HRP20140675T1 - Elisa za vegf - Google Patents
Elisa za vegf Download PDFInfo
- Publication number
- HRP20140675T1 HRP20140675T1 HRP20140675TT HRP20140675T HRP20140675T1 HR P20140675 T1 HRP20140675 T1 HR P20140675T1 HR P20140675T T HRP20140675T T HR P20140675TT HR P20140675 T HRP20140675 T HR P20140675T HR P20140675 T1 HRP20140675 T1 HR P20140675T1
- Authority
- HR
- Croatia
- Prior art keywords
- reagent
- antibody
- vegf
- biological sample
- detecting
- Prior art date
Links
- 101100372758 Danio rerio vegfaa gene Proteins 0.000 title 1
- 101150030763 Vegfa gene Proteins 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 8
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 239000012472 biological sample Substances 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 6
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000006166 lysate Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
Claims (20)
1. Postupak in vitro za otkrivanje vaskularnog endotelnog faktora rasta (VEGF) oblika (VEGF110+) u biološkom uzorku, naznačen time, da obuhvaća sljedeće korake:
(a) kontakt i inkubacija biološkog uzorka sa zahvaćenim reagensom koji je imobiliziran na krutom nosaču, pri čemu taj zahvaćeni reagens je monoklonalno protutijelo 5C3 proizvedeno iz hibridoma 5C3.1.1 ATCC deponiranog pod brojem PTA-7737;
(b) odvajanje biološkog uzorka iz imobiliziranog zahvaćenog reagensa;
(c) kontakt imobiliziranog zahvaćenog reagensa – ciljanog molekularnog kompleksa s otkrivajućim protutijelom koje se veže na KDR-receptor i/ili FLT1-receptor domene vezanja od VEGF ili koje se veže na epitop u VEGF 1-110; i
(d) mjerenje razine VEGF110+ spojenog na zahvaćeni reagens uporabom sredstva za detekciju za otkrivajuće protutijelo.
2. Postupak prema zahtjevu 1, naznačen time, da se biološki uzorak izolira iz ljudskog pojedinca.
3. Postupak prema zahtjevu 2, naznačen time, da ljudski pojedinac je vaskularni pacijent, dijabetički pacijent ili pacijent koji boluje od raka, a korak (d) nadalje obuhvaća usporedbu sa standardnom krivuljom za određivanje razine VEGF u usporedbi s istom kod zdravog pojedinca.
4. Postupak prema zahtjevu 1, naznačen time, da biološki uzorak je tumorski lizat, plazma, serum ili urin.
5. Postupak prema zahtjevu 1, naznačen time, da se imobilizirani zahvaćeni reagens oblaže na mikrotiterskoj ploči.
6. Postupak prema zahtjevu 1, naznačen time, da otkrivajuće protutijelo je takvo protutijelo koje se može izravno otkriti.
7. Postupak prema zahtjevu 6, naznačen time, da otkrivajuće protutijelo se pojačava s fluorimetričkim reagensom.
8. Postupak prema zahtjevu 7, naznačen time, da otkrivajuće protutijelo se biotinilira, a sredstvo za detekciju je avidin-peroksidaza ili streptavidin-peroksidaza i 3,3’,5,5’-tetrametil benzidin.
9. Postupak prema zahtjevu 1, naznačen time, da otkrivajuće protutijelo je MAb A4.6.1.
10. Imunoanalitička garnitura za otkrivanje VEGF110+ u biološkom uzorku, naznačena time, da garnitura obuhvaća:
(a) monoklonalno protutijelo 5C3 proizvedeno pomoću hibridoma 5C3.1.1 ATCC deponiranog pod brojem PTA-7737, kao zahvaćeni reagens; i
(b) otkrivajuće protutijelo koje se veže na KDR-receptor i/ili FLT1-receptor domene vezanja od VEGF ili koje se veže na epitop u VEGF 1-110, kao detekcijski reagens.
