HRP20120827T1 - Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1 - Google Patents

Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1 Download PDF

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Publication number
HRP20120827T1
HRP20120827T1 HRP20120827AT HRP20120827T HRP20120827T1 HR P20120827 T1 HRP20120827 T1 HR P20120827T1 HR P20120827A T HRP20120827A T HR P20120827AT HR P20120827 T HRP20120827 T HR P20120827T HR P20120827 T1 HRP20120827 T1 HR P20120827T1
Authority
HR
Croatia
Prior art keywords
cys
cyclic peptide
arg
asp
ala
Prior art date
Application number
HRP20120827AT
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English (en)
Croatian (hr)
Inventor
Roland Jahns
Valérie JAHNS
Martin Lohse
Viacheslav Nikolaev
Original Assignee
Julius-Maximilians-Universität Würzburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julius-Maximilians-Universität Würzburg filed Critical Julius-Maximilians-Universität Würzburg
Publication of HRP20120827T1 publication Critical patent/HRP20120827T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
HRP20120827AT 2007-08-24 2008-08-22 Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1 HRP20120827T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07016637 2007-08-24
PCT/EP2008/006932 WO2009027063A2 (en) 2007-08-24 2008-08-22 MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING β1-ADRENOCEPTOR ANTIBODIES

Publications (1)

Publication Number Publication Date
HRP20120827T1 true HRP20120827T1 (hr) 2012-11-30

Family

ID=40130559

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120827AT HRP20120827T1 (hr) 2007-08-24 2008-08-22 Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1

Country Status (13)

Country Link
US (1) US9062095B2 (https=)
EP (3) EP2197900B9 (https=)
JP (3) JP5248610B2 (https=)
CN (2) CN101835793B (https=)
AU (1) AU2008291296B2 (https=)
CA (1) CA2697108C (https=)
DK (1) DK2197900T3 (https=)
ES (1) ES2391358T3 (https=)
HR (1) HRP20120827T1 (https=)
PL (1) PL2197900T3 (https=)
PT (1) PT2197900E (https=)
SI (1) SI2197900T1 (https=)
WO (1) WO2009027063A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101835793B (zh) * 2007-08-24 2014-04-23 乌利班-马克西姆利安大学 抑制β1-肾上腺素受体抗体的突变双环化受体肽
MX2011007882A (es) * 2009-01-27 2011-11-04 Univ Wuerzburg J Maximilians HOMOLOGOS-PEPTIDO NOVEDOSO PARA INHIBIR ANTICUERPOS ß1- ADRENOCEPTORES.
DE102010018878B4 (de) 2009-04-30 2013-09-26 Julius-Maximilians-Universität Würzburg Neue Zell-Linie zur Fluoreszenz-basierten Detektion von funktionell aktiven Antikörpern und Autoantikörpern gegen den Beta1-adrenergen Rezeptor
EP2402016A1 (en) * 2010-06-29 2012-01-04 Charité - Universitätsmedizin Berlin Aptamers that inhibit interaction between antibody and 1st or 2nd extracellular loop of human beta-1-adrenergic receptor
JP2014519329A (ja) 2011-06-10 2014-08-14 コリムン ゲーエムベーハー ヒトβ１−アドレノレセプター（β１−ＡＲ）に対する結合化合物および自己−抗β１−ＡＲ抗体の測定におけるその使用
MX356107B (es) 2012-02-16 2018-05-15 Atyr Pharma Inc Histidil-arnt sintetasas para tratar enfermedades autoinmunes e inflamatorias.
CN105378075B (zh) 2013-03-15 2022-04-05 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
JPWO2015022953A1 (ja) * 2013-08-14 2017-03-02 国立大学法人 長崎大学 血液脳関門障害改善剤
CN110536694A (zh) 2017-04-20 2019-12-03 Atyr 医药公司 用于治疗肺部炎症的组合物和方法
CN108218963B (zh) * 2018-01-19 2020-10-13 首都医科大学 一种环肽及其制备方法和用途
TW202100556A (zh) * 2019-03-14 2021-01-01 美商建南德克公司 使用her2 t細胞依賴性雙特異性抗體之治療
EP3715374A1 (en) 2019-03-23 2020-09-30 Ablevia biotech GmbH Compound for the sequestration of undesirable antibodies in a patient
US11986536B2 (en) 2019-03-23 2024-05-21 Ablevia Biotech Gmbh Compound for the sequestration of undesirable antibodies in a patient
IL301332A (en) * 2020-09-23 2023-05-01 Ablevia Biotech Gmbh Compound for the prevention or treatment of autoantibody-mediated conditions
CN112266330B (zh) * 2020-10-15 2023-02-24 长沙博源医疗科技有限公司 一种甲氧基肾上腺素衍生物、免疫原、抗甲氧基肾上腺素特异性抗体及其制备方法与应用
EP4392430A4 (en) 2021-08-27 2026-04-29 Univ Yale Molecular degraders of extracellular proteins
JP2023117892A (ja) * 2022-02-14 2023-08-24 公益財団法人 鷹揚郷 ヘプシジン結合ペプチド
CN120647762B (zh) * 2025-06-16 2026-01-23 首都医科大学附属北京友谊医院 一种抗β1-AR-ECII抗体及其应用

