HRP20151214T1 - Pripravak za inhalaciju koji sadrži aklidinij za lijeäśenje kroniäśne opstruktivne pluä†ne bolesti - Google Patents
Pripravak za inhalaciju koji sadrži aklidinij za lijeäśenje kroniäśne opstruktivne pluä†ne bolesti Download PDFInfo
- Publication number
- HRP20151214T1 HRP20151214T1 HRP20151214TT HRP20151214T HRP20151214T1 HR P20151214 T1 HRP20151214 T1 HR P20151214T1 HR P20151214T T HRP20151214T T HR P20151214TT HR P20151214 T HRP20151214 T HR P20151214T HR P20151214 T1 HRP20151214 T1 HR P20151214T1
- Authority
- HR
- Croatia
- Prior art keywords
- aclidinium
- use according
- pharmaceutical preparation
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
- ASMXXROZKSBQIH-VITNCHFBSA-N aclidinium Chemical compound C([C@@H](C(CC1)CC2)OC(=O)C(O)(C=3SC=CC=3)C=3SC=CC=3)[N+]21CCCOC1=CC=CC=C1 ASMXXROZKSBQIH-VITNCHFBSA-N 0.000 title claims 26
- 229940019903 aclidinium Drugs 0.000 title claims 19
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 title claims 4
- 239000000203 mixture Substances 0.000 title claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 13
- 239000013543 active substance Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 229960005012 aclidinium bromide Drugs 0.000 claims 7
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical group OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims 6
- 229960000193 formoterol fumarate Drugs 0.000 claims 6
- 239000000843 powder Substances 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 2
- 229940124748 beta 2 agonist Drugs 0.000 claims 2
- 229960004436 budesonide Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 229940112141 dry powder inhaler Drugs 0.000 claims 2
- 229960000289 fluticasone propionate Drugs 0.000 claims 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical group C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 2
- 229960002848 formoterol Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 2
- 229960004017 salmeterol Drugs 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Claims (18)
1. Farmaceutski pripravak koji sadrži aklidinij u obliku suhog praha farmaceutski prihvatljive soli u smjesi s farmaceutski prihvatljivim nosačem suhog praha, pružajući odmjerenu nominalnu dozu aklidinija jednaku 400 µg (plus/minus 10 %) aklidinijevog bromida za primjenu inhalacijom u liječenju kronične opstruktivne plućne bolesti.
2. Farmaceutski pripravak za primjenu prema zahtjevu 1, u obliku formulacije suhog praha za jednu dozu koja sadrži jednu odmjerenu nominalnu dozu aklidinija jednaku400 mikrograma (plus/minus 10 %) aklidinijevog bromida.
3. Farmaceutski pripravak za primjenu prema zahtjevu 1, u obliku formulacije suhog praha za više doza namijenjenu za primjenu u višedoznom inhalatoru suhog praha kalibriranom da isporuči odmjerenu nominalnu dozu aklidinija jednaku 400 mikrograma (plus/minus 10 %) aklidinijevog bromida.
4. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih zahtjeva, naznačen time, što (a) farmaceutski prihvatljiva sol aklidinija je aklidinijev bromid i/ili (b) farmaceutski prihvatljivi nosač su čestice laktoze.
5. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih zahtjeva, naznačen time, što težinski omjer aklidinija naspram nosača iznosi od 1:25 do 1:75.
6. Farmaceutski pripravak za primjenu prema zahtjevu 5, naznačen time, što težinski omjer aklidinija naspram nosača iznosi od 1:50 do 1:75.
7. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih zahtjeva, naznačen time, što je (a) prosječni promjer čestica aklidinija unutar 2-5 μm i/ili (b) čestice nosača imaju promjer d10 od 90-160 μm, promjer d50 od 170-270 μm i promjer d90 od 290-400 μm.
8. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih zahtjeva, naznačen time, što farmaceutski pripravak dalje sadrži djelotvornu količinu jedne ili više dodatnih aktivnih tvari odabranih iz β2 agonista, inhibitora PDE IV i kortikosteroida.
9. Farmaceutski pripravak za primjenu prema zahtjevu 8, naznačen time, što je dodatna aktivna tvar odabrana iz formoterola, salmeterola, budezonida i flutikazon propionata, u slobodnom obliku ili u obliku farmaceutski prihvatljive soli.