11. Garnitura prema zahtjevu 10, naznačena time, da nadalje obuhvaća kruti nosač za zahvaćeni reagens.
12. Garnitura prema zahtjevu 11, naznačena time, da je zahvaćeni reagens imobiliziran na krutom nosaču.
13. Garnitura prema zahtjevu 12, naznačena time, da je zahvaćeni reagens obložen na mikrotiterskoj ploči.
14. Garnitura prema zahtjevu 13, naznačena time, da nadalje obuhvaća sredstvo za detekciju za otkrivanje protutijela.
15. Garnitura prema zahtjevu 14, naznačena time, da sredstvo za detekciju je kolorimetričko.
16. Garnitura prema zahtjevu 10, naznačena time, da nadalje obuhvaća pročišćeni VEGF kao antigenski standard.
17. Garnitura prema zahtjevu 10, naznačena time, da otkrivajuće protutijelo je MAb A4.6.1.
18. Protutijelo 5C3, naznačeno time, da se može dobiti ili proizvesti pomoću hibridoma 5C3.1.1 deponiranog pod brojem PTA-7737.
19. Protutijelo prema zahtjevu 18, naznačeno time, da je konjugirano na oznaku koja se može otkriti.
20. Hibridom 5C3.1.1, naznačen time, da je deponiran u ATCC pod brojem uloška PTA-7737.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82820306P | 2006-10-04 | 2006-10-04 | |
| PCT/US2007/080310 WO2008060777A2 (en) | 2006-10-04 | 2007-10-03 | Elisa for vegf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140675T1 true HRP20140675T1 (hr) | 2014-10-10 |
Family
ID=39301650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140675TT HRP20140675T1 (hr) | 2006-10-04 | 2014-07-15 | Elisa za vegf |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US20080227119A1 (hr) |
| EP (3) | EP2069798B1 (hr) |
| JP (1) | JP6025294B2 (hr) |
| KR (2) | KR101720887B1 (hr) |
| CN (2) | CN101523220B (hr) |
| AR (2) | AR063125A1 (hr) |
| AU (1) | AU2007319654B2 (hr) |
| BR (1) | BRPI0715239A2 (hr) |
| CA (1) | CA2663012C (hr) |
| DK (2) | DK2069798T3 (hr) |
| ES (2) | ES2584322T3 (hr) |
| HK (3) | HK1130090A1 (hr) |
| HR (1) | HRP20140675T1 (hr) |
| HU (1) | HUE030082T2 (hr) |
| IL (1) | IL197374A (hr) |
| MX (2) | MX2009003562A (hr) |
| NZ (1) | NZ613646A (hr) |
| PL (2) | PL2457929T3 (hr) |
| PT (1) | PT2069798E (hr) |
| RS (1) | RS53387B (hr) |
| RU (2) | RU2517301C2 (hr) |
| SI (2) | SI2069798T1 (hr) |
| TW (2) | TWI541251B (hr) |
| WO (1) | WO2008060777A2 (hr) |
| ZA (1) | ZA200901518B (hr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009110A1 (en) * | 2003-07-08 | 2005-01-13 | Xiao-Jia Chang | Methods of producing antibodies for diagnostics and therapeutics |
| PL2457929T3 (pl) | 2006-10-04 | 2016-12-30 | Test ELISA dla VEGF | |
| WO2011031986A1 (en) | 2009-09-10 | 2011-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health | Assays for soluble il-15 receptor alpha |
| KR20130126576A (ko) * | 2010-07-19 | 2013-11-20 | 에프. 호프만-라 로슈 아게 | 항암요법에 반응할 가능성이 증가된 환자를 확인하는 방법 |
| WO2012010551A1 (en) * | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy |
| CN102207504A (zh) * | 2011-03-23 | 2011-10-05 | 北京华创远航科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
| CN102435743B (zh) * | 2011-09-15 | 2014-10-15 | 北京健平九星生物医药科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
| CN102426240B (zh) * | 2011-09-19 | 2014-10-15 | 北京健平金星生物科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
| KR20140099277A (ko) * | 2011-12-19 | 2014-08-11 | 에프. 호프만-라 로슈 아게 | 다중특이적 결합제의 자유 결합 파트너의 검출 방법 |
