HRP20192215T1 - Rekombinantni hvt vektori za ekspresiju antigena od ptičjih patogena i njihove uporabe - Google Patents
Rekombinantni hvt vektori za ekspresiju antigena od ptičjih patogena i njihove uporabe Download PDFInfo
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- HRP20192215T1 HRP20192215T1 HRP20192215TT HRP20192215T HRP20192215T1 HR P20192215 T1 HRP20192215 T1 HR P20192215T1 HR P20192215T T HRP20192215T T HR P20192215TT HR P20192215 T HRP20192215 T HR P20192215T HR P20192215 T1 HRP20192215 T1 HR P20192215T1
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- vsb1
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- 241000271566 Aves Species 0.000 title claims 7
- 239000000427 antigen Substances 0.000 title claims 7
- 239000013598 vector Substances 0.000 title claims 5
- 244000052769 pathogen Species 0.000 title claims 3
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 229960005486 vaccine Drugs 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 241001502481 Meleagrid alphaherpesvirus 1 Species 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 241000702626 Infectious bursal disease virus Species 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 241000701063 Gallid alphaherpesvirus 1 Species 0.000 claims 2
- 101150104684 UL44 gene Proteins 0.000 claims 2
- 101150081415 UL55 gene Proteins 0.000 claims 2
- 101150029683 gB gene Proteins 0.000 claims 2
- 101150002378 gC gene Proteins 0.000 claims 2
- 241000008921 Avian coronavirus Species 0.000 claims 1
- 241001519465 Avian metapneumovirus Species 0.000 claims 1
- 241001516406 Avian orthoreovirus Species 0.000 claims 1
- 241001136161 Avibacterium Species 0.000 claims 1
- 241000589994 Campylobacter sp. Species 0.000 claims 1
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 201000006082 Chickenpox Diseases 0.000 claims 1
- 241000193464 Clostridium sp. Species 0.000 claims 1
- 208000003495 Coccidiosis Diseases 0.000 claims 1
- 241000304695 Eimeria sp. Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000701047 Gallid alphaherpesvirus 2 Species 0.000 claims 1
- 206010023076 Isosporiasis Diseases 0.000 claims 1
- 241000204022 Mycoplasma gallisepticum Species 0.000 claims 1
- 241000202942 Mycoplasma synoviae Species 0.000 claims 1
- 241000606580 Pasteurella sp. Species 0.000 claims 1
- 241000125945 Protoparvovirus Species 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000607149 Salmonella sp. Species 0.000 claims 1
- 241001223089 Tremovirus A Species 0.000 claims 1
- 206010046980 Varicella Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 244000309743 astrovirus Species 0.000 claims 1
- 241000701792 avian adenovirus Species 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 238000002255 vaccination Methods 0.000 claims 1
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Claims (8)
1. Pripravak ili cjepivo, naznačen/o time, da obuhvaća rekombinantni vektor herpesvirusa purana (HVT – engl. herpesvirus of turkey), pri čemu HVT vektor nadalje obuhvaća ili:
a) NDV-F-gen koji ima polinukleotidnu sekvencu prikazanu u SEQ ID BR:1, koji je operativno povezan s SV40 promotorom i SV40 poliA-signalom, i umetnut je u IG1 lokus od HVT genoma; ili
b) NDV-F-gen koji ima polinukleotidnu sekvencu prikazanu u SEQ ID BR:5, koji je operativno povezan s SV40 promotorom i SV40 poliA-signalom, i umetnut je u IG1 lokus od HVT genoma.
2. Pripravak ili cjepivo prema patentnom zahtjevu 1, naznačen/o time, da nadalje obuhvaća jedan ili više SB1 vektora pri čemu je SB1 vektor odabran iz skupine koja se sastoji od sljedećih: vSB1-009, vSB1-010, vSB1-004, vSB1-006, vSB1-007 i vSB1-008, dok vSB1-009 obuhvaća SV40 promotor i polinukleotid optimiziran kodonom, koji kodira NDV-F-antigen iz genotipa CA02, umetnut u UL44 lokus od SB1 genoma, vSB1-010 obuhvaća CMV promotor zamorca i polinukleotid koji kodira NDV-F-antigen iz genotipa VIId, umetnut u SORF4-US2 lokus od SB1 genoma, vSB1-004 obuhvaća mCMV IE promotor i polinukleotid koji kodira NDV-F-antigen iz genotipa VIId, umetnut u US10 lokus od SB1 genoma, vSB1-006 obuhvaća SV40 promotor i polinukleotid optimiziran kodonom, koji kodira NDV-F-antigen iz genotipa VIId, umetnut u UL55/LORF5 lokus od SB1 genoma, vSB1-008 obuhvaća SV40 promotor i polinukleotid optimiziran kodonom, koji kodira NDV-F-antigen iz genotipa CA02, umetnut u UL55/LORF5 lokus od SB1 genoma, i vSB1-007 obuhvaća SV40 promotor i polinukleotid optimiziran kodonom, koji kodira NDV-F-antigen iz genotipa VIId, umetnut u UL44 lokus od SB1 genoma.
