMT202400438T1 (it) 2016-04-14 2024-11-15 Ose Immunotherapeutics Nuovi anticorpi anti-sirpa e loro applicazioni terapeutiche
ES2909835T3 (es) 2016-04-15 2022-05-10 Univ Leland Stanford Junior Métodos para determinar y alcanzar dosis terapéuticamente efectivas de agentes anti-CD47 en el tratamiento del cáncer
WO2017184553A1 (en) * 2016-04-18 2017-10-26 Baylor College Of Medicine Cancer gene therapy targeting cd47
WO2017190148A1 (en) 2016-04-29 2017-11-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for the prevention and treatment of surgical adhesions
US11560433B2 (en) 2016-05-27 2023-01-24 Albert Einstein College Of Medicine Methods of treatment by targeting VCAM1 and MAEA
US10277886B2 (en) 2016-07-19 2019-04-30 Gopro, Inc. Mapping of spherical image data into rectangular faces for transport and decoding across networks
US10995152B2 (en) * 2016-10-26 2021-05-04 The Board Of Trustees Of The Leland Stanford Junior University Modified immunoglobulin hinge regions to reduce hemagglutination
US11446315B2 (en) 2016-11-03 2022-09-20 Pf Argentum Ip Holdings Llc Enhancement of CD47 blockade therapy by proteasome inhibitors
CA3042583A1 (en) 2016-11-03 2018-05-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by hdac inhibitors
KR102129067B1 (ko) * 2016-12-29 2020-07-08 한국과학기술연구원 신규 엑소좀 계열 항암제
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
IL267862B2 (en) 2017-01-05 2024-05-01 Kahr Medical Ltd A SIRPalpha-41BBL FUSION PROTEIN AND METHODS OF USE THEREOF
HRP20230937T1 (hr) 2017-01-05 2023-11-24 Kahr Medical Ltd. Pd1-41bbl fuzijski protein i metode korištenja istog
AU2018205276A1 (en) 2017-01-06 2019-07-18 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
CN110312527A (zh) 2017-01-30 2019-10-08 小利兰·斯坦福大学托管委员会 用于干细胞移植的非基因毒性预处理方案
EP3589368A4 (en) 2017-02-28 2021-03-24 The Board of Trustees of the Leland Stanford Junior University ANTIFIBROTIC ACTIVITY OF CD47 BLOCKING
WO2018165015A1 (en) 2017-03-09 2018-09-13 The Board Of Trustees Of The Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of cd47 pathway
PT3642242T (pt) 2017-06-21 2024-04-16 Univ Leland Stanford Junior Parâmetros de dosagem para terapias de direcionamento de cd47 para malignidades hematológicas
WO2019014391A1 (en) 2017-07-12 2019-01-17 Synlogic Operating Company, Inc. MICROORGANISMS PROGRAMMED TO PRODUCE IMMUNOMODULATORS AND ANTICANCER THERAPEUTIC AGENTS IN TUMOR CELLS
NZ761568A (en) 2017-08-02 2022-11-25 Phanes Therapeutics Inc Anti-cd47 antibodies and uses thereof
WO2019047885A1 (en) * 2017-09-07 2019-03-14 Dingfu Biotarget Co., Ltd. IMMUNOCONJUGATES COMPRISING ALPHA REGULATORY SIGNAL PROTEIN
WO2019061012A1 (zh) * 2017-09-26 2019-04-04 南京凯地生物科技有限公司 靶向cd47的特异性嵌合抗原受体t细胞的制备及其应用
CN111511766B (zh) 2017-10-13 2024-06-07 Ose免疫疗法 修饰的抗SIRPa抗体及其应用
AU2018351006B2 (en) 2017-10-18 2024-08-29 Forty Seven, LLC Anti-CD47 agent-based ovarian cancer therapy
US11771764B2 (en) 2017-11-06 2023-10-03 Pfizer Inc. CD47 blockade with radiation therapy
US11180552B2 (en) 2017-12-01 2021-11-23 Seagen Inc. CD47 antibodies and uses thereof for treating cancer
JP6961090B2 (ja) * 2017-12-08 2021-11-05 ハンクス バイオファーマシューティクス，インコーポレイテッド 抗ｐｄ−１／ｃｄ４７二重特異性抗体及びその適用
