BRPI0511793A - proteìnas quiméricas isoladas de lumazina sintase modificada - Google Patents
proteìnas quiméricas isoladas de lumazina sintase modificadaInfo
- Publication number
- BRPI0511793A BRPI0511793A BRPI0511793-3A BRPI0511793A BRPI0511793A BR PI0511793 A BRPI0511793 A BR PI0511793A BR PI0511793 A BRPI0511793 A BR PI0511793A BR PI0511793 A BRPI0511793 A BR PI0511793A
- Authority
- BR
- Brazil
- Prior art keywords
- chimeric proteins
- vaccines
- antibodies
- lumazine synthase
- pharmaceutical compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01009—Riboflavin synthase (2.5.1.9)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
PROTEìNAS QUIMéRICAS ISOLADAS DE LUMAZINA SINTASE MODIFICADA. A presente invenção refere-se a proteínas quiméricas isoladas incluindo até dez cópias de peptídeos, polipeptídeos ou domínios de proteína inseridas no termina amino de Brucella spp. à enzima lumazina sintase. A seqüências de nucleotídeos que codificam as proteínas quiméricas. A vetores, plasmídeos e células transformadas utilizados para a expressão de proteínas. A anticorpos monoclonais e policlonais induzidos pelas proteínas quiméricas. A hibridomas que produzem os anticorpos monoclonais. A vacinas e compostos farmacêuticos incluindo as proteínas quiméricas, seqüências de nucleotídeos e anticorpos. A um método para induzir uma resposta imune em organismos superiores incluindo a administração de quantidade efetivas das vacinas e compostos farmacêuticos. A biossensores incluindo as proteínas quiméricas. A conjugados de proteína formados pelas proteínas quiméricas e um ligante ligados por meio de ligações covalentes e não covalentes. Aos usos das proteínas quiméricas, seqüências de nucleotídeos, vetores, plasmídeos, células transformadas, anticorpos, hibridomas, conjugados, biossensores, vacinas e compostos farmacêuticos. à estrutura quaternária das proteínas quiméricas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP040101923A AR044603A1 (es) | 2004-06-03 | 2004-06-03 | Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones |
PCT/US2005/019289 WO2005121330A2 (en) | 2004-06-03 | 2005-06-03 | Isolated chimeric proteins of modified lumazine synthase |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0511793A true BRPI0511793A (pt) | 2008-01-15 |
BRPI0511793B1 BRPI0511793B1 (pt) | 2018-10-23 |
BRPI0511793B8 BRPI0511793B8 (pt) | 2021-05-25 |
Family
ID=35503729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0511793A BRPI0511793B8 (pt) | 2004-06-03 | 2005-06-03 | proteínas quiméricas isoladas de lumazina sintase modificada |
Country Status (10)
Country | Link |
---|---|
US (1) | US8685670B2 (pt) |
EP (1) | EP1776456B1 (pt) |
CN (1) | CN101133163B (pt) |
AR (1) | AR044603A1 (pt) |
BR (1) | BRPI0511793B8 (pt) |
CA (1) | CA2569401C (pt) |
DK (1) | DK1776456T3 (pt) |
ES (1) | ES2413159T3 (pt) |
MX (1) | MXPA06013984A (pt) |
WO (1) | WO2005121330A2 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2913702C (en) * | 2013-05-27 | 2023-08-01 | Inmunova S.A. | Chimeras of brucella lumazine synthase and beta subunit of ab5 toxins |
US10688175B2 (en) | 2015-10-13 | 2020-06-23 | Daniel C. Carter | NSP10 self-assembling fusion proteins for vaccines, therapeutics, diagnostics and other nanomaterial applications |
CN109196104B (zh) * | 2016-04-11 | 2023-01-31 | 生源霸科乌拉圭有限公司 | 用于病毒性疾病的广效型疫苗 |
CN106636138A (zh) * | 2017-01-12 | 2017-05-10 | 李增魁 | 一种针对羊种3型布鲁氏菌感染的dna疫苗及其制备方法 |