3. Pripravak ili cjepivo prema patentnom zahtjevu ili zahtjevu 2, naznačen/o time, da nadalje obuhvaća farmaceutski ili veterinarski prihvatljiv/o nosač, kemijski dodatak, transportno sredstvo ili pomoćno sredstvo.
4. Pripravak ili cjepivo prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen/o time, da se upotrebljava u postupku cijepljenja životinje, pri čemu taj postupak obuhvaća najmanje jednu primjenu pripravka ili cjepiva.
5. Pripravak ili cjepivo prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen/o time, da se upotrebljava u postupku induciranja zaštitne reakcije kod životinje, protiv NDV i opcionalno, protiv jednog ili više daljnjih ptičjih patogena, pri čemu taj postupak obuhvaća najmanje jednu primjenu pripravka ili cjepiva.
6. Pripravak ili cjepivo za uporabu prema patentnom zahtjevu 5, naznačen/o time, da postupak je režim primjene prime-boost-sustava cijepljenja.
7. Pripravak ili cjepivo za uporabu prema patentnom zahtjevu 5 ili zahtjevu 6, naznačen/o time, da je daljnji ptičji patogen odabran iz skupine koja se sastoji od sljedećih: zarazni virus kokošjeg bursitisa (engl. Infectious Bursal Disease Virus - IBDV) (primjerice IBDV ili virus Gumboro-bolesti), virus Marekove bolesti (engl. Marek's Disease Virus - MDV), zarazni virus laringotraheitisa (engl. Infectuous Laryngotracheitis Virus – ILTV), virus ptičjeg encefalomijelitisa, ptičji reovirus, ptičji paramiksovirus, ptičji metapneumovirus, virus ptičje gripe, ptičji adenovirus, virus kokošjih kozica, ptičji koronavirus, ptičji rotavirus, ptičji parvovirus, ptičji astrovirus i virus kokošje anemije, kokcidioza (Eimeria sp.), Campylobacter sp., Salmonella sp., Mycoplasma gallisepticum, Mycoplasma synoviae, Pasteurella sp., Avibacterium sp., E. coli i Clostridium sp.
8. Pripravak ili cjepivo za uporabu prema bilo kojem od patentnih zahtjeva 4 do 7, naznačen/o time, da životinja je ptica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161564877P | 2011-11-30 | 2011-11-30 | |
US201261694957P | 2012-08-30 | 2012-08-30 | |
EP17179863.0A EP3251691B1 (en) | 2011-11-30 | 2012-11-29 | Recombinant hvt vectors expressing antigens of avian pathogens and uses thereof |
Publications (1)
Publication Number | Publication Date |
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HRP20192215T1 true HRP20192215T1 (hr) | 2020-02-21 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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HRP20190525TT HRP20190525T4 (hr) | 2011-11-30 | 2012-11-29 | Rekombinantni vektori gallid herpesvirusa 3 (mdv serotip 2) koji eksprimiraju antigene ptičjih patogena i njihove uporabe |
HRP20192215TT HRP20192215T1 (hr) | 2011-11-30 | 2019-12-10 | Rekombinantni hvt vektori za ekspresiju antigena od ptičjih patogena i njihove uporabe |
HRP20192241TT HRP20192241T1 (hr) | 2011-11-30 | 2019-12-12 | Rekombinantni hvt vektori za ekspresiju antigena od ptičjih patogena i njihove uporabe |
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HRP20190525TT HRP20190525T4 (hr) | 2011-11-30 | 2012-11-29 | Rekombinantni vektori gallid herpesvirusa 3 (mdv serotip 2) koji eksprimiraju antigene ptičjih patogena i njihove uporabe |
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EP (7) | EP3578199A1 (hr) |
JP (1) | JP6149301B2 (hr) |
KR (1) | KR102013135B1 (hr) |
CN (3) | CN104159604B (hr) |
AR (2) | AR090401A1 (hr) |
