SI2621916T1 - Derivati benzazola kot ligandi receptorja histamina H4 - Google Patents

Derivati benzazola kot ligandi receptorja histamina H4

Info

Publication number
SI2621916T1
SI2621916T1 SI201130817A SI201130817A SI2621916T1 SI 2621916 T1 SI2621916 T1 SI 2621916T1 SI 201130817 A SI201130817 A SI 201130817A SI 201130817 A SI201130817 A SI 201130817A SI 2621916 T1 SI2621916 T1 SI 2621916T1
Authority
SI
Slovenia
Prior art keywords
histamine
receptor ligands
benzazole derivatives
benzazole
derivatives
Prior art date
Application number
SI201130817A
Other languages
English (en)
Slovenian (sl)
Inventor
Isabelle Berrebi-Bertrand
Xavier Billot
Thierry Calmels
Marc Capet
Denis Danvy
Stephane Krief
Olivier Labeeuw
Jeanne-Marie Lecomte
Nicolas Levoin
Xavier Ligneau
Philippe Robert
Jean-Charles Schwartz
Original Assignee
Bioprojet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioprojet filed Critical Bioprojet
Publication of SI2621916T1 publication Critical patent/SI2621916T1/sl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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SI201130817A 2010-09-27 2011-09-27 Derivati benzazola kot ligandi receptorja histamina H4 SI2621916T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20100306038 EP2447263A1 (en) 2010-09-27 2010-09-27 Benzazole derivatives as histamine H4 receptor ligands
PCT/EP2011/066782 WO2012041860A1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands
EP11761383.6A EP2621916B1 (en) 2010-09-27 2011-09-27 Benzazole derivatives as histamine h4 receptor ligands

Publications (1)

Publication Number Publication Date
SI2621916T1 true SI2621916T1 (sl) 2016-06-30

Family

ID=43513798

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201130817A SI2621916T1 (sl) 2010-09-27 2011-09-27 Derivati benzazola kot ligandi receptorja histamina H4

Country Status (16)

Country Link
US (2) US8802664B2 (https=)
EP (2) EP2447263A1 (https=)
JP (1) JP5922128B2 (https=)
CN (1) CN103228643B (https=)
CA (1) CA2812686C (https=)
CY (1) CY1117416T1 (https=)
DK (1) DK2621916T3 (https=)
ES (1) ES2571335T3 (https=)
HR (1) HRP20160398T1 (https=)
HU (1) HUE027252T2 (https=)
MX (1) MX339460B (https=)
PL (1) PL2621916T3 (https=)
RS (1) RS54737B1 (https=)
SI (1) SI2621916T1 (https=)
SM (1) SMT201600262B (https=)
WO (1) WO2012041860A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2598844C2 (ru) 2011-04-19 2016-09-27 Сауди Бейсик Индастриз Корпорейшн Кобальт-молибденовый катализатор на углеродной подложке
EP2855456B1 (en) * 2012-05-04 2017-03-29 Novartis AG Complement pathway modulators and uses thereof
EP2671870A1 (en) * 2012-06-05 2013-12-11 Bioprojet Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications
EP3378476A1 (en) 2012-06-08 2018-09-26 Sensorion H4 receptor inhibitors for treating tinnitus
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