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US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
KR20020047177A (ko) * 1999-09-21 2002-06-21 아피나 이문테히닉 게엠베하 확장성 심근질환을 유발하는 자동항체를 제거하기 위한펩티드
CA2389524A1 (en) * 1999-11-05 2001-05-17 The Regents Of The University Of California Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
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JP4541490B2 (ja) * 2000-04-07 2010-09-08 株式会社カネカ 拡張型心筋症用吸着体
WO2001083693A2 (en) 2000-04-28 2001-11-08 Glaxo Group Limited Compounds having affinity for the vascular endothelial growth factor receptor-2 (vegfr-2) and associated uses
CN1988914A (zh) * 2001-08-23 2007-06-27 西兰制药公司 胞间通讯易化化合物的新医学用途
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WO2004069863A2 (en) * 2003-02-04 2004-08-19 New York University Constrained hiv v3 loop peptides as immunogens and receptor antagonists
EP1536020A1 (en) 2003-11-26 2005-06-01 Bayerische Julius-Maximilians-Universität Würzburg Means and methods for optical determination of cAMP in vitro and in vivo
EP1866335B1 (en) * 2005-03-31 2013-10-16 Julius-Maximilians-Universität Würzburg MEANS FOR THE INHIBITION OF ANTI- ß1-ADRENERGIC RECEPTOR ANTIBODIES
CN101835793B (zh) * 2007-08-24 2014-04-23 乌利班-马克西姆利安大学 抑制β1-肾上腺素受体抗体的突变双环化受体肽

Also Published As

Publication number Publication date
AU2008291296B2 (en) 2014-02-06
EP2559698B1 (en) 2014-11-12
JP2010536356A (ja) 2010-12-02
CN103992406A (zh) 2014-08-20
WO2009027063A3 (en) 2009-07-23
CA2697108A1 (en) 2009-03-05
CN101835793A (zh) 2010-09-15
ES2391358T3 (es) 2012-11-23
WO2009027063A2 (en) 2009-03-05
JP2013176369A (ja) 2013-09-09
CN101835793B (zh) 2014-04-23
EP2559698A3 (en) 2013-03-06
EP2559698A2 (en) 2013-02-20
EP2497777A2 (en) 2012-09-12
PL2197900T3 (pl) 2012-12-31
HK1176363A1 (en) 2013-07-26
EP2497777A3 (en) 2012-10-10
JP5248610B2 (ja) 2013-07-31
US9062095B2 (en) 2015-06-23
EP2197900A2 (en) 2010-06-23
JP2013138679A (ja) 2013-07-18
PT2197900E (pt) 2012-10-24
DK2197900T3 (da) 2012-10-22
CA2697108C (en) 2018-05-22
EP2197900B1 (en) 2012-08-01
AU2008291296A1 (en) 2009-03-05
EP2197900B9 (en) 2013-01-09
US20100209445A1 (en) 2010-08-19
SI2197900T1 (sl) 2012-11-30

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