| KR20140114415A (ko) | 2012-01-13 | 2014-09-26 | 제넨테크, 인크. | Vegf 길항제로의 치료를 위한 환자를 확인하기 위한 생물학적 마커 |
| MX349661B (es) * | 2012-02-01 | 2017-08-08 | Hoffmann La Roche | Metodo para la deteccion de una molecula de union de un enlazador multiespecifico. |
| CN102645530B (zh) * | 2012-04-06 | 2014-06-18 | 上海蓝怡科技有限公司 | 甲状腺素酶联免疫体外诊断试剂盒中酶结合物稀释液的制备方法 |
| MX346146B (es) | 2012-07-13 | 2017-03-09 | Hoffmann La Roche | Metodo para detectar un aglutinante multiespecifico. |
| RU2016107435A (ru) | 2013-09-13 | 2017-10-18 | Дженентек, Инк. | Композиции и способы обнаружения и количественного определения белка клеток-хозяев в клеточных линиях и рекомбинантные полипептидные продукты |
| WO2015038888A1 (en) | 2013-09-13 | 2015-03-19 | Genentech, Inc. | Methods and compositions comprising purified recombinant polypeptides |
| AU2014336016B2 (en) | 2013-10-17 | 2019-12-19 | Sartar Therapeutics Ltd | Compositions comprising phosphodiesterase inhibitors for use in the treatment of a solid tumor in a human patient |
| RU2589286C1 (ru) * | 2015-02-03 | 2016-07-10 | Федеральное государственное бюджетное научное учреждение "Томский научно-исследовательский институт онкологии" (Томский НИИ онкологии) | Способ прогнозирования исхода заболевания у больных метастатическим раком почки |
| RU2622005C2 (ru) * | 2015-11-24 | 2017-06-08 | Федеральное государственное бюджетное учреждение "Государственный научный центр дерматовенерологии и косметологии" Минздрава России (ФГБУ ГНЦДК Минздрава России) | СПОСОБ ПОЛУЧЕНИЯ СЕЛЕКТИВНОГО ИММУНОСОРБЕНТА ДЛЯ УДАЛЕНИЯ АНТИТЕЛ-IgG К ДЕСМОГЛЕИНУ 3 ТИПА ИЗ СЫВОРОТКИ КРОВИ БОЛЬНЫХ ПУЗЫРЧАТКОЙ |
| CN105510595A (zh) * | 2015-12-01 | 2016-04-20 | 邹检平 | 基于量子点CdTe检测人血清中VEGF浓度的试剂盒及其使用方法 |
| JP2019523404A (ja) | 2016-07-15 | 2019-08-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 全ｖｅｇｆ−ａのレベルを検出するための方法及び手段 |
| CN107167588A (zh) * | 2017-03-28 | 2017-09-15 | 马杰 | 用于检测血清中血管内皮生长因子的抗体及试剂盒 |
| RU2732013C1 (ru) * | 2019-12-11 | 2020-09-10 | Федеральное бюджетное учреждение науки "Государственный научный центр прикладной микробиологии и биотехнологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ПМБ) | Способ сенсибилизации планшета для иммуноферментного анализа нерастворимыми белковыми антигенами |
| CN111044734A (zh) * | 2019-12-30 | 2020-04-21 | 上海复星长征医学科学有限公司 | 一种用于检测血管内皮生长因子的检测试剂盒及其制备方法和使用方法 |
| KR20220157228A (ko) | 2021-05-20 | 2022-11-29 | 대한민국(질병관리청장) | 보툴리눔 독소 a에 특이적인 항체, 이를 생산하는 하이브리도마 세포주, 및 이를 이용한 보툴리눔 독소 a 진단 키트 |
| CN117805397A (zh) * | 2024-02-29 | 2024-04-02 | 军科正源（北京）药物研究有限责任公司 | 检测游离vegf的方法 |
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| FR2046920B1 (hr) | 1969-06-19 | 1974-05-03 | Citizen Watch Co Ltd | |
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| ATE315789T1 (de) * | 1999-11-16 | 2006-02-15 | Genentech Inc | Elisa für vegf |
| RU2271010C2 (ru) * | 2004-03-31 | 2006-02-27 | Общество с ограниченной ответственностью "Фирма МонА" | Способ иммуноферментного анализа для определения фактора виллебранда, моноклональное антитело к фактору виллебранда (варианты) и штамм гибридных культивируемых клеток животных mus. musculus l. - продуцент моноклональных антител к фактору виллебранда (варианты) |
| AU2006226891A1 (en) * | 2005-03-24 | 2006-09-28 | Beth Israel Deaconess Medical Center | Methods of diagnosing fetal trisomy 13 or a risk of fetal trisomy 13 during pregnancy |