BR (1) | BR112014013276B1 (hr) |
CA (1) | CA2857025C (hr) |
CO (1) | CO7061033A2 (hr) |
CY (3) | CY1121528T1 (hr) |
DK (3) | DK2785373T3 (hr) |
ES (3) | ES2785045T3 (hr) |
HK (4) | HK1247832A1 (hr) |
HR (3) | HRP20190525T4 (hr) |
HU (3) | HUE047724T2 (hr) |
IN (1) | IN2014CN04833A (hr) |
LT (3) | LT2785374T (hr) |
ME (1) | ME03433B (hr) |
MX (2) | MX361893B (hr) |
PE (1) | PE20141482A1 (hr) |
PH (2) | PH12014501174A1 (hr) |
PL (3) | PL2785374T5 (hr) |
PT (3) | PT2785373T (hr) |
RS (3) | RS59893B1 (hr) |
RU (1) | RU2620936C2 (hr) |
SI (3) | SI2785374T1 (hr) |
UA (1) | UA118651C2 (hr) |
WO (2) | WO2013082327A1 (hr) |
ZA (1) | ZA201403804B (hr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3146727C (en) | 2011-10-21 | 2023-10-31 | Intervet International B.V. | Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens |
PE20141482A1 (es) | 2011-11-30 | 2014-11-08 | Merial Ltd | Vectores recombinantes de hvt que expresan antigenos de patogenos de aves y sus usos |
EP2644702A1 (en) | 2012-03-30 | 2013-10-02 | Ceva Sante Animale | Multivalent recombinant avian herpes virus and vaccine for immunizing avian species |
AR097029A1 (es) * | 2013-07-26 | 2016-02-17 | Intervet Int Bv | Aceleración de la respuesta inmune inducida por virus vectorial en aves, composición, uso, método para la vacunación y método para acelerar la respuesta inmune |
EP2845904A1 (en) * | 2013-09-06 | 2015-03-11 | Ceva Sante Animale | Recombinant Marek's disease viruses and uses thereof |
AR103245A1 (es) * | 2014-12-24 | 2017-04-26 | Intervet Int Bv | Vacuna vectorial basada en hvt (herpes virus de los pavos) frente a nd (enfermedad de newcastle) - ibd (enfermedad de gumboro) mejorada |
US10537628B2 (en) | 2015-08-10 | 2020-01-21 | The Texas A&M University System | Recombinant turkey herpesvirus vaccines and uses thereof |
WO2017216287A1 (en) | 2016-06-17 | 2017-12-21 | Intervet International B.V. | Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and infectious bursal disease virus antigens |
JOP20190088A1 (ar) * | 2016-10-21 | 2019-04-21 | Us Agriculture | نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها |
KR102617503B1 (ko) * | 2016-12-14 | 2023-12-29 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 조류 병원체의 다중 항원을 발현하는 재조합 hvt 벡터 및 그를 포함하는 백신 |
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EP3391903B1 (en) * | 2017-04-21 | 2022-02-23 | The Pirbright Institute | Recombinant gallid herpesvirus 3 vaccines encoding heterologous avian pathogen antigens |
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WO2019147869A2 (en) * | 2018-01-24 | 2019-08-01 | Virogin Biotech Canada Ltd | Recombinant viral vaccines |
CN109468315B (zh) * | 2018-12-07 | 2021-09-07 | 袁隆平农业高科技股份有限公司 | 水稻耐淹基因Sub1共显性分子标记及应用 |
CN113226363A (zh) | 2018-12-21 | 2021-08-06 | 法国诗华大药厂 | 含有多个外来基因的重组禽疱疹病毒 |
US11464849B2 (en) * | 2019-09-11 | 2022-10-11 | Zoetis Services Llc | Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof |
CN110872578B (zh) * | 2019-11-29 | 2022-09-16 | 扬州优邦生物药品有限公司 | 一株变异株传染性法氏囊病毒、亚单位疫苗及其制备方法和应用 |
US11299517B2 (en) * | 2020-04-15 | 2022-04-12 | The United States Of America, As Represented By The Secretary Of Agriculture | Recombinant vaccine against Marek's disease and Newcastle disease |
MA58717A1 (fr) | 2020-06-17 | 2023-06-28 | Boehringer Ingelheim Vetmedica Gmbh | Vecteurs hvt recombinants exprimant l'hémagglutinine de la grippe et compositions immunogènes, et leur fabrication et leurs utilisations |
