HRP20161643T1 - Uređaj za transdermalno davanje opioida otporan na zlouporabu - Google Patents
Uređaj za transdermalno davanje opioida otporan na zlouporabu Download PDFInfo
- Publication number
- HRP20161643T1 HRP20161643T1 HRP20161643TT HRP20161643T HRP20161643T1 HR P20161643 T1 HRP20161643 T1 HR P20161643T1 HR P20161643T T HRP20161643T T HR P20161643TT HR P20161643 T HRP20161643 T HR P20161643T HR P20161643 T1 HRP20161643 T1 HR P20161643T1
- Authority
- HR
- Croatia
- Prior art keywords
- copolymers
- transdermal
- transdermal administration
- microspheres
- ethylene
- Prior art date
Links
- 230000037317 transdermal delivery Effects 0.000 title claims abstract 4
- 239000003402 opiate agonist Substances 0.000 claims abstract 4
- 229920000642 polymer Polymers 0.000 claims 9
- 229920001577 copolymer Polymers 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 6
- 239000004005 microsphere Substances 0.000 claims 6
- -1 polyethylene Polymers 0.000 claims 5
- 239000010410 layer Substances 0.000 claims 4
- 239000003401 opiate antagonist Substances 0.000 claims 3
- 229920001296 polysiloxane Polymers 0.000 claims 3
- 229920002367 Polyisobutene Polymers 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 239000012790 adhesive layer Substances 0.000 claims 2
- 229920001971 elastomer Polymers 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920000193 polymethacrylate Polymers 0.000 claims 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 239000004709 Chlorinated polyethylene Substances 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims 1
- 229920002433 Vinyl chloride-vinyl acetate copolymer Polymers 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920000139 polyethylene terephthalate Polymers 0.000 claims 1
- 239000005020 polyethylene terephthalate Substances 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 239000005033 polyvinylidene chloride Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229920006163 vinyl copolymer Polymers 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B3/00—Destroying solid waste or transforming solid waste into something useful or harmless
- B09B3/0075—Disposal of medical waste
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B09—DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
- B09B—DISPOSAL OF SOLID WASTE NOT OTHERWISE PROVIDED FOR
- B09B2101/00—Type of solid waste
- B09B2101/65—Medical waste
- B09B2101/68—Transdermal patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Environmental & Geological Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (9)
1. Uređaj za transdermalno davanje koji sadrži:
sloj polimerne matrice koji sadrži opioidni agonist s međusobno izmiješanim mikrosferama koje sadrže opioidni antagonist, te naznačen time da su mikrosfere u promjeru srednje veličine 1 do 500 µm.
2. Uređaj za transdermalno davanje prema zahtjevu 1, naznačen time da mikrosfere sadrže opioidni antagonist dispergiran u polimernoj matrici.
3. Uređaj za transdermalno davanje prema zahtjevu 1, naznačen time da su mikrosfere u promjeru srednje veličine od 125 do 200 µm, od 50 do 100 µm, od 1 do 200 µm, od 1 do 100 µm, ili od 1 do 300 µm.
4. Uređaj za transdermalno davanje prema bilo kojem od zahtjeva 1 do 3, naznačen time da se opioidni antagonist može osloboditi ako se uređaj za transdermalno davanje žvače, kvasi, buši, trga, ili podvrgava bilo kakvom drugom postupku koji narušava integritet mikrosfera; i/ili pri čemu se učinak opioidnog agonista barem djelomično blokira kada se uređaj za davanje žvače, gnječi ili rastapa u otapalu, ili podvrgava bilo kakvom drugom postupku koji narušava integritet mikrosfera, te se primjenjuje oralno, intranazalno, parenteralno ili sublingvalno.