10. Farmaceutski pripravak za primjenu prema zahtjevu 9, naznačen time, što je (a) dodatna aktivna tvar formoterol fumarat u količini od 5-25 µg po dozi ili je (b) dodatna aktivna tvar formoterol fumarat u količini od 6 µg po dozi ili je (c) dodatna aktivna tvar formoterol fumarat u količini od 12 µg po dozi.
11. Aklidinij u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za primjenu u liječenju kronične opstruktivne plućne bolesti u bolesnika kojem je potrebno takvo liječenje, pri čemu se spomenuta primjena sastoji od davanja inhalacijom jednom ili dvaput dnevno odmjerene nominalne doze aklidinija jednake 400 mikrograma (plus/minus 10 %) aklidinijevog bromida.
12. Aklidinij u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za primjenu prema zahtjevu 11, pri čemu se spomenuta primjena sastoji od davanja farmaceutskog pripravka prema bilo kojem zahtjevu od 1 do 10.
13. Aklidinij u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za primjenu prema zahtjevu 11 ili 12, pri čemu se spomenuta primjena dalje sastoji od davanja djelotvorne količine jedne ili više dodatnih aktivnih tvari odabranih iz β2 agonista, inhibitora PDE IV i kortikosteroida.
14. Aklidinij u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za primjenu prema zahtjevu 13, naznačen time, što je dodatna aktivna tvar odabrana iz formoterola, salmeterola, budezonida i flutikazon propionata, u slobodnom obliku ili u obliku farmaceutski prihvatljive soli.
15. Aklidinij u slobodnom obliku ili u obliku farmaceutski prihvatljive soli za primjenu prema zahtjevu 14, naznačen time, što je (a) dodatna aktivna tvar formoterol fumarat u količini od 5-25 µg po dozi ili je (b) dodatna aktivna tvar formoterol fumarat u količini od 6 µg po dozi ili je (c) dodatna aktivna tvar formoterol fumarat u količini od 12 µg po dozi.
16. Primjena aklidinija u slobodnom obliku ili u obliku farmaceutski prihvatljive soli u proizvodnji lijeka za liječenje kronične opstruktivne plućne bolesti u bolesnika kojem je potrebno takvo liječenje, pri čemu se spomenuta primjena sastoji od davanja inhalacijom jednom ili dvaput dnevno odmjerene nominalne doze aklidinija jednake 400 mikrograma (plus/minus 10 %) aklidinijevog bromida.
17. Primjena prema zahtjevu 16, naznačena time, što se sastoji od davanja farmaceutskog pripravka kao što je definirano u bilo kojem zahtjevu od 1 do 10.
18. Višedozni inhalator suhog praha koji sadrži aklidinij, kalibriran da nakon aktiviranja isporuči odmjerenu nominalnu dozu aklidinija jednaku 400 mikrograma (plus/minus 10 %) aklidinijevog bromida.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08382010A EP2100599A1 (en) | 2008-03-13 | 2008-03-13 | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
PCT/EP2009/001832 WO2009112274A2 (en) | 2008-03-13 | 2009-03-13 | Novel dosage and formulation |
EP09719213.2A EP2265257B2 (en) | 2008-03-13 | 2009-03-13 | Inhalation composition containing aclidinium for treatment of chronic obstructive pulmonary disease |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20151214T1 true HRP20151214T1 (hr) | 2015-12-18 |
HRP20151214T4 HRP20151214T4 (hr) | 2024-01-05 |
Family
ID=39645012
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220929TT HRP20220929T3 (hr) | 2008-03-13 | 2009-03-13 | Sastav za inhalaciju koji sadrži aklidinij za liječenje astme |
HRP20151214TT HRP20151214T4 (hr) | 2008-03-13 | 2009-03-13 | Pripravak za inhalaciju koji sadrži aklidinij za liječenje kronične opstruktivne plućne bolesti |