CN112996819A (zh) * | 2018-08-16 | 2021-06-18 | 纪念斯隆-凯特琳癌症中心 | 细胞分选系统及使用方法 |
EP4004018A1 (en) | 2019-07-24 | 2022-06-01 | GlaxoSmithKline Biologicals SA | Modified human cytomegalovirus proteins |
CN110922488A (zh) * | 2019-11-08 | 2020-03-27 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | 一种含EB病毒gp350的自组装纳米颗粒及制备方法和应用 |
CN111217918B (zh) * | 2020-03-04 | 2020-11-10 | 中山大学 | 一种基于2,4-二氧四氢喋啶合酶的新型冠状病毒s蛋白双区域亚单位纳米疫苗 |
WO2021245611A1 (en) | 2020-06-05 | 2021-12-09 | Glaxosmithkline Biologicals Sa | Modified betacoronavirus spike proteins |
CN114621352B (zh) * | 2020-12-10 | 2024-01-23 | 中国科学院大连化学物理研究所 | 硅融合蛋白及制备和应用 |
CN112458054B (zh) * | 2020-12-25 | 2023-03-31 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种快速扩增体外nk细胞的方法 |
WO2023144665A1 (en) | 2022-01-28 | 2023-08-03 | Glaxosmithkline Biologicals Sa | Modified human cytomegalovirus proteins |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
ATE412434T1 (de) | 1998-11-30 | 2008-11-15 | Cytos Biotechnology Ag | Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung |
DE19910102B4 (de) * | 1999-03-08 | 2006-06-01 | Fischer, Markus, Dr.rer.nat. | Proteinkonjugate, Verfahren, Vektoren, Proteine und DNA zu deren Herstellung, deren Verwendung, sowie Arzneimittel und Impfstoffe mit einem Gehalt derselben |
US20040014158A1 (en) * | 1999-03-08 | 2004-01-22 | Adelbert Bacher | Protein conjugates, methods, vectors, proteins and DNA for producing them, their use, and medicaments and vaccines containing a certain quantity of said protein conjugates |
GB9929151D0 (en) | 1999-12-09 | 2000-02-02 | Univ Cambridge Tech | Peptide and polypeptide display |
CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
AU2003300831A1 (en) * | 2002-12-11 | 2004-06-30 | Hawaii Biotech, Inc. | Recombinant vaccine against flavivirus infection |
-
2004
- 2004-06-03 AR ARP040101923A patent/AR044603A1/es active IP Right Grant
-
2005
- 2005-06-03 MX MXPA06013984A patent/MXPA06013984A/es active IP Right Grant
- 2005-06-03 WO PCT/US2005/019289 patent/WO2005121330A2/en active Application Filing
- 2005-06-03 DK DK05760780.6T patent/DK1776456T3/da active
- 2005-06-03 ES ES05760780T patent/ES2413159T3/es active Active
- 2005-06-03 US US11/569,957 patent/US8685670B2/en active Active
- 2005-06-03 CN CN200580026046XA patent/CN101133163B/zh active Active
- 2005-06-03 BR BRPI0511793A patent/BRPI0511793B8/pt active IP Right Grant
- 2005-06-03 CA CA2569401A patent/CA2569401C/en active Active
- 2005-06-03 EP EP05760780A patent/EP1776456B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1776456B1 (en) | 2013-02-20 |
US20090087435A1 (en) | 2009-04-02 |
BRPI0511793B1 (pt) | 2018-10-23 |
WO2005121330A2 (en) | 2005-12-22 |
MXPA06013984A (es) | 2007-03-01 |
DK1776456T3 (da) | 2013-05-27 |
AR044603A1 (es) | 2005-09-21 |
ES2413159T3 (es) | 2013-07-15 |
BRPI0511793B8 (pt) | 2021-05-25 |
CA2569401A1 (en) | 2005-12-22 |
CN101133163A (zh) | 2008-02-27 |
CA2569401C (en) | 2017-03-07 |
EP1776456A2 (en) | 2007-04-25 |
WO2005121330A3 (en) | 2007-11-01 |
US8685670B2 (en) | 2014-04-01 |
CN101133163B (zh) | 2013-04-24 |
EP1776456A4 (en) | 2008-06-18 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C12N 9/06 Ipc: C12N 9/10 (2006.01), C12N 15/54 (2006.01), A61K 38 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette] | ||
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/10/2018, OBSERVADAS AS CONDICOES LEGAIS. |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/06/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |