JP2012502986A5 - - Google Patents

Download PDF

Info

Publication number
JP2012502986A5
JP2012502986A5 JP2011527808A JP2011527808A JP2012502986A5 JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5 JP 2011527808 A JP2011527808 A JP 2011527808A JP 2011527808 A JP2011527808 A JP 2011527808A JP 2012502986 A5 JP2012502986 A5 JP 2012502986A5
Authority
JP
Japan
Prior art keywords
substituted
unsubstituted
methyl
heterocycloalkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011527808A
Other languages
English (en)
Japanese (ja)
Other versions
JP5608655B2 (ja
JP2012502986A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/005119 external-priority patent/WO2010033168A2/en
Publication of JP2012502986A publication Critical patent/JP2012502986A/ja
Publication of JP2012502986A5 publication Critical patent/JP2012502986A5/ja
Application granted granted Critical
Publication of JP5608655B2 publication Critical patent/JP5608655B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011527808A 2008-09-18 2009-09-14 P2x3受容体活性のモジュレーター Expired - Fee Related JP5608655B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19258108P 2008-09-18 2008-09-18
US61/192,581 2008-09-18
US11822808P 2008-11-26 2008-11-26
US61/118,228 2008-11-26
US18091509P 2009-05-25 2009-05-25
US61/180,915 2009-05-25
PCT/US2009/005119 WO2010033168A2 (en) 2008-09-18 2009-09-14 Amide compounds, compositions and uses thereof

Publications (3)

Publication Number Publication Date
JP2012502986A JP2012502986A (ja) 2012-02-02
JP2012502986A5 true JP2012502986A5 (https=) 2012-08-30
JP5608655B2 JP5608655B2 (ja) 2014-10-15

Family

ID=41328566

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011527808A Expired - Fee Related JP5608655B2 (ja) 2008-09-18 2009-09-14 P2x3受容体活性のモジュレーター

Country Status (5)

Country Link
US (2) US20110237578A1 (https=)
EP (1) EP2346825A2 (https=)
JP (1) JP5608655B2 (https=)
CA (1) CA2737038A1 (https=)
WO (1) WO2010033168A2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010009561A (es) * 2008-02-29 2010-09-24 Renovis Inc Compuestos amida, composiciones y usos de los mismos.
MX2011008362A (es) 2009-02-13 2011-08-24 Shionogi & Co Derivado novedoso de triazina y composicion farmaceutica que comprende el mismo.
EP2445889B1 (en) * 2009-06-22 2016-08-10 F.Hoffmann-La Roche Ag Novel benzoxazolone -substituted arylamides
DK2604595T3 (en) 2010-08-10 2016-05-23 Shionogi & Co TRIAZINE DERIVATIVES AND PHARMACEUTICAL RELATIONSHIP CONTAINING THIS AND PROVIDING ANALGETIC ACTIVITY
WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists
WO2016084922A1 (ja) * 2014-11-28 2016-06-02 塩野義製薬株式会社 1,2,4-トリアジン誘導体およびその医薬組成物
HUE058009T2 (hu) 2014-12-09 2022-06-28 Bayer Ag 1,3-Tiazol-2-il szubsztituált benzamid-származékok
US10183937B2 (en) 2014-12-09 2019-01-22 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides
CN107207449B (zh) 2015-04-23 2020-11-10 豪夫迈·罗氏有限公司 用于治疗精神障碍的四唑衍生物
CN107709311B (zh) * 2015-07-14 2020-09-25 豪夫迈·罗氏有限公司 2-苯基-6-咪唑基-吡啶-4-甲酰胺衍生物及其作为eaat3抑制剂的用途
CN107922391B (zh) * 2015-08-12 2020-09-25 豪夫迈·罗氏有限公司 吡啶和嘧啶衍生物
CN108137566B (zh) * 2015-10-06 2021-05-25 豪夫迈·罗氏有限公司 三唑衍生物
CN109563049B (zh) 2016-10-14 2022-11-29 豪夫迈·罗氏有限公司 作为eaat3抑制剂的咪唑化合物
WO2018165612A1 (en) 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
US11938114B2 (en) 2017-03-10 2024-03-26 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
CN110770224B (zh) 2017-03-10 2022-11-18 罗格斯新泽西州立大学 作为外排泵抑制剂的吲哚衍生物
EP3630109A4 (en) 2017-05-26 2021-03-17 Rutgers, the State University of New Jersey BACTERIAL EFFLUX PUMP INHIBITORS
WO2019005841A1 (en) * 2017-06-26 2019-01-03 Rutgers, The State University Of New Jersey THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
CA3115939A1 (en) * 2018-10-10 2020-04-16 Bellus Health Cough Inc. Treatment of pruritus with p2x3 antagonists
CN111377970B (zh) * 2018-12-28 2022-12-23 广东阿格蕾雅光电材料有限公司 一种n`n`c`n型四齿铂(ii)配合物的制备及应用
AU2020228760A1 (en) 2019-02-25 2021-09-23 Glaxosmithkline Intellectual Property (No. 3) Limited Treatment with P2X3 modulators
CN114222741B (zh) 2019-05-31 2025-12-30 奇斯药制品公司 作为p2x3抑制剂的吡啶并嘧啶类衍生物
BR112021022099A2 (pt) 2019-05-31 2021-12-28 Chiesi Farm Spa Derivados de amino quinazolina como inibidores de p2x3
CN115397813A (zh) * 2020-04-16 2022-11-25 豪夫迈·罗氏有限公司 联苯衍生物
AU2021388923A1 (en) 2020-11-27 2023-05-25 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
JP2023550830A (ja) 2020-11-27 2023-12-05 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ P2x3阻害剤としての(アザ)キノリン4-アミン誘導体
KR20230113289A (ko) 2020-11-27 2023-07-28 키에시 파르마슈티시 엣스. 피. 에이. P2x3 억제제로서 프탈라진 유도체

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2731469A (en) * 1953-10-23 1956-01-17 Searle & Co N-dialkylaminoalkyl derivatives of diarylisonicotinamides
JPS6413083A (en) * 1987-07-07 1989-01-17 Akishiro Nakamura Streptonigrin derivative and medicinal composition
US4916145A (en) * 1987-07-10 1990-04-10 Hoffmann-La Roche Inc. Substituted n-[(pyridyl)alkyl]aryl-carboxamide
GB9600063D0 (en) 1996-01-03 1996-03-06 Fujisawa Pharmaceutical Co Guaridine derivatives
US6037324A (en) * 1996-01-04 2000-03-14 Leukosite, Inc. Inhibitors of MAdCAM-1-mediated interactions and methods of use therefor
AU2001294557A1 (en) 2000-09-11 2002-03-26 Merck And Co., Inc. Thrombin inhibitors
WO2002070469A2 (en) 2001-03-05 2002-09-12 Icos Corporation Selective pde3b inhibitors and use of the same in therapy
ES2249589T3 (es) 2001-05-18 2006-04-01 Abbott Laboratories Trisustituido-n-((1s)-1,2,3,4-tetrahidro-1-naftalenil)benzamidas que inhiben receptores que contienen antagonistas p2x3 y p2x2/3.
WO2008011131A2 (en) * 2006-07-21 2008-01-24 Takeda Pharmaceutical Company Limited Amide compounds
AR037460A1 (es) 2001-11-30 2004-11-10 Smithkline Beecham Plc Compuesto de hidroxietileno, composicion farmaceutica que lo comprende, uso del mismo para la fabricacion de un medicamento y procedimiento para su preparacion
EP1503997A1 (en) * 2002-05-14 2005-02-09 Axys Pharmaceuticals, Inc. Cysteine protease inhibitors
WO2004052921A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
AU2004277981B2 (en) 2003-10-03 2009-10-01 Merck & Co., Inc. Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease
WO2005113514A2 (en) * 2004-05-07 2005-12-01 Janssen Pharmaceutica, N.V. Substituted pyrimidines as inhibitors of bacterial type iii protein secretion systems
AU2005245376A1 (en) 2004-05-13 2005-12-01 Merck & Co., Inc. Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
TW200640877A (en) * 2005-04-28 2006-12-01 Actelion Pharmaceuticals Ltd Pyrimidine derivatives
WO2007017510A2 (de) 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Isophthalsäurediamide zur behandlung der alzheimer erkrankung
US20100144681A1 (en) 2005-08-11 2010-06-10 Klaus Fuchs Compounds for the treatment of alzheimer's disease
CN102659774A (zh) * 2005-08-15 2012-09-12 弗·哈夫曼-拉罗切有限公司 作为p2x3拮抗剂的哌啶和哌嗪衍生物
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
WO2007115409A1 (en) 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
EP2592070B1 (en) * 2006-06-29 2016-08-31 F. Hoffmann-La Roche AG Tetrazole-substituted arylamides
MX2009002046A (es) * 2006-08-24 2009-03-06 Astrazeneca Ab Derivados de morfolino pirimidina utiles en el tratamiento de trastornos proliferativos.
AR063258A1 (es) * 2006-10-13 2009-01-14 Actelion Pharmaceuticals Ltd Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos.
EP2091927B1 (en) * 2006-11-09 2011-07-20 F. Hoffmann-La Roche AG Thiazole and oxazole-substituted arylamides
WO2008119773A1 (en) 2007-03-30 2008-10-09 Medivir Ab Amide derivatives as inhibitors of aspartyl proteases
CA2703909A1 (en) * 2007-10-31 2009-05-07 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
AU2008319309B2 (en) 2007-10-31 2012-09-06 Merck Sharp & Dohme Llc P2X3 receptor antagonists for treatment of pain
CA2708791C (en) 2007-12-17 2016-06-21 F. Hoffmann-La Roche Ag Imidazole-substituted arylamides and uses thereof as p2x receptor antagonists
US7989454B2 (en) 2007-12-17 2011-08-02 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
ES2417182T3 (es) 2007-12-17 2013-08-06 F. Hoffmann-La Roche Ag Nuevas arilamidas sustituidas con pirazol
EP2234989B1 (en) 2007-12-17 2014-08-13 F. Hoffmann-La Roche AG Tetrazole-substituted arylamide derivatives and their use as p2x3 and/or p2x2/3 purinergic receptor antagonists
ES2542245T3 (es) 2007-12-17 2015-08-03 F. Hoffmann-La Roche Ag Derivados de arilamida sustituido con triazol y su utilización como antagonistas del receptor purinérgico P2x3 y/o P2x2/3
ES2534199T3 (es) * 2008-10-31 2015-04-20 Merck Sharp & Dohme Corp. Antagonistas del receptor P2X3 para el tratamiento del dolor
EP2379518B1 (en) 2008-12-16 2014-05-07 F. Hoffmann-La Roche AG Thiadiazole-substituted arylamides
US8946231B2 (en) 2009-03-23 2015-02-03 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
WO2010111058A1 (en) 2009-03-23 2010-09-30 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
AU2010229144B2 (en) 2009-03-23 2012-07-12 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
EP2445889B1 (en) 2009-06-22 2016-08-10 F.Hoffmann-La Roche Ag Novel benzoxazolone -substituted arylamides
CN102574778B (zh) 2009-06-22 2015-01-07 弗·哈夫曼-拉罗切有限公司 新的联苯基和苯基-吡啶酰胺类化合物

