JP5917418B2 - 乳がんを治療するための併用療法 - Google Patents
乳がんを治療するための併用療法 Download PDFInfo
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- JP5917418B2 JP5917418B2 JP2012557175A JP2012557175A JP5917418B2 JP 5917418 B2 JP5917418 B2 JP 5917418B2 JP 2012557175 A JP2012557175 A JP 2012557175A JP 2012557175 A JP2012557175 A JP 2012557175A JP 5917418 B2 JP5917418 B2 JP 5917418B2
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- capecitabine
- ixabepilone
- tgfβ
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- antagonist
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Description
本出願は、2010年3月12日付けで出願された米国特許仮出願第61/313,515号の優先権を主張するものである。同仮許出願は、参照によりその全体が本明細書に組み込まれるものとする。
本発明は、乳がんを治療するための組成物及び方法に関する。特に、本発明は、乳がんを治療するために、形質転換成長因子β(TGFβ)アンタゴニストを1若しくは複数の化学療法薬剤と組み合わせて投与することに関する。
腫瘍体積=長さ×幅2×0.52
腫瘍体積=長さ×幅2×0.52
腫瘍体積=長さ×幅2×0.52
Claims (18)
- 対象の乳がんを治療するための薬剤を製造するための組成物の使用であって、
前記組成物は、カペシタビン及びイクサベピロンと組み合わされた治療有効量の形質転換成長因子β(TGFβ)アンタゴニストを含み、
前記TGFβアンタゴニストは、カペシタビン及びイクサベピロンの乳がん治療効果を高め、前記TGFβアンタゴニストは、抗TGFβ抗体であることを特徴とする使用。 - 請求項1に記載の使用であって、
前記抗体が、汎中和抗TGFβ抗体であることを特徴とする使用。 - 請求項1に記載の使用であって、
前記抗体が、抗TGFβモノクローナル抗体であることを特徴とする使用。 - 請求項1に記載の使用であって、
カペシタビン及びイクサベピロンと組み合わされた前記TGFβアンタゴニストが、原発腫瘍の成長を抑制することを特徴とする使用。 - 請求項1に記載の使用であって、
カペシタビン及びイクサベピロンと組み合わされた前記TGFβアンタゴニストが、転移を抑制することを特徴とする使用。 - 請求項1に記載の使用であって、
カペシタビン及びイクサベピロンと組み合わされた前記TGFβアンタゴニストが、原発腫瘍から肺への転移を抑制することを特徴とする使用。 - 対象における乳がんの腫瘍の成長を抑制するための薬剤を製造するための組成物の使用であって、
前記組成物は、カペシタビン及びイクサベピロンと組み合わされた治療有効量の形質転換成長因子β(TGFβ)アンタゴニストを含み、
前記TGFβアンタゴニストは、カペシタビン及びイクサベピロンが乳がんの腫瘍の成長を抑制する効果を高め、前記TGFβアンタゴニストは、抗TGFβ抗体であることを特徴とする使用。 - 請求項7に記載の使用であって、
前記抗体が、汎中和抗TGFβ抗体であることを特徴とする使用。 - 請求項7に記載の使用であって、
前記抗体が、抗TGFβモノクローナル抗体であることを特徴とする使用。 - 請求項7に記載の使用であって、
カペシタビン及びイクサベピロンと組み合わされた前記TGFβアンタゴニストが、原発腫瘍の成長を抑制することを特徴とする使用。 - 請求項7に記載の使用であって、
カペシタビン及びイクサベピロンと組み合わされた前記TGFβアンタゴニストが、転移を抑制することを特徴とする使用。 - 請求項7に記載の使用であって、
カペシタビン及びイクサベピロンと組み合わされた前記TGFβアンタゴニストが、原発腫瘍から肺への転移を抑制することを特徴とする使用。 - 対象の乳がんを治療するための医薬組成物であって、
治療有効量の形質転換成長因子β(TGFβ)アンタゴニスト、カペシタビン及びイクサベピロンを含み、
前記TGFβアンタゴニストが、カペシタビン及びイクサベピロンの乳がん治療効果を高めるための有効量で含まれ、
前記TGFβアンタゴニストは、抗TGFβ抗体であることを特徴とする組成物。 - 請求項13に記載の組成物であって、
前記抗体が、汎中和抗TGFβ抗体であることを特徴とする組成物。 - 請求項13に記載の組成物であって、
前記抗体が、抗TGFβモノクローナル抗体であることを特徴とする組成物。 - 対象の乳がんを治療するためのキットであって、
治療有効量の形質転換成長因子β(TGFβ)アンタゴニスト、カペシタビン及びイクサベピロンを含み、
前記TGFβアンタゴニストが、カペシタビン及びイクサベピロンの乳がん治療効果を高めるための有効量で含まれ、
前記TGFβアンタゴニストは、抗TGFβ抗体であることを特徴とするキット。 - 請求項16に記載のキットであって、
前記抗体が、汎中和抗TGFβ抗体であることを特徴とするキット。 - 請求項16に記載のキットであって、
前記抗体が、抗TGFβモノクローナル抗体であることを特徴とするキット。
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US31351510P | 2010-03-12 | 2010-03-12 | |
US61/313,515 | 2010-03-12 | ||
PCT/US2011/027589 WO2011112609A1 (en) | 2010-03-12 | 2011-03-08 | Combination therapy for treating breast cancer |
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