JP2010524930A5 - - Google Patents
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- Publication number
- JP2010524930A5 JP2010524930A5 JP2010504040A JP2010504040A JP2010524930A5 JP 2010524930 A5 JP2010524930 A5 JP 2010524930A5 JP 2010504040 A JP2010504040 A JP 2010504040A JP 2010504040 A JP2010504040 A JP 2010504040A JP 2010524930 A5 JP2010524930 A5 JP 2010524930A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- pyrimidin
- dihydro
- benzonitrile
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C(C)(C=CC=C1N(CC2)Cc3c2ncnc3NC(*)*)C=C1C#N Chemical compound C*C(C)(C=CC=C1N(CC2)Cc3c2ncnc3NC(*)*)C=C1C#N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92510907P | 2007-04-17 | 2007-04-17 | |
| US60/925,109 | 2007-04-17 | ||
| US1051208P | 2008-01-08 | 2008-01-08 | |
| US61/010,512 | 2008-01-08 | ||
| PCT/US2008/004208 WO2008130481A1 (en) | 2007-04-17 | 2008-03-31 | 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524930A JP2010524930A (ja) | 2010-07-22 |
| JP2010524930A5 true JP2010524930A5 (https=) | 2011-04-07 |
| JP5498374B2 JP5498374B2 (ja) | 2014-05-21 |
Family
ID=39875785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504040A Expired - Fee Related JP5498374B2 (ja) | 2007-04-17 | 2008-03-31 | ２−シアノフェニル縮合複素環式化合物および組成物、ならびにその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8076345B2 (https=) |
| EP (1) | EP2139334B1 (https=) |
| JP (1) | JP5498374B2 (https=) |
| CN (1) | CN101677569B (https=) |
| CA (1) | CA2682692A1 (https=) |
| CY (1) | CY1114382T1 (https=) |
| DK (1) | DK2139334T3 (https=) |
| ES (1) | ES2427999T3 (https=) |
| HR (1) | HRP20130867T1 (https=) |
| PL (1) | PL2139334T3 (https=) |
| PT (1) | PT2139334E (https=) |
| WO (1) | WO2008130481A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010009561A (es) | 2008-02-29 | 2010-09-24 | Renovis Inc | Compuestos amida, composiciones y usos de los mismos. |
| WO2010066629A2 (en) * | 2008-12-09 | 2010-06-17 | F. Hoffmann-La Roche Ag | Novel azaindoles |
| UA112517C2 (uk) | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| AU2014253493B2 (en) * | 2010-07-06 | 2016-04-14 | Novartis Ag | Tetrahydro-pyrido-pyrimidine derivatives |
| JP2014518256A (ja) * | 2011-06-27 | 2014-07-28 | ノバルティス アーゲー | テトラヒドロ−ピリド−ピリミジン誘導体の固体形態および塩類 |
| DK2790705T3 (en) | 2011-12-15 | 2018-03-12 | Novartis Ag | Use of inhibitors of the activity or function of PI3K |
| CN103497149A (zh) * | 2013-10-08 | 2014-01-08 | 南京复兴生物科技有限公司 | 一种5-氨甲基吡啶衍生物的制备方法 |
| HUE058009T2 (hu) | 2014-12-09 | 2022-06-28 | Bayer Ag | 1,3-Tiazol-2-il szubsztituált benzamid-származékok |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| WO2017049498A1 (zh) * | 2015-09-23 | 2017-03-30 | 前湾医药科技（深圳）有限公司 | 一种咪唑并吡啶类化合物与在制备pi3k抑制剂中的应用 |
| CN113727758A (zh) * | 2019-03-01 | 2021-11-30 | 锐新医药公司 | 双环杂环基化合物及其用途 |
| CN114222741B (zh) | 2019-05-31 | 2025-12-30 | 奇斯药制品公司 | 作为p2x3抑制剂的吡啶并嘧啶类衍生物 |
| BR112021022099A2 (pt) | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| CN116194446A (zh) * | 2020-08-06 | 2023-05-30 | 北京泰德制药股份有限公司 | Sos1抑制剂、包含其的药物组合物及其用途 |
| JP2023550830A (ja) | 2020-11-27 | 2023-12-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐ２ｘ３阻害剤としての（アザ）キノリン４－アミン誘導体 |
| AU2021388923A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| KR20230113289A (ko) | 2020-11-27 | 2023-07-28 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 프탈라진 유도체 |
| US11993580B1 (en) | 2022-12-02 | 2024-05-28 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3424760A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| US3424761A (en) | 1966-03-07 | 1969-01-28 | Robins Co Inc A H | 3-ureidopyrrolidines |
| DE2502588A1 (de) | 1975-01-23 | 1976-07-29 | Troponwerke Dinklage & Co | Basisch substituierte derivate des 7-amino-2-chinolons, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| ATE306481T1 (de) | 1999-05-12 | 2005-10-15 | Ortho Mcneil Pharm Inc | Pyrazolecarboxamide zur behandlung von fettleibigkeit und anderen erkrankungen |
| US7087589B2 (en) * | 2000-01-14 | 2006-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methanocarba cycloakyl nucleoside analogues |
| US6531478B2 (en) | 2000-02-24 | 2003-03-11 | Cheryl P. Kordik | Amino pyrazole derivatives useful for the treatment of obesity and other disorders |
| JP2004525071A (ja) | 2000-07-20 | 2004-08-19 | ニューロジェン コーポレイション | カプサイシン受容体リガンド |
| CA2432578C (en) | 2001-01-02 | 2008-04-01 | F. Hoffmann-La Roche Ag | Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| GB0206033D0 (en) | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
| AU2003242252A1 (en) * | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| GB0225908D0 (en) | 2002-11-06 | 2002-12-11 | Pfizer Ltd | Treatment of female sexual dysfunction |
| WO2004056774A2 (en) | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| TW200530235A (en) * | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
| US7297700B2 (en) * | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| MX2007013595A (es) * | 2005-05-04 | 2008-01-24 | Renovis Inc | Compuestos heterociclicos fusionados y composiciones y usos de estos. |
| CA2682162C (en) * | 2007-04-02 | 2016-05-10 | Renovis, Inc. | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
| US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
-
2008
- 2008-03-31 JP JP2010504040A patent/JP5498374B2/ja not_active Expired - Fee Related
- 2008-03-31 WO PCT/US2008/004208 patent/WO2008130481A1/en not_active Ceased
- 2008-03-31 EP EP08742430.5A patent/EP2139334B1/en not_active Not-in-force
- 2008-03-31 CN CN200880016706.XA patent/CN101677569B/zh not_active Expired - Fee Related
- 2008-03-31 PL PL08742430T patent/PL2139334T3/pl unknown
- 2008-03-31 HR HRP20130867AT patent/HRP20130867T1/hr unknown
- 2008-03-31 ES ES08742430T patent/ES2427999T3/es active Active
- 2008-03-31 DK DK08742430.5T patent/DK2139334T3/da active
- 2008-03-31 CA CA002682692A patent/CA2682692A1/en not_active Abandoned
- 2008-03-31 US US12/080,253 patent/US8076345B2/en not_active Expired - Fee Related
- 2008-03-31 PT PT87424305T patent/PT2139334E/pt unknown
-
2011
- 2011-12-12 US US13/323,748 patent/US20120149700A1/en not_active Abandoned
-
2013
- 2013-09-16 CY CY20131100796T patent/CY1114382T1/el unknown
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