HRP20220919TT HRP20220919T3 (hr) | 2008-03-13 | 2009-03-13 | Sastav za inhalaciju koji sadrži aklidinij za liječenje kronične opstruktivne bolesti pluća |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220929TT HRP20220929T3 (hr) | 2008-03-13 | 2009-03-13 | Sastav za inhalaciju koji sadrži aklidinij za liječenje astme |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220919TT HRP20220919T3 (hr) | 2008-03-13 | 2009-03-13 | Sastav za inhalaciju koji sadrži aklidinij za liječenje kronične opstruktivne bolesti pluća |
Country Status (37)
Country | Link |
---|---|
US (3) | US20110020412A1 (hr) |
EP (5) | EP2100599A1 (hr) |
JP (3) | JP2011513451A (hr) |
KR (3) | KR20180125055A (hr) |
CN (2) | CN102083416A (hr) |
AR (1) | AR070835A1 (hr) |
AU (1) | AU2009224895B9 (hr) |
BR (1) | BRPI0905775B1 (hr) |
CA (1) | CA2716724C (hr) |
CL (1) | CL2009000602A1 (hr) |
CO (1) | CO6290636A2 (hr) |
CY (1) | CY1116926T1 (hr) |
DK (3) | DK2954889T3 (hr) |
EC (1) | ECSP10010300A (hr) |
ES (3) | ES2551307T5 (hr) |
FI (1) | FI2265257T4 (hr) |
HK (1) | HK1145815A1 (hr) |
HR (3) | HRP20220929T3 (hr) |
HU (3) | HUE059019T2 (hr) |
IL (3) | IL206354A0 (hr) |
LT (2) | LT2954889T (hr) |
ME (1) | ME02286B (hr) |
MX (2) | MX2010008235A (hr) |
MY (1) | MY177027A (hr) |
NZ (1) | NZ585857A (hr) |
PE (3) | PE20141036A1 (hr) |
PL (3) | PL2954891T3 (hr) |
PT (3) | PT2954889T (hr) |
RS (3) | RS54241B2 (hr) |
RU (3) | RU2608713C3 (hr) |
SG (1) | SG188825A1 (hr) |
SI (3) | SI2954889T1 (hr) |
TW (1) | TWI439296B (hr) |
UA (1) | UA101652C2 (hr) |
UY (1) | UY31687A1 (hr) |
WO (1) | WO2009112274A2 (hr) |
ZA (1) | ZA201003900B (hr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
ES2298049B1 (es) | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
EP2100599A1 (en) * | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100598A1 (en) * | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2510928A1 (en) * | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
EP2666465A1 (en) * | 2012-05-25 | 2013-11-27 | Almirall, S.A. | Novel dosage and formulation |
WO2014007771A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising muscarinic receptor antagonist |
EA201590030A1 (ru) * | 2012-07-05 | 2015-09-30 | Арвен Айлак Санайи Ве Тиджарет А.С. | Ингаляторы сухого порошка, содержащие носитель, отличный от лактозы, и третий компонент |
WO2014007772A2 (en) | 2012-07-05 | 2014-01-09 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhalation compositions comprising glucose anhydrous |
EA201590019A1 (ru) * | 2012-07-05 | 2015-09-30 | Арвен Айлак Санайи Ве Тиджарет А.С. | Ингаляторы сухого порошка, содержащие носитель, отличный от лактозы |
PL2931275T3 (pl) | 2012-12-17 | 2022-09-05 | Almirall S.A. | Aklidyna do zastosowania w zwiększaniu aktywności fizycznej w codziennym życiu u pacjenta z przewlekłą obturacyjną chorobą płuc |
EP2991626A1 (en) * | 2013-04-29 | 2016-03-09 | Sanofi SA | Inhalable pharmaceutical compositions and the inhaler devices containing them |
EP2923702A1 (en) * | 2014-03-28 | 2015-09-30 | Universite De Liege | Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease |
ES2682105T3 (es) | 2014-05-12 | 2018-09-18 | Verona Pharma Plc | Nuevo tratamiento |
CZ2015257A3 (cs) * | 2015-04-16 | 2016-10-26 | Zentiva, K.S. | Způsob pro zmenšování velikosti částic bromidu [(3R)-1-(3-fenoxypropyl)chinuklidin-1-ium-3-yl] 2-hydroxy-2,2-bis(2-thienyl)acetátu |
CN107823193B (zh) * | 2017-11-16 | 2021-02-05 | 广州迈达康医药科技有限公司 | 一种阿地溴铵吸入型粉雾剂及其制备方法 |
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