CN109971716B (zh) * 2017-12-28 2023-08-01 上海细胞治疗研究院 自分泌cd47抗体的egfr特异性car-t细胞及其用途
PT3752190T (pt) 2018-02-12 2022-11-18 Forty Seven Inc Regime anticancerígeno usando anticorpos anti-cd47 e anti-cd20
CN108484774B (zh) * 2018-03-09 2021-11-05 上海高菲生物科技有限公司 一种SIRPα融合蛋白及其制备方法和用途
CN112105646A (zh) 2018-03-13 2020-12-18 Ose免疫疗法 抗人SIRPa v1抗体的用途和生产抗SIRPa v1抗体的方法
US20210040219A1 (en) * 2018-03-13 2021-02-11 Trillium Therapeutics Inc. Improvements in cd47 blockade therapy by egfr antibody
CN108872569A (zh) * 2018-06-19 2018-11-23 浠思（上海）生物技术有限公司 利用HTRF一步法筛选CD47/SIRP alpha阻断剂的方法
JP7368809B2 (ja) 2018-07-10 2023-10-25 国立大学法人神戸大学 抗ＳＩＲＰα抗体
CA3104778A1 (en) 2018-07-11 2020-01-16 Kahr Medical Ltd. Pd1-4-1bbl variant fusion protein and methods of use thereof
BR112021000360A2 (pt) 2018-07-11 2021-04-13 Kahr Medical Ltd. Proteína de fusão variante sirpalpha-4-1bbl e métodos de uso da mesma
KR102129522B1 (ko) * 2018-07-26 2020-07-02 한국과학기술연구원 암세포 특이적 항암 단백질-형광 복합체 및 이를 포함하는 암의 진단 및 영상화용 조성물
US20210347848A1 (en) 2018-08-31 2021-11-11 ALX Oncology Inc. Decoy polypeptides
CN112739384A (zh) * 2018-09-04 2021-04-30 延龄草治疗公司 用于疾病治疗的cd47阻断和parp抑制
CN109306017B (zh) * 2018-10-12 2021-02-09 倍而达药业（苏州）有限公司 一种基于SIRP-αD1突变体制备的重组蛋白及应用
US20220002385A1 (en) * 2018-11-07 2022-01-06 Daiichi Sankyo Company, Limited Method of improving blood kinetics of peptide
CN111303293B (zh) 2018-11-14 2022-08-30 杭州尚健生物技术有限公司 一种融合蛋白及其用途
KR20210094609A (ko) 2018-11-28 2021-07-29 포티 세븐, 인코포레이티드 절제 레짐에 대해 저항성인 유전적으로 변형된 hspc
CA3121273A1 (en) * 2018-11-29 2020-06-04 Trillium Therapeutics Inc. Biomarkers for cd47 blockade therapy
EA202191763A1 (ru) 2018-12-21 2022-03-10 Озе Иммьюнотерапьютикс Бифункциональная молекула анти-pd-1/sirp
CA3134102A1 (en) 2019-03-18 2020-09-24 Ludwig Institute For Cancer Research Ltd A2/ny-eso-1 specific t cell receptors and uses thereof
JP7710997B2 (ja) 2019-05-31 2025-07-22 エーエルエックス オンコロジー インコーポレイテッド 免疫チェックポイント阻害剤と組み合わせてｓｉｒｐアルファｆｃ融合によりがんを治療する方法
CN114206912B (zh) 2019-06-07 2025-02-11 Alx肿瘤生物技术公司 用于在血清学测定中减少结合cd47的药物的干扰的方法和试剂
WO2020257196A1 (en) * 2019-06-17 2020-12-24 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating infections by blocking pathogen mimics of cd47
CN120775062A (zh) 2019-07-16 2025-10-14 吉利德科学公司 Hiv疫苗及其制备和使用方法
CN118178645A (zh) 2019-10-18 2024-06-14 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
CA3153636A1 (en) 2019-10-31 2021-05-06 Forty Seven, Inc. Anti-cd47 and anti-cd20 based treatment of blood cancer
EP4065101A1 (en) 2019-11-27 2022-10-05 ALX Oncology Inc. Combination therapies for treating cancer
AU2020412875A1 (en) 2019-12-24 2022-06-23 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
PH12022552122A1 (en) 2020-02-14 2024-01-29 Jounce Therapeutics Inc Antibodies and fusion proteins that bind to ccr8 and uses thereof
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
EP4139003A4 (en) * 2020-04-24 2024-08-21 Georgia State University Research Foundation, Inc. SIRPA-DEFICIENT MACROPHAGES FOR THE TREATMENT OF CANCER
JP2023528341A (ja) 2020-06-01 2023-07-04 エーエルエックス オンコロジー インコーポレイテッド 低メチル化剤を含むがんを治療するための併用療法
