HRP20160398T1 - Derivati benzazola kao ligandi receptora histamina h4 - Google Patents

Derivati benzazola kao ligandi receptora histamina h4 Download PDF

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Publication number
HRP20160398T1
HRP20160398T1 HRP20160398TT HRP20160398T HRP20160398T1 HR P20160398 T1 HRP20160398 T1 HR P20160398T1 HR P20160398T T HRP20160398T T HR P20160398TT HR P20160398 T HRP20160398 T HR P20160398T HR P20160398 T1 HRP20160398 T1 HR P20160398T1
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HR
Croatia
Prior art keywords
methyl
methylpiperidin
yloxy
benzimidazol
phenyl
Prior art date
Application number
HRP20160398TT
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English (en)
Croatian (hr)
Inventor
Isabelle Berrebi-Bertrand
Xavier Billot
Thierry Calmels
Marc Capet
Denis Danvy
Stéphane Krief
Olivier Labeeuw
Jeanne-Marie Lecomte
Nicolas Levoin
Xavier Ligneau
Philippe Robert
Jean-Charles Schwartz
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Bioprojet
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Publication date
Application filed by Bioprojet filed Critical Bioprojet
Publication of HRP20160398T1 publication Critical patent/HRP20160398T1/hr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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HRP20160398TT 2010-09-27 2011-09-27 Derivati benzazola kao ligandi receptora histamina h4 HRP20160398T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20100306038 EP2447263A1 (en) 2010-09-27 2010-09-27 Benzazole derivatives as histamine H4 receptor ligands
PCT/EP2011/066782 WO2012041860A1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands
EP11761383.6A EP2621916B1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands

Publications (1)

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HRP20160398T1 true HRP20160398T1 (hr) 2016-05-20

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HRP20160398TT HRP20160398T1 (hr) 2010-09-27 2011-09-27 Derivati benzazola kao ligandi receptora histamina h4

Country Status (16)

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US (2) US8802664B2 (https=)
EP (2) EP2447263A1 (https=)
JP (1) JP5922128B2 (https=)
CN (1) CN103228643B (https=)
CA (1) CA2812686C (https=)
CY (1) CY1117416T1 (https=)
DK (1) DK2621916T3 (https=)
ES (1) ES2571335T3 (https=)
HR (1) HRP20160398T1 (https=)
HU (1) HUE027252T2 (https=)
MX (1) MX339460B (https=)
PL (1) PL2621916T3 (https=)
RS (1) RS54737B1 (https=)
SI (1) SI2621916T1 (https=)
SM (1) SMT201600262B (https=)
WO (1) WO2012041860A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2598844C2 (ru) 2011-04-19 2016-09-27 Сауди Бейсик Индастриз Корпорейшн Кобальт-молибденовый катализатор на углеродной подложке
EP2855456B1 (en) * 2012-05-04 2017-03-29 Novartis AG Complement pathway modulators and uses thereof
EP2671870A1 (en) * 2012-06-05 2013-12-11 Bioprojet Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications
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