HRP20171703T1 - Predfuzijski antigeni rsv f - Google Patents
Predfuzijski antigeni rsv f Download PDFInfo
- Publication number
- HRP20171703T1 HRP20171703T1 HRP20171703TT HRP20171703T HRP20171703T1 HR P20171703 T1 HRP20171703 T1 HR P20171703T1 HR P20171703T T HRP20171703T T HR P20171703TT HR P20171703 T HRP20171703 T HR P20171703T HR P20171703 T1 HRP20171703 T1 HR P20171703T1
- Authority
- HR
- Croatia
- Prior art keywords
- rsv
- fusion polypeptide
- polypeptide according
- fusion
- cysteine residue
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 230000004927 fusion Effects 0.000 claims 9
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 4
- 101100107610 Arabidopsis thaliana ABCF4 gene Proteins 0.000 claims 2
- 101100068078 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GCN4 gene Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- -1 benzonaphthyridine compound Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000006384 oligomerization reaction Methods 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000005829 trimerization reaction Methods 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- 108091000126 Dihydroorotase Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 230000000091 immunopotentiator Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (12)
1. Predfuzijski polipeptid F iz respiratornog sincicijskog virusa (RSV), naznačen time što područje HRA, ostaci 137-239 iz referentnog proteina RSV F sa SEQ ID NO:1, sadrži ubačeni cisteinski ostatak, te što područje DIII, ostaci 51-98 i 206-308 iz referentnog proteina RSV F sa SEQ ID NO:1, sadrži ubačeni cisteinski ostatak, gdje se formira disulfidna veza između ubačenog cisteinskog ostatka u području HRA i ubačenog cisteinskog ostatka u području DIII, koja stabilizira predfuzijski polipeptid RSV F.
2. Predfuzijski polipeptid RSV F u skladu s patentnim zahtjevom 1, naznačen time što su navedene cisteinske mutacije međusobno udaljene otprilike 10 Å.
3. Predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnim zahtjevom 1 ili 2, naznačen time što je predfuzijski polipeptid RSV F topljiva ektodomena RSV F.
4. Predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što dodatno sadrži heterolognu oligomerizacijsku domenu, epitop ili signalni peptid.
5. Predfuzijski polipeptid RSV F u skladu s patentnim zahtjevom 4, naznačen time što je navedena heterologna oligomerizacijska domena trimerizacijska domena.
6. Predfuzijski polipeptid RSV F u skladu s patentnim zahtjevom 5, naznačen time što se trimerizacijsku domenu bira između hemaglutinina iz virusa influence, SARS šiljka, HIV gp41, NadA, modificiranog GCN4, GCN4 ili ATCaze.
7. Imunogeni pripravak, naznačen time što sadrži predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnih zahtjeva 1 do 6 i, izborno, adjuvans.
8. Imunogeni pripravak u skladu s patentnim zahtjevom 7, naznačen time što se adjuvans bira iz skupine koju čine: aluminijeva sol, emulzija skvalena u vodi, benzonaftiridinski spoj, fosfolipidni spoj, niskomolekulski imunopotencijator i kombinacije bilo kojeg od gore navedenog.
9. Izolirana nukleinska kiselina, naznačena time što kodira predfuzijski polipeptid RSV F u skladu s bilo kojim od patentnih zahtjeva 1 do 6.
10. Izolirana nukleinska kiselina u skladu s patentnim zahtjevom 9, naznačena time što je samoreplicirajuća molekula RNA.
11. Imunogeni pripravak, naznačen time što sadrži samoreplicirajuću molekulu RNA u skladu s patentnim zahtjevom 10 i, izborno, sustav za unos RNA.