WO2022003568A1 (en) 2020-06-30 2022-01-06 Dcprime B.V. Use of leukemia-derived cells in ovarian cancer vaccines
WO2022010806A1 (en) 2020-07-06 2022-01-13 ALX Oncology Inc. Methods for reducing the interference of drugs that bind therapeutic targets expressed on blood cells in serological assays
CN114057888A (zh) * 2020-07-30 2022-02-18 三生国健药业（上海）股份有限公司 一种SIRPα-Fc融合蛋白
JP7446953B2 (ja) * 2020-08-27 2024-03-11 株式会社三共 遊技機
KR102557016B1 (ko) * 2020-09-22 2023-07-20 비피진 주식회사 암 치료를 위한 cd47 바인더 및 리포좀 복합체
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
US20220196651A1 (en) * 2020-12-06 2022-06-23 ALX Oncology Inc. Multimers for reducing the interference of drugs that bind cd47 in serological assays
EP4304633A1 (en) 2021-03-12 2024-01-17 Mendus B.V. Methods of vaccination and use of cd47 blockade
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
JP2024515211A (ja) 2021-04-27 2024-04-05 ファイザー・インク Ｄｈｆｒ阻害剤を用いたｃｄ４７遮断療法の増強
IL308400A (en) 2021-05-13 2024-01-01 Alx Oncology Inc Combined therapies for cancer treatment
KR20240023628A (ko) 2021-06-23 2024-02-22 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
US11932634B2 (en) 2021-06-23 2024-03-19 Gilead Sciences, Inc. Diacylglycerol kinase modulating compounds
KR20240023629A (ko) 2021-06-23 2024-02-22 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
CN117396478A (zh) 2021-06-23 2024-01-12 吉利德科学公司 二酰基甘油激酶调节化合物
WO2023003331A1 (en) * 2021-07-19 2023-01-26 Yuhan Corporation Sirp-alpha variants and use thereof
AU2022375782A1 (en) 2021-10-28 2024-05-02 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds
US20250235504A1 (en) 2021-10-29 2025-07-24 Pfizer Inc. Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy
CN118139874A (zh) * 2021-11-01 2024-06-04 山东先声生物制药有限公司 SIRPa突变体及其应用
US20250367255A1 (en) 2021-11-08 2025-12-04 Pfizer Inc. Enhancement Of CD47 Blockade Therapy With Anti-VEGF Agents
WO2023107954A1 (en) 2021-12-08 2023-06-15 Dragonfly Therapeutics, Inc. Antibodies targeting 5t4 and uses thereof
US20230203202A1 (en) 2021-12-08 2023-06-29 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and 5t4
AU2022421675A1 (en) * 2021-12-21 2024-05-02 Fbd Biologics Limited ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF
CN118488946A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
US20250051441A1 (en) * 2021-12-23 2025-02-13 Fbd Biologics Limited Cd47/4-1bb-targeting protein complex and methods of use thereof
KR20240133694A (ko) * 2022-01-18 2024-09-04 에프비디 바이올로직스 리미티드 Cd47/pd-l1 표적화 단백질 복합체 및 이의 사용 방법
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Ｐａｒｐ７抑制劑
EP4479084A1 (en) 2022-02-14 2024-12-25 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
ES2999273T3 (en) 2022-03-17 2025-02-25 Gilead Sciences Inc Ikaros zinc finger family degraders and uses thereof
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
US20230365648A1 (en) 2022-03-24 2023-11-16 Bitterroot Bio, Inc. Sirp-alpha fusion polypeptides with modified fc domains
WO2023183890A1 (en) 2022-03-24 2023-09-28 Bitterroot Bio, Inc. Multivalent sirp-alpha fusion polypeptides
JP2025509662A (ja) 2022-03-24 2025-04-11 ギリアード サイエンシーズ， インコーポレイテッド Ｔｒｏｐ－２発現がんを治療するための併用療法
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
