HRP20171902T1 - Farmaceutski oblik za doziranje za oralnu primjenu inhibitora iz obitelji bcl-2 - Google Patents
Farmaceutski oblik za doziranje za oralnu primjenu inhibitora iz obitelji bcl-2 Download PDFInfo
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- HRP20171902T1 HRP20171902T1 HRP20171902TT HRP20171902T HRP20171902T1 HR P20171902 T1 HRP20171902 T1 HR P20171902T1 HR P20171902T T HRP20171902T T HR P20171902TT HR P20171902 T HRP20171902 T HR P20171902T HR P20171902 T1 HRP20171902 T1 HR P20171902T1
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (18)
1. Farmaceutski oblik za doziranje koji sadržava proizvod u obliku čvrste disperzije koji sadržava farmaceutski aktivni sastojak, najmanje jedan farmaceutski prihvatljiv polimer koji sadržava homopolimer ili kopolimer N-vinil pirolidona i najmanje jedan farmaceutski prihvatljiv solubilizator koji sadržava tokoferilni spoj s polialkilen glikolnom skupinom, naznačen time, da je navedeni farmaceutski aktivni sastojak N-(4-(4-((2-(4-klorfenil) -5,5-dimetil-l-cikloheks-l-en-l-il)metil)piperazin-l-il)benzoil)-4-(((lR)-3-(morfolin-4-il)-l-((fenilsulfanil)metil)propil)amino)-3-((trifluorometil)sulfonil)benzensulfonamid ili njegova sol ili hidrat.
2. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da farmaceutski prihvatljivo otapalo sadržava alfa tokoferil polietilen glikol sukcinat.
3. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da sadržava nehlapljivo otapalo za farmaceutski aktivni sastojak, a navedeno otapalo je tekućina pri sobnoj temperaturi.
4. Oblik za doziranje u skladu s patentnim zahtjevom 3, naznačen time, da je navedeno nehlapljivo otapalo propilen glikol.
5. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da je navedeni farmaceutski prihvatljiv polimer kopolimer N-vinilpirolidona i vinil acetata.
6. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da je navedeni farmaceutski aktivni sastojak odabran iz skupine koju čine slobodna baza, natrijeva sol i dihidrokloridna sol N-(4-(4- ((2-(4- klorfenil) -5,5-dimetil-l-cikloheks-l-en- 1-il) metil )piperazin-l-il )benzoil)-4-((( lR)-3-( morfolin-4-il)-1- ((fenil sulfanil) metil)propil)amino)-3-((trifluorometil)sulfonil)benzensulfonamida i njihove kombinacije.
7. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da sadržava najmanje jedan aditiv odabran između regulatora protoka, sredstava za raspršivanje, punila i maziva.
8. Oblik za doziranje u skladu s patentnim zahtjevom 7, naznačen time, da sadržava regulator protoka, a regulator protoka sadržava koloidni silicijev dioksid.
9. Oblik za doziranje u skladu s patentnim zahtjevom 7, naznačen time, da sadržava sredstvo za raspršivanje, a sredstvo za raspršivanje sadržava umreženu natrijevu karboksimetil celulozu.
10. Oblik za doziranje u skladu s patentnim zahtjevom 7, naznačen time, da sadržava lubrikant, a lubrikant sadržava natrij stearil fumarat.
11. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da kruti disperzijski proizvod sadržava od oko 0,5 do 40 % težinskih udjela farmaceutski aktivnog sastojka, 40 do 97,5 % težinskih udjela navedenog barem jednog farmaceutski prihvatljivog polimera, 2 do 20 % težinskih udjela navedenog najmanje jednog solubilizatora i 0 do 15 % težinskih udjela aditiva.
12. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da sadržava manje od 1,5 % težinskih udjela sulfoksidnih produkata raspadanja aktivnog sastojka, u odnosu na težinu aktivnog sastojka ili manje od 1,2 % težinskih udjela sulfoksidnih produkata raspadanja aktivnog sastojka, u odnosu na težinu aktivnog sastojka ili manje od 0,9 % težinskih udjela sulfoksidnih proizvoda raspadanja aktivnog sastojka, u odnosu na težinu aktivnog sastojka.
