HRP20161449T1 - Genski proizvodi koji su diferecijalno izraženi u tumorima i njihova primjena - Google Patents

Genski proizvodi koji su diferecijalno izraženi u tumorima i njihova primjena Download PDF

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Publication number
HRP20161449T1
HRP20161449T1 HRP20161449TT HRP20161449T HRP20161449T1 HR P20161449 T1 HRP20161449 T1 HR P20161449T1 HR P20161449T T HRP20161449T T HR P20161449TT HR P20161449 T HRP20161449 T HR P20161449T HR P20161449 T1 HRP20161449 T1 HR P20161449T1
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HR
Croatia
Prior art keywords
antibody
tumor
acid sequence
pharmaceutical composition
associated antigen
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Application number
HRP20161449TT
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English (en)
Croatian (hr)
Inventor
Özlem TÜRECI
Ugur Sahin
Michael Koslowski
Stefan Fritz
Harald-Gerhard Geppert
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Ganymed Pharmaceuticals Ag
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Publication of HRP20161449T1 publication Critical patent/HRP20161449T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01002—Guanylate cyclase (4.6.1.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Hospice & Palliative Care (AREA)
HRP20161449TT 2004-05-18 2005-05-18 Genski proizvodi koji su diferecijalno izraženi u tumorima i njihova primjena HRP20161449T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004024617A DE102004024617A1 (de) 2004-05-18 2004-05-18 Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
EP05745559.4A EP1749027B1 (de) 2004-05-18 2005-05-18 Differentiell in tumoren exprimierte genprodukte und deren verwendung
PCT/EP2005/005410 WO2005113587A2 (de) 2004-05-18 2005-05-18 Differentiell in tumoren exprimierte genprodukte und deren verwendung

Publications (1)

Publication Number Publication Date
HRP20161449T1 true HRP20161449T1 (hr) 2016-12-16

Family

ID=34968689

Family Applications (4)

Application Number Title Priority Date Filing Date
HRP20161449TT HRP20161449T1 (hr) 2004-05-18 2005-05-18 Genski proizvodi koji su diferecijalno izraženi u tumorima i njihova primjena
HRP20170879TT HRP20170879T1 (hr) 2004-05-18 2017-06-08 Genetski proizvodi koji su diferencijalno izraženi u tumorima i njihova primjena
HRP20181013TT HRP20181013T1 (hr) 2004-05-18 2018-07-02 Genski proizvodi koji su diferencijalno izraženi u tumorima i njihovo korištenje
HRP20210494TT HRP20210494T1 (hr) 2004-05-18 2021-03-26 Genski proizvodi koji su diferencijalno izraženi u tumorima i njihove primjene

Family Applications After (3)

Application Number Title Priority Date Filing Date
HRP20170879TT HRP20170879T1 (hr) 2004-05-18 2017-06-08 Genetski proizvodi koji su diferencijalno izraženi u tumorima i njihova primjena
HRP20181013TT HRP20181013T1 (hr) 2004-05-18 2018-07-02 Genski proizvodi koji su diferencijalno izraženi u tumorima i njihovo korištenje
HRP20210494TT HRP20210494T1 (hr) 2004-05-18 2021-03-26 Genski proizvodi koji su diferencijalno izraženi u tumorima i njihove primjene

Country Status (19)

Country Link
US (4) US9044382B2 (enExample)
EP (7) EP2371849A1 (enExample)
JP (5) JP5242160B2 (enExample)
AU (1) AU2005245593B2 (enExample)
CA (2) CA2984563A1 (enExample)
CY (4) CY1118271T1 (enExample)
DE (1) DE102004024617A1 (enExample)
DK (4) DK2380903T3 (enExample)
ES (4) ES2847025T3 (enExample)
HR (4) HRP20161449T1 (enExample)
HU (4) HUE035289T2 (enExample)
LT (4) LT2371848T (enExample)
ME (2) ME02889B (enExample)
PL (4) PL1749027T3 (enExample)
PT (4) PT1749027T (enExample)
RS (4) RS57437B1 (enExample)
SI (4) SI2380903T1 (enExample)
TR (1) TR201809165T4 (enExample)
WO (1) WO2005113587A2 (enExample)

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EP2392593B1 (de) 2018-08-01
RS61395B1 (sr) 2021-02-26
ME02889B (me) 2018-04-20
PT3401327T (pt) 2021-02-11
JP2016185943A (ja) 2016-10-27
US9044382B2 (en) 2015-06-02
SI1749027T1 (sl) 2017-01-31
DK3401327T3 (da) 2021-04-06
EP3401327A1 (de) 2018-11-14
SI2371848T1 (sl) 2018-10-30
EP1749027A2 (de) 2007-02-07
HUE030620T2 (en) 2017-06-28
EP2392593A2 (de) 2011-12-07
ES2847025T3 (es) 2021-07-30
DE102004024617A1 (de) 2005-12-29
US20210145700A1 (en) 2021-05-20
RS56140B1 (sr) 2017-10-31
EP2380903A1 (de) 2011-10-26
CY1119233T1 (el) 2018-02-14
PL2380903T3 (pl) 2017-10-31
JP2013121346A (ja) 2013-06-20
WO2005113587A2 (de) 2005-12-01
PT2380903T (pt) 2017-07-12
CY1118271T1 (el) 2017-06-28
EP2371848B1 (de) 2018-04-18
TR201809165T4 (tr) 2018-07-23
EP2392593A3 (de) 2012-06-06
DK2380903T3 (en) 2017-07-17
AU2005245593B2 (en) 2011-10-20
EP2380903B1 (de) 2017-04-05
EP2371848A1 (de) 2011-10-05
JP6218881B2 (ja) 2017-10-25
LT2380903T (lt) 2017-07-10
EP1749027B1 (de) 2016-08-10
PT1749027T (pt) 2016-11-07
LT2371848T (lt) 2018-07-25
ES2627962T3 (es) 2017-08-01
DK2371848T3 (en) 2018-07-23
HRP20170879T1 (hr) 2017-12-01
EP2383288A2 (de) 2011-11-02
EP2371849A1 (de) 2011-10-05
EP2383288A3 (de) 2012-02-15
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LT3401327T (lt) 2021-02-25
SI3401327T1 (sl) 2021-05-31
JP2016189775A (ja) 2016-11-10
HRP20210494T1 (hr) 2021-05-14
PL3401327T3 (pl) 2021-05-04
PL1749027T3 (pl) 2017-01-31
HUE040399T2 (hu) 2019-03-28
JP6080831B2 (ja) 2017-02-15
CY1120789T1 (el) 2019-12-11
US20080166350A1 (en) 2008-07-10
HRP20181013T1 (hr) 2018-08-24
CY1123733T1 (el) 2022-05-27
WO2005113587A3 (de) 2006-05-18
SI2380903T1 (sl) 2017-08-31
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RS57437B1 (sr) 2018-09-28
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