KR20250004824A (ko) 2022-04-21 2025-01-08 길리애드 사이언시즈, 인코포레이티드 Kras g12d 조절 화합물
JP2025517619A (ja) * 2022-05-06 2025-06-10 ビオシオン インコーポレイテッド Ｃｄ４０及びｃｄ４７を標的とする組換え融合タンパク質
JP2025518578A (ja) 2022-05-25 2025-06-17 ファイザー・インク がんの処置のためのｓｉｒｐアルファ融合タンパク質の投薬レジメン
KR20250022059A (ko) 2022-06-01 2025-02-14 알렉소 온콜로지 인크. 요로상피 암종 치료를 위한 병용 요법
WO2024006929A1 (en) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Cd73 compounds
EP4554628A1 (en) 2022-07-12 2025-05-21 Gilead Sciences, Inc. Hiv immunogenic polypeptides and vaccines and uses thereof
WO2024015634A2 (en) * 2022-07-15 2024-01-18 Nutcracker Therapeutics, Inc. Mrna therapies including sirp-alpha
WO2024040151A1 (en) 2022-08-18 2024-02-22 Pfizer Inc. Sirp alpha fusion protein and anti-cd38 antibody combination therapies
WO2024064668A1 (en) 2022-09-21 2024-03-28 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
KR20250116736A (ko) 2022-12-09 2025-08-01 화이자 인코포레이티드 Cd47 차단제 및 항-bcma/항-cd3 이중특이성 항체 병용 요법
CN120344257A (zh) 2022-12-09 2025-07-18 美国辉瑞有限公司 Cd47阻断剂和抗cd20/抗cd3双特异性抗体组合疗法
AU2023409398A1 (en) 2022-12-22 2025-06-05 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024193635A1 (en) * 2023-03-22 2024-09-26 Wangzhi LI Sirp variants and uses thereof
WO2024215754A1 (en) 2023-04-11 2024-10-17 Gilead Sciences, Inc. Kras modulating compounds
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
TW202511298A (zh) * 2023-05-31 2025-03-16 香港商Ｆｂｄ生物製劑有限公司 靶向ｃｄ４７／ｐｄ—ｌ１之蛋白質複合物及其使用方法
WO2025006720A1 (en) 2023-06-30 2025-01-02 Gilead Sciences, Inc. Kras modulating compounds
US20250100998A1 (en) 2023-07-26 2025-03-27 Gilead Sciences, Inc. Parp7 inhibitors
WO2025024663A1 (en) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Parp7 inhibitors
WO2025054530A1 (en) 2023-09-08 2025-03-13 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
US20250376484A1 (en) 2024-05-21 2025-12-11 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541615B1 (en) * 1996-11-15 2003-04-01 Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. SIRP proteins and uses thereof
CA2383041A1 (en) * 1999-06-11 2000-12-21 Human Genome Sciences, Inc. 49 human secreted proteins
US7691970B2 (en) * 2003-08-25 2010-04-06 Pieris Ag Muteins of a bilin-binding protein with affinity for a given target
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
EP2573112A1 (en) 2007-10-11 2013-03-27 The Hospital For Sick Children Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
EA201100947A1 (ru) * 2008-12-19 2012-02-28 Новартис Аг Растворимые полипептиды, предназначенные для применения при лечении аутоиммунных и воспалительных нарушений
ES2539141T3 (es) 2009-05-15 2015-06-26 University Health Network Composiciones y métodos para tratar cánceres hematológicos dirigiéndose a la interacción SIRPalfa - CD47
PT2804617T (pt) * 2012-01-17 2020-09-10 Univ Leland Stanford Junior Reagentes sirp-alfa de alta afinidade
PL3656869T5 (pl) * 2014-08-26 2025-06-09 The Board Of Trustees Of The Leland Stanford Junior University Wszczepienie komórek macierzystych z kombinacją środka, który celuje w komórki macierzyste i modulowanie sygnałowania immunoregulatorowego