13. Oblik za doziranje u skladu s patentnim zahtjevom 1, naznačen time, da je smjesa dobivena taljenjem i skrućivanjem.
14. Oblik za doziranje u skladu s patentnim zahtjevom 1, za uporabu u postupku liječenja proliferacijskog poremećaja, naznačen time, da uključuje oblik za doziranje u skladu s patentnim zahtjevom 1 subjektu kojem je to potrebno.
15. Oblik za doziranje za uporabu u skladu s patentnim zahtjevom 14, naznačen time, da je proliferativni poremećaj odabran između tumora i karcinoma.
16. Oblik za doziranje za uporabu u skladu s patentnim zahtjevom 15, naznačen time, da je proliferativni poremećaj odabran iz skupine koju čine mezoteliom, rak mjehura, rak gušterače, rak kože, rak glave ili vrata, kožni ili intraokularni melanom, rak jajnika, rak dojke, rak maternice, rak jajovoda, rak endometrija, rak grlića maternice, rak vagine, rak vulve, rak kostiju, rak grlića maternice, rak debelog crijeva, rak rektuma, rak analnog područja, rak želuca, gastrointestinalni rak (rak želuca, kolorektalni rak i rak dvanaesnika), kronična limfocitna leukemija, akutna limfocitna leukemija, rak jednjaka, rak tankog crijeva, rak endokrinog sustava, rak tiroidne žlijezde, rak paratiroidne žlijezde, rak nadbubrežne žlijezde, sarkom mekog tkiva, rak uretre, rak penisa, rak testisa, hepatocelularni rak (jetre i žučnih kanala), primarni ili sekundarni tumor centralnog živčanog sustava, primarni ili sekundarni tumor mozga, Hodgkinova bolest, kronična ili akutna leukemija, kronična mijeloična leukemija, limfocitni limfom, limfoblastična leukemija, folikularni limfom, limfoidne maligne bolesti uzrokovane T-stanicama ili B-stanicama, melanom, višestruki mijelom, rak usne šupljine, rak jajnika, rak ne-malih stanica pluća, rak prostate, rak malih stanica pluća, rak bubrega i mokraćovoda, rak bubrežnih stanica, rak bubrežne čašice, neoplazam središnjeg živčanog sustava, primarni limfom centralnog živčanog sustava, ne-Hodgkinov limfom, tumori spinalne osi, gliom moždanog stabla, adenom hipofize, rak ovojnice nadbubrežne žlijezde, rak žučnog mjehura, rak slezene, kolangiokarcinom, fibrosarkom, neuroblastom, retinoblastom i njihove kombinacije.
17. Postupak za pripravu farmaceutskog oblika doziranja koji sadržava proizvod u obliku čvrste disperzije u skladu s patentnim zahtjevom 1, naznačen time, da obuhvaća: (a) pripremu homogene taline farmaceutski aktivnog sastojka ili njegove soli ili hidrata, najmanje jednog farmaceutski prihvatljivog polimera koji sadržava homopolimer ili kopolimer N-vinil pirolidona i najmanje jedan solubilizator koji sadržava tokoferilni spoj s polialkilen glikolnom skupinom, navedeni farmaceutski aktivni sastojak je N-(4-(4-((2-(4-klorfenil)-5,5- dimetil-l-cikloheks-l-en-l-il)metil)piperazin-l-il)benzoil)-4-(((lR)-3-(morfolin-4-il)-l-((fenilsulfanil)metil)propil)amino)-3-((trifluorometil)sulfonil)benzensulfonamid ili njegova sol ili hidrat i (b) ostavljanje taline da se skrutne kako bi se dobio kruti disperzijski produkt.
