RU2017126030A - Улучшенная вакцина против nd-ibd на основе вектора hvt - Google Patents

Улучшенная вакцина против nd-ibd на основе вектора hvt Download PDF

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RU2017126030A
RU2017126030A RU2017126030A RU2017126030A RU2017126030A RU 2017126030 A RU2017126030 A RU 2017126030A RU 2017126030 A RU2017126030 A RU 2017126030A RU 2017126030 A RU2017126030 A RU 2017126030A RU 2017126030 A RU2017126030 A RU 2017126030A
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ndv
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Иван ВЕРСТЕГЕН
Паулус Якобус Антониус СОНДЕРМЕЙЕР
Пауль ВЕРМЭЙ
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Интервет Интернэшнл Б.В.
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Claims (22)

1. Экспрессирующая кассета рекомбинантной ДНК, содержащая в направлении от 5' к 3' и в указанном порядке:
промотор предраннего гена 1 цитомегаловируса мыши (IE1 mCMV),
ген вирусного белка 2 (VP2) вируса инфекционного бурсита (IBDV),
терминатор транскрипции,
промотор предраннего гена 1 цитомегаловируса человека (IE1 hCMV),
ген белка слияния (F) вируса болезни Ньюкасла (NDV).
2. Экспрессирующая кассета рекомбинантной ДНК по п.1, где одно, или несколько, или все из используемых условий выбраны из группы, состоящей из следующего: промотор гена IE1 mCMV представляет собой полный промотор; ген VP2 IBDV кодирует белок VP2 IBDV классического типа; терминатор транскрипции содержит область терминатора и область поли-A; терминатор транскрипции получают из вируса обезьян 40 (SV40); промотор гена IE1 hCMV представляет собой основной промотор; ген F NDV получают из лентогенного штамма NDV; экспрессирующая кассета содержит дополнительный терминатор транскрипции, расположенный ниже гена F NDV; и дополнительный терминатор транскрипции получают из гена IE1 hCMV.
3. Молекула рекомбинантной ДНК, содержащая экспрессирующую кассету рекомбинантной ДНК по любому из пп. 1 или 2.
4. Рекомбинантный вирус герпеса индеек (HVT), содержащий экспрессирующую кассету рекомбинантной ДНК по любому из пп. 1 или 2, где экспрессирующая кассета вставлена в область US генома рекомбинантного HVT.
5. Клетка-хозяин, содержащая рекомбинантный HVT по п.4.
6. Способ конструирования рекомбинантного HVT по п.4, где указанный способ включает вставку экспрессирующей кассеты рекомбинантной ДНК по любому из пп. 1 или 2 в область US генома рекомбинантного HVT.
7. Вакцина для домашней птицы, содержащая рекомбинантный HVT по п.4 и/или клетку-хозяина по п.5 и фармацевтически приемлемый носитель.
8. Вакцина по п.7, содержащая по меньшей мере один дополнительный иммуноактивный компонент.
9. Способ получения вакцины по п.7, включающий стадии:
- инфицирования клеток-хозяев рекомбинантным HVT по п.4,
- сбора инфицированных клеток-хозяев и
- смешивания собранных инфицированных клеток-хозяев с фармацевтически приемлемым носителем.
10. Рекомбинантный HVT по п.4 для применения в вакцине для домашней птицы.
11. Применение экспрессирующей кассеты по любому из пп. 1 или 2, молекулы рекомбинантной ДНК по п.3, рекомбинантного HVT по п.4, клетки-хозяина по п.5 или любого их сочетания для получения вакцины для домашней птицы.
12. Применение вакцины по любому из пп. 7 или 8 для профилактики или снижения инфекции IBDV и/или NDV или ассоциированных симптомов заболевания.
13. Способ профилактики или снижения инфекции IBDV и/или NDV или ассоциированных симптомов заболевания, включающий введение домашней птице вакцины по любому из пп. 7 или 8.
14. Способ вакцинации домашней птицы, включающий стадию вакцинации указанной домашней птицы вакциной по любому из пп. 7 или 8.
RU2017126030A 2014-12-24 2015-12-23 Улучшенная вакцина против nd-ibd на основе вектора hvt RU2692013C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14200340 2014-12-24
EP14200340.9 2014-12-24
PCT/EP2015/081121 WO2016102647A1 (en) 2014-12-24 2015-12-23 Improved hvt-vectored nd-ibd vaccine

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RU2017126030A3 RU2017126030A3 (ru) 2019-01-24
RU2017126030A true RU2017126030A (ru) 2019-01-24
RU2692013C2 RU2692013C2 (ru) 2019-06-19

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JP (1) JP6246985B1 (ru)
CN (1) CN107002097B (ru)
AR (1) AR103245A1 (ru)
BR (1) BR112017013595A2 (ru)
ES (1) ES2648672T3 (ru)
HU (1) HUE035364T2 (ru)
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IL299033A (en) 2020-06-17 2023-02-01 Boehringer Ingelheim Vetmedica Gmbh Recombinant HVT vectors expressing influenza hemagglutinin and immunogenic compounds, production and uses thereof
BR112023004123A2 (pt) 2020-09-07 2023-04-04 Intervet Int Bv Vacina de haste da ha para alvos positivos de anticorpos de ha
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