HRP20140452T1 - Farmaceutske formulacije protiv zlouporabe droga - Google Patents

Farmaceutske formulacije protiv zlouporabe droga Download PDF

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HRP20140452T1
HRP20140452T1 HRP20140452AT HRP20140452T HRP20140452T1 HR P20140452 T1 HRP20140452 T1 HR P20140452T1 HR P20140452A T HRP20140452A T HR P20140452AT HR P20140452 T HRP20140452 T HR P20140452T HR P20140452 T1 HRP20140452 T1 HR P20140452T1
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Croatia
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granule
group
core
compounds
mass
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HRP20140452AT
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Pascal Suplie
Christophe Lebon
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Debregeas Et Associes Pharma
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Publication of HRP20140452T1 publication Critical patent/HRP20140452T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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Claims (9)

1. Granula, naznačena time, da ima strukturu tipa jezgre omotane ljuskom, pri čemu je jezgra odabrana od netopivih nosača, te je posebno odabrana iz skupine koju čine polioli, gume, derivati silicija, derivati kalcija ili kalija, mineralni spojevi ka što su dikalcij fosfati, trikalcij fosfati, kalcij karbonati, saharoza, derivati celuloze, posebno mikrokristalična celuloza, etilceluloza i hidroksipropilmetilceluloza, škrob, te njihove mješavine, pri čemu spomenuta ljuska sadrži djelotvorni sastojak koji je različite tvari od one u jezgri i koji opkoljava jezgru, gdje spomenuti djelotvorni sastojak predstavlja između 0,5% i 60% mase od ukupne mase spomenute granule, dok ljuska granule nadalje sadrži sljedeće spojeve: - jedno ili više bojila topivih u vodenim ili alkoholnim otapalima, - jedno ili više metalnih pigmentacijskih sredstava, - jedan ili više spojeva koji oslobađaju plinove, - jedan ili više gorkih sredstava.
2. Granula prema zahtjevu 1, naznačena time, da je spoj koji oslobađa plinove odabran iz skupine koju čine karbonati i bikarbonati, a posebno je odabran iz skupine koju čine natrijev bikarbonat, natrijev glicinski karbonat, kalijev bikarbonat, magnezijev bikarbonat i kalcijev bikarbonat.
3. Granula prema zahtjevu 1 ili 2, naznačena time, da metalna pigmentacijska sredstva su pigmenti na bazi titanij dioksida, a nalaze se na površini spomenute granule.
4. Granula prema bilo kojem od zahtjeva 1 do 3, naznačena time, da je djelotvorni sastojak odabran iz skupine koju čine antalgetici i analgetici.
5. Granula prema bilo kojem od zahtjeva 1 do 3, naznačena time, da je djelotvorni sastojak odabran iz skupine koju čine morfij sulfat, oksikodon, gama-hidroksibutirična kiselina ili jedna od njihovih soli, buprenorfin, modafinil, dekstropropoksifen, metadon, tramadol, nalbufin, tetrahidrokanabinol i benzodiazepini.
6. Granula prema bilo kojem od zahtjeva 1 do 5, naznačena time, da je gorko sredstvo odabrano iz skupine koju čine denatonij benzoat, ekstrakti gencijane, kinin, kafein, brucin, kvasin, propil tiouracil (PROP), feniltiokarbamid (PTC), astringentski spojevi kao što su tanini, okusi grejpfruta i okusi gorkog kakaa.
7. Granula prema bilo kojem od zahtjeva 1 do 6, naznačena time, da sadrži bojilo od 0,2% do 4% po masi, metalne pigmente od 0,1% do 5% po masi i spojeve koji oslobađaju plinove od 5% do 20% po masi, na bazi ukupne mase granule.
8. Granula prema bilo kojem od zahtjeva 1 do 7, naznačena time, da kruta jezgra predstavlja od 10% do 85% mase od ukupne mase granule.
9. Farmaceutski sastav, naznačen time, da obuhvaća granule prema bilo kojem od zahtjeva 1 do 8.
HRP20140452AT 2009-08-12 2014-05-21 Farmaceutske formulacije protiv zlouporabe droga HRP20140452T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0955642A FR2949062B1 (fr) 2009-08-12 2009-08-12 Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
PCT/FR2010/051697 WO2011018583A2 (fr) 2009-08-12 2010-08-11 Nouvelles formulations pharmaceutiques contre le mésusage des médicaments