18. Postupak u skladu s patentnim zahtjevom 17, naznačen time, da nadalje obuhvaća mljevenje navedenog proizvoda u obliku čvrste disperzije i komprimiranje navedenog proizvoda u obliku čvrste disperzije u tabletu ili punjenje navedenog krutog disperzijskog produkta u čahuru kapsule.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18513009P | 2009-06-08 | 2009-06-08 | |
| EP15184904.9A EP2982366B1 (en) | 2009-06-08 | 2010-06-08 | Pharmaceutical dosage form for oral administration of a bcl-2 family inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171902T1 true HRP20171902T1 (hr) | 2018-01-26 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151342TT HRP20151342T1 (hr) | 2009-06-08 | 2010-06-08 | Farmaceutski oblik doziranja za oralnu primjenu inhibitora iz obitelji bcl-2 |
| HRP20171902TT HRP20171902T1 (hr) | 2009-06-08 | 2017-12-07 | Farmaceutski oblik za doziranje za oralnu primjenu inhibitora iz obitelji bcl-2 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151342TT HRP20151342T1 (hr) | 2009-06-08 | 2010-06-08 | Farmaceutski oblik doziranja za oralnu primjenu inhibitora iz obitelji bcl-2 |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US9642796B2 (hr) |
| EP (3) | EP3272334B1 (hr) |
| JP (2) | JP5872459B2 (hr) |
| KR (2) | KR101751216B1 (hr) |
| CN (2) | CN102802606A (hr) |
| AR (2) | AR077021A1 (hr) |
| AU (1) | AU2010258367B2 (hr) |
| BR (2) | BR122018076978B1 (hr) |
| CA (1) | CA2763441C (hr) |
| CL (1) | CL2011003054A1 (hr) |
| CO (1) | CO6480964A2 (hr) |
| CR (1) | CR20170037A (hr) |
| CY (1) | CY1119663T1 (hr) |
| DK (2) | DK2982366T3 (hr) |
| DO (2) | DOP2011000375A (hr) |
| EC (1) | ECSP12011580A (hr) |
| ES (2) | ES2551860T3 (hr) |
| HR (2) | HRP20151342T1 (hr) |
| HU (2) | HUE035727T2 (hr) |
| IL (2) | IL216494A (hr) |
| LT (1) | LT2982366T (hr) |
| MX (1) | MX2011013164A (hr) |
| MY (1) | MY159824A (hr) |
| NO (1) | NO2982366T3 (hr) |
| NZ (1) | NZ597241A (hr) |
| PE (2) | PE20121084A1 (hr) |
| PL (2) | PL2440177T3 (hr) |
| PT (2) | PT2982366T (hr) |
| RU (2) | RU2568599C2 (hr) |
| SG (1) | SG176264A1 (hr) |
| SI (2) | SI2982366T1 (hr) |
| SM (1) | SMT201500317B (hr) |
| TW (2) | TWI471321B (hr) |
| UA (1) | UA104471C2 (hr) |
| UY (1) | UY32695A (hr) |
| WO (1) | WO2010143074A2 (hr) |
| ZA (1) | ZA201108853B (hr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI471321B (zh) | 2009-06-08 | 2015-02-01 | 亞培公司 | Ｂｃｌ－２族群抑制劑之口服醫藥劑型 |
| BR112012031516A2 (pt) | 2010-06-09 | 2016-11-08 | Abbott Lab | dispersões sólidas contendo inibidores de quinase |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| CA2811805A1 (en) * | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| CN107266435A (zh) | 2010-11-23 | 2017-10-20 | Abbvie 公司 | 细胞凋亡诱导剂的盐和晶形 |
| SG190399A1 (en) | 2010-11-23 | 2013-06-28 | Abbvie Inc | Methods of treatment using selective bcl-2 inhibitors |
| KR102191562B1 (ko) * | 2012-11-07 | 2020-12-15 | 에스케이바이오팜 주식회사 | 난용성 약물의 고체분산체 및 이의 제조방법 |
| WO2014160071A1 (en) * | 2013-03-14 | 2014-10-02 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US10111897B2 (en) | 2013-10-03 | 2018-10-30 | Duke University | Compositions and methods for treating cancer with JAK2 activity |
| EA201691827A1 (ru) * | 2014-03-12 | 2017-01-30 | Новартис Аг | Конкретные участки для модификации антител с целью получения иммуноконъюгатов |
| CA2942186C (en) * | 2014-06-18 | 2023-06-27 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition comprising non-ionic surfactants |
