CN101677569B - 2-氰基苯基稠合杂环化合物及其组合物和用途 - Google Patents

2-氰基苯基稠合杂环化合物及其组合物和用途 Download PDF

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Publication number
CN101677569B
CN101677569B CN200880016706.XA CN200880016706A CN101677569B CN 101677569 B CN101677569 B CN 101677569B CN 200880016706 A CN200880016706 A CN 200880016706A CN 101677569 B CN101677569 B CN 101677569B
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pyrimidin
benzonitrile
pyrido
dihydro
methyl
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CN101677569A (zh
Inventor
魏志良
M·A·J·当克藤
J·金凯德
M·G·凯利
D·奥马赫尼
王展
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Evotec GmbH
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Evotec GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Immunology (AREA)
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  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880016706.XA 2007-04-17 2008-03-31 2-氰基苯基稠合杂环化合物及其组合物和用途 Expired - Fee Related CN101677569B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92510907P 2007-04-17 2007-04-17
US60/925,109 2007-04-17
US1051208P 2008-01-08 2008-01-08
US61/010,512 2008-01-08
PCT/US2008/004208 WO2008130481A1 (en) 2007-04-17 2008-03-31 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

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CN101677569A CN101677569A (zh) 2010-03-24
CN101677569B true CN101677569B (zh) 2014-01-22

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US (2) US8076345B2 (https=)
EP (1) EP2139334B1 (https=)
JP (1) JP5498374B2 (https=)
CN (1) CN101677569B (https=)
CA (1) CA2682692A1 (https=)
CY (1) CY1114382T1 (https=)
DK (1) DK2139334T3 (https=)
ES (1) ES2427999T3 (https=)
HR (1) HRP20130867T1 (https=)
PL (1) PL2139334T3 (https=)
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DK2790705T3 (en) 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
CN103497149A (zh) * 2013-10-08 2014-01-08 南京复兴生物科技有限公司 一种5-氨甲基吡啶衍生物的制备方法
HUE058009T2 (hu) 2014-12-09 2022-06-28 Bayer Ag 1,3-Tiazol-2-il szubsztituált benzamid-származékok
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
WO2017049498A1 (zh) * 2015-09-23 2017-03-30 前湾医药科技（深圳）有限公司 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用
CN113727758A (zh) * 2019-03-01 2021-11-30 锐新医药公司 双环杂环基化合物及其用途
CN114222741B (zh) 2019-05-31 2025-12-30 奇斯药制品公司 作为p2x3抑制剂的吡啶并嘧啶类衍生物
BR112021022099A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
CN116194446A (zh) * 2020-08-06 2023-05-30 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
JP2023550830A (ja) 2020-11-27 2023-12-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体
AU2021388923A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
KR20230113289A (ko) 2020-11-27 2023-07-28 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 프탈라진 유도체
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JP5498374B2 (ja) 2014-05-21
DK2139334T3 (da) 2013-09-23
US8076345B2 (en) 2011-12-13
EP2139334A1 (en) 2010-01-06
PT2139334E (pt) 2013-10-02
ES2427999T3 (es) 2013-11-05
CN101677569A (zh) 2010-03-24
US20080275037A1 (en) 2008-11-06
JP2010524930A (ja) 2010-07-22
EP2139334B1 (en) 2013-07-03
US20120149700A1 (en) 2012-06-14
WO2008130481A1 (en) 2008-10-30
EP2139334A4 (en) 2011-06-22
CA2682692A1 (en) 2008-10-30
PL2139334T3 (pl) 2013-11-29
CY1114382T1 (el) 2016-08-31

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