JP7198083B2 (ja) * 2015-08-26 2022-12-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Ｃｄ４７遮断及び免疫同時刺激アゴニストを用いた標的細胞の枯渇亢進
KR102024554B1 (ko) * 2018-02-26 2019-09-24 엘지전자 주식회사 유도 가열 장치 및 유도 가열 장치의 제어 방법

Also Published As

Publication number Publication date
US20150071905A1 (en) 2015-03-12
EP3766511A1 (en) 2021-01-20
CA2861307A1 (en) 2013-07-25
JP2021176873A (ja) 2021-11-11
JP2020143104A (ja) 2020-09-10
AU2013209736C1 (en) 2017-12-14
LT2804617T (lt) 2020-09-10
RS60606B1 (sr) 2020-08-31
US9944911B2 (en) 2018-04-17
HK1253217A1 (zh) 2019-06-14
CA2861307C (en) 2021-05-25
CY1123419T1 (el) 2021-12-31
JP6460796B2 (ja) 2019-01-30
ES2816647T3 (es) 2021-04-05
US20180195054A1 (en) 2018-07-12
EP2804617B9 (en) 2021-04-07
JP6742279B2 (ja) 2020-08-19
HUE050875T2 (hu) 2021-01-28
SI2804617T1 (sl) 2020-10-30
JP2018021016A (ja) 2018-02-08
EP2804617A1 (en) 2014-11-26
EP2804617A4 (en) 2015-11-25
EP2804617B1 (en) 2020-06-24
WO2013109752A1 (en) 2013-07-25
AU2013209736B2 (en) 2017-09-07
JP6783361B2 (ja) 2020-11-11
CN104136037A (zh) 2014-11-05
US12195532B2 (en) 2025-01-14
DK2804617T3 (da) 2020-08-10
JP6918179B2 (ja) 2021-08-11
JP2020007329A (ja) 2020-01-16
PL2804617T3 (pl) 2020-11-30
AU2013209736A1 (en) 2014-08-07
US20250223355A1 (en) 2025-07-10
CN104136037B (zh) 2018-02-23
US11208481B2 (en) 2021-12-28
SMT202000689T1 (it) 2021-01-05
HK1201757A1 (en) 2015-09-11
JP2015504899A (ja) 2015-02-16
US20220064293A1 (en) 2022-03-03
PT2804617T (pt) 2020-09-10
CN107880100A (zh) 2018-04-06

Similar Documents

Publication Publication Date Title
HRP20201285T1 (hr) Reagensi sirp-alfa visokog afiniteta
AU2018264321A1 (en) Bispecific recombinant protein and use thereof
Liu et al. Core–shell molecularly imprinted polymer nanoparticles with assistant recognition polymer chains for effective recognition and enrichment of natural low-abundance protein
NZ603623A (en) Tcr complex immunotherapeutics
CN103819559B (zh) 一种抗间皮素纳米抗体及其编码基因和该纳米抗体的用途
MX2012000316A (es) Anticuerpos humanizados para el receptor 2 tipo toll y usos de los mismos.
IL275497B (en) Serum proteins with type iii fibronectin binding domains
FI4073098T3 (fi) Ultrapitkävaikutteiset insuliini-Fc-fuusioproteiinit ja niiden käyttömenetelmät
Ballesteros et al. Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1)
HRP20150799T1 (hr) Sastavi i postupci za protutijela protiv komplementnog proteina c5
CN103387990A (zh) 上皮细胞粘附分子的核酸适体EpCAM B及其制备方法
MX2019009382A (es) Anticuerpo anti-humano de anexina a1.
CN105037547B (zh) 基于afp抗原的afp纳米抗体a18
RU2016126425A (ru) Пептиды, связывающие cd44
CN117050165A (zh) 一种靶向猴痘病毒的抗体、其抗原结合片段及其用途
CN112048018A (zh) 一种嵌合t细胞生长因子及其应用
CN102634487B (zh) Gpc3单克隆抗体杂交瘤细胞株8g6及其制备方法和应用
CN102671185A (zh) 少棘蜈蚣多肽毒素omega-SLPTX-Ssm1a的应用
CN104650185A (zh) 一条与猪瘟e0蛋白相结合的多肽序列及其应用
WO2009126898A3 (en) Humanized monoclonal antibodies that specifically bind and/or neutralize japanese encephalitis virus( (jev) and their use
CN103772501A (zh) Vegf抗体及其制备方法和用途
CN110669109A (zh) 一种酶联标签短肽及其应用
CN102250217A (zh) 华南雨蛙促皮肤损伤修复多肽及其基因和应用
Minamihata et al. Photosensitizer and polycationic peptide-labeled streptavidin as a nano-carrier for light-controlled protein transduction
CN109081870B (zh) 一种抗人促绒毛膜促性腺激素β亚单位的纳米抗体及核酸分子和应用