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HRP20140452T1 true HRP20140452T1 (hr) 2014-07-04

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HRP20140452AT HRP20140452T1 (hr) 2009-08-12 2014-05-21 Farmaceutske formulacije protiv zlouporabe droga

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US (1) US8999392B2 (hr)
EP (1) EP2464342B1 (hr)
JP (1) JP5608746B2 (hr)
KR (1) KR101450974B1 (hr)
CN (1) CN102573801B (hr)
AR (1) AR077865A1 (hr)
AU (1) AU2010283609B2 (hr)
CA (1) CA2771054C (hr)
CL (1) CL2012000377A1 (hr)
CY (1) CY1115195T1 (hr)
DK (1) DK2464342T3 (hr)
EA (1) EA021856B1 (hr)
ES (1) ES2465523T3 (hr)
FR (1) FR2949062B1 (hr)
HK (1) HK1172845A1 (hr)
HR (1) HRP20140452T1 (hr)
IL (1) IL218071A (hr)
IN (1) IN2012DN01859A (hr)
MA (1) MA33522B1 (hr)
MX (1) MX2012001879A (hr)
NZ (1) NZ598471A (hr)
PE (1) PE20120916A1 (hr)
PL (1) PL2464342T3 (hr)
PT (1) PT2464342E (hr)
SG (1) SG180306A1 (hr)
SI (1) SI2464342T1 (hr)
SM (1) SMT201400076B (hr)
TN (1) TN2012000069A1 (hr)
TW (1) TWI465261B (hr)
UA (1) UA104902C2 (hr)
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EP2464342A2 (fr) 2012-06-20
TWI465261B (zh) 2014-12-21
DK2464342T3 (da) 2014-06-02
SI2464342T1 (sl) 2014-07-31
IL218071A (en) 2015-10-29
KR101450974B1 (ko) 2014-10-15
AR077865A1 (es) 2011-09-28
JP5608746B2 (ja) 2014-10-15
EP2464342B1 (fr) 2014-02-26
IN2012DN01859A (hr) 2015-08-21
CL2012000377A1 (es) 2012-12-07
EA201200275A1 (ru) 2012-07-30
PE20120916A1 (es) 2012-08-08
CN102573801B (zh) 2013-08-21
TW201119689A (en) 2011-06-16
WO2011018583A2 (fr) 2011-02-17
TN2012000069A1 (fr) 2013-09-19
WO2011018583A3 (fr) 2011-04-07
HK1172845A1 (en) 2013-05-03
PL2464342T3 (pl) 2014-07-31
ZA201201712B (en) 2012-11-28
MX2012001879A (es) 2012-06-12
AU2010283609A1 (en) 2012-03-29
MA33522B1 (fr) 2012-08-01
ES2465523T3 (es) 2014-06-06
IL218071A0 (en) 2012-04-30
BR112012003286A2 (pt) 2016-03-01
CA2771054A1 (fr) 2011-02-17
JP2013501763A (ja) 2013-01-17
SMT201400076B (it) 2014-09-08
PT2464342E (pt) 2014-05-28
SG180306A1 (en) 2012-06-28
EA021856B1 (ru) 2015-09-30
US20120164228A1 (en) 2012-06-28
KR20120050476A (ko) 2012-05-18
UA104902C2 (uk) 2014-03-25
CY1115195T1 (el) 2017-01-04
FR2949062A1 (fr) 2011-02-18
CN102573801A (zh) 2012-07-11
FR2949062B1 (fr) 2011-09-02
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US8999392B2 (en) 2015-04-07
CA2771054C (fr) 2017-02-21

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