Similar Documents

Publication Publication Date Title
JP2012502986A5 (https=)
JP2008534511A5 (https=)
US10526291B2 (en) Potent dual BRD4-kinase inhibitors as cancer therapeutics
ES2234564T3 (es) Compuestos de tipo amida y su uso en medicina.
CA2787756C (en) Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof
JP2011514894A5 (https=)
JP5600754B2 (ja) ピラジン誘導体および神経障害の処置におけるそれらの使用
JP5603308B2 (ja) ヘッジホッグ経路調節剤としての化合物および組成物
JP5579704B2 (ja) フェニルおよびベンゾジオキシニル置換インダゾール誘導体
US8906914B2 (en) Ethylene diamine modulators of fatty acid hydrolase
EP1438973A1 (en) Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
JP2014525425A5 (https=)
JP2023540661A (ja) CCR8阻害剤を使用してTregsを標的とする方法および組成物
JP2015533782A (ja) スルファモイル−アリールアミド及びb型肝炎の治療のための薬剤としてのその使用
US9988390B2 (en) Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP2010524930A5 (https=)
EP2488486A1 (en) Hematopoietic growth factor mimetic small molecule compounds and their uses
WO2015054474A1 (en) Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
CN101537001A (zh) 作为jak-stat3信号通路抑制剂的化合物的应用
JP2004507538A (ja) 二環式複素環化合物、これらの化合物を含む薬剤、それらの使用、及びその生成方法
WO2007139230A1 (ja) 7員環化合物並びにその製造法および医薬用途
JP5509070B2 (ja) 神経変性疾患の治療のためのアリールアミドピリミドン誘導体
CN108368060B (zh) 一类嘧啶类衍生物激酶抑制剂
JPWO2008136377A1 (ja) 二環式複素環化合物
WO2005063689A1 (ja) ベンズアミド誘導体