HRP20150146T1 - Derivati kromenona s protu tumourskom aktivnošä†u - Google Patents

Derivati kromenona s protu tumourskom aktivnošä†u Download PDF

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Publication number
HRP20150146T1
HRP20150146T1 HRP20150146TT HRP20150146T HRP20150146T1 HR P20150146 T1 HRP20150146 T1 HR P20150146T1 HR P20150146T T HRP20150146T T HR P20150146TT HR P20150146 T HRP20150146 T HR P20150146T HR P20150146 T1 HRP20150146 T1 HR P20150146T1
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HR
Croatia
Prior art keywords
alkyl
pharmaceutically acceptable
formula
acceptable salt
alkoxy
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HRP20150146TT
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English (en)
Croatian (hr)
Inventor
Bernard Christophe Barlaam
Sebastien Louis Degorce
Christine Marie Paul Lambert-Van Der Brempt
Remy Robert Morgentin
Patrick Ple
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Astrazeneca Ab
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Publication of HRP20150146T1 publication Critical patent/HRP20150146T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HRP20150146TT 2009-10-27 2010-10-25 Derivati kromenona s protu tumourskom aktivnošä†u HRP20150146T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306017 2009-10-27
EP10769052.1A EP2493870B1 (en) 2009-10-27 2010-10-25 Chromenone derivatives with anti -tumour activity
PCT/GB2010/051788 WO2011051704A1 (en) 2009-10-27 2010-10-25 Chromenone derivatives with anti-tumour activity

Publications (1)

Publication Number Publication Date
HRP20150146T1 true HRP20150146T1 (hr) 2015-05-22

Family

ID=43085922

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20150146TT HRP20150146T1 (hr) 2009-10-27 2010-10-25 Derivati kromenona s protu tumourskom aktivnošä†u

Country Status (41)

Country Link
US (5) US8399460B2 (OSRAM)
EP (1) EP2493870B1 (OSRAM)
JP (2) JP5657010B2 (OSRAM)
KR (1) KR101738195B1 (OSRAM)
CN (2) CN102712615B (OSRAM)
AR (1) AR078786A1 (OSRAM)
AU (1) AU2010311107B9 (OSRAM)
BR (1) BR112012010124B8 (OSRAM)
CA (1) CA2776994C (OSRAM)
CL (1) CL2012001056A1 (OSRAM)
CO (1) CO6541528A2 (OSRAM)
CR (1) CR20120217A (OSRAM)
CU (1) CU20120069A7 (OSRAM)
CY (1) CY1116143T1 (OSRAM)
DK (1) DK2493870T3 (OSRAM)
DO (1) DOP2012000124A (OSRAM)
EA (1) EA020523B9 (OSRAM)
EC (1) ECSP12011838A (OSRAM)
ES (1) ES2530943T3 (OSRAM)
GT (1) GT201200126A (OSRAM)
HN (1) HN2012000889A (OSRAM)
HR (1) HRP20150146T1 (OSRAM)
IL (1) IL219191A0 (OSRAM)
IN (1) IN2012DN03328A (OSRAM)
ME (1) ME02050B (OSRAM)
MX (1) MX2012005027A (OSRAM)
MY (1) MY179833A (OSRAM)
NI (1) NI201200081A (OSRAM)
NZ (1) NZ599457A (OSRAM)
PE (1) PE20130149A1 (OSRAM)
PH (1) PH12012500804A1 (OSRAM)
PL (1) PL2493870T3 (OSRAM)
PT (1) PT2493870E (OSRAM)
RS (1) RS53813B1 (OSRAM)
SA (1) SA110310808B1 (OSRAM)
SI (1) SI2493870T1 (OSRAM)
SM (1) SMT201500036B (OSRAM)
TW (1) TWI483939B (OSRAM)
UA (1) UA107474C2 (OSRAM)
UY (1) UY32978A (OSRAM)
WO (1) WO2011051704A1 (OSRAM)

