HRP20130867T1 - Kondenzirani heterocikliäśki spojevi 2-cijanofenila, te njihovi pripravci i uporaba - Google Patents

Kondenzirani heterocikliäśki spojevi 2-cijanofenila, te njihovi pripravci i uporaba Download PDF

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Publication number
HRP20130867T1
HRP20130867T1 HRP20130867AT HRP20130867T HRP20130867T1 HR P20130867 T1 HRP20130867 T1 HR P20130867T1 HR P20130867A T HRP20130867A T HR P20130867AT HR P20130867 T HRP20130867 T HR P20130867T HR P20130867 T1 HRP20130867 T1 HR P20130867T1
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Croatia
Prior art keywords
pyrido
pyrimidin
dihydro
benzonitrile
methyl
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HRP20130867AT
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English (en)
Croatian (hr)
Inventor
Zhi-Liang Wei
Matthew Alexander James Duncton
John Kincaid
Michael G. Kelly
Donogh O'mahony
Zhan Wang
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Evotec Ag
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Publication of HRP20130867T1 publication Critical patent/HRP20130867T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
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    • A61P11/02Nasal agents, e.g. decongestants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
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    • AHUMAN NECESSITIES
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20130867AT 2007-04-17 2008-03-31 Kondenzirani heterocikliäśki spojevi 2-cijanofenila, te njihovi pripravci i uporaba HRP20130867T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92510907P 2007-04-17 2007-04-17
US1051208P 2008-01-08 2008-01-08
PCT/US2008/004208 WO2008130481A1 (en) 2007-04-17 2008-03-31 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

Publications (1)

Publication Number Publication Date
HRP20130867T1 true HRP20130867T1 (hr) 2013-10-25

Family

ID=39875785

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20130867AT HRP20130867T1 (hr) 2007-04-17 2008-03-31 Kondenzirani heterocikliäśki spojevi 2-cijanofenila, te njihovi pripravci i uporaba

Country Status (12)

Country Link
US (2) US8076345B2 (https=)
EP (1) EP2139334B1 (https=)
JP (1) JP5498374B2 (https=)
CN (1) CN101677569B (https=)
CA (1) CA2682692A1 (https=)
CY (1) CY1114382T1 (https=)
DK (1) DK2139334T3 (https=)
ES (1) ES2427999T3 (https=)
HR (1) HRP20130867T1 (https=)
PL (1) PL2139334T3 (https=)
PT (1) PT2139334E (https=)
WO (1) WO2008130481A1 (https=)

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MX2010009561A (es) 2008-02-29 2010-09-24 Renovis Inc Compuestos amida, composiciones y usos de los mismos.
WO2010066629A2 (en) * 2008-12-09 2010-06-17 F. Hoffmann-La Roche Ag Novel azaindoles
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
AU2014253493B2 (en) * 2010-07-06 2016-04-14 Novartis Ag Tetrahydro-pyrido-pyrimidine derivatives
JP2014518256A (ja) * 2011-06-27 2014-07-28 ノバルティス アーゲー テトラヒドロ−ピリド−ピリミジン誘導体の固体形態および塩類
DK2790705T3 (en) 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
CN103497149A (zh) * 2013-10-08 2014-01-08 南京复兴生物科技有限公司 一种5-氨甲基吡啶衍生物的制备方法
HUE058009T2 (hu) 2014-12-09 2022-06-28 Bayer Ag 1,3-Tiazol-2-il szubsztituált benzamid-származékok
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2017049498A1 (zh) * 2015-09-23 2017-03-30 前湾医药科技(深圳)有限公司 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用
CN113727758A (zh) * 2019-03-01 2021-11-30 锐新医药公司 双环杂环基化合物及其用途
CN114222741B (zh) 2019-05-31 2025-12-30 奇斯药制品公司 作为p2x3抑制剂的吡啶并嘧啶类衍生物
BR112021022099A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
CN116194446A (zh) * 2020-08-06 2023-05-30 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
JP2023550830A (ja) 2020-11-27 2023-12-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ P2x3阻害剤としての(アザ)キノリン4-アミン誘導体
AU2021388923A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
KR20230113289A (ko) 2020-11-27 2023-07-28 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 프탈라진 유도체
US11993580B1 (en) 2022-12-02 2024-05-28 Neumora Therapeutics, Inc. Methods of treating neurological disorders

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US7087589B2 (en) * 2000-01-14 2006-08-08 The United States Of America As Represented By The Department Of Health And Human Services Methanocarba cycloakyl nucleoside analogues
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CA2682162C (en) * 2007-04-02 2016-05-10 Renovis, Inc. Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof
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Publication number Publication date
JP5498374B2 (ja) 2014-05-21
DK2139334T3 (da) 2013-09-23
US8076345B2 (en) 2011-12-13
EP2139334A1 (en) 2010-01-06
PT2139334E (pt) 2013-10-02
ES2427999T3 (es) 2013-11-05
CN101677569A (zh) 2010-03-24
US20080275037A1 (en) 2008-11-06
JP2010524930A (ja) 2010-07-22
EP2139334B1 (en) 2013-07-03
US20120149700A1 (en) 2012-06-14
WO2008130481A1 (en) 2008-10-30
EP2139334A4 (en) 2011-06-22
CA2682692A1 (en) 2008-10-30
PL2139334T3 (pl) 2013-11-29
CN101677569B (zh) 2014-01-22
CY1114382T1 (el) 2016-08-31

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