| CN105616419A (zh) * | 2014-11-07 | 2016-06-01 | 江苏豪森药业集团有限公司 | 含有细胞周期蛋白抑制剂固体分散体的药物组合物及其制备方法 |
| BR112018069530B1 (pt) | 2016-02-29 | 2021-02-17 | F. Hoffmann-La Roche Ag | composições de forma de dosagem que compreendem um inibidor da tirosina quinase de bruton |
| JOP20190191A1 (ar) | 2017-02-22 | 2019-08-08 | Astrazeneca Ab | وحدات شجرية علاجية |
| US11872237B2 (en) * | 2018-12-28 | 2024-01-16 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition and preparation method thereof |
| US11285159B2 (en) | 2019-11-05 | 2022-03-29 | Abbvie Inc. | Dosing regimens for use in treating myelofibrosis and MPN-related disorders with navitoclax |
| CN115484933A (zh) * | 2020-02-24 | 2022-12-16 | 广州麓鹏制药有限公司 | 含有bcl2抑制剂的热熔挤出固体分散体 |
| EP4251137A4 (en) * | 2020-11-25 | 2024-10-16 | Ascentage Pharma (Suzhou) Co., Ltd. | SOLID DISPERSION, PHARMACEUTICAL PREPARATIONS, MANUFACTURING PROCESSES AND USE THEREOF |
| CA3203995A1 (en) * | 2021-01-08 | 2022-07-14 | David A. Roth | Treatment regimens with fixed doses of tamibarotene |
| CN113520995B (zh) * | 2021-08-16 | 2023-03-10 | 海南鑫开源医药科技有限公司 | 一种离子敏感型眼用原位凝胶、其制备方法及应用 |
| TW202345857A (zh) * | 2022-03-08 | 2023-12-01 | 美商昂科斯克塞爾醫療有限責任公司 | 他波司他之穩定調配物 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665379A (en) * | 1990-09-28 | 1997-09-09 | Pharmacia & Upjohn Aktiebolag | Lipid particle forming matrix, preparation and use thereof |
| GB9309509D0 (en) * | 1993-05-07 | 1993-06-23 | Merck Patent Gmbh | Thrombin inhibitors |
| IL111004A (en) * | 1993-09-30 | 1998-06-15 | American Home Prod | Oral formulations of rapamycin |
| US5536729A (en) * | 1993-09-30 | 1996-07-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
| AU692506B2 (en) * | 1993-11-17 | 1998-06-11 | Ibah, Inc. | Transparent liquid for encapsulated drug delivery |
| US5759548A (en) * | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| US5538737A (en) * | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
| BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
| US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
| US5891469A (en) | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
| BE1011899A6 (fr) * | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| DE19913692A1 (de) | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
| DE19929361A1 (de) | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
| US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| US6982281B1 (en) * | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
| US20060183776A9 (en) * | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
| US20020055631A1 (en) * | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
| UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| CN1527830A (zh) * | 2001-01-31 | 2004-09-08 | �Ʒ� | 用作pde4同工酶的抑制剂的醚衍生物 |
| GB0123400D0 (en) * | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| JP4598399B2 (ja) * | 2002-02-04 | 2010-12-15 | エラン ファーマ インターナショナル，リミティド | 表面安定剤としてリゾチームを有するナノ粒子組成物 |
| MY135609A (en) * | 2002-02-26 | 2008-05-30 | Astrazeneca Ab | Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative |
| MY129850A (en) * | 2002-04-29 | 2007-05-31 | Merck Sharp & Dohme | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| US20060177430A1 (en) * | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
| US8025899B2 (en) * | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US20050048112A1 (en) | 2003-08-28 | 2005-03-03 | Jorg Breitenbach | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US7973161B2 (en) * | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| US7790190B2 (en) | 2004-03-20 | 2010-09-07 | Yasoo Health, Inc. | Aqueous emulsions of lipophile solubilized with vitamin E TPGS and linoleic acid |
