HRP20160932T1 - Kombinirana terapija za liječenje raka dojke - Google Patents
Kombinirana terapija za liječenje raka dojke Download PDFInfo
- Publication number
- HRP20160932T1 HRP20160932T1 HRP20160932TT HRP20160932T HRP20160932T1 HR P20160932 T1 HRP20160932 T1 HR P20160932T1 HR P20160932T T HRP20160932T T HR P20160932TT HR P20160932 T HRP20160932 T HR P20160932T HR P20160932 T1 HRP20160932 T1 HR P20160932T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- tgfß
- breast cancer
- antagonist
- agent
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title claims 5
- 208000026310 Breast neoplasm Diseases 0.000 title claims 5
- 238000002648 combination therapy Methods 0.000 title 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 12
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 12
- 239000005557 antagonist Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 4
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims 4
- 229960004117 capecitabine Drugs 0.000 claims 4
- FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 claims 4
- 229960002014 ixabepilone Drugs 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Claims (16)
1. Farmaceutski pripravak za liječenje raka dojke kod subjekta, koji sadrži: terapijski učinkovitu količinu antagonista transformirajućeg faktora rasta beta (TGFß), kapecitabina, te iksabepilon, naznačen time da je navedeni antagonist TGFß prisutan u količini koja učinkovito pojačava učinkovitost kapecitabina i iksabepilona u liječenju navedenog raka dojke.
2. Pripravak prema zahtjevu 1, naznačen time da navedeni antagonist TGFß je sredstvo koje blokira vezivanje TGFß proteina na njegov receptor.
3. Pripravak prema zahtjevu 2, naznačen time da navedeno sredstvo je protein.
4. Pripravak prema zahtjevu 3, naznačen time da navedeno sredstvo je anti-TGFß protutijelo.
5. Pripravak prema zahtjevu 4, naznačen time da navedeno protutijelo je pan neutralizirajuće anti-TGFß protutijelo.
6. Pripravak prema zahtjevu 4, naznačen time da navedeno protutijelo je anti-TGFß monoklonsko protutijelo.
7. Pripravak prema zahtjevu 6, naznačen time da navedeno protutijelo je humanizirano protutijelo koje sadrži jedan ili više CDR-ova iz 1D11.
8. Pripravak prema zahtjevu 2, naznačen time da navedeni TGFß protein je TGFß-1, -2, -3, ili njihova kombinacija.
9. Komplet za liječenje raka dojke kod subjekta, koji sadrži: terapijski učinkovitu količinu antagonista transformirajućeg faktora rasta beta (TGFß), kapecitabin, te iksabepilon, naznačen time da je navedeni antagonist TGFß prisutan u količini koja učinkovito pojačava učinkovitost kapecitabina i iksabepilona u liječenju navedenog raka dojke.
10. Komplet prema zahtjevu 9, naznačen time da navedeni TGFß antagonist je sredstvo koje blokira vezanje TGFß proteina na njegov receptor.
11. Komplet prema zahtjevu 10, naznačen time da navedeno sredstvo je protein.
12. Komplet prema zahtjevu 11, naznačen time da navedeno sredstvo je anti-TGFß protutijelo.
13. Komplet prema zahtjevu 12, naznačen time da navedeno protutijelo je pan neutralizirajuće anti-TGFß protutijelo.
14. Komplet prema zahtjevu 13, naznačen time da navedeno protutijelo je anti-TGFß monoklonsko protutijelo.
15. Komplet prema zahtjevu 14, naznačen time da navedeno protutijelo je humanizirano protutijelo koje sadrži jedan ili više CDR-ova iz 1D11.
16. Komplet prema zahtjevu 10, naznačen time da navedeni TGFß protein je TGFß-1, -2, -3, ili njihova kombinacija.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31351510P | 2010-03-12 | 2010-03-12 | |
| EP14187507.0A EP2835053B1 (en) | 2010-03-12 | 2011-03-08 | Combination therapy for treating breast cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160932T1 true HRP20160932T1 (hr) | 2016-10-07 |
Family
ID=44563812
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160932TT HRP20160932T1 (hr) | 2010-03-12 | 2016-07-22 | Kombinirana terapija za liječenje raka dojke |
| HRP20181757TT HRP20181757T1 (hr) | 2010-03-12 | 2018-10-24 | Kombinirana terapija za liječenje raka dojke |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181757TT HRP20181757T1 (hr) | 2010-03-12 | 2018-10-24 | Kombinirana terapija za liječenje raka dojke |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8911736B2 (hr) |
| EP (4) | EP3117709B1 (hr) |
| JP (2) | JP5917418B2 (hr) |
| CY (1) | CY1117831T1 (hr) |
| DK (2) | DK2835053T3 (hr) |
| ES (2) | ES2584433T3 (hr) |
| HK (1) | HK1206936A1 (hr) |
| HR (2) | HRP20160932T1 (hr) |
| HU (2) | HUE027831T2 (hr) |
| LT (1) | LT3117709T (hr) |
| ME (1) | ME02464B (hr) |
| PL (2) | PL3117709T3 (hr) |
| PT (2) | PT2835053T (hr) |
| RS (2) | RS54972B1 (hr) |
| SI (2) | SI3117709T1 (hr) |
| SM (1) | SMT201600253B (hr) |
| TR (1) | TR201816180T4 (hr) |
| WO (1) | WO2011112609A1 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE027831T2 (en) * | 2010-03-12 | 2016-11-28 | Genzyme Corp | Combination therapy for breast cancer |
| WO2013078286A1 (en) * | 2011-11-22 | 2013-05-30 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting tgf beta signaling |
| TWI664979B (zh) | 2013-03-11 | 2019-07-11 | 健臻公司 | 經生物工程之抗-ＴＧＦ-β抗體及抗原結合片段 |
| WO2016094697A2 (en) | 2014-12-10 | 2016-06-16 | The Regents Of The University Of Colorado, A Body Corporate | Targeting breast cancer therapy based on stromal subtypes and cd146 composition |
| GB201503438D0 (en) * | 2015-02-27 | 2015-04-15 | Ucl Business Plc | Antibodies |
| US10616698B2 (en) * | 2015-03-18 | 2020-04-07 | Med-El Elektromedizinische Geraete Gmbh | Fixation of a bone conduction floating mass transducer |
| KR102647231B1 (ko) | 2018-08-02 | 2024-03-13 | 삼성전자주식회사 | 반도체 소자 및 이의 제조방법 |
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| WO2008145403A1 (en) | 2007-06-01 | 2008-12-04 | Synthon B.V. | Processes related to making capecitabine |
| DE102008002395A1 (de) * | 2008-06-12 | 2009-12-17 | Biotronik Vi Patent Ag | Wirkstoffbeladenes Implantat |
| HUE027831T2 (en) * | 2010-03-12 | 2016-11-28 | Genzyme Corp | Combination therapy for breast cancer |
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2011
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