5. Uređaj za transdermalno davanje prema bilo kojem od zahtjeva 1 do 4, naznačen time da sloj polimerne matrice sadrži materijal odabran iz skupine koju čine polietilen, polipropilen, kopolimeri etilen/propilen, etilen/etilakrilat kopolimeri, kopolimeri etilenvinil acetat, silikoni, guma, gumasti sintetski homopolimeri, kopolimeri ili blok polimeri, poliakrilni esteri i njihovi kopolimeri, poliuretani, poliizobutilen, klorirani polietilen, polivinilklorid, vinil klorid-vinil acetat kopolimer, polimetakrilatni polimer (hidrogel), poliviniliden klorid, poli(etilen tereftalat), kopolimer etilen-vinil alkohol, kopolimer etilen-viniloksietanol, silikoni (npr., silikonski kopolimeri kao kopolimeri polisiloksan-polimetakrilat), celulozni polimeri (npr., etil celuloza, i celulozni esteri), polikarbonati, politetrafluoretilen i njihove smjese.
6. Uređaj za transdermalno davanje prema zahtjevu 5, naznačen time da je matrica odabrana iz skupine koju čine silikonski polimeri, silikonski polimeri koji se mogu umrežavati, kopolimeri koji imaju dimetil i/ili dimetilvinil siloksanske jedinice koje se mogu umrežavati, blok kopolimeri bazirani na stirenu i 1,3-dienima, poliizobutileni, polimeri bazirani na akrilatu i/ili metakrilatu.
7. Uređaj za transdermalno davanje prema bilo kojem od prethodnih zahtjeva, naznačen time da dodatno sadrži ljepljivi sloj koji je susjedan, te je u kontaktu sa, slojem polimerne matrice i propustan je za opioidni agonist.
8. Uređaj za transdermalno davanje prema bilo kojem od zahtjeva 1 i 3 do 6, naznačen time da sloj polimerne matrice je ljepljivi sloj.
9. Uređaj za transdermalno davanje prema bilo kojem od zahtjeva 1 do 8, naznačen time da uređaj za transdermalno davanje je uređaj odabran iz skupine koju čine transdermalni zavoj, transdermalni flaster, transdermalni disk, te iontoforetski transdermalni uređaj.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54719604P | 2004-02-23 | 2004-02-23 | |
EP10010922.2A EP2351555B1 (en) | 2004-02-23 | 2005-02-15 | Abuse resistance opioid transdermal delivery device |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20161643T1 true HRP20161643T1 (hr) | 2017-01-27 |
Family
ID=34910866
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090363T HRP20090363T1 (hr) | 2004-02-23 | 2009-06-24 | Transdermalni injektor opioida rezistentan na zlouporabu |
HRP20140076TT HRP20140076T1 (hr) | 2004-02-23 | 2014-01-23 | Uređaj za transdermalnu dostavu opioida otporan na zlouporabu |
HRP20161643TT HRP20161643T1 (hr) | 2004-02-23 | 2016-12-05 | Uređaj za transdermalno davanje opioida otporan na zlouporabu |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090363T HRP20090363T1 (hr) | 2004-02-23 | 2009-06-24 | Transdermalni injektor opioida rezistentan na zlouporabu |
HRP20140076TT HRP20140076T1 (hr) | 2004-02-23 | 2014-01-23 | Uređaj za transdermalnu dostavu opioida otporan na zlouporabu |
Country Status (27)
Country | Link |
---|---|
US (2) | US20080233178A1 (hr) |
EP (3) | EP1718258B1 (hr) |
JP (2) | JP2007523167A (hr) |
KR (1) | KR100789227B1 (hr) |
CN (1) | CN1921814B (hr) |
AT (1) | ATE426399T1 (hr) |
AU (2) | AU2005216053B2 (hr) |
BR (1) | BRPI0507210A (hr) |
CA (1) | CA2556624C (hr) |
CY (3) | CY1109155T1 (hr) |
DE (1) | DE602005013490D1 (hr) |
DK (3) | DK2074989T3 (hr) |