| US7318503B2 (en) * | 2004-04-26 | 2008-01-15 | Akebono Corporation (North America) | Pad retaining clips |
| FR2875409B1 (fr) * | 2004-09-17 | 2010-05-07 | Sanofi Aventis | Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose |
| PT1888550E (pt) | 2005-05-12 | 2014-09-03 | Abbvie Bahamas Ltd | Promotores de apoptose |
| CN1706371B (zh) | 2005-05-27 | 2010-11-10 | 沈阳药科大学 | 一种高效的马蔺子素制剂及其制备方法 |
| CN101325944B (zh) | 2005-10-11 | 2013-01-16 | 耶路撒冷希伯来大学伊萨姆研究开发公司 | 用于鼻部给药的组合物 |
| CA2626579A1 (en) * | 2005-10-25 | 2007-05-03 | Abbott Laboratories | Formulation comprising a drug of low water solubility and method of use thereof |
| US7151188B1 (en) | 2005-11-16 | 2006-12-19 | General Electric Company | Process for the production of mercaptoalkylalkoxysilanes |
| US20080085313A1 (en) * | 2006-05-15 | 2008-04-10 | Given Bruce D | Methods and compositions for treatment of sleep apnea |
| EP2037919A2 (en) * | 2006-06-30 | 2009-03-25 | Schering Corporation | Method of using substituted piperidines that increase p53 activity |
| EP1880715A1 (en) | 2006-07-19 | 2008-01-23 | Abbott GmbH & Co. KG | Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same |
| EP2061560A2 (en) * | 2006-09-05 | 2009-05-27 | Abbott Laboratories | Bcl inhibitors for treating platelet excess |
| US20080182845A1 (en) * | 2006-11-16 | 2008-07-31 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
| RU2351352C2 (ru) | 2007-04-09 | 2009-04-10 | Закрытое акционерное общество "Санкт-Петербургский институт фармации" | Твердая нанокомпозиция для доставки биологически активных веществ |
| US8536157B2 (en) | 2007-04-13 | 2013-09-17 | The University Of Melbourne | Non-steroidal compounds |
| EP3424525A1 (en) * | 2007-10-12 | 2019-01-09 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| MX2010006260A (es) * | 2007-12-06 | 2010-08-23 | Abbott Lab | Composiciones orales de abt-263 para tratar cancer. |
| CN101220008B (zh) | 2008-01-21 | 2011-04-27 | 中国科学院广州生物医药与健康研究院 | 化合物abt-263的合成方法 |
| US8168784B2 (en) * | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| US20100280031A1 (en) | 2009-04-30 | 2010-11-04 | Paul David | Lipid formulation of apoptosis promoter |
| US20100297194A1 (en) * | 2009-04-30 | 2010-11-25 | Nathaniel Catron | Formulation for oral administration of apoptosis promoter |
| US8728516B2 (en) | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
| US8362013B2 (en) * | 2009-04-30 | 2013-01-29 | Abbvie Inc. | Salt of ABT-263 and solid-state forms thereof |
| US20100278921A1 (en) * | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
| US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI471321B (zh) | 2009-06-08 | 2015-02-01 | 亞培公司 | Ｂｃｌ－２族群抑制劑之口服醫藥劑型 |
| TWI532484B (zh) | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
| AU2010260226A1 (en) * | 2009-06-18 | 2012-02-02 | Abbvie Inc. | Stable nanoparticulate drug suspension |
| CN105820138A (zh) | 2009-09-20 | 2016-08-03 | Abbvie 公司 | 用于治疗bcl-2蛋白相关疾病的abt-263晶体形式和溶剂化物 |
| JP5779591B2 (ja) | 2009-12-22 | 2015-09-16 | アッヴィ・インコーポレイテッド | Ａｂｔ−２６３カプセル剤 |
| CN101798292A (zh) | 2010-03-29 | 2010-08-11 | 无锡好芳德药业有限公司 | ABT-263衍生的新型Bcl-2蛋白抑制剂的制备 |
| JP6095678B2 (ja) | 2011-11-11 | 2017-03-15 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | 薬剤パッケージ用の不動態化、ｐＨ保護又は滑性皮膜、被覆プロセス及び装置 |
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