| PL2457929T3 (pl) | 2006-10-04 | 2016-12-30 | Test ELISA dla VEGF |
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2007
- 2007-10-03 PL PL11189401.0T patent/PL2457929T3/pl unknown
- 2007-10-03 AU AU2007319654A patent/AU2007319654B2/en active Active
- 2007-10-03 SI SI200731464T patent/SI2069798T1/sl unknown
- 2007-10-03 WO PCT/US2007/080310 patent/WO2008060777A2/en active Application Filing
- 2007-10-03 MX MX2009003562A patent/MX2009003562A/es unknown
- 2007-10-03 CN CN200780036803.0A patent/CN101523220B/zh active Active
- 2007-10-03 AR ARP070104393 patent/AR063125A1/es active IP Right Grant
- 2007-10-03 PL PL07868362T patent/PL2069798T3/pl unknown
- 2007-10-03 EP EP07868362.0A patent/EP2069798B1/en active Active
- 2007-10-03 HU HUE11189401A patent/HUE030082T2/en unknown
- 2007-10-03 ES ES11189401.0T patent/ES2584322T3/es active Active
- 2007-10-03 DK DK07868362T patent/DK2069798T3/da active
- 2007-10-03 NZ NZ61364607A patent/NZ613646A/en unknown
- 2007-10-03 PT PT78683620T patent/PT2069798E/pt unknown
- 2007-10-03 RS RSP20140350 patent/RS53387B/en unknown
- 2007-10-03 US US11/866,560 patent/US20080227119A1/en not_active Abandoned
- 2007-10-03 BR BRPI0715239-6A2A patent/BRPI0715239A2/pt active Search and Examination
- 2007-10-03 SI SI200731810A patent/SI2457929T1/sl unknown
- 2007-10-03 CN CN201310406549.6A patent/CN103454434B/zh active Active
- 2007-10-03 KR KR1020157005110A patent/KR101720887B1/ko active IP Right Grant
- 2007-10-03 TW TW102139875A patent/TWI541251B/zh active
- 2007-10-03 JP JP2009531581A patent/JP6025294B2/ja active Active
- 2007-10-03 EP EP11189401.0A patent/EP2457929B1/en active Active
- 2007-10-03 ES ES07868362.0T patent/ES2470682T3/es active Active
- 2007-10-03 DK DK11189401.0T patent/DK2457929T3/en active
- 2007-10-03 RU RU2009116611/15A patent/RU2517301C2/ru active
- 2007-10-03 ZA ZA200901518A patent/ZA200901518B/en unknown
- 2007-10-03 EP EP16167119.3A patent/EP3103812B1/en active Active
- 2007-10-03 KR KR1020097009095A patent/KR101551984B1/ko active IP Right Grant
- 2007-10-03 TW TW96137100A patent/TWI429654B/zh active
- 2007-10-03 CA CA2663012A patent/CA2663012C/en active Active
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2009
- 2009-03-03 IL IL197374A patent/IL197374A/en active IP Right Grant
- 2009-04-02 MX MX2014011461A patent/MX342791B/es unknown
- 2009-10-16 HK HK09109608A patent/HK1130090A1/xx unknown
- 2009-10-16 HK HK12108559.2A patent/HK1168361A1/zh unknown
-
2010
- 2010-06-17 US US12/817,827 patent/US8449885B2/en active Active
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2012
- 2012-10-25 US US13/660,563 patent/US9146245B2/en active Active
-
2014
- 2014-02-05 RU RU2014104113/15A patent/RU2014104113A/ru not_active Application Discontinuation
- 2014-07-15 HR HRP20140675TT patent/HRP20140675T1/hr unknown
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2015
- 2015-07-30 US US14/814,139 patent/US9625462B2/en active Active
-
2017
- 2017-02-08 AR ARP170100313A patent/AR107561A2/es unknown
- 2017-03-13 US US15/456,846 patent/US20170276683A1/en not_active Abandoned
- 2017-06-13 HK HK17105832.2A patent/HK1232236A1/zh unknown
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