ES (3) | ES2447547T3 (hr) |
HK (1) | HK1097177A1 (hr) |
HR (3) | HRP20090363T1 (hr) |
HU (1) | HUE030128T2 (hr) |
IL (1) | IL177452A (hr) |
LT (1) | LT2351555T (hr) |
ME (2) | ME01116B (hr) |
NO (1) | NO338647B1 (hr) |
NZ (1) | NZ549576A (hr) |
PL (3) | PL1718258T3 (hr) |
PT (3) | PT1718258E (hr) |
RS (3) | RS55297B1 (hr) |
SI (3) | SI2351555T1 (hr) |
WO (1) | WO2005081825A2 (hr) |
ZA (1) | ZA200606251B (hr) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
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US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
AU2005202477B2 (en) * | 2004-03-03 | 2005-12-15 | Vital Health Sciences Pty Ltd | Alkaloid formulations |
DE102004019916A1 (de) * | 2004-04-21 | 2005-11-17 | Grünenthal GmbH | Gegen Missbrauch gesichertes wirkstoffhaltiges Pflaster |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
CA2575587C (en) * | 2004-08-03 | 2014-06-17 | Vital Health Sciences Pty Ltd | Carrier for enteral administration |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
EP1802258A4 (en) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | BIOSYNCHRONE TRANSDERMAL MEDICINES |
DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
US20090239827A1 (en) * | 2005-03-03 | 2009-09-24 | Esra Ogru | Compounds having lipid lowering properties |
WO2006133506A1 (en) | 2005-06-17 | 2006-12-21 | Vital Health Sciences Pty Ltd | A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
CA2629046C (en) * | 2005-12-13 | 2014-04-08 | Biodelivery Sciences International, Inc. | Abuse resistant transmucosal drug delivery device |
KR101486228B1 (ko) * | 2006-06-19 | 2015-01-26 | 알파마 파머슈티컬스 엘엘씨 | 약제학적 조성물 |
KR101230804B1 (ko) | 2006-07-21 | 2013-02-08 | 바이오딜리버리 사이언시스 인터내셔널 인코포레이티드 | 향상된 흡수를 갖는 경점막 전달 장치 |
WO2008063301A2 (en) * | 2006-10-11 | 2008-05-29 | Alpharma, Inc. | Pharmaceutical compositions |
DE102007021549A1 (de) * | 2007-05-08 | 2008-11-13 | Novosis Ag | Transdermales therapeutisches System enthaltend mindestens zwei Opioide |
US8623387B2 (en) * | 2007-11-22 | 2014-01-07 | Medrx Co., Ltd. | External preparation composition comprising fatty acid-based ionic liquid as active ingredient |
BRPI0906467C1 (pt) | 2008-01-25 | 2021-05-25 | Gruenenthal Gmbh | forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada |
CN102026629B (zh) * | 2008-03-25 | 2015-01-14 | 帝国制药株式会社 | 透皮吸收制剂 |
US20090246265A1 (en) * | 2008-03-26 | 2009-10-01 | Alltranz Inc. | Abuse deterrent transdermal formulations of opiate agonists and agonist-antagonists |
EP2298313A4 (en) * | 2008-05-15 | 2013-08-21 | Nippon Zoki Pharmaceutical Co | PHARMACEUTICAL COMPOSITION FOR EXTERNAL APPLICATION CONTAINING PROCHLORPERAZINE |
EP2296624A1 (de) * | 2008-06-09 | 2011-03-23 | Boehringer Ingelheim International GmbH | Neue emulsionen zur herstellung von arzneimitteln |
US20110311630A1 (en) * | 2008-06-09 | 2011-12-22 | Boehringer Ingelheim International Gmbh | Novel embedment particles for inhalation |
JP5667183B2 (ja) | 2009-07-22 | 2015-02-12 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 加熱溶融押出成型した制御放出性投与剤型 |
CN102639118B (zh) | 2009-07-22 | 2015-07-29 | 格吕伦塔尔有限公司 | 氧化稳定的抗干扰剂型 |
EP2531047A4 (en) | 2010-02-05 | 2014-03-19 | Phosphagenics Ltd | CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE |
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