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EA201692267A1 (ru) 2014-06-13 2017-06-30 Джилид Сайэнс, Инк. Ингибиторы фосфатидилинозитол-3-киназы
JP6383810B2 (ja) 2014-06-13 2018-08-29 ギリアード サイエンシーズ, インコーポレイテッド ホスファチジルイノシトール3−キナーゼ阻害剤としてのキナゾリノン誘導体
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WO2015191752A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CN104803921A (zh) * 2015-03-14 2015-07-29 长沙深橙生物科技有限公司 一种苯取代嘧啶衍生物的制备方法
CN104744376A (zh) * 2015-03-14 2015-07-01 长沙深橙生物科技有限公司 一种2-异丙基嘧啶衍生物的制备方法
KR101766731B1 (ko) 2015-06-23 2017-08-10 충남대학교산학협력단 강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물
EP3359533B1 (en) * 2015-10-09 2021-11-17 Janssen Pharmaceutica NV Quinoxaline and pyridopyrazine derivatives as pi3kbeta inhibitors
WO2018057808A1 (en) 2016-09-23 2018-03-29 Gilead Sciences, Inc. Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors
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AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
KR20210141214A (ko) * 2020-05-15 2021-11-23 제이투에이치바이오텍 (주) 3원환 화합물 및 이의 의약 용도
CN117615763A (zh) * 2021-02-01 2024-02-27 健道生物医药有限公司 磷酸肌醇3激酶β抑制剂及其组合物和制备方法
US20230014445A1 (en) * 2021-05-03 2023-01-19 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
BR112023022940A2 (pt) * 2021-05-03 2024-01-23 Petra Pharma Corp Inibidores alostéricos de cromenona de fosfoinositídeo 3-quinase (pi3k) para o tratamento de doenças
IL308776A (en) * 2021-05-27 2024-01-01 Petra Pharma Corp Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer
TW202329930A (zh) 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
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Also Published As

Publication number Publication date
NI201200081A (es) 2012-11-07
CN104447657A (zh) 2015-03-25
US20110098271A1 (en) 2011-04-28
CA2776994A1 (en) 2011-05-05
AU2010311107B9 (en) 2014-06-19
SI2493870T1 (sl) 2015-03-31
IN2012DN03328A (OSRAM) 2015-10-23
US20140194419A1 (en) 2014-07-10
SMT201500036B (it) 2015-05-05
AU2010311107A1 (en) 2012-05-03
EA020523B1 (ru) 2014-11-28
MY179833A (en) 2020-11-17
CN104447657B (zh) 2016-08-17
CU20120069A7 (es) 2012-10-15
ME02050B (me) 2015-05-20
JP5872016B2 (ja) 2016-03-01
ES2530943T3 (es) 2015-03-09
US20160272607A1 (en) 2016-09-22
PL2493870T3 (pl) 2015-04-30
MX2012005027A (es) 2012-09-07
UA107474C2 (uk) 2015-01-12
EA201200618A1 (ru) 2012-12-28
PE20130149A1 (es) 2013-03-10
RS53813B1 (sr) 2015-06-30
GT201200126A (es) 2014-03-03
US20160060240A1 (en) 2016-03-03
SA110310808B1 (ar) 2013-11-24
KR101738195B1 (ko) 2017-05-19
TWI483939B (zh) 2015-05-11
US8399460B2 (en) 2013-03-19
EP2493870B1 (en) 2014-12-17
JP5657010B2 (ja) 2015-01-21
CN102712615B (zh) 2014-12-17
HK1174027A1 (en) 2013-05-31
EP2493870A1 (en) 2012-09-05
JP2015078202A (ja) 2015-04-23
DK2493870T3 (en) 2015-02-23
US9718800B2 (en) 2017-08-01
CA2776994C (en) 2017-10-31
TW201121960A (en) 2011-07-01
UY32978A (es) 2011-05-31
NZ599457A (en) 2014-04-30
BR112012010124A2 (pt) 2016-06-07
US20130158026A1 (en) 2013-06-20
JP2013508449A (ja) 2013-03-07
AU2010311107B2 (en) 2014-03-27
CR20120217A (es) 2012-06-28
IL219191A0 (en) 2012-06-28
HN2012000889A (es) 2015-08-03
CN102712615A (zh) 2012-10-03
PH12012500804A1 (en) 2022-10-03
CO6541528A2 (es) 2012-10-16
US8673906B2 (en) 2014-03-18
KR20120098724A (ko) 2012-09-05
HK1206335A1 (zh) 2016-01-08
WO2011051704A1 (en) 2011-05-05
CY1116143T1 (el) 2017-02-08
DOP2012000124A (es) 2012-07-15
ECSP12011838A (es) 2012-06-29
BR112012010124B8 (pt) 2021-05-25
PT2493870E (pt) 2015-02-18
CL2012001056A1 (es) 2012-10-05
US9029374B2 (en) 2015-05-12
BR112012010124B1 (pt) 2021-02-17
EA020523B9 (ru) 2015-01-30
AR078786A1 (es) 2011-11-30

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