CA2812686C - Benzazole derivatives as histamine h4 receptor ligands - Google Patents

Benzazole derivatives as histamine h4 receptor ligands Download PDF

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Publication number
CA2812686C
CA2812686C CA2812686A CA2812686A CA2812686C CA 2812686 C CA2812686 C CA 2812686C CA 2812686 A CA2812686 A CA 2812686A CA 2812686 A CA2812686 A CA 2812686A CA 2812686 C CA2812686 C CA 2812686C
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Prior art keywords
methylpiperidin
methyl
yloxy
benzimidazol
phenyl
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CA2812686A
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English (en)
French (fr)
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CA2812686A1 (en
Inventor
Isabelle Berrebi-Bertrand
Xavier Billot
Thierry Calmels
Marc Capet
Denis Danvy
Stephane Krief
Olivier Labeeuw
Jeanne-Marie Lecomte
Nicolas Levoin
Xavier Ligneau
Philippe Robert
Jean-Charles Schwartz
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Bioprojet SC
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Bioprojet SC
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CA2812686A 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands Active CA2812686C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10306038.0 2010-09-27
EP20100306038 EP2447263A1 (en) 2010-09-27 2010-09-27 Benzazole derivatives as histamine H4 receptor ligands
PCT/EP2011/066782 WO2012041860A1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands

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CA2812686A1 CA2812686A1 (en) 2012-04-05
CA2812686C true CA2812686C (en) 2019-04-02

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CA2812686A Active CA2812686C (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands

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US (2) US8802664B2 (https=)
EP (2) EP2447263A1 (https=)
JP (1) JP5922128B2 (https=)
CN (1) CN103228643B (https=)
CA (1) CA2812686C (https=)
CY (1) CY1117416T1 (https=)
DK (1) DK2621916T3 (https=)
ES (1) ES2571335T3 (https=)
HR (1) HRP20160398T1 (https=)
HU (1) HUE027252T2 (https=)
MX (1) MX339460B (https=)
PL (1) PL2621916T3 (https=)
RS (1) RS54737B1 (https=)
SI (1) SI2621916T1 (https=)
SM (1) SMT201600262B (https=)
WO (1) WO2012041860A1 (https=)

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RU2598844C2 (ru) 2011-04-19 2016-09-27 Сауди Бейсик Индастриз Корпорейшн Кобальт-молибденовый катализатор на углеродной подложке
EP2855456B1 (en) * 2012-05-04 2017-03-29 Novartis AG Complement pathway modulators and uses thereof
EP2671870A1 (en) * 2012-06-05 2013-12-11 Bioprojet Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications
EP3378476A1 (en) 2012-06-08 2018-09-26 Sensorion H4 receptor inhibitors for treating tinnitus
CN104710341A (zh) * 2015-02-13 2015-06-17 佛山市赛维斯医药科技有限公司 一类含双酰肼和萘基结构的化合物、制备方法及其用途
WO2019051469A1 (en) * 2017-09-11 2019-03-14 Krouzon Pharmaceuticals, Inc. Octahydrocyclopenta[c]pyrrole allosteric inhibitors of shp2
DK3486243T3 (da) * 2017-11-15 2020-06-08 Bioprojet Soc Civ Benzimidazolderivater som dobbelthistamin H1 og histamin H4-receptorligander
CN113278409B (zh) * 2021-06-22 2022-04-29 西南石油大学 一种高温酸化缓蚀剂
CN119086786B (zh) * 2024-11-08 2025-02-14 南京恒远科技开发有限公司 叔丁基-(s)-[2-(2-氰基-4,4-二氟吡咯烷-1-基)-2-氧乙基]氨基甲酸酯光学异构体的检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI803127L (fi) * 1979-10-03 1981-04-04 Glaxo Group Ltd Heterocykliska foereningar
IT1154888B (it) * 1980-11-12 1987-01-21 Menarini Sas Derivati del benzofurano 2-sostituiti e relativi metodi di preparazione
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JPH05339266A (ja) * 1992-06-05 1993-12-21 Kaken Pharmaceut Co Ltd 新規なピペリジン誘導体
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
CA2467718C (en) 2001-12-21 2011-04-26 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
EP1687452A4 (en) * 2003-09-30 2008-08-06 Centocor Inc HUMAN HINGE-CORE MIMETICORPS, COMPOSITIONS, METHODS AND APPLICATIONS THEREOF
EP1673348B1 (en) * 2003-09-30 2009-04-01 Janssen Pharmaceutica N.V. Benzoimidazole compounds
EP1642577A1 (en) * 2004-09-07 2006-04-05 Laboratorios del Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of central neuropathic pain
WO2006107784A1 (en) 2005-04-05 2006-10-12 Eli Lilly And Company Imidazopyridazine compounds
CA2707441A1 (en) 2008-01-09 2009-07-16 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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