JP2002539829A5 - - Google Patents
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- Publication number
- JP2002539829A5 JP2002539829A5 JP2000608747A JP2000608747A JP2002539829A5 JP 2002539829 A5 JP2002539829 A5 JP 2002539829A5 JP 2000608747 A JP2000608747 A JP 2000608747A JP 2000608747 A JP2000608747 A JP 2000608747A JP 2002539829 A5 JP2002539829 A5 JP 2002539829A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- arg
- replaced
- substituted
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 description 71
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 238000006467 substitution reaction Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 108091005804 Peptidases Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 241000406195 Nonala Species 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- XWIHRGFIPXWGEF-UHFFFAOYSA-N propafenone hydrochloride Chemical compound Cl.CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 XWIHRGFIPXWGEF-UHFFFAOYSA-N 0.000 description 2
- 230000017854 proteolysis Effects 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000012871 acute dyspnea Diseases 0.000 description 1
- 206010069351 acute lung injury Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12683999P | 1999-03-30 | 1999-03-30 | |
| US14007399P | 1999-06-21 | 1999-06-21 | |
| US60/140,073 | 1999-06-21 | ||
| US14707199P | 1999-08-04 | 1999-08-04 | |
| US60/147,071 | 1999-08-04 | ||
| US16052499P | 1999-10-20 | 1999-10-20 | |
| US60/160,524 | 1999-10-20 | ||
| US16066999P | 1999-10-21 | 1999-10-21 | |
| US60/160,669 | 1999-10-21 | ||
| US17274499P | 1999-12-20 | 1999-12-20 | |
| US60/172,744 | 1999-12-20 | ||
| US17818400P | 2000-01-26 | 2000-01-26 | |
| US60/178,184 | 2000-01-26 | ||
| US60/126,839 | 2000-02-18 | ||
| PCT/US2000/006418 WO2000058466A2 (en) | 1999-03-30 | 2000-03-20 | Protease resistant flint analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539829A JP2002539829A (ja) | 2002-11-26 |
| JP2002539829A5 true JP2002539829A5 (https=) | 2007-05-24 |
| JP4590504B2 JP4590504B2 (ja) | 2010-12-01 |
Family
ID=27568834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000608747A Expired - Fee Related JP4590504B2 (ja) | 1999-03-30 | 2000-03-20 | プロテアーゼ耐性ｆｌｉｎｔ類似体 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1165781B1 (https=) |
| JP (1) | JP4590504B2 (https=) |
| AT (1) | ATE371737T1 (https=) |
| AU (1) | AU3739500A (https=) |
| CA (1) | CA2368767C (https=) |
| DE (1) | DE60036199T2 (https=) |
| ES (1) | ES2291197T3 (https=) |
| WO (1) | WO2000058466A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7285267B2 (en) | 1997-01-14 | 2007-10-23 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6α & 6β |
| CA2277925A1 (en) | 1997-01-14 | 1998-07-16 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6.alpha. and 6.beta. |
| JP4303883B2 (ja) | 1997-09-18 | 2009-07-29 | ジェネンテック・インコーポレーテッド | ＤｃＲ３ポリペプチドというＴＮＦＲ相同体 |
| EP1165780A2 (en) * | 1999-03-30 | 2002-01-02 | Eli Lilly And Company | Flint polypeptide analogs |
| AU1189101A (en) * | 1999-10-20 | 2001-04-30 | Eli Lilly And Company | Therapeutic applications of flint polypeptides |
| WO2002060947A2 (en) * | 2001-02-01 | 2002-08-08 | Eli Lilly And Company | Glycoforms a fas ligand inhibitory protein analog |
| WO2002060949A2 (en) * | 2001-02-01 | 2002-08-08 | Eli Lilly And Company | Glycoforms a fas ligand inhibitory protein analog |
| EP1447093A1 (en) | 2003-02-14 | 2004-08-18 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibition of the CD95 ligand/receptor system for the treatment of neurological disorders and injuries |
| CA3112788A1 (en) * | 2018-09-05 | 2020-03-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Oncolytic virus platform to treat hematological cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2277925A1 (en) * | 1997-01-14 | 1998-07-16 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6.alpha. and 6.beta. |
| JP4303883B2 (ja) * | 1997-09-18 | 2009-07-29 | ジェネンテック・インコーポレーテッド | ＤｃＲ３ポリペプチドというＴＮＦＲ相同体 |
| AU3369199A (en) * | 1998-03-30 | 1999-10-18 | Eli Lilly And Company | Therapeutic applications of mature flint (mflint) polypeptides or opg3, a memberof the tnf receptor superfamily |
-
2000
- 2000-03-20 AU AU37395/00A patent/AU3739500A/en not_active Abandoned
- 2000-03-20 ES ES00916264T patent/ES2291197T3/es not_active Expired - Lifetime
- 2000-03-20 CA CA002368767A patent/CA2368767C/en not_active Expired - Fee Related
- 2000-03-20 WO PCT/US2000/006418 patent/WO2000058466A2/en not_active Ceased
- 2000-03-20 EP EP00916264A patent/EP1165781B1/en not_active Expired - Lifetime
- 2000-03-20 JP JP2000608747A patent/JP4590504B2/ja not_active Expired - Fee Related
- 2000-03-20 DE DE60036199T patent/DE60036199T2/de not_active Expired - Lifetime
- 2000-03-20 AT AT00916264T patent/ATE371737T1/de not_active IP Right Cessation
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