12. Imunogeni pripravak u skladu s patentnim zahtjevom 7, 8 ili 11, naznačen time što je namijenjen upotrebi kao medikament.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486005P | 2011-05-13 | 2011-05-13 | |
| PCT/US2012/037773 WO2012158613A1 (en) | 2011-05-13 | 2012-05-14 | Pre-fusion rsv f antigens |
| EP12722057.2A EP2707385B1 (en) | 2011-05-13 | 2012-05-14 | Pre-fusion rsv f antigens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171703T1 true HRP20171703T1 (hr) | 2017-12-15 |
Family
ID=46124783
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171703TT HRP20171703T1 (hr) | 2011-05-13 | 2017-11-08 | Predfuzijski antigeni rsv f |
| HRP20200451TT HRP20200451T1 (hr) | 2011-05-13 | 2020-03-18 | Predfuzijski antigeni f iz rsv |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200451TT HRP20200451T1 (hr) | 2011-05-13 | 2020-03-18 | Predfuzijski antigeni f iz rsv |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US20140248314A1 (hr) |
| EP (2) | EP2707385B1 (hr) |
| JP (1) | JP2014519819A (hr) |
| CN (1) | CN103842374A (hr) |
| AU (1) | AU2012255971A1 (hr) |
| BR (1) | BR112013029169B1 (hr) |
| CA (1) | CA2835644C (hr) |
| CY (2) | CY1119849T1 (hr) |
| DK (2) | DK3275892T3 (hr) |
| ES (2) | ES2651143T3 (hr) |
| FR (1) | FR23C1046I1 (hr) |
| HR (2) | HRP20171703T1 (hr) |
| HU (2) | HUE048777T2 (hr) |
| LT (2) | LT2707385T (hr) |
| MX (1) | MX351011B (hr) |
| NO (1) | NO2707385T3 (hr) |
| PL (2) | PL2707385T3 (hr) |
| PT (2) | PT2707385T (hr) |
| RS (1) | RS56748B1 (hr) |
| RU (1) | RU2013155485A (hr) |
| SG (1) | SG194755A1 (hr) |
| SI (2) | SI2707385T1 (hr) |
| WO (1) | WO2012158613A1 (hr) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20220756T1 (hr) | 2009-07-15 | 2022-09-02 | Glaxosmithkline Biologicals S.A. | Proteinski pripravci rsv f i postupci za izradu istih |
| WO2012006369A2 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation of large mammals with low doses of rna |
| HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
| ES2557382T3 (es) | 2010-07-06 | 2016-01-25 | Glaxosmithkline Biologicals Sa | Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN |
| EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| DK4066855T3 (da) | 2010-08-31 | 2023-02-20 | Glaxosmithkline Biologicals Sa | Pegylerede liposomer til forsyning af RNA, der koder for immunogen |
| HRP20220796T1 (hr) | 2010-10-01 | 2022-10-14 | ModernaTX, Inc. | Ribonukleinske kiseline koje sadrže n1-metil-pseudouracil i njihove uporabe |
| TR201903651T4 (tr) | 2010-10-11 | 2019-04-22 | Glaxosmithkline Biologicals Sa | Antijen uygulama platformları. |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US11896636B2 (en) * | 2011-07-06 | 2024-02-13 | Glaxosmithkline Biologicals Sa | Immunogenic combination compositions and uses thereof |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3492109B1 (en) | 2011-10-03 | 2020-03-04 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| RS63244B1 (sr) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Kompozicije modifikovane mrna |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
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| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| WO2014028429A2 (en) | 2012-08-14 | 2014-02-20 | Moderna Therapeutics, Inc. | Enzymes and polymerases for the synthesis of rna |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| MX2015008847A (es) * | 2013-01-10 | 2015-10-30 | Novartis Ag | Composiciones inmunogenicas de virus de influenza y usos de las mismas. |
| WO2014160463A1 (en) * | 2013-03-13 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prefusion rsv f proteins and their use |
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| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| PL403149A1 (pl) * | 2013-03-14 | 2014-09-15 | Celon Pharma Spółka Akcyjna | Nowe związki pochodne pirazolilobenzo[d]imidazolu |
| AU2014239583B2 (en) | 2013-03-14 | 2020-07-02 | Children's Healthcare Of Atlanta, Inc. | Recombinant RSV with silent mutations, vaccines, and methods related thereto |
| US9060975B2 (en) * | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
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| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
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| JP7020917B2 (ja) | 2015-01-20 | 2022-02-16 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | キメラｒｓｖ／ｂｐｉｖ３ ｆタンパクを発現する組換えヒト／ウシパラインフルエンザウイルス３（ｂ／ｈｐｉｖ３）およびその使用 |
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| RU2723039C2 (ru) * | 2015-12-23 | 2020-06-08 | Пфайзер Инк. | Мутанты белка f rsv |
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| KR102506895B1 (ko) | 2016-04-05 | 2023-03-08 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 용해성 융합-전 rsv f 단백질 |
| KR102421049B1 (ko) | 2016-05-30 | 2022-07-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정화된 융합-전 rsv f 단백질 |
| WO2017207477A1 (en) | 2016-05-30 | 2017-12-07 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion rsv f proteins |
| US10842862B2 (en) * | 2016-10-03 | 2020-11-24 | University Of Massachusetts | Methods for immunizing pre-immune subjects against respiratory syncytial virus (RSV) |
| CN106432436A (zh) * | 2016-11-28 | 2017-02-22 | 烟台偌帝生物工程有限公司 | 一种牛呼吸道胞合体病毒抗原蛋白 |
| CN106749556A (zh) * | 2016-11-28 | 2017-05-31 | 烟台偌帝生物工程有限公司 | 一种牛呼吸道胞合体病毒抗原蛋白 |
| CN106749555A (zh) * | 2016-11-28 | 2017-05-31 | 烟台偌帝生物工程有限公司 | 一种牛呼吸道胞合体病毒抗原蛋白 |
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| HRP20220756T1 (hr) | 2009-07-15 | 2022-09-02 | Glaxosmithkline Biologicals S.A. | Proteinski pripravci rsv f i postupci za izradu istih |
| US9405700B2 (en) | 2010-11-04 | 2016-08-02 | Sonics, Inc. | Methods and apparatus for virtualization in an integrated circuit |
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2012
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2021
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2022
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