BR112017013595A2 - cassete de expressão de dna recombinante, molécula de dna recombinante, vírus herpes de peru recombinante, célula hospedeira, métodos para construção de um vírus herpes de peru recombinante, para preparação de uma vacina, para prevenir ou reduzir infecção por vírus da doença bursal infecciosa e/ou vírus da doença de newcastle ou sinais associados de doença e para vacinação das aves, vacina para aves, e, usos de um cassete de expressão e de uma vacina. - Google Patents

cassete de expressão de dna recombinante, molécula de dna recombinante, vírus herpes de peru recombinante, célula hospedeira, métodos para construção de um vírus herpes de peru recombinante, para preparação de uma vacina, para prevenir ou reduzir infecção por vírus da doença bursal infecciosa e/ou vírus da doença de newcastle ou sinais associados de doença e para vacinação das aves, vacina para aves, e, usos de um cassete de expressão e de uma vacina.

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Publication number
BR112017013595A2
BR112017013595A2 BR112017013595A BR112017013595A BR112017013595A2 BR 112017013595 A2 BR112017013595 A2 BR 112017013595A2 BR 112017013595 A BR112017013595 A BR 112017013595A BR 112017013595 A BR112017013595 A BR 112017013595A BR 112017013595 A2 BR112017013595 A2 BR 112017013595A2
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BR
Brazil
Prior art keywords
vaccine
recombinant
bird
expression cassette
virus
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BR112017013595A
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English (en)
Inventor
Verstegen Iwan
Vermeij Paul
Jacobus Antonius Sondermeijer Paulus
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Intervet Int Bv
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52282550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112017013595(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of BR112017013595A2 publication Critical patent/BR112017013595A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Abstract

a presente invenção se refere a uma vacina de nd-ibd vetorizada com hvt nova e melhorada compreendendo um hvt recombinante compreendendo o gene vp2 de ibdv e o gene f de ndv a um alvo animal. o hvt recombinante pode ser usado em uma vacina para aves, que apresenta boa replicação viral do vetor, efetiva expressão do gene f de ndv e vp2 de ibdv, imunoproteção melhorada contra nd e ibd e estabilidade genética melhorada sobre os construtos do estado da técnica.
BR112017013595A 2014-12-24 2015-12-23 cassete de expressão de dna recombinante, molécula de dna recombinante, vírus herpes de peru recombinante, célula hospedeira, métodos para construção de um vírus herpes de peru recombinante, para preparação de uma vacina, para prevenir ou reduzir infecção por vírus da doença bursal infecciosa e/ou vírus da doença de newcastle ou sinais associados de doença e para vacinação das aves, vacina para aves, e, usos de um cassete de expressão e de uma vacina. BR112017013595A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14200340 2014-12-24
PCT/EP2015/081121 WO2016102647A1 (en) 2014-12-24 2015-12-23 Improved hvt-vectored nd-ibd vaccine

Publications (1)

Publication Number Publication Date
BR112017013595A2 true BR112017013595A2 (pt) 2018-03-06

Family

ID=52282550

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017013595A BR112017013595A2 (pt) 2014-12-24 2015-12-23 cassete de expressão de dna recombinante, molécula de dna recombinante, vírus herpes de peru recombinante, célula hospedeira, métodos para construção de um vírus herpes de peru recombinante, para preparação de uma vacina, para prevenir ou reduzir infecção por vírus da doença bursal infecciosa e/ou vírus da doença de newcastle ou sinais associados de doença e para vacinação das aves, vacina para aves, e, usos de um cassete de expressão e de uma vacina.

Country Status (12)

Country Link
US (1) US10308956B2 (pt)
EP (1) EP3185899B1 (pt)
JP (1) JP6246985B1 (pt)
CN (1) CN107002097B (pt)
AR (1) AR103245A1 (pt)
BR (1) BR112017013595A2 (pt)
ES (1) ES2648672T3 (pt)
HU (1) HUE035364T2 (pt)
MX (1) MX2017008504A (pt)
PL (1) PL3185899T3 (pt)
RU (1) RU2692013C2 (pt)
WO (1) WO2016102647A1 (pt)

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HUE061405T2 (hu) 2016-06-17 2023-06-28 Intervet Int Bv Nem patogén Marek-betegség vírus konstruktok, amelyek fertõzõ laryngotracheitis vírus és fertõzõ bursitis vírus antigéneket kódolnak
EP3554536B1 (en) 2016-12-14 2022-10-26 Boehringer Ingelheim Animal Health USA Inc. Recombinant hvt vectors expressing multiple antigens of avian pathogens, and vaccines comprising them
CN107099513B (zh) * 2017-06-22 2020-07-14 北京邦卓生物科技有限公司 一种共表达ndv hn和ibdv vp2基因的hvt的构建及其应用
WO2019072964A1 (en) 2017-10-12 2019-04-18 Intervet International B.V. RECOMBINANT NON-PATHOGENIC MAREK DISEASE VIRUS CONSTRUCTS ENCODING MULTIPLE HETEROLOGOUS ANTIGENS
JP7448475B2 (ja) 2017-12-20 2024-03-12 インターベット インターナショナル ベー． フェー． 細胞関連アルファヘルペスウイルスワクチン用の改善された希釈液
CN109320594B (zh) * 2018-11-13 2021-09-28 四川大学 一种禽传染性支气管炎和新城疫的病毒样颗粒、制备方法及应用
CN110331135A (zh) * 2019-07-18 2019-10-15 扬州大学 表达基因vii型新城疫病毒融合蛋白的重组火鸡疱疹病毒候选疫苗株及制备方法
EP4028510A1 (en) 2019-09-11 2022-07-20 Zoetis Services LLC Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof
BR112022010825A2 (pt) 2019-12-20 2022-08-23 Intervet Int Bv Vacina de vetor hvt multivalente
BR112022025733A2 (pt) 2020-06-17 2023-03-07 Boehringer Ingelheim Vetmedica Gmbh Vetores hvt recombinantes expressando hemaglutinina de influenza e composições imunogênicas, e produção e usos dos mesmos
JP2023539771A (ja) 2020-09-07 2023-09-19 インターベット インターナショナル ベー． フェー． Ｈａ抗体陽性ターゲットのためのｈａステムワクチン
CN112501139B (zh) * 2020-12-11 2023-03-21 新乡学院 一株重组新城疫病毒毒株及其制备方法和应用
WO2022136623A1 (en) 2020-12-24 2022-06-30 Intervet International B.V. Multivalent hvt vector vaccine
WO2023213946A1 (en) 2022-05-05 2023-11-09 Intervet International B.V. New multivalent hvt vector vaccine

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Also Published As

Publication number Publication date
WO2016102647A1 (en) 2016-06-30
US20170306353A1 (en) 2017-10-26
RU2017126030A (ru) 2019-01-24
AR103245A1 (es) 2017-04-26
ES2648672T3 (es) 2018-01-05
CN107002097B (zh) 2021-06-15
EP3185899A1 (en) 2017-07-05
MX2017008504A (es) 2017-10-11
RU2692013C2 (ru) 2019-06-19
JP6246985B1 (ja) 2017-12-13
US10308956B2 (en) 2019-06-04
RU2017126030A3 (pt) 2019-01-24
JP2018501792A (ja) 2018-01-25
CN107002097A (zh) 2017-08-01
HUE035364T2 (en) 2018-05-02
EP3185899B1 (en) 2017-10-18
PL3185899T3 (pl) 2018-01-31

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