CN112206317B (zh) * | 2020-10-12 | 2023-09-22 | 浙江省淡水水产研究所 | 一种草鱼出血病二价核酸菌蜕疫苗的制备方法 |
MX2023004358A (es) | 2020-10-15 | 2023-07-25 | Ceva Sante Animale | Hvt recombinante y usos de este. |
CN114317827B (zh) * | 2022-01-07 | 2023-03-24 | 河南省农业科学院 | 一种鉴别不同血清型马立克病病毒感染与免疫的多重pcr引物、方法及应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
US4708871A (en) | 1983-03-08 | 1987-11-24 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
EP0256092B1 (en) | 1986-01-27 | 1998-04-08 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
JP2779447B2 (ja) | 1988-03-20 | 1998-07-23 | 財団法人阪大微生物病研究会 | 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体 |
EP0431668B1 (en) | 1989-12-04 | 1995-02-15 | Akzo Nobel N.V. | Recombinant herpesvirus of turkeys and live vector vaccines derived thereof |
EP0575491B1 (en) | 1991-03-07 | 2003-08-13 | Virogenetics Corporation | Genetically engineered vaccine strain |
BE1004877A3 (fr) | 1991-05-27 | 1993-02-16 | Solvay | Virus de l'avipox recombinant, culture de cellules infectees par ce virus et vaccins pour la volaille derives de ce virus. |
US6183753B1 (en) | 1994-08-09 | 2001-02-06 | Schering-Plough Veterinary Corp. | Recombinant chimeric virus and uses thereof |
US5853733A (en) | 1993-02-26 | 1998-12-29 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
FR2719056B1 (fr) | 1994-04-20 | 1996-09-06 | Rhone Merieux | Herpesvirus transformés pour exprimer gD in vitro. |
PT776361E (pt) * | 1994-08-09 | 2007-04-30 | Schering Plough Ltd | Herpesvírus recombinantes de perus e suas utilizações |
RU2059414C1 (ru) * | 1994-12-09 | 1996-05-10 | Государственная Курская биофабрика - Фирма "БИОК" | Поливалентная вакцина для профилактики болезни марека и способ ее изготовления |
FR2728795B1 (fr) * | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire |
JPH104956A (ja) * | 1996-06-21 | 1998-01-13 | Univ Michigan State | マレク病ワクチン製造のための維持可能な細胞株の改良 |
FR2751225B1 (fr) * | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique aviaire |
EP1537877A3 (en) | 1996-10-11 | 2005-08-03 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
EP1026246B1 (en) * | 1997-10-03 | 2006-11-29 | Zeon Corporation | Avian infectious herpesvirus recombinants and recombinant vaccines prepared with the use of the same |
EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
US6299882B1 (en) | 1999-04-09 | 2001-10-09 | Schering Corporation | UL54.5 of Marek's disease virus (MDV) |
KR100354972B1 (ko) | 2000-04-11 | 2002-10-05 | 대한민국 | 닭전염성기관지염 바이러스 s1 단백질을 발현하는유전자재조합 마렉바이러스 및 그의 제조방법 |
US6764684B2 (en) * | 2001-09-28 | 2004-07-20 | Zeon Corporation | Avian herpesvirus-based recombinant infectious bursal disease vaccine |
US6866852B2 (en) * | 2002-01-31 | 2005-03-15 | Zeon Corporation | Recombinant herpesvirus of turkeys and use thereof |
KR100801180B1 (ko) * | 2006-09-26 | 2008-02-05 | 주식회사 고려비엔피 | 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신 |
EP2419132B1 (en) * | 2009-04-15 | 2014-06-25 | Ceva Sante Animale | Recombinant avian herpes virus vectors and vaccine for immunizing waterfowl species |
PE20141482A1 (es) | 2011-11-30 | 2014-11-08 | Merial Ltd | Vectores recombinantes de hvt que expresan antigenos de patogenos de aves y sus usos |
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