CY1117831T1 - Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη του καρκινου του μαστου - Google Patents

Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη του καρκινου του μαστου

Info

Publication number
CY1117831T1
CY1117831T1 CY20161100731T CY161100731T CY1117831T1 CY 1117831 T1 CY1117831 T1 CY 1117831T1 CY 20161100731 T CY20161100731 T CY 20161100731T CY 161100731 T CY161100731 T CY 161100731T CY 1117831 T1 CY1117831 T1 CY 1117831T1
Authority
CY
Cyprus
Prior art keywords
breast cancer
combination therapy
therapeutic treatment
cancer therapeutic
treatment
Prior art date
Application number
CY20161100731T
Other languages
English (en)
Inventor
Jay Harper
Scott Michael Lonning
Frank James Hsu
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of CY1117831T1 publication Critical patent/CY1117831T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Η εφεύρεση παρέχει συνθέσεις και μεθόδους για τη θεραπευτική αγωγή του καρκίνου του μαστού. Ειδικώς, η εφεύρεση αφορά τη χορήγηση ενός ανταγωνιστή βήτα Μετασχηματιστικού Παράγοντα Ανάπτυξης (TGFβ) σε συνδυασμό με καπεσιταβίνη και ιξαβεπιλόνη για τη θεραπευτική αγωγή καρκίνου.
CY20161100731T 2010-03-12 2016-07-26 Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη του καρκινου του μαστου CY1117831T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31351510P 2010-03-12 2010-03-12
EP11753944.5A EP2544541B1 (en) 2010-03-12 2011-03-08 Combination therapy for treating breast cancer

Publications (1)

Publication Number Publication Date
CY1117831T1 true CY1117831T1 (el) 2017-05-17

Family

ID=44563812

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100731T CY1117831T1 (el) 2010-03-12 2016-07-26 Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη του καρκινου του μαστου

Country Status (18)

Country Link
US (3) US8911736B2 (el)
EP (4) EP2835053B1 (el)
JP (2) JP5917418B2 (el)
CY (1) CY1117831T1 (el)
DK (2) DK2835053T3 (el)
ES (2) ES2694288T3 (el)
HK (1) HK1206936A1 (el)
HR (2) HRP20160932T1 (el)
HU (2) HUE040107T2 (el)
LT (1) LT3117709T (el)
ME (1) ME02464B (el)
PL (2) PL3117709T3 (el)
PT (2) PT2835053T (el)
RS (2) RS57942B1 (el)
SI (2) SI3117709T1 (el)
SM (1) SMT201600253B (el)
TR (1) TR201816180T4 (el)
WO (1) WO2011112609A1 (el)

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Also Published As

Publication number Publication date
JP6289528B2 (ja) 2018-03-07
US8911736B2 (en) 2014-12-16
PT2835053T (pt) 2016-07-14
PT3117709T (pt) 2018-11-15
US20130034549A1 (en) 2013-02-07
US20150086547A1 (en) 2015-03-26
HRP20160932T1 (hr) 2016-10-07
HUE040107T2 (hu) 2019-02-28
DK2835053T3 (en) 2016-08-15
JP5917418B2 (ja) 2016-05-11
EP3117709B1 (en) 2018-08-01
HK1206936A1 (zh) 2016-01-22
HRP20181757T1 (hr) 2019-01-25
ES2694288T3 (es) 2018-12-19
EP3406141B1 (en) 2020-10-14
SI2835053T1 (sl) 2016-09-30
EP2835053A1 (en) 2015-02-11
EP2544541A4 (en) 2013-07-31
JP2016164174A (ja) 2016-09-08
US10507242B2 (en) 2019-12-17
WO2011112609A1 (en) 2011-09-15
ME02464B (me) 2017-02-20
SMT201600253B (it) 2016-08-31
RS54972B1 (sr) 2016-11-30
EP2544541B1 (en) 2014-10-08
US9539325B2 (en) 2017-01-10
EP2835053B1 (en) 2016-04-27
LT3117709T (lt) 2018-11-26
PL2835053T3 (pl) 2016-12-30
US20170319691A1 (en) 2017-11-09
JP2013522210A (ja) 2013-06-13
RS57942B1 (sr) 2019-01-31
HUE027831T2 (en) 2016-11-28
DK3117709T3 (en) 2018-11-26
TR201816180T4 (tr) 2018-11-21
EP3406141A1 (en) 2018-11-28
PL3117709T3 (pl) 2019-01-31
ES2584433T3 (es) 2016-09-27
SI3117709T1 (sl) 2018-12-31
EP3117709A1 (en) 2017-01-18
EP2544541